Gastrulation - Human Embryology - 3rd Week [Animated] - MedicoVisual

In this video, Dr. Aizaz from MedicoVisual explains the process of Gastrulation [Third week of Human Embryology] using 3D and 2D animations and memes.
00:00 Intro
01:40 Bilaminar germ disc
02:23 Epiblasts release Hyaluronic acid
03:12 Formation of Primitive streak and Primitive/Hensen's node
04:44 Role of Primitive streak in Axis determination
05:26 Role of Anterior Visceral Endoderm in inhibition of Primitive streak at cranial end
06:20 Why is Anterior Visceral Endoderm called "Anterior"
08:19 E-cadherin downregulation and epithelium to mesenchymal transition
09:17 What are Bottle cells or Flask cells and Mesenchymal cells
10:24 Formation Primitive Groove and Primitive Pit
12:54 Hypobasts are displaced to Yolk sac endoderm that induces formation of Blood islands
16:20 Sacrococcygeal Teratoma
18:02 Why Gastrulation is named so when there is no formation of GIT during this process
20:37 Review
Website: www.medicovisual.com
Email: [e-mail]

[@MedicoVisual]

At 05:52, there is a mistake. Hypoblast cells give important instructions to overlying *"Epiblast cells"* [Not Hypoblasts]

[@anwarulhaq535]

Good easily understandable presentation.it is very helpfull for first professional students

[@MedicoVisual]

@@anwarulhaq535 Thank you

[@ubairaaltaf1324]

How is left and right determined?

[@MedicoVisual]

@@ubairaaltaf1324 primitive strak is at the caudal side. Anything to the right of primitive streak is right sided and anything to its left is left sided. Simple as that.

[@ubairaaltaf1324]

@@MedicoVisual Dont we need to know where the face of embryo is pointing for determination of rt and left?

[@farazsaleem3417]

This is premium stuff ! Idk how content of this Quality is still free !

[@MedicoVisual]

Thanks a lot for such words of appreciation

[@alifazal414]

May god bless this man, infinite thanks!

[@pratikshyarijal1913]

I am a second year medical student. Embryology has always been tough for me because I couldn't imagine. We had studied about gastrulation in first year but my orientation was lacking. I came to this video after watching 3D tour of second week of development. I can't thank you enough. Now my orientation is clear. I could finally understand every bits and pieces. Thank you for this animation sir. Love from Nepal 🇳🇵

[@MedicoVisual]

Thank you so much for your appreciation

[@kesavnag9962]

We should thank you. U shouldn't thank us because u made it easy to understand and explained each and every question that I have..! Once again thank you🙏🙏🙏 bro 😘😘

[@MedicoVisual]

So nice of you. I am blessed to have such audience 😊

[@firdusarayasmin3245]

Never seen such amazing lectures on you tube. Don't know how to thank you. Skipped embryology in my first year but now watching you videos have made embryology easy for me.

[@MedicoVisual]

Wonderful! Thank you so much for appreciation.

[@waqasman3067]

Sir please tell me about area pellucida

[@ashiqhussain8919]

I am an associate professor of Anatomy and teach at medical school but on this channel I am a student, nothing more to say.

[@MedicoVisual]

I am honoured, professor. 🤗

[@dyjfrtujfdw]

that was the most sensed and perfect lecture of emberyology i ever had🤩🤩😍😍😍😍😍😍😍😍thanks a loooot

[@elahanoor7048]

The fact that you put blood island in actual form of island xD Thank you so so much for thesw amazing animations ! They are brain cell savers

[@mmott3432]

6:22 😂 That was unexpected and added to an already great show

[@shefanjahan3306]

Excellent content! Please don’t stop ever.

[@missionncert85]

Sir ur a life saver in mbbs first year ,i try to many platform like Marrow,prepladder but can't understand the concept, Thank u so much ,God bless u ,stay always happy ❤

[@misBugzHere]

Sir,this sequence of lectures,your way of explaining each nd every step is beyond the words "Thank You"...May Allah Almighty bless u with whatever you want(Amen).🤲🏼♥️

[@MedicoVisual]

So nice of you. Thank you so much for your appreciation.

[@kaavyadharsini7422]

Thankyou very much sir for making me visualize the concept.I will never forget it.

[@ahyaanmasrat1458]

Ur lecture r the best ones...thanku so much..

[@harmanpreetkaur4608]

I am first year med student and your lectures are really helping me a lot to understand the concepts.Thanku soo much!

[@vasanthipillay9812]

I love the way you teach. You have a good sense of humour. As well you can make a complex topic very simple and easy to understand. Only good teachers can do this. Thank you for this class :-)

[@manyaagrawal9964]

Great job of making a difficult thing to be explained in detail with so much ease.....

[@hamzaanees2811]

Jazakallah khair sir.! Thank you so so so much.

[@WalidAhmadAria-pg5nv]

What a great explanation😮😮😮❤❤❤

[@vishweshpatel1997]

another best video on the topic !!!

[@MedicoVisual]

Wow, thanks!

[@anwarsultana1776]

Very retainable and easily understandable lecturr

[@nithyasreeoruganty]

This 3D visualization and your explanation helps us a lot to understand embryology in a simple and easy way..Thankyou so much sir..

[@KailashSharma-sz9mh]

Sir I am amazed with deepens of the knowledge and animation

[@ellios5734]

I feel so lucky that I found such good video, very well explained thank you very much please keep making videos like this.

[@MedicoVisual]

I too am so lucky to have such nice audience who regularly motivate me to work harder on this project. Thank you so very much for this uplifting comment. You are most welcome.

[@sharika5019]

​​@@MedicoVisualyour lectures are awesome n a visual treat n understandably illustrated. Thank u!😊.keep making more medical lectures please

[@lavanyagoyal1525]

this is the best !! GREAT JOB!! pls make more videos of more and more topics.U will make mbbs so much easier!!

[@MedicoVisual]

I will try my best

[@anchalkharyal4158]

Thanks no words to explain your work 🙏

[@MedicoVisual]

My pleasure 😊

[@pseudodoctor2797]

Simply briliant. Keep growing bro. You are great.

[@MedicoVisual]

Thank you so much

[@sauravsinha1151]

I am a first year mbbs student Very much worried about how to approach Embryology but now you made it easy for me Thanks a lot sir ❤️❤️

[@mamunasharif3067]

Please sir continue your lectures...they are so helpful for university students

[@deepgaming1360]

Sir I can't thank you enough! , you are just amazing!!!...

[@MedicoVisual]

You are most welcome

[@medstudent7583]

Thank u so much , your videos are so helpful

[@MedicoVisual]

Most welcome! I am so glad that you like them.

[@muthuraj8901]

Good work buddy thank you 😊 🙏

[@BilalAli-se5uw]

Visual conceptualisation Logical Reasoning Rare Very Rare in embryology ❤

[@MedicoVisual]

Such a beautiful comment. Thanks

[@welcome_medico]

Thanks sir you aree doing great job.... thanks for explaining things so nicely.. earlier i was finding difficulty in understanding the embryology....in textbooks it is written in very confusing way... thankyou sir

[@RoquiaNaveed-uz4fd]

Amazing sir it's really very helpful for any student 👍

[@bublisoniyak6227]

Thank you so so much 😭❤️🙌

[@MedicoVisual]

You're so welcome!

[@WalidAhmadAria-pg5nv]

Awesome ❤❤❤

[@kamranwani396]

Sir I was facing alot of difficulties in this topic but after watching your video I understand everything and also all my doubts are clear now ,plzzz sir. Make videos of more chapters sir ,❤❤❤❤

[@elaishine395]

Super sir thaks very mach i have got a big help from the diagram

[@yusufkurdi3582]

I have questions is the primitive streak give information to create human body ?? Some people say primitive streak is responsible for creating human body (embryo) is that true ??

[@MedicoVisual]

Yes that's true

[@yusufkurdi3582]

@@MedicoVisual so the primitive streak is giving the full information for creating our eyes ears heart and everything else in our body ??

[@disconnectedaccount422]

i love youuuuuu sir thank you very much

[@user-bo9bp9fk5t]

I like when he get angry about the names😂

[@areebanadeem4988]

Best...best.....best.....best........you're BEST❤

[@DrMSSR_tips_tricks]

Op explaination ...need more

[@razerblue6677]

You presented and answered questions i didn't even think of! Amazing work! You earned a sub from me😄. Please keep up the AMAZING work! Love from Sri lanka 🇱🇰❤

[@futurezoologist9177]

It's amazing

[@maiklrock324]

Indeed 💙💙

[@maiklrock324]

Is the primitive streak give information to create human body ????

[@yusufkurdi3582]

Sorry for asking again but is the primitive streak give information to create our body or it just help ????? please I need the answer 💚

[@treverzuze6723]

Thank you medicoVisual , and I kindly have some questions Doctor, that I would like to ask.

[@MedicoVisual]

Sure. Please ask

[@yusufkurdi3582]

so primitive streak give informations to create human body (embryo) ????? I need the answer and I love the video ❤👍

[@houriak848]

Sir i have a question when the epiblast in periphery migrate goward the center ofc the adhesive junction gonna be broken so the cell can migrate when they reach primitive streak thy gonna establish another junctions so we need we break it down so they can migration down through the groove ?

[@MedicoVisual]

Yes, that's correct. Intercellular junctions are broken and the epithelial cells are converted to mesenchymal cells.

[@fatimahkadiku7368]

Thank u so much for this explanation. I'm literally watching and clapping. However, I would like to know where the splanchnic mesoderm came from because I used to think it was so e of the cells from the ectoderm layer that formed it.

[@MedicoVisual]

I sincerely apologize for the late reply. And thank you so much for your appreciation. The origin of extra-embryonic mesoderm (both splanchnopleuric and somatopleuric) is controversial. Most people believe that it arise from hypoblast cells. (specifically, yolk sac endoderm). While some say they arise from cytotrophoblast or from epiblast. There is some contribution from the epiblast as well. During gastrulation, some of the epiblast cells migrate laterally to contribute towards the extra-emrbyonic mesoderm. In summary, there is no definite answer to this question. But most common view is that they originate from "Yolk Sac Endoderm". Watch the video on Second Week part 2 to learn more: kzbin.info/www/bejne/boDOoWN8r7ydjqM

[@yousrabk1111]

hello can i ask a question please? what is the name of the app or site that you use for these presentations

[@MedicoVisual]

For 3D modeling and Animation; I use Blender. For 2D graphics and presentation; I use PowerPoint.

[@yusufkurdi3582]

Please brother its really important 🧠 is the primitive streak give information to create human body (embryo) ??

[@MedicoVisual]

Information for whole of the human being is in every cell starting from zygote (in the form of DNA). Epiblast forms the complete human. The primitive streak "guides" the epiblast in forming the three germ layers. So in a sense we can say that primitive streak contains the info to create human being.

[@yusufkurdi3582]

@@MedicoVisual thank you so much ❤ so the primitive streak has information to create human embryo rights ??

[@MedicoVisual]

@@yusufkurdi3582 yes

[@yusufkurdi3582]

@@MedicoVisual this question was so important to me thank you and I love the video by the way 💙👍great explanation

[@MedicoVisual]

@@yusufkurdi3582 always welcome. By the way, I am curious why is this question so important for you?

[@maiklrock324]

to be sure that the caudal eminence was the primitive streak / in goggle just write 👉 (the caudal eminence derived from the primitive streak)

[@aakashsahupoetry7373]

Thank you 😊 Sir can you suggest me best book for embryology mbbs. 1st proff

[@taashin2863]

Are the first blood cells that form in the yolk sack coming from epiblast or hypoblast origin? As I understand it’s coming from hypoblast so it’s not completely true that the epiblast gives rise to all types of cells in the embryo because some blood cells formed by hypoblast right ? Or am I wrong ?

[@MedicoVisual]

Blood cells develop neither from epiblast nor from hypoblast. They develop from the mesoderm.

[@taashin2863]

@@MedicoVisual Thank you very much for your answer doctor Do you mean the extra or the intra embryonic mesoderm ? And doesn’t that mean there are embryonic cells that doesn’t form by the epiblast ?

[@MedicoVisual]

@@taashin2863 you are always welcome :-) Most of the blood cells are derived from the IntraEmbryonic mesoderm.. However some early blood cells are derived from the blood islands that form within the extraembryonic mesoderm. The origin of extraembryonic mesoderm is controversial. Most people believe that it arise from hypoblast cells. (specifically, yolk sac endoderm). While some say they arise from cytotrophoblast or from epiblast. So if the hypoblast origin of extraembryonic mesoderm is true, then yes, early blood cells are NOT epiblastic in origin. Great question though

[@taashin2863]

Thank you very much Doctor I appreciate your help

[@MedicoVisual]

@@taashin2863 Always welcome 🙂

[@annettaannasheby5604]

Please teach development of head and neck

[@MedicoVisual]

A complete 3D course on Head and Neck Embryology is already available at MedicoVisual (www.medicovisual.com/courses/premium-head-and-neck-embryology-masterclass-excluding-development-of-teeth). Also check the free video from that course: kzbin.info/www/bejne/sJjZg2mMqrJ_odk Feel free to contact if you need any help in enrolling. Email: [e-mail]. WhatsApp [phone]

[@alisha7739]

Sir please make video on cvs embryology

[@MedicoVisual]

Thank you for the comment. CVS Embryology will be provided as a part of paid course. Details will be announced soon

[@goodbook6000]

Your videos are just amazing ....... I have.paused the video to do the comment .. How can i talk to you personally??

[@MedicoVisual]

Email: [e-mail] WhatsApp: [phone]

[@nainaalam9482]

please upload videos on cell biology topics ...

[@MedicoVisual]

Thanks for the feedback. I will work on it.

[@maiklrock324]

where the *** is anterior here?😂😂😂🤣🤣

[@maiklrock324]

and to be sure that coccyx (tailbone) was the caudal eminence / in goggle just write 👉 (the coccyx arises from the caudal eminence)

[@zalanibrahim5611]

is mesoderm and mesenchyme same ?

[@MedicoVisual]

There are two main type of embryonic cells: 1. Epithelial cells: that are structurally defined properly i.e. They have specific shape like Cuboidal, Columnar, Squamous etc. Furthermore, the epithelial cells are inter-connected with each other through cell-to-cell interactions. 2. Mesenchymal cells: On the other hand, are irregularly shaped and are not connected with each other. They are interspersed in a ground substance. The mesoderm is the major source of mesenchyme. That is why often in literature specially during teaching 3rd week, these terms are interchangeably used. But please note that mesenchyme can also arise from Neural Crest Cells. And sometimes by other layers.

[@zalanibrahim5611]

@@MedicoVisual Thank You for detailed answer ❤

[@MedicoVisual]

Always welcome

[@fimanekamatthias175]

"because it looks like a monster "😭

[@MedicoVisual]

What looks like a monster?

[@elwasad5710]

Conventions my friends conventions 😅

[@KRVERMA-pt7jt]

It feels illegal to watch it for free!!

[@MedicoVisual]

Thanks a lot for your kind appreciation. Feeling so grateful

[@shefanjahan3306]

So true!

[@maiklrock324]

In goggle just write 👉 (the coccyx is the remnant of caudal eminence) 🙂💚

[@maiklrock324]

Somany Muslims talked about this Islam miracle the primitive streak / but I just wanted to be sure that the primitive streak is involved of creating the human embryo 💙

[@user-ms5ei7jp1e]

I really like your videos and they are really helpful, but please please don't say bad words.

[@MedicoVisual]

What type of bad words?

[@user-lu1cj3pv5t]

🇮🇶 ❤️

[@vishalmaharajan6712]

man i love you😘😘 am not gay though😂😂😂

[@MedicoVisual]

Love u too (platonic love) 🤗😂

[@vishalmaharajan6712]

@@MedicoVisual 😂😂

[@maiklrock324]

prophet Muhammad he said: god created humans from (coccyx) tail bone / and science says this coccyx before it was (the caudal eminence) and this (caudal eminence) before it was (the primitive streak) 🧠🧠🧠

[@yusufkurdi3582]

I was gonna tell you why this question so important to me but you asked anyway / I can prove my claim on Google if you want just ask me anytime / thank you again you really helped me ❤💚

[@maiklrock324]

now I shared the reference of this hadith with you with proof on Google / good bye and good luck ❤👋