Gate Control Theory of Pain, Animation

How non-painful inputs close the gate to painful inputs, relieving pain. This video is available for instant download licensing here: www.alilamedicalmedia.com/-/g...
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Voice by : Marty Henne
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The gate control theory of pain states that the transmission of pain signals can be modulated at the spinal cord level, by non-painful inputs as well as descending signals from the brain. Non-painful inputs typically “close the gate” to painful inputs, reducing pain.
Pain sensation is mediated by pain receptors, or nociceptors, which are essentially nerve endings of first-order neurons in the pain pathway. The axons of these neurons form small-diameter nerve fibers of 2 types: “fast” fibers A-delta responsible for the initial sharp pain perceived at the time of injury, and “slow” C-fibers responsible for a dull, longer-lasting pain. First-order neurons travel by way of spinal nerves to the spinal cord, where they synapse with second-order neurons, which, together with third-order neurons, carry pain signals to the brain.
However, according to the gate theory of pain, perception of pain is not simply due to stimulation of nociceptors. There is a so-called “nerve gate” located in the dorsal horn of the spinal cord that controls the passage of pain signals to the brain. This nerve gate consists essentially of interneurons that inhibit second-order neurons, thereby stopping or reducing signal transmission.
When nociceptors are activated, they stimulate second-order neurons, and at the same time, inhibit the inhibitory interneurons, thus opening the gate, allowing transmission of pain signals.
Now, if the area is also stimulated by other, non-noxious stimuli, such as touch, pressure or changes of temperature; a different type of nerve fiber - large diameter A-beta, is activated, and this reactivates the inhibitory neurons, stopping the transmission of pain signals. This mechanism underlies the pain-relieving effect of skin rubbing, or heat or cold packs. It is also the basis of pain treatment procedures such as transcutaneous nerve stimulation, which delivers a small electrical current to activate non-nociceptive receptors in the skin.
The brain can also send signals to the spinal cord to modulate the pain gate. Examples of such signals are endorphins - morphine-like substances released by the brain in response to pain. In addition to lowering pain perception by the brain, endorphins reduce transmission of pain signals between the first- and second-order neurons by 2 mechanisms: preventing the release of a key neurotransmitter - substance P, and inhibiting action potentials in postsynaptic neurons. Production of endorphins may be induced by a number of factors including pleasurable activities, excitement, meditation, laughter, and vigorous exercise. Endorphins action underlies the pain-relieving effect of physical exercise, positive state of mind; and explains, for example, why athletes may not feel pain from an injury until the exciting game is over.

[@Alilamedicalmedia]

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[@ZakBellinger]

Very cool. I always thought the effect of an icepack reducing swelling removed the pain, but didn't fully comprehend how just removing the swelling diminished the pain. Thank you for explaining the real mechanism behind this!

[@Alilamedicalmedia]

That is also true, and it's a different mechanism - inflammation activates pain receptors, so reducing inflammation = reducing pain signals. That's why when there is inflammation/swelling, icepacks are used and not hot packs.

[@user-os4fs6rr2r]

Literally what my prof failed to teach me in 3 classes, was taught to me in less than 5 minutes, awesome! thanks!

[@yuhin4694]

Change college 😂😅

[@naveentotiger8011]

I wont get nice sleep until watching ur concepts....that relating to wt real world is... God bless u

[@Lili-cv1de]

Great video! Thank you 🫶🏻

[@timekiller8403]

I have no Idea why does not have Alila Media Million Subs yet

[@timsnow9168]

thank you sir. very good explanation.

[@sanity6241]

Fantastic, thank you!

[@pathfinder5190]

Amazing explanation!!

[@tbarkali9677]

That’s so great.. keep up sir

[@baronherford5324]

Great information

[@zainabmahuvawala5178]

thank you

[@mortadhaqasim959]

Amazing

[@mbbs_111]

You made my day !

[@mariamhossam5103]

Thanks 😊

[@user-py5re4xp2d]

Very nice explanation sir,tq very much

[@Alilamedicalmedia]

You're most welcome

[@abdokasem1320]

Thank u❤

[@monikawilliamson8369]

Dziękujemy.

[@Alilamedicalmedia]

Thanks for the Super Thanks!

[@allegro2us]

Thanks!

[@Alilamedicalmedia]

Welcome, and Thanks for the Super Thanks!

[@simoxk7797]

Very interesting 🧐

[@sybiletatsadjieu9996]

Thanks 👏🏽

[@dreamerRichness]

Sir amazing videos just I wanna how u make it such types awesome editing and animation in this video

[@Alilamedicalmedia]

We use Adobe Illustrator and After Effect. You can find all tutorials online!

[@dreamerRichness]

@@Alilamedicalmedia amazing work sir I really inspired

[@dannyhany2767]

how does physiotherapy manipulation inhibit pain

[@user-no4yy6uv1e]

Pain leads to sadness can sadness leads to physical pain instantly

[@philipk.5951]

Nociceptors are not pain receptors as pain is a perception, something that an individual experiences, not an input and is created first of all in the brain. Nociceptors do trnsport signals to the brain that can and cannot be interpreted as pain, due to mood, experience and many other factors that modulate pain experience

[@filipek7553]

Could be longer - with some key spots to stop the pain f.e.

[@asrarabdullah9280]

❤❤❤❤❤❤❤❤❤

[@sametmutluo]

Can you translate the things mentioned in the video into text and write them here? Please

[@avinashjoshi7152]

Yes please

[@hopeshineseternal]

Click the three dots and open transcript

[@AllSven]

Is this why dentists shake your cheek when they give injections?

[@flaminmongrel6955]

no

[@marvinoagare4853]

Obviously not

[@user-ii6wr8xx6m]

Thats distraction

[@HDAngCC]

Yes!

[@sweetiepie4328]

It's to loosen the muscle or Also your brain can't focus on two things at the same time. It may but it's work and not automatically done so messing with your cheek / getting injected... you are distracted by the touch and stinlmulating your cheek vs the the injection

[@LordDuckoo]

A delta passes stimulus at rates of 100 meters per second

[@JeniJoy369]

Yeah Yeah I'm sure you know it all

[@Th3BigBoy]

What was the purpose behind this aggressive comment?

[@JeniJoy369]

@Big Boy idk that was last year and I suffer from a lot of pain that nothing helps so was probably just being a cranky B

[@Th3BigBoy]

@Neko Man I see. Well, I certainly hope your pain goes away quickly. Try to pray to Jesus Christ perhaps he will grant you relief. It's worked for me when human doctors have failed. Anyway, be blessed.

[@maimoonkhan3612]

Amazing