Gene Structure Heterogeneity and Loop Extrusion Drive Transcriptional Noise in Human Cells

  Рет қаралды 1,276

Center for Physical Genomics and Engineering

Center for Physical Genomics and Engineering

11 ай бұрын

Nick Gilbert, PhD - Professor of Chromatin Biology, Medical Research Council Human Genetics Unit at the University of Edinburgh, Scotland, UK
Transcriptional noise, or heterogeneity, provides phenotypic variation within a cell population, but the molecular basis for this phenomenon is unclear. In this study we use computer simulations based on biophysical principles of genome organisation to simultaneously predict 3D structure and transcriptional output of human chromatin genome-wide. Exploration of this dataset shows that genes can adopt different 3D structures, while influential nodes within a locus control structural diversity and are linked to gene function. Furthermore, structural snapshots from within simulations show that transcription strongly correlates with the formation of protein-mediated microphase separated clusters of promoters and enhancers, and concomitantly transcriptional noise is determined by gene structure heterogeneity and loop extrusion.
The Monthly Seminar on Physical Genomics is a public lecture series sponsored by the Center for Physical Genomics at Northwestern University, the Robert H. Lurie Comprehensive Cancer Center, and NIH Grants T32GM142604 and U54CA268084. CPGE's (growing) archive of public seminars and talks can be found at:physicalgenomics.northwestern...

Пікірлер: 1
@EdT.-xt6yv
@EdT.-xt6yv 11 ай бұрын
4:00 7:00 structure 12:00 models
Physical Genomics Training Program Research Showcase
55:50
Center for Physical Genomics and Engineering
Рет қаралды 2,1 М.
Towards an Understanding of Chromatin Remodeler Function in Development at Single-Cell Resolution
51:40
Center for Physical Genomics and Engineering
Рет қаралды 171
Inside Out 2: Who is the strongest? Joy vs Envy vs Anger #shorts #animation
00:22
路飞太过分了,自己游泳。#海贼王#路飞
00:28
路飞与唐舞桐
Рет қаралды 38 МЛН
4. Molecular Genetics I
1:33:35
Stanford
Рет қаралды 2,2 МЛН
3D Chromatin Rewiring During Melanoma Phenotypic Transition - Pietro Berico
1:02:00
Center for Physical Genomics and Engineering
Рет қаралды 58
80 Year Olds Share Advice for Younger Self
12:22
Sprouht
Рет қаралды 1,7 МЛН
Lao Tzu - The Art of Not Trying
13:22
After Skool
Рет қаралды 548 М.
We Need to Rethink Exercise - The Workout Paradox
12:00
Kurzgesagt – In a Nutshell
Рет қаралды 6 МЛН
The moment we stopped understanding AI [AlexNet]
17:38
Welch Labs
Рет қаралды 859 М.
Animations of unseeable biology | Drew Berry | TED
9:09
TED
Рет қаралды 2,5 МЛН
Generative AI in a Nutshell - how to survive and thrive in the age of AI
17:57
But what is CRISPR-Cas9? An animated introduction to Gene Editing. #some2
10:02
Powerhouse of the Cell
Рет қаралды 316 М.
Klavye İle Trafik Işığını Yönetmek #shorts
0:18
Osman Kabadayı
Рет қаралды 8 МЛН
📱магазин техники в 2014 vs 2024
0:41
djetics
Рет қаралды 682 М.
Как бесплатно замутить iphone 15 pro max
0:59
ЖЕЛЕЗНЫЙ КОРОЛЬ
Рет қаралды 8 МЛН
Что делать если в телефон попала вода?
0:17
Лена Тропоцел
Рет қаралды 3,4 МЛН