Towards an Understanding of Chromatin Remodeler Function in Development at Single-Cell Resolution

David Gorkin, PhD - Assistant Professor of Biology, Emory University
Many chromatin regulators are essential for mammalian development, and mutations in chromatin regulators cause a variety of human developmental disorders. However, the developmental cell types and gene regulatory networks that rely on each chromatin regulator for their proper function are not well characterized. Together with collaborators at the Jackson Laboratory and UCSD, the Gorkin lab is leveraging mouse knockout lines lacking key epigenetic regulators linked to human disease in order to interrogate the effects of chromatin regulator loss during developmental at the molecular level, and with single-cell resolution. In this talk, Dr. Gorkin will give an update on the progress of this effort and look ahead to future opportunities and challenges.
The Monthly Seminar on Physical Genomics is a public lecture series sponsored by the Center for Physical Genomics at Northwestern University, the Robert H. Lurie Comprehensive Cancer Center, and NIH Grants T32GM142604 and U54CA268084. CPGE's (growing) archive of public seminars and talks can be found at: physicalgenomics.northwestern...