Genetics and Parkinson's disease | Nervous system diseases | NCLEX-RN | Khan Academy

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THIS VIDEO HELPED ME PASS MY FINALS

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I thought the most common mutations for PD were GBA mutations

[@DrMoHoops]

Approximately 15 percent of people with Parkinson disease have a family history of this disorder. Familial cases of Parkinson disease can be caused by mutations in the LRRK2, PARK2, PARK7, PINK1, or SNCA gene, or by alterations in genes that have not been identified. Mutations in some of these genes may also play a role in cases that appear to be sporadic (not inherited). Alterations in certain genes, including GBA and UCHL1, do not cause Parkinson disease but appear to modify the risk of developing the condition in some families. Variations in other genes that have not been identified probably also contribute to Parkinson disease risk. ghr.nlm.nih.gov/condition/parkinson-disease#genes