Genetics Terms

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My goal is to reduce educational disparities by making education FREE.
These videos help you score extra points on medical school exams (USMLE, COMLEX, etc.)
For educational purposes only; NOT medical or other advice.
Some videos contain mild profanity and hyperbole solely used to assist with memorization. Viewer discretion advised.
Opinions are entirely my own.

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[@ayham2000ify]

rip

[@johnkevin1104]

variable expressivity = 1 gene, different phenotype in 2 or more people pleiotropy = 1 gene, different phenotype in one person mnemonic: pleiotropy has 1 word, variable expressivity has 2 words

[@no1name17]

the hero we needed in quarantine

[@TJPetersongottalovelearning]

I legit went looking for this video last week and was like, "I bet Dirty has something on genetics!". You rock Dirty!

[@samirel-sawaf8744]

Thank you so much for these videos, I just became a patron! I'm taking STEP 1 in 2 weeks and I've literally written in time in my study schedule to review many of your videos, which have also helped me get through my classes this year! You're the best.

[@laurenpc880]

Dirty Medicine saves me every single time! Literally just finished a practice exam and went "well, I don't remember any of these terms", and then your video pops up!

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Made is so much easy in order to study for my biochemistry shelf exam. Thank you for making such easy videos where we can understand these concepts!

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[@halfricandoll8662]

Definitely donating, you’ve helped with Genetics AND Biochem, I can’t thank you enough

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I felt attacked by the first 20 seconds LOL. much needed vid!!

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you are the BEST!!! please please please do some more videos on immunology or inflammation next! thank you for everything you've gotten me so many poitns

[@Ray-qr7wt]

This is the BEST!! Thank you!!

[@Drmahmoudsam]

Great, Simple explanation. Well done man!

[@thewhitch85]

You are the best ! I am from Perú and I am not able to understand each word you say .You Explain excellent. Thanks !

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You’ve been truly missed Dirty!

[@ramyasmruthismruthi1623]

dr dirty!!! all ur videos are so awesome , i have my step 1 exam in 2 weeks , trying to watch all ur videos , i hope to post my pass status after 4 weeks ...... please dont stop posting the usmle content and could u please start with step 2 question bank videos too

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Just subscribed to the channel keep making the good stuff thanks

[@jasondenhaese693]

Another term that tripped me up (even though it seems obvious) was "Dominant Negative" mutation... It's synonymous with an autosomal dominant disease, but worded super weird (i.e. the dominant mutation leading to a negative, which is the disorder). Maybe this is just a COMLEX thing, but I'm pretty sure I saw it on NBMEs.

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thanks so much.. amazing video.

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Thank you!! You're the besttt

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Man u are amazing thank u a lot respect

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That’s true , I appreciate your spirit and thank you so much 🙏

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Outstanding teacher

[@rahmakamil1993]

Thank you , Teşekkür ederim , 감사합니다, شكراً ، спасибо

[@yaya-fv9eg]

Thank you very much for your wonderful explanation ❤️✨️🦋

[@joannaroy5270]

Thanks for the video. Could you please explain 'Loss of heterozygosity' and 'Dominant negative mutation'?

[@user-qs2ci1oi9m]

спасибо большое.thank you .

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Thank u so much dirty...u r a true savior✌🏼

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Life saver!🙌🏻

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Thank you!

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When are you coming out with your own anki deck?

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Thank you so muchhhh.. This is so helpful

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I can't see the patreon link or find an account in there :/ you said you have the link in the description.

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[@tane1038]

Honestly whenever I’m having trouble with a concept I rush to YT to see if there’s a dirty med video on it and when I do find it I sigh a sigh of relief lol 😂😂

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Awesome

[@Lucky-ff9pd]

Hi Can you do a video on saline and when to give what percentage?

[@monzilachowdhury6590]

Thank you so much :)

[@wicterwterr4245]

Very helpful

[@nehadharap700]

Hey! Please make a video on the newly updated genetics terms 😭

[@MsAldil]

Tysm

[@nurlandav6356]

👍👍👍

[@sejlaturnadzic5034]

Can you contrast locus heterogeneity with allelic heterogeneity? For some reason I always confuse these

[@HavenCross]

1 year later, did he ever do it? currently studying for step 1 lmao

[@sejlaturnadzic5034]

@@HavenCross na I’m post step 2 now 😂

[@nicolebrent9351]

Exam is in 6 days and I am sooo thankful

[@shawnli9284]

Can you make more genetics videos please

[@aryanspatel514]

can I bypass BNB vids and rely solely on dirty for genetics?

[@Be1smaht]

I like these terms they are very very easy points like so easy

[@minamelka860]

can anyone please help me how to differentiate Pleiotropy vs Variable expressivity...since both start out with the same 1 gene issue---> multiple expressity.....

[@DirtyMedicine]

Pleiotropy is the mere presence of greater than 1 symptom Variable Expressivity is more about the spectrum of SEVERITY Think of Pleiotropy as number of symptoms, whereas Expressivity is the severity of symptoms

[@yashsolanki6404]

Pleiotropy is same person and variable expressively is in different persons

[@karinawood1341]

My understanding is that in Pleiotropy one gene can have completely different phenotypes, but in Variable expressivity same gene can have varying severity. Both terms are not mutually exclusive. Gene A can have phenotype X and phenotype Y (Pleiotropy), and phenotype X can be really severe in one person and very mild in another (variable expressivity).

[@connormccarthy2650]

bro my exam is on friday ty sir

[@jacobdavis3225]

literally facepalmed when I saw the terms haha...then you bring up PTSD lolol

[@reemabdullah9877]

Increased severity OR decreased age onset. Minor correction. They dont have to both together. Thanks for the awesome videosss :DDDDD Greatly appreciate ur work.

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Loads of love for you dirty medicine

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非常棒

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0:55 I would if my mom would change my bank account into checking!

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Mosiacism is most important

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Quality medical education should be (mostly) free

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Thank you!