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In the late 1600s, a distinguished English polymath, Robert Hooke, and an eccentric Dutch cloth-merchant, Antonie van Leeuwenhoek, look into their hand-made microscopes. What they see introduces a radical concept that alters both biology and medicine forever. It is the fact that complex, living organisms are assemblages of tiny, self-contained, self-regulating units. Our organs, our physiology, ourselves are built from these compartments. Hooke christens them “cells.”
The discovery of cells enabled the birth of a new type of medicine: Genomic Medicine. A hip fracture, cardiac arrest, Alzheimer’s, AIDS, lung cancer - all could be re-conceived as the results of cells, or a cellular ecosystem, functioning abnormally. And all could be treated by therapeutic, gene-based manipulations of cells. This revolution in cell biology is still in progress: It represents one of the most significant advances in science and medicine. In this presentation, Dr. Siddhartha Mukherjee will provide an overview of the past, present and future of genomic medicines and discuss the societal and ethical obligations for global democratization of these potentially curative therapies.