GLP-1 Agonists for Weight Loss: A Side-by-Side Comparison

Which GLP-1 agonist is strongest? Let’s compare all the common GLP-1 agonists (Wegovy vs Ozempic vs Rybelsus vs Saxenda vs Victoza vs Trulicity vs Byetta vs Bydureon vs Adlyxin vs Tanzeum) for weight loss. Find out which option may be right for you!
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0:00 Intro
0:42 What are GLP-1 agonists?
2:53 Names, uses, and dosing comparisons
5:03 Side effect comparisons
6:36 Availability and cost comparisons
7:23 Weight loss comparisons
8:44 Summary
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Dr. Brian Yeung, ND: brianyeungnd.com/about/
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Medical: Dr. Brian Yeung, ND received his Doctor of Naturopathic Medicine degree from the Canadian College of Naturopathic Medicine in 2013. His use of “doctor” or “Dr.” in relation to himself solely refers to that degree. Dr. Yeung is currently a practicing Naturopathic Doctor with additional prescribing authority and IV therapy certification in Ontario. This video is for general informational purposes only. It should not be used to self-diagnose and it is not a substitute for a medical exam, cure, treatment, diagnosis, and prescription or recommendation. It does not create a doctor-patient relationship between Dr. Yeung and you. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. BrianYeungND and Dr. Brian Yeung, ND are not liable or responsible for any advice, course of treatment, diagnosis or any conclusions drawn, services or product you obtain through this video or site.

[@m.macdog5113]

Thankyou for all of this information. Great to see all of this in an easy comparison format. I have read the med journal report for ozempic and you are on point

[@gracecopeland4815]

Adylxin is being discontinued as of January 1, 2023. They had a wonderful savings program which was very helpful while my insurance refused to cover trulicity. We finally got them to go cover the trulicity so switching back to it. Thank you so much for this graphic. I did not lose a lot of weight on adlyxin and was on it almost a year. It DID help with my A1C and fasting insulin though!

[@GarrickPinon]

This was awesome 👏🏽

[@user-mu5wq1vm3z]

thanks for the clear explanation of the semiglutide drugs!

[@BeauCS]

Very very helpful

[@hudsonchalmers6504]

Very Helpful. My physician did not give me any warnings or info. It was learn as you go, which has been unpleasant. Had to switch from Trulicity to Ozempic as a shortage developed. Ozempic was not godd, more side effects. This month could not get Ozempic so had to get Trulicity. This is in South Africa

[@BigFred458]

I had to wait three weeks to get my first 3 pins of Ozempic (Summer, 2022) and this fall (2022) it took around a month to get my fourth pin of Ozempic. Mississippi USA

[@carolmartha8449]

This is a fantastic video compared to all other videos as an Indian doctor , this is educational

[@Share721]

Can you do a video on semaglutide vs tirzepatide

[@hazelnutcase357]

Why did they discontinue Bydureon? Now I am stuck with Byetta which is not as good. (Don't get 24/7 sugar control) All the other injections which "they" claim are the same made me feel bad and I go to the loo every hour or so day and night so I didn't get much sleep. If anyone from the company that produced Bydureon is reading, please research to make a better needle and bring the product back. (A Gilligan's Island needle was a small price to pay for feeling normal and sleeping through the night.) AND advertise when you bring back. If anyone has the same toileting issue (going every hour or so with urge) make your voice heard.

[@santarosadoc]

What about Mounjaro?

[@natashasd9003]

Thank you for your video, doctor! I am overweight and have type 2 diabetes. I was on Ozempic and lost 10 kg on 0.25 and 0.5 mg. My weight stalled at 1 mg. I developed somewhat unusual side effect - panic attacks and had to stop Ozempic. I was prescribed Mounjaro. No weight loss on 2.5 mg and again unusual side effect - numbness and tingling. I want to try Trulicity, but you mentioned that if you had bad side effect in one GLP-1 agonist you most likely would have it on another. Not sure what to do...

[@RavenWolfDrum69]

Intermittent fasting,low carb high protein diet EXERCISE. DONT TAKE EASY WAT OUT . DO NATURALLY.

[@nicki8732]

Am on Bydureon two weeks now And I’ve lost 10 lbs already . I’m full all the time I eat cause I know I have to . So I guess it’s working so far for weight lost for me .

[@noname0662]

Is it worth it ?

[@daphne201239]

​@noname0662 have got noticed extra hair loss? Just wondering because with calorie restrictions under 800 that's usually a side effect.

[@silversurfer8237]

Some doctors are willing to prescribe Ozempic on an off label basis for weight-loss. Are there any links you could share directing us on how to look for such doctors? Thank you.

[@user-wt1qb6os4b]

I recently just got prescribed Ozempic for weightloss because I have PCOS and losing weight is hard even with proper diet and exercise.

[@jessicaturnbull6628]

Do these use MRNA?

[@chookfeather]

I’m borderline Type 2 and insulin resistant with liver fibrosis and gall stones. I is h one of these could help me

[@MistyisCrafty]

I tried ozempic and could not tolerate it. Then tried Trulicity and have done very well for quite a while. It does seem like it's not as effective as it was before. I'm thinking of trying Mounjaro to see if it may help.

[@RC-SATX]

Would there be much of a difference if you switch from Rybelsus to Wegovy? I noticed you classified Rybelsus as a non-weight loss medication. Thank you in advance.

[@BrianYeungND]

Wegovy is likely stronger for weight loss due to its much higher bioavailable dose, and yes, Rybelsus is technically a medication for diabetes, not weight loss. Novo Nordisk is currently developing a weight loss version of Rybelsus.

[@RC-SATX]

@@BrianYeungND Thank you. I've been trying the oral version with very little results and kept wondering why?

[@kite6864]

@@RC-SATX there's going to be 25mg and 50mg versions of Rybelsus soon... they will probably be better at weight loss (just that much more compared to 14mg- can't imagine the side effects though)

[@RC-SATX]

@@kite6864Thank you for that piece of information. I'll keep an eye out for it.

[@sfiv1987]

​@BrianYeungND hi any updates on nova regarding the weight loss pill version?

[@nenadcubric2663]

No Jardiance?

[@aantix]

With the shortage of Wegovy, couldn't patients administer Rybelsus sublingually daily for effectively the same approximate dose?

[@BrianYeungND]

It would be the same medication, but dosing would be difficult to approximate due to one being injected and one being oral.

[@bfourney]

Or just order generic semaglutide

[@cornellkirk8946]

@@bfourney where from? Would this be like semaglutide IE once weekly injections

[@void________]

Should Contrave and Plenity be on this list?

[@BrianYeungND]

Those medications aren't GLP-1 agonists.

[@mimsicle1]

Showing a syringe at the beginning of this video and stating the large needle every day is misleading. It looks more like a pen and the needle is 4mm which just breaks the skin. A Naturalpathic doctor tends to be anti medication in the first place.

[@emmanueltorres5200]

Forgot mounjaro

[@billcrowell5096]

This is useful. I'm a T2D trying to get my glucose down with Low Carb/Keto and Intermittent Fasting. I have Paradoxical Hyperglycemia - my glucose stays > 100 despite the fact that I'm not eating any carbs. A GLP-1 agonist is better than taking insulin, but the question becomes which one? I have a family history of Thyroid cancer and I have low thyroid hormones needing supplementation. IMHO, GLP-1 should be used as part of a plan to reduce fat, improve health combined with low carb and not as a license to eat carbs and sugar.

[@joanie84h85]

Are they all injectables 😳

[@BrianYeungND]

At the moment yes, but very likely an oral version of ozempic for weight loss will hit the market in the future (currently under Rybelsus for diabetes).

[@hazelnutcase357]

Thin needle, you don't feel it and if you do a mosquito is much worse. New needles are good.

[@bfourney]

Yes, the most effective medications generally are

[@joanie84h85]

Afraid

[@hazelnutcase357]

Thin needle, you don't feel it and if you do a mosquito is much worse. New needles are good.

[@joanie84h85]

I’m already of needles yuck

[@hazelnutcase357]

Thin needle, you don't feel it and if you do a mosquito is much worse. New needles are good.

[@nicki8732]

I hate needles too, but it’s not that bad