Gluconeogenesis Pathway Made Simple - BIOCHEMISTERY

[@aizamd]

It is important to note that oxaloacetate cannot cross outside the mitochondrion. It has to be converted to Malate, which will be transported to the cytosol via Malate-Aspartate Shuttle. Malate (now in cytosol) is then converted back to oxaloacetate (because of high amount of NAD+ in the cytosol) allowing phosphoenolpyruvate kinase to catalyze it into phosphoenol pyruvate. 😊

[@AnkitaSingh-wh2qq]

Thnxx for the information ❤

[@dylanmuneku9291]

Thank you very much

[@Jelieto]

Ok I'm here to learn a bit about a low carb high fat diet and I have absolutely no idea what you're talking about 🤣

[@nathanhaigler8139]

Very clear description. Thank you

[@patiencechepkorir5596]

True Aiza....thumbs up 😌 for being keen

[@juststudies8341]

4:38 The enzyme used to convert Phosphonenolpyruvate to Pyruvate is Pyruvate Kinase not PFK1. It's written in biochem textbooks and can also be found online when you search for step 10 of glycolysis

[@osamaaldweik]

100%

[@HanSoloxcs]

Yeah..fuck this video.

[@madanmohanmishra7407]

Yes bro you are correct actually small mistakes by him during editing,and copy and paste mechanism

[@shaistamehdimehdi3038]

Yes

[@MegaFadzai]

you're right.

[@ALMLSAN]

Hexokinase also converts glucose to glucose 6 phosphate. Glucokinase does the same job but specifically in the liver. Thanks for the video 👍

[@Natasha_Mirza]

Glucokinase is 4th form of hexokinase. So you can also say it hexokinase.

[@yadinoori7372]

@@Natasha_Mirza yeah i was about to reply with that

[@queennoor6474]

Hexokinase is an enzyme that help glucose convert into fructose 6 phosphate

[@DrSultanV]

very helpful and simplifying, but please avoid mistakes such as the pfk mistake in the step 10 of glycolysis. this could be misleading for students who are having an exam. at least put a correction in the comments or the discription.

[@jadumonigogoi403]

no donations no corrections,correct ion can be done at glucokinase/hexokinase,phosphofructokinase/pyruvate kinase, malate/oxaloacetate shunt. huh.

[@allinone-ps3ou]

Sir I am watching your channel from last 1year I really love the way you share the topics to us,becouse you have been teaching us sir I have started my channel on KZbin just getting inspiring from you i started my channel last weak only,I really thank you a lot for making me inspire sir.

[@merlinjohn7381]

Channel name ?

[@aniketdas7803]

Very helpful. Explain the topic in a very crisp and profound manner. Thank you.

[@fajarqadeer5505]

Your channel makes my concepts always clear. This is really superb way to understand anyone.

[@aishwarya6362]

Found it on the last day of preparation. Helps a lot :)

[@HR_51_FBD]

Can you make me understand....in more simplified way..

[@punyaprasadini]

Thank you very much sir. ❤ from Sri Lanka

[@MEDSimplified]

Most welcome!

[@sariasultan5370]

wait the enzyme which converts PEP to pyruvate is pyruvate kinase not phophorfructokinase

[@hasithaliyanaarachchi3648]

u ar correct..its not PFK

[@alons222]

yes you are right!! terrible error!

[@MrPridizzle]

Saria Sultan good eye, good eye

[@mohanjr]

I saw it even me right now

[@DrSultanV]

I saw it and I rolled down to see an explanation and here you are lol

[@darkmaster1803]

I like your videos. They are short and easy but please don't make mistakes in enzymes or steps.

[@dr.baleeghwsaby8829]

ههههههههههههههههههههه صح

[@NagulanMusical19]

I think glucokinase which converts Glucose to Glucose 6 phosphate, only can be found in the Liver. Usually, Glycolysis can occur in all cells, so Hexokinase is the one that would replace glucokinase.

[@IshwariPetkar]

Thank you so much sir from Maharashtra

[@prashantbhandari7953]

4: 38 it is Pyruvate kinase not phosphofructokinase. BTW good 👍video.

[@pinakichall5462]

4:38

[@ayubabukarosman985]

From somalia thnks , for u lecture, it is very nice

[@aishuaish3763]

And also...the oxaloacetate inside the mitochondria is first converted to mate which is transferred to cytoplasm where it again become oxaloacetate

[@hellohari85]

Pyruvate-->Acetyl coA-->OAA-->Malate(crosses mitochondria) ---> PEP ( in the cytosol)

[@bethusilegamedze946]

Glucose is converted to G6P by enzyme Kinase and it's called the phosphorylation step(1st step) and ADP is converted to ATP as it is energy investment phase with the cofactor Mg2+

[@victorvk2506]

thanku so much. this video helped me to understand gluconeogenesis.

[@drmidhunjn]

Best explanation in short time every found in internet. Thanks for explaining once more about Glycolysis

[@rayaroy519]

You should also mention that Glucose to G6P is converted by Glucokinse/Hexokinase as Glucokinase is only present in hepatocytes and B-cells of pancreas.

[@rimshasaif6026]

Such a great videos...splendid.. May u get success in every field.. Plz do it on anothers topics of biochemitry.

[@laibahafeez592]

Please make a video on pentose phosphate pathway

[@TheMGPforlife]

Thankyou ! Great revision for my metabolism exam 😄

[@MEDSimplified]

+TheMGPforlife most welcome

[@devkumarrathva1580]

sir this video is helpful for mbbs ?

[@diptiranjanbiswal6277]

Itz. Amazing Lecture __100% understanding thnks to MedSimplified

[@sanjaykumarskr579]

Verithanam 🔥🌟

[@drdineshraja5335]

Great outline of this pathway sir👏👏

[@drumartinez1918]

man this stuff is like better than khan academy, very nice work

[@shehlamahr9621]

Thanks a lot sir...Its really very helpful.. 💖 JazakAllah JazakAllah 🙏

[@itsnourrr6699]

cute you are muslim

[@whatapainx5420]

The best explanation 👍🏻👍🏻👍🏻👍🏻👍🏻👍🏻👍🏻

[@faridalam798]

This is the best I have ever seen

[@nystagmus]

You should redo this video with the corrections because it really is very good on how your layout things so simply. It is excellent so I suggest you re- do the video with corrections.

[@MEDSimplified]

I took your advise to the heart brother. New videos on carbohydrate metabolism coming in a few weeks ok. 😉😉😉😉😉😉

[@nystagmus]

MEDSimplified thank you for teaching

[@Supra_green_505]

This video help me in my project 😊

[@saptashreegavali7363]

Thankyou soo much !!!!! U really help in understanding biochemistry easily 💛

[@vinniedolly716]

Dear Sir, your videos are excellent. Please make a video on glycogenolysis also.

[@ahmadayyash3032]

Thaaank you very much I like your videos so much Best wishes

[@rasikawade9852]

You explain in the simplest way possible..just one request please try to cover the portion in details

[@rashim.jbajaj]

Great explanation

[@saherali6662]

best channel ever

[@kaldanHamil]

Oxaloacetate is impermeable to mitochondrial membrane it is converted to malate and then transported to cytosol and oxaloacetate is regenerated by malate dehydrogenase enzyme

[@gouthamreddy3419]

TQ short and relavent for mbbs

[@jhanavijhanavi3958]

Wah!!! What explanation it easy to understand and write by own thanks alot sir ur explanation is superb 🙏

[@jagan2058]

very easy to understand the concepts and steps...pls add more topics

[@EasyMedEasyway]

Great work broda.👏👏😍

[@sayalisarode8686]

Your lec are best ... 👍👍

[@gulzareen3182]

Best teaching method 👍

[@chandakumari9299]

Made it clear , voice was good too ☺

[@nasreenkhan694]

Thanks it's very sufficient and helpful

[@mak8721]

I like your videos sir. These are helpful

[@jessicap713]

thank you for this!! saving me in my macro metabolism class!

[@victorwang3629]

7 minutes video worth more than my lecturer slides lmaooo

[@masalakshmidevi2810]

Thank u very much. It is a nice video . Try to make hmp shunt also.

[@athiraraj8854]

Please make a video on HMP shunt, your videos are just easy and good

[@aardishasah2949]

Thank you❤ so much 😊

[@abdulraimi766]

HELPED ME A LOT THANKS MAN!

[@shaktisingh2742]

Thnx dude got the notes for gluconeogenisis😉

[@divyabalani7382]

very useful video at last I got it thank u so much medsimplified...

[@srikantpanda7993]

NIce Explanation Thanks

[@Om_Parmar]

Please make the video on HMP shunt pathway!

[@aditiboro4123]

very nice. also glycerol part of fat and not fat is converted to glucose

[@spiceup4100]

Very Good 🙂

[@musikaaffection8570]

Thank you soo much sir 🥰✌️

[@sangitasharma4692]

4:55 pyruvate is directly converted to oxaloacetate or is first converted to acytyl coA then oxaloacetate as in krebs cycle

[@07akshayar46]

Your videos are super 👌nice. Put videos for Amino acid metabolism and lipid metabolism. Fast As soon as possible.

[@dr.baleeghwsaby8829]

انت مبدع شكرا جزيلا لك from yemen thanks

[@tejashreedurgi2935]

Superb sir thanks very much

[@Khatri54]

please make a video on cori cycle

[@aishuaish3763]

The third irreversible enzyme is pyruvate kinase

[@sohaibshah197]

4:15 hexose kinase change glucose to glucose 6 phosphate ❤

[@sandipchauhan6593]

Thank you sir 🙏

[@jordanc9100]

I was under the impression that gluconeogenesis could be classified as the creation of new glucose from non-carbohydrate sources - i.e., shuttling fructose into gluconeogenesis at the liver so it can be released to the rest of the peripheral organs as glucose.

[@ria555ria]

Enzyme that converts phosphoenol pyruvate to pyruvate is pyruvate kinase

[@k.rajkumar8650]

Please make video on Glyoxylate pathway

[@sarahjohny162]

Very helpful😊

[@syedwaqar-1944]

Nyc sir N ur voice is osmmm 👌👌👌👌

[@carakapawana]

After from mitochondria where the oxalo go?

[@chaitalichakraborty7023]

It really helped me

[@moka100original2]

Thank you.

[@drmanojgupta61]

It's Pyruvate Kinase which converts PEP to Pyruvate in glycolysis. By mistaken it was written Phosphofructokinase.

[@human2951]

Why did you not discuss Regulation of gluconeogenesis?

[@sakshidhepale9342]

Thanks a lot sir....🙏

[@thamisanqadeputy7695]

i was confused but after 7 minutes I now understand this process

[@fabiyiadeola2417]

thamisanqa deputy lmao what about the 04

[@mohammedalmutasim4630]

it,s very simplicity thank you

[@gouriiiiii]

I have a doubt. When glycerol is used as a substrate, gycerol-3-phosphate is formed and it gets converted to dihydroxy acetone phosphate for reverse reaction. Can't the glycerol-3-phosphate directly participate in the reverse reaction?

[@iliyasuharuna5906]

qn excellent work

[@Discovery_and_Change]

I was trying to learn about fat being burned through gluconeogenesis

[@shifanashifana35783]

Thank u so much sir....all ur videos are really awesome and i can understand well....can u please make a video on HMP shunt pathway ??

[@sayalisarode8686]

When phosphoenol pyruvate will convert to pyruvate enzyme should pyruvate kinase......you are saying phosphofructokinase So can you plzz guide what it should be sir...

[@seandiorsimapuka3714]

Phosphoenopyruvate is conveted to pyruvate by the enzyme Enolase not phosphofructokinase

[@farwaraza4893]

Make a video on glycogenesis plz 🙏🙏🙏🙏

[@dhoom2080]

this channel helped me ALOT , much thx for u

[@caleb6709]

How often and in what amounts does this process actually happen during fasting? I've hear of gluconeogenesis happening with amino acids, but I think fatty acids actually convert to ketone bodies, not glucose, during fasting that lasts more than 24-48 hours. I'm willing to be that this reversal of pyruvate back to glucose happens on a very small scale, or maybe a temporary emergency situation when glyocogen stores are extremely low. I'm also willing to bet that muscle tissue used for energy is low as well during a fast. It only makes sense that during fasting, the body is smart enough to utilize the stored fuel in adipose tissue as it's primary source.

[@caleb6709]

Also, when it comes to fatty acid metabolism; two glycerol backbones of triglycerides can form one glucose molecule. Perhaps this is what you mean't by fatty acids being converted into glucose. This form of gluconeogenesis happens on a small scale as well, but it does portent that dietary carbohydrate intake may be completely unnecessary.

[@SaadHussain199]

Sir very nice

[@avinashavi3465]

thank you

[@justbirjethings]

Can you upload glycogenesis, glycolysis, etc and hmp shunt?

[@MEDSimplified]

+Aishwarya Birje U can find the video on glycolysis but j our channel. Glycogenesis and hmp shunt will also be uploaded soon mam

[@justbirjethings]

MEDSimplified Glycogenolysis* 👅 my bad!

[@justbirjethings]

MEDSimplified and thanks!

[@ashishpandor1970]

MEDSimplified hmp shunt pathway ?

[@rohinirao7466]

Please upload protein metabolism..nucleic acid metabolism video...

[@ezrakorir3249]

Magnificent share I like your videos

[@sudharsanr4299]

Plss Upload video on pentose sugar pathway, nitrogen metabolism and nucleic acid metabolism it will be helpful for my exam

[@balwankaushik8666]

Please make more videos of biochemistry like on HMP shunt ,proteins metabolism , ketone bodies etc

[@tamsila7211]

Very helpful