Metabolism | Pentose Phosphate Pathway

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Ninja Nerds!
In this lecture Professor Zach Murphy will present on the pentose phosphate pathway. We discuss how glucose can use an alternative pathway to make NADPH's, which are essential in antioxidant reactions, cholesterol synthesis, and fatty acid synthesis. It's also important in the synthesis of nucleotides. We hope you enjoy this lecture and be sure to support us below!
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[@vjbele]

I got a 98 on my biochem exam because of this vid; keep doing what you're doing bro!

[@serva8334]

Tomorrow I will have mine

[@vjbele]

@@serva8334 good luck!

[@fejiroedeki9014]

I concur

[@nhattranminh2970]

congrats! I hope I can do it.

[@mudassarbutt7728]

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[@jonathanissa3123]

It is sad that I got more out of this video than in 3 lectures from my university professor. Some people really should not teach, thank you for being someone who is reliably good at teaching.

[@someguyontheinternet4277]

your med school split the pentose phosphate pathway into 3 lectures my med school put it in as a single slide in a different lecture

[@A-K.14]

same here

[@estherkhondowe62]

L

[@Nejiglenna]

It was barely mentioned at our medschool university (just randomly inbetween something else) and then it popped up multiple times on the exam where we were just supposed to memorize a random enzyme at a certain step etc. It is fair to say that the majority is up for credit test as the first midterm was just as bad. I wish they tested us in understanding rather than pointless memorization.

[@maheethpattem5262]

im sure after few years ninja nerd science is going to be one of the most effective medical videos on KZbin, the way you explain things we cant forget.

[@ogunyemisherif1638]

I am a Biochemistry student from Nigeria and I have benefitted stupendously from your videos. I can't for the life of me fathom how you developed these teaching skills. Thanks so much. Please do more.

[@bensmainebensmaine7635]

who would choose biochem as a major :"))))))

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​@@bensmainebensmaine7635Mind yo business.

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people who have mental issues like us​@@bensmainebensmaine7635

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May god bless you.. Never stop making videos.. Really love ur channel.. U saved my life 😭😭

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Don’t skip ads, or don’t skip the commercials, it’s they way also of earning money. At least we help them earn by not skipping the commercials, so they can make more videos in the future😍

[@emmamorgan6690]

I never comment on videos on KZbin but I have to just to say this guy is amazing. I was ready to quit my course after my metabolism lecture as it made me want to cry. I left my lecture halfway through and then the following day I found these videos, and not only did I understand it all, I actually really enjoyed it. Thank you so much!!!!

[@saroosh4193]

the same thing 💕

[@jessicagrover1359]

I missed 2 weeks of lecture due to illness and this video cleared everything up!! So wonderfully organized!! Thanks to everyone in the comments making the small corrections too. You are all saving my grade

[@learnenglishwithridwan]

A little note to take at 17:17 very important correction... it's unfortunate we can not draw diagrams in the comment section but I hope this piece helps out .. 😆😂😂 Ribulose 5-phosphate is first epimerized to xylulose 5-phosphate. Transketolase catalyzes the transfer of a two-carbon fragment from a ketose donor to an aldose acceptor .In its first appearance in the pentose phosphate pathway, transketolase transfers C-1 and C-2 of xylulose 5-phosphate to ribose 5-phosphate, forming the seven-carbon product sedoheptulose 7-phosphate . The remaining three-carbon fragment from xylulose is glyceraldehyde 3-phosphate.

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Ninger Ned, you got to pin this comment. 📍📍📍

[@aakasha2816]

I had the same doubt

[@omarghoonem6173]

أنا كنت لسي هكتب دا برضو ميرسي لكومنت حضرتك

[@lariss640]

Thankkk uuuuuu

[@abhijitsrichandan]

Can you explain same for trans aldolase

[@meme07770]

There’s no words can describe how much I’m grateful for you and your team ❤

[@akankshaatulkar7349]

Thank you.. god bless you for adding this series on KZbin.

[@GodfreyMann]

24:52 is where he explains the point of this pathway. Basically, there are two phases: (a) Oxidative Phase that can generate NADPH and Ribose-5-P. (b) Non-Oxidative Phase that makes Ribose-5-P without NADPH using glycolytic intermediates, and in reverse it can make glycolytic intermediates from Ribose-5-P. Note: Glyceraldehyde-3-P (GA3) in steps (5) & (7) can be funnelled into glycolysis or gluconeogenesis.

[@joymumo8173]

Thankyou for taking your time to make these videos,you have no idea how helpful they are.

[@LaChilena09]

love the way you teach it. makes SO much more sense and you're very clear and very calm when speaking and makes it so much easier to understand this. THANK YOU!

[@benediktatu4573]

You deserve to have millions of views! YOU ARE THE BEST! KEEP UP THE GOOD WORK! Thank you very much. I wish my professors were like you...

[@rjenchan]

I remember my book in Medicine called "HARPER'S BIOCHEMISTRY". LOVE YOUR SHIRT!

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your videos are exactly a masterpiece!!! the intonation is perfect and it's your art that you make the audience to company you through the lesson keep going please!

[@tazbibi6876]

I wanted to say thank you for the amazing video and teaching skills which you posses. I simply could NOT pass my biochemistry exam today. I had the shortest time ever to cover the topics and your videos helped me achieve the understanding in the best condensed and effect manner possible. Thank you to the Ninja Nerd Science/medicine. And to Zack Murphy. Thank you so much. You were a God send! God bless!

[@thebeets6055]

It's impossible to teach such concepts via 1 lecture. Your videos are incredible. Thank you

[@sandraschmelzer9961]

All your videos are so relevant as I study for my RDN exam. Thank you so much for putting all these together and explaining the details as well as the big picture.

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You cannot imagine how much grateful I am for finding your channel! You did a great job here!

[@fayyoosh7870]

Me too !

[@vladghies3002]

I am studying in first year in a medica school in Romania and these videos are really helping me to understand biochemistry:)) I am very grateful to the author of the videos

[@eliasali9383]

You and AK lectures are spectacular! Will do my best to support you bud, keep up the great work.

[@alchemist585a]

Great stuff! I am going thru ur biochem videos just for fun. I remember, as a student long ago, loving the maze of the various metabolic pathways. For each pathway, there three points that must be made and emphasized. 1. The key, rate-limiting enzymes/reactions. 2. The main purpose or role of the pathway. What primary purpose does it serve? 3. The net energy balance (yield or cost) You described the pathway and what it is good for beautifully.

[@maxruphio5515]

Just cant express in words how helpful your vedio are. They have helped me a lot in building concepts and then going into detail of each concept.

[@sheilamakena6253]

Love your videos, very informative! Theres a slight error i feel you made though; its the xylulose -5-phosphate that donates the two carbons NOT the ribose-5-phosphate. The xylulose-5-phosphate is the donor ketose and the ribose-5-phosphate is the acceptor aldose which becomes glyceraldehyde-3-phosphate.

[@NinjaNerdOfficial]

+Shiru Nugi yes you are correct sorry for that mistake!

[@emmaaynajar6023]

i have also confusion plzz..correct it ...show me some diagramtic view of this

[@ysmusujit]

Also product formed is sedoheptulose, not seduloheptose

[@wisdomappiah7409]

That's true Thanks for accepting your mistake💙💙💙💙

[@muscledeep]

@@ysmusujit 7Psedoheptulose to be precise

[@amyokazak9114]

Kudos to Professor Zach for consistently delivering top-notch educational content! The clear explanations and engaging presentation make learning complex topics a breeze. Keep up the fantastic work!

[@mol_biologist30]

Just a busy day of being a Ninjanerd🌟 Your lectures are truly life-saving !!

[@noursamy7163]

I’m new as a teacher, u make every single topic as so easy I’m really lucky to hear u. Best of luck

[@shibanithyagarajan7308]

this is amazing! This gave me a clear understanding of this pathway. God bless!

[@NinjaNerdOfficial]

+Shibani Thyaga rajan So happy the ninja nerd team could help you!

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@@NinjaNerdOfficial in italiano

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There're so many things this sucker is used for. Love it sir❤❤❤

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thank you for all your videos you have helped me more then any professor or TA ever will!

[@anabrundic2630]

best videos! u first saved me with your anatomy videos, now with biochemistry videos!!! thank you from the bottom of my heart!

[@user-js6to2jh6f]

Grateful is an understatement! Thank you for making these!!

[@alexessholt8202]

Saved my life and thousands of dollars of my tuition. Thank you prof!!

[@clover2196]

This is my first ever comment on KZbin...never felt the need to do it...but sir ! ..i am so thankful to you ...you are a gem of a person ...THANKYOU SO MUCH! ...thank you for making studying easier

[@myforever13]

Thank you for these videos, I still don't remember everything but, with these vids I start seeing some connections between the pathways that feel like maybe I understand

[@rohanpatil4142]

AMAAZING EXPLANATION!! thankyou so much for making biochemistry so interesting!!!

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Thank you sooooo much. Mr.Ninja. Im on the first year of medical school. This makes me want to learn more, makes me feel like it good to know, it is super cool to understand. You just light up my world. Promise will be a good doctor.

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This is some serious great job man. Much respect and a big thank you for this help seriously 👍👌

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You have made learning so easy and fun!!!

[@sahilratnakarmokashi6154]

Sir thank you for making it understand so clearly.

[@nareemanzangana2816]

I don't know how are you making these videos for free. Thank you sooo much Best video about this subject ever...

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well-constructed and simplified hours of lectures!

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I love this channel for making my MBBS life easy...its my dream to meet you Teacher❤️

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You are really saving my biochemistry grade!!

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2 years old video and it’s still saving lives! Thank you, that MUDr. in front of my name is partly gonna be there because of you ❤️❤️

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Having G6PD deficiency I am fascinated by your complete breakdown of what would happen in my body without the deficiency vs what is happening. Awesome video! Also, I get like...shamwow vibes or something from this...."then you get this, what can happen what does this give you!?" (feel like I'm gonna win the prize), but I think that's why you kept my attention so well-played sir!

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Thank you for making all these very helpful videos. They’ve been life saving for me

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Saving my life also,God bless you, Merry Christmas ninja bro

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Great! Wouldnt know what to do without all these videos

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I've an exam tomorrow and I dunno how I'm storing all this in my brain 😭

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U good now bro ?

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You are a truly great teacher.

[@majinbuu6382]

amazing...the teaching methods are so simple and easy to grasp...thank u so much

[@stefanieneufeld3017]

Love your videos! Just a tiny correction: Xylulose-5-Phosphate becomes GA3P and Ribose-5-Phosphate becomes Seduheptulose-7-Phosphate in the reaction catalysed by Transketolase.

[@jiro5523]

Finally..i was looking if anyone wrote this comment😄

[@Rubara3034]

Exactly thanks for noting this

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Dude love your videos, i study medicine in argentina but everything is so easy to understand that it doesn't matter being in english, awesome man , saved my year!

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Now I started to believe why ninjas are helpful to us , you are our ninja Hattori 😍...

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Zach, one day we'll meet and I'll tell to all of my Gratefullness.You Rock.

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Your videos sir they educate me more than any lecture 🙏🙏🙏 I really appreciate

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Thank you Ninja nerd for helping us all Med students...

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Thank you so much sir.your vedios are really very helpfull.The way you explain things is simply amazing ....once again thank you.😊

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Love your channel... When ever i have any queries related biochem i certainly look forward to your videos😃

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What a great explanation !!!keep up the great work

[@danielledamico1051]

literally saving my life

[@Girl_from_HillsUk01]

You cleared all my doubts. Thanks a lot for making such an informative video (From Uttrakhand, India)

[@natimintesnot8065]

as usual you really impressed not only us, the subject too!

[@tinacdkh]

You are AMAZING!!! SO grateful for your videos, and I agree with the others - I'm learning more from your videos than from my biochem class. So wrong... Thank you, thank you, THANK YOU!🤗

[@maianhnguyen8939]

thank you for making this video ^^ you've just saved me from this crazy pentose 5 phosphate pathway.

[@hadas8731]

Just wanted to tell you that the first time I tried to study biochimestrey for my exam I got 56..than I discovered your videos, study with them, took the exam again and got 100!!!!thank you so so much!youre a m a z i n g ! I still hate biochimestrey though lol...😋

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Ninja I owe you all of my education please keep going on

[@SadhuBiochemist]

Great pathway recitation!

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Honestly this has helped me so much

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This is so making me pass my biochem exam tomorrow morning... Thanks

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Thanks sir! You answered all my questions I had!

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your videos make metabolism look less overwhelming and more understandable. youre amazinggggggg thank u!!!!!!!!!!!!

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+supercalified that's awesome! I'm so happy that we were able to help!

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i love the way you explained

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Highly effective method of teaching

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it's was sooo perfect and sweet to learn, thank you so much and please keep on posting more 🙏🏻

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I'm a huge fan of Ninja Nerd Science Videos! They are the best!

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We love your support!!

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Ninja Nerd Science I hope I can support your work ( by God's will )even more soon! It's amazing!

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A lot of thanks for conceptual lectures May you live long

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This took my teacher 3 hours to explain and I still had no clue what he was talking about. Then Ninja Nerd comes and explains everything perfectly in 34 minutes 🥲

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love your video you always make things so easy keep it up

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finally i can write about HMP shunt in next coming exam....☺thank u so much sir

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This guy is so f*****g awesome. Besides, his accent is really cool..

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U rock nerd scientist, Ur videos are wow, please can u also do a video on uronic acid pathway and alot others.

[@P.Phalguni]

The best ever teacher in d universe.....lots of love zack❤