Metabolism | Pentose Phosphate Pathway

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Ninja Nerds!
In this lecture Professor Zach Murphy will present on the pentose phosphate pathway. We discuss how glucose can use an alternative pathway to make NADPH's, which are essential in antioxidant reactions, cholesterol synthesis, and fatty acid synthesis. It's also important in the synthesis of nucleotides. We hope you enjoy this lecture and be sure to support us below!
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#ninjanerd #PentosePhosphatePathway #Metabolism

[@vjbele]

I got a 98 on my biochem exam because of this vid; keep doing what you're doing bro!

[@serva8334]

Tomorrow I will have mine

[@vjbele]

@@serva8334 good luck!

[@fejiroedeki]

I concur

[@nhattranminh2970]

congrats! I hope I can do it.

[@mudassarbutt7728]

@@biasedjedi4353 l

[@jonathanissa3123]

It is sad that I got more out of this video than in 3 lectures from my university professor. Some people really should not teach, thank you for being someone who is reliably good at teaching.

[@someguyontheinternet4277]

your med school split the pentose phosphate pathway into 3 lectures my med school put it in as a single slide in a different lecture

[@A-K.14]

same here

[@estherkhondowe62]

L

[@Nejiglenna]

It was barely mentioned at our medschool university (just randomly inbetween something else) and then it popped up multiple times on the exam where we were just supposed to memorize a random enzyme at a certain step etc. It is fair to say that the majority is up for credit test as the first midterm was just as bad. I wish they tested us in understanding rather than pointless memorization.

[@ogunyemisherif1638]

I am a Biochemistry student from Nigeria and I have benefitted stupendously from your videos. I can't for the life of me fathom how you developed these teaching skills. Thanks so much. Please do more.

[@bensmainebensmaine7635]

who would choose biochem as a major :"))))))

[@obafemiomobosola190]

​@@bensmainebensmaine7635Mind yo business.

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people who have mental issues like us​@@bensmainebensmaine7635

[@odeleyeoluwafunmilayobolaj5843]

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[@emmamorgan6690]

I never comment on videos on KZbin but I have to just to say this guy is amazing. I was ready to quit my course after my metabolism lecture as it made me want to cry. I left my lecture halfway through and then the following day I found these videos, and not only did I understand it all, I actually really enjoyed it. Thank you so much!!!!

[@saroosh4193]

the same thing 💕

[@maheethpattem5262]

im sure after few years ninja nerd science is going to be one of the most effective medical videos on KZbin, the way you explain things we cant forget.

[@Crystal_._t.s]

U were right 😊

[@learnenglishwithridwan]

A little note to take at 17:17 very important correction... it's unfortunate we can not draw diagrams in the comment section but I hope this piece helps out .. 😆😂😂 Ribulose 5-phosphate is first epimerized to xylulose 5-phosphate. Transketolase catalyzes the transfer of a two-carbon fragment from a ketose donor to an aldose acceptor .In its first appearance in the pentose phosphate pathway, transketolase transfers C-1 and C-2 of xylulose 5-phosphate to ribose 5-phosphate, forming the seven-carbon product sedoheptulose 7-phosphate . The remaining three-carbon fragment from xylulose is glyceraldehyde 3-phosphate.

[@ridwansalifu6987]

Ninger Ned, you got to pin this comment. 📍📍📍

[@aakasha2816]

I had the same doubt

[@omarghoonem6173]

أنا كنت لسي هكتب دا برضو ميرسي لكومنت حضرتك

[@lariss640]

Thankkk uuuuuu

[@abhijitsrichandan]

Can you explain same for trans aldolase

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Don’t skip ads, or don’t skip the commercials, it’s they way also of earning money. At least we help them earn by not skipping the commercials, so they can make more videos in the future😍

[@meme07770]

There’s no words can describe how much I’m grateful for you and your team ❤

[@Panicpossum24]

I missed 2 weeks of lecture due to illness and this video cleared everything up!! So wonderfully organized!! Thanks to everyone in the comments making the small corrections too. You are all saving my grade

[@GodfreyMann]

24:52 is where he explains the point of this pathway. Basically, there are two phases: (a) Oxidative Phase that can generate NADPH and Ribose-5-P. (b) Non-Oxidative Phase that makes Ribose-5-P without NADPH using glycolytic intermediates, and in reverse it can make glycolytic intermediates from Ribose-5-P. Note: Glyceraldehyde-3-P (GA3) in steps (5) & (7) can be funnelled into glycolysis or gluconeogenesis.

[@dr.wafaaeyaid3283]

Thank you I am a Physician who diagnosed couple of patients with trasaldolase deficiency that was named after my name “Eyaid syndrome” . Your great video is the best one to explain the PPP Wish u the best

[@tariqjagmag]

Dr. Wafaa Eyaid does giving nac (n acetyl cysteine)help patients with transaldolase def?

[@vladghies3002]

I am studying in first year in a medica school in Romania and these videos are really helping me to understand biochemistry:)) I am very grateful to the author of the videos

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Ninja I owe you all of my education please keep going on

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The entire world is carried by people like this guy

[@clover2196]

This is my first ever comment on KZbin...never felt the need to do it...but sir ! ..i am so thankful to you ...you are a gem of a person ...THANKYOU SO MUCH! ...thank you for making studying easier

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You cannot imagine how much grateful I am for finding your channel! You did a great job here!

[@fayyoosh7870]

Me too !

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Thank you Ninja nerd for helping us all Med students...

[@noursamy7163]

I’m new as a teacher, u make every single topic as so easy I’m really lucky to hear u. Best of luck

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Thankyou for taking your time to make these videos,you have no idea how helpful they are.

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This took my teacher 3 hours to explain and I still had no clue what he was talking about. Then Ninja Nerd comes and explains everything perfectly in 34 minutes 🥲

[@its_Dr.Glass-Man]

There're so many things this sucker is used for. Love it sir❤❤❤

[@kuku4220]

Only needed 24 mins to understand this....kudos to uh harpers heroes

[@nareemanzangana2816]

I don't know how are you making these videos for free. Thank you sooo much Best video about this subject ever...

[@koftasam]

Waah ninja beta waah Kamal kr Diya tune .tum jio hazaro saal

[@sylviaani7991]

If biochemistry was a person it would have been you cause you really make biochem look easy😮 thank you so much prof

[@Rahul-jq3ko]

Now I started to believe why ninjas are helpful to us , you are our ninja Hattori 😍...

[@Theprofessionalsurgeon]

YESSSS IM SO HAPPY I FOUND THE VIDEO EVEN BEFORE I START THE VIDEO!!

[@thebeets6055]

It's impossible to teach such concepts via 1 lecture. Your videos are incredible. Thank you

[@rjenchan]

I remember my book in Medicine called "HARPER'S BIOCHEMISTRY". LOVE YOUR SHIRT!

[@amyokazak9114]

Kudos to Professor Zach for consistently delivering top-notch educational content! The clear explanations and engaging presentation make learning complex topics a breeze. Keep up the fantastic work!

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You deserve to have millions of views! YOU ARE THE BEST! KEEP UP THE GOOD WORK! Thank you very much. I wish my professors were like you...

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your videos are exactly a masterpiece!!! the intonation is perfect and it's your art that you make the audience to company you through the lesson keep going please!

[@tammyreed9735]

You do a great job! Thank you for the clarity. I'm a very visual learner and would appreciate at the end of your videos, if you could step away so the audience can see the entire board. Thank you again!

[@NinjaNerdOfficial]

Members of the ninjanerd.org website get full access to pre and post-lecture whiteboard resources, as well as the lecture notes! - TG

[@rickbaruah2216]

I got 96 in biochem special paper only because of you sir. Thank you so much for all the hard work that you do❤

[@kanijfatimamemoshi5602]

I love this channel for making my MBBS life easy...its my dream to meet you Teacher❤️

[@alexessholt8202]

Saved my life and thousands of dollars of my tuition. Thank you prof!!

[@christianmendoza3634]

thank you for all your videos you have helped me more then any professor or TA ever will!

[@anabrundic2630]

best videos! u first saved me with your anatomy videos, now with biochemistry videos!!! thank you from the bottom of my heart!

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This guy is so f*****g awesome. Besides, his accent is really cool..

[@wrxefx3931]

Having G6PD deficiency I am fascinated by your complete breakdown of what would happen in my body without the deficiency vs what is happening. Awesome video! Also, I get like...shamwow vibes or something from this...."then you get this, what can happen what does this give you!?" (feel like I'm gonna win the prize), but I think that's why you kept my attention so well-played sir!

[@assejyojtopilam]

your videos make metabolism look less overwhelming and more understandable. youre amazinggggggg thank u!!!!!!!!!!!!

[@NinjaNerdOfficial]

+supercalified that's awesome! I'm so happy that we were able to help!

[@hamnamalhi4721]

I've an exam tomorrow and I dunno how I'm storing all this in my brain 😭

[@ARHAYEMXD]

U good now bro ?

[@alchemist585a]

Great stuff! I am going thru ur biochem videos just for fun. I remember, as a student long ago, loving the maze of the various metabolic pathways. For each pathway, there three points that must be made and emphasized. 1. The key, rate-limiting enzymes/reactions. 2. The main purpose or role of the pathway. What primary purpose does it serve? 3. The net energy balance (yield or cost) You described the pathway and what it is good for beautifully.

[@shibanithyagarajan7308]

this is amazing! This gave me a clear understanding of this pathway. God bless!

[@NinjaNerdOfficial]

+Shibani Thyaga rajan So happy the ninja nerd team could help you!

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2 years old video and it’s still saving lives! Thank you, that MUDr. in front of my name is partly gonna be there because of you ❤️❤️

[@sandraschmelzer9961]

All your videos are so relevant as I study for my RDN exam. Thank you so much for putting all these together and explaining the details as well as the big picture.

[@P.Phalguni]

The best ever teacher in d universe.....lots of love zack❤

[@carolnawanyambe427]

This is so making me pass my biochem exam tomorrow morning... Thanks

[@Deejavu_life]

I got 25 in my physiology test by watching your videos (it was out of 30)thanks

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You are really saving my biochemistry grade!!

[@mol_biologist30]

Just a busy day of being a Ninjanerd🌟 Your lectures are truly life-saving !!

[@tazbibi6876]

I wanted to say thank you for the amazing video and teaching skills which you posses. I simply could NOT pass my biochemistry exam today. I had the shortest time ever to cover the topics and your videos helped me achieve the understanding in the best condensed and effect manner possible. Thank you to the Ninja Nerd Science/medicine. And to Zack Murphy. Thank you so much. You were a God send! God bless!

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Dude love your videos, i study medicine in argentina but everything is so easy to understand that it doesn't matter being in english, awesome man , saved my year!

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I really cannot appreciate you enough you're way too good buh ,Thank you prof.

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Great! Wouldnt know what to do without all these videos

[@theak3991]

thank you, I did not understand anything after watching my uni lecture, but now it makes perfect sense!

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great great great. Med school would be much harder without u

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You are a very great doctor , I have understood biochemistry very much even though I am an Arabic student I do understand you 🇾🇪💜💜💜🇾🇪

[@stefanieneufeld3017]

Love your videos! Just a tiny correction: Xylulose-5-Phosphate becomes GA3P and Ribose-5-Phosphate becomes Seduheptulose-7-Phosphate in the reaction catalysed by Transketolase.

[@jiro5523]

Finally..i was looking if anyone wrote this comment😄

[@Rubara3034]

Exactly thanks for noting this

[@Maddie-u4g]

Grateful is an understatement! Thank you for making these!!

[@zekzimbappe5311]

I have my biochem lessons in french and im here watching this since its similair Hope i get more than 50% in the exam the day after tommorow PS: i like how i get recommended only the videos about the lessons i find hard and in right order well played KZbin rly well played

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Thank you for making all these very helpful videos. They’ve been life saving for me

[@akankshaatulkar7349]

Thank you.. god bless you for adding this series on KZbin.

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Thanks dr.zach for your effort , hope you get the fruits of it ❤

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You cleared all my doubts. Thanks a lot for making such an informative video (From Uttrakhand, India)

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wow, the skill to memorize and explain the subject in these videos is awesome :O

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Thank you sooooo much. Mr.Ninja. Im on the first year of medical school. This makes me want to learn more, makes me feel like it good to know, it is super cool to understand. You just light up my world. Promise will be a good doctor.

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Just cant express in words how helpful your vedio are. They have helped me a lot in building concepts and then going into detail of each concept.

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Watching to gain more understanding and prepare for my exam on Wednesday! Thank you!!

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AMAAZING EXPLANATION!! thankyou so much for making biochemistry so interesting!!!

[@MusicInsteadOfLife]

In my biochemistry book the reactions are kinda different; After ribulose-5-P becomes Xilulose-5-P + Ribose-5-P then i have these reactions: >Xilulose-5-P reacts with the transketolase enzyme and TPP as a kofactor and gives -> glyceraldehyde-3-P + Glycoaldehyde radical. >Then Ribose-5-P reacts with the glyceraldehyde radical and gives-> sedoheptulose-7-P >Sedoheptulose-7-P reacts with the glyceraldehyde-3-P [transaldose enzyme] and gives-> eritroso-4-P + fructose-6-P. I don’t know why though...

[@aaliamustafa1509]

Yeah, ofcourse it is great, I mean zach is teaching us🤩🤩🤩🤩 He is on next level

[@emmanuelkai2967]

Thanks Ninja Nerd you have made my learning easier you are the best💪💪teacher in this earth as per my view

[@yalcntimuray5020]

it helped so much. i had a bias towards biochem before this video. thanks from Turkey

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You're such a talented lecturer

[@eliasali9383]

You and AK lectures are spectacular! Will do my best to support you bud, keep up the great work.

[@sheilamakena6253]

Love your videos, very informative! Theres a slight error i feel you made though; its the xylulose -5-phosphate that donates the two carbons NOT the ribose-5-phosphate. The xylulose-5-phosphate is the donor ketose and the ribose-5-phosphate is the acceptor aldose which becomes glyceraldehyde-3-phosphate.

[@NinjaNerdOfficial]

+Shiru Nugi yes you are correct sorry for that mistake!

[@emmaaynajar6023]

i have also confusion plzz..correct it ...show me some diagramtic view of this

[@ysmusujit]

Also product formed is sedoheptulose, not seduloheptose

[@wisdomappiah7409]

That's true Thanks for accepting your mistake💙💙💙💙

[@muscledeep]

@@ysmusujit 7Psedoheptulose to be precise

[@Killer-queen21981]

Dude honestly you're my hero God bless you 😭💗

[@sahilratnakarmokashi6154]

Sir thank you for making it understand so clearly.

[@rizwanilyas4289]

Highly effective method of teaching

[@jeelol1355]

Zach, one day we'll meet and I'll tell to all of my Gratefullness.You Rock.

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He is saving my grade what is this guy’s name he is the best!

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You are doing a great work! I have my biochemistry exam in 3 hours, your videos are of huge help right now. The way you explain it helps me connect information and remember easily. Thank you

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You are blessing us with your videos sir, i literally had no idea to learn biochemistry, thank you lotsssss

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You're always the best. My ninja nerd . please! Keep on making more videos. Congratulations

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You are the best of bests doctor I have ever seen

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If I get high mark from biochemistry tomorrow, it will be with your help. Thank you for understandable videos!

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did you get that high mark?

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Gunel Aslanova did you get

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@@rayaneb5186 he died

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Gunel Aslanova Rest In Peace.

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LOL

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I'm a huge fan of Ninja Nerd Science Videos! They are the best!

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We love your support!!

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Ninja Nerd Science I hope I can support your work ( by God's will )even more soon! It's amazing!

[@alimkhan7349]

A lot of thanks for conceptual lectures May you live long

[@LaChilena09]

love the way you teach it. makes SO much more sense and you're very clear and very calm when speaking and makes it so much easier to understand this. THANK YOU!

[@ramadhanoruch8463]

Fantastic young scientist. Congratulations.

[@stelamwaka9471]

Anyone listening to this remember xylulose 5 phosphate is the one giving 2 carbons to ribose 5 phosphate to form sedoheptulose 7 phosphate leaving it as glyceraldehyde 3 phosphate 😊✌

[@fmbahmed5576]

well-constructed and simplified hours of lectures!

[@GeorgeC-to9dh]

So much clearer than uni

[@mathewsmwale3837]

Your videos sir they educate me more than any lecture 🙏🙏🙏 I really appreciate

[@medusafreakyaw]

glad i found you since i got exam tomorrow and i've got no idea about this processes. thanks!!!

[@NinjaNerdOfficial]

+medusafreakyaw i'm so happy that we were able to help you! Best of luck on your exam!

[@sudhanshumagade2641]

You are saving my medical career

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You have made learning so easy and fun!!!