Glucosamine and Metabolic Health: What You Need to Know

Glucosamine and Metabolic Health: What You Need to Know | Dr. Ben Bikman

Рет қаралды 27,806

Күн бұрын

Пікірлер: 110

@larrylmatthews4211 2 ай бұрын

Just a couple of comments . I started taking glucosamine and chondroitin in the 80s as a preventative measure. I had a couple of friends that swore by the benefits. I had no issues and was skeptical (I still am). But I am 73 years old and never had a join pain or even discomfort. Being a retired research engineer, I still am not sure that the supplement should get the credit. But I won’t stop now! As an aside, my HOMA- IR is 1.2, insulin is 4, uric acid is always below 4. Maybe I am just lucky. I watch all of your content as well as Drs Johnson and Lustig. Thanks

@jenswalks 2 ай бұрын

I have medical evidence that for me, at least, glucosamine most definitely works. In my early thirties I started getting pins-and-needles in the fingers of my left hand. At first I didn't worry but after three weeks of non-stop pins-and-needles, I finally went to my doctor. Her diagnosis was that the cartilaginous disk between two of the vertebrae in my neck was wearing away. This meant that a major nerve running through my spine and down my arm was being rubbed a bit by bone. This was causing minor damage to the nerve, manifesting in the pins-and-needles in my fingers. She said that over time, as the disk continued to wear away the pins-and-needles sensation would increase and become painful and that when the pain got to a point where I could bear it no longer, I would have to go into hospital to have the two vertebrae in question fused together. Needless to say I was aghast and asked if there was any way to determine whether this was indeed happening. She said yes, and sent me for a CT scan of my neck. Sure enough, on a wear-scale of 1-3 with 1 being minor deterioration, 2 being medium and 3 being severe, my disk scored a 2. I appealed to my doctor for anything I could do to avoid this operation and she said that some people found glucosamine effective. She warned me that it didn't work for everyone but that if it was going to work at all it would be at least 8 weeks before I'd notice any difference. I immediately started taking glucosamine and almost 8 weeks to the day, my pins-and-needles stopped. I continued to take the glucosamine for a full year and during that time the problem never returned. However I was curious. I went to my doctor and asked whether there would be any evidence that my disk had been repaired. She thought it was worth checking and so sent me for another CT scan. This time the scan showed my disk as being completely normal, with no sign of any deterioration whatever. Thinking I was cured, I stopped taking the glucosamine. Two months later the pins-and-needles started again. I went back to taking it and have been doing so for the last 38 years. During that period there was one time when the pins-and-needles returned. It was after I'd started mixing the powder into my morning bowl of hot porridge. I did a Google search and discovered that the efficacy of glucosamine is destroyed by heat. I went back to mixing it with a cold drink and once again defeated the pins-and-needles. My daily dose was always small - about 1/4 of a teaspoon but last year (in which I was turning 69) the pins-and-needles returned. Assuming that my ageing body now required a larger dose, I upped the glucosamine to 1/2 a teaspoon per day. That did the trick, so I'm now on half a teaspoon of glucosamine a day. Recently I had the opportunity to try out a CGM and did so for 10 days. I've been a carnivore for that last two and a half years, so wasn't expecting my blood glucose to be high and it wasn't. However I was interested in seeing how it would respond when I took the glucosamine. These days I take it dissolved in the juice of half a lemon (yes I know lemon juice isn't carnivore but it's the only plant material apart from cups of tea, that I consume). I always take my glucosamine & lemon juice with a meaty meal and I was interested to see that it made no particular difference at all. My blood glucose rose slightly with all my meals but the meal with glucosamine made little to no difference. Here's something else of interest. I went through menopause in my early thirties and dexa scans back then showed I had osteopenia. I did a year of Fosamax and HRT which helped but I stopped them after that. However, in the subsequent years my bones continued to slowly improve. I'm now close to 70 and the dexa scans show that my bone density is in the normal range for my age group. I suspect all those years on glucosamine might have something to do with that. For me, glucosamine has been a marvellous, somewhat magical substance that has prevented years of pain and operations on my spine. (I'm also completely fine in all my other joints.)

@jodihartsfield 2 ай бұрын

Thank you for taking the time to write this. I have similar symptoms, and will now be trying this. THANK YOU!! 🤗

@jenswalks 2 ай бұрын

@@jodihartsfield You're welcome. Hope your result will be as satisfactory as mine was. :-)

@ladybird169 2 ай бұрын

Thank you very much for your time!

@lindabirmingham603 2 ай бұрын

Thanks for sharing with such detail! I had similar issues with my neck as well as fibromyalgia for decades. Carnivore healed my neck as well as my other chronic pain. Oxalates were a large part of the problem as I ate a lot of high oxalate nuts, spinach, black tea, whole wheat bread, and dark chocolate. I also drink lemon juice as it helps bind and clear the oxalates.

@Shadow-bs1iu 2 ай бұрын

Thanks very much for this detailed reply. I’m looking to start taking glucosamine for my painful knee that has been worn slightly due to patellar maltracking

@nickjiang2645 2 ай бұрын

I have diabetes for more than 7 years. After 9 months of keto diet this year, my A1C is normal. TG/HDL is very low indicating less insulin resistance. During holiday I tried some unketo foods, my fasting glucose increased to very high levels. I have taken glucosamine for about 10 years. Based on this lecture, I think I need to try with different approach for my knee problems. Always appreciate doctor’s lectures and podcasts.

@silviahayakawa6655 2 ай бұрын

What about MSM? That helps my joints.

@tinajames2940 2 ай бұрын

I would listen to you teach any subject. You are so very easy to listen to and learn from. Thank you!

@drhanafayyad4347 2 ай бұрын

Absolutely; I rejoice when finding a new lecture by Dr Bikman that can enlighten my brain n raise my spirits😅

@smthB4 2 ай бұрын

Apologies for stupidity - how do I get the paper references?

@Dr-Agonfly 2 ай бұрын

Thank you yet again for your attention and insights. Primary care physician in the Seattle area here. I’ve been intermittent fasting for 2 years now (eating two meals 2-8p, minimal snacking, emphasizing protein and fat, reducing simple carbs). Lost 32 pounds. But more importantly for this discussion, the arthralgia in my knees is completely gone. My guess is any autophagy happening during my fasting is “eating up” the junk in my knee joints. I tried increasing my protein intake by taking a bolus of 20g around 11a. Knee pain returned. Curious. And I no longer need to take glucosamine, which helped me in the past. Metabolic health for the win.

@angieobes9835 2 ай бұрын

When I went off grains and veg, any pain in joints went away. So is it the fasting, of which I only do standard overnight (12 -14hr), or getting the anti nutrients out (tannins, oxalates, phytates etc)? It's an interesting thing.

@deepost2604 2 ай бұрын

My glucose level has been running in the prediabetic range in recent months. Age 82, and my doc tells me to keep on with low carb. I was going to start glucosamine, but decided against it after listening to this segment. I’m doing everything I can to restore cartilage and certainly don’t need anything that is going increase insulin resistance.

@happynjoyousnfree 2 ай бұрын

What are you doing to restore cartilage? I'm 62 but have osteoarthritis originally diagnosed when I was 25.

@deepost2604 2 ай бұрын

@@happynjoyousnfree I buy a rotisserie chicken, strip the meat off, and boil the bones with Apple cider vinegar. This produces bone broth that is a gelatin. I favor this because I know it is loaded with collagen. Then I add the cooked chicken and various veggies to that broth to make soups. I drink a shake that has collagen and whey in it. D3+K is important to get the bones to absorb the collagen. I’m doing some resistance with weights…simple stuff like walking with dumbbells in my hands. I have a vibration plate and do 3 sessions per day for 10 minutes each at 30hz. Beyond that I do infrared sessions with a light panel that is supposed to penetrate to the level of the bones. Downside….Bone improvement is very SLOW. I’ve been doing all this for a year but my doc says another Dexa scan is not useful prior to the 2 year recommendations. The sense is WORKING BLIND…Even when I get another Dexa, they are notoriously unreliable. So, I continue to work at this figuring if I avoid fractures, it’s indicative of success….Age 82

@jolantamsk3894 2 ай бұрын

@@deepost2604 Thank you for sharing!

@philipmarx1819 2 ай бұрын

If you want to reduce your blood glucose levels, try a little resistance training. It’s made a big difference for my wife.

@deepost2604 2 ай бұрын

@@philipmarx1819 Yes, I am doing resistance training as well. Usually more reps with lighter weights. 10 reps with 10 pounds=100 and a 40 pound bag of garden soil is about my legal limit!

@JillCao 2 ай бұрын

On glucosamine raising fasting glucose, sharing my one data point: my fasting glucose went from 79 to 89 after taking Schiff’s Movefree (glucosamine hydrochloride) for five months due to injury. I have a family history of diabetes on both sides. On low carb (80-70g per day) for three years. Resistance trains 3-4 days week. HIIT once a week. Averaging 12k steps a day. Latest A1C is 5.4. A1C was borderline prediabetic before low carb.

@LowCarbLowDrama 2 ай бұрын

For nearly a decade, I took substantial doses of glucosamine for my knee joints on my doctor's advice. However, pre-post imaging showed that I had lost cartilage in both knees during that time, gained weight, became hypertensive and diabetic, and the pain only worsened. By going low-carb keto carnivore 5 years ago, knee pain vanished.

@wadesimpson-e8p 2 ай бұрын

Would be so good if you can link studies

@StangspringDK 2 ай бұрын

@@wadesimpson-e8p Google is your friend. You could google: pubmed glucosamine blood glucose Also, look into the research by Richard Johnson on fructose and uric acid. KZbin tends to remove comments that includes links.

@StangspringDK 2 ай бұрын

pmc.ncbi.nlm.nih.gov/articles/PMC6190977 pmc.ncbi.nlm.nih.gov/articles/PMC5532800/ pmc.ncbi.nlm.nih.gov/articles/PMC3197219/

@jdxx59 2 ай бұрын

@@wadesimpson-e8pstudies? They are describing their personal experience.

@hikingmom.d 2 ай бұрын

Being an avid hiker, I used to take move free every day for years, thinking it did me well, however, the last few years before I went carnivore, it didn't seem to work as well...the hip and si joint pain came back. After I went carnivore/ketovore, I quit my $20+ monthly habit and haven't needed it. The grains caused the inflammation that kept my joints inflammed.

@fannyalbi9040 2 ай бұрын

grains drain minerals. lack minerals cause discomfort

@fiddlerJohn 2 ай бұрын

I love these lectures. I'm learning. Thank you.

@fiddlerJohn 2 ай бұрын

" More knowledge Better Health."

@fronniebealer7808 2 ай бұрын

I am so glad this topic came up. I never got the benefit that many swore they did. I quit years ago. Now I know for me, there is nothing good about it

@timguinn5376 2 ай бұрын

Works wonders for me

@2009raindrop 2 ай бұрын

Thank you for this video. I guess what surprises me the most is that this effect (insulin resistance) of glucosamine was even studied at all. (It kind of makes me now wonder about other supplements.) Thank you so much for bringing these studies to our attention.

@esther.f.g 2 ай бұрын

Thank you. Could you please make a video on how to treat arthritis and joint pain with more detail? what you say at the end is helpful but I think that it can be a good idea to make a video with more details

@brigittel9556 2 ай бұрын

Thank you so much for another great insight. This is exactly the reason why I sold my vitamin store because I had more and more the feeling that I also only treated symptoms and not the cause of illnesses. Most of my clients were not really interested in changing their diet but only wanted a quick fix.

@tartgreenapple1 2 ай бұрын

I've been taking glucosamine for years because I've definitely had arthritis issues. I suspect I have some insulin resistance. I never once thought the supplements could affect that. Thanks.

@briankuwabara4337 2 ай бұрын

I’ve been taking glucosamine for over 20 years having low back pain and other joint aches. I thought this supplement would prevent the aches from getting worse. They didn’t get better until I took went low carb and leaned out. I’m dropping this supplement to see what impact it has on my glucose levels. Thanks for another amazing lecture.

@mr8966 2 ай бұрын

Crushed it again Bikman!!

@zarimohammadinia2120 2 ай бұрын

Thank you very much indeed spenfing your precious time for helping us.🙏🌱☘️🌿

@CindyRoberson-b9m 2 ай бұрын

Perhaps some of the benefits I've felt from taking a product containing glucosamine were from the OTHER ingredients in it. Type 2 diabetes runs in my family, so I am glad to learn of ways to improve my metabolic health! Thank you

@aeroclouds Ай бұрын

17 years running up and down ladders with weight as a pebbledasher led to aching joints. Started on high dose G & C at age 50. Noticed the difference after 2 months. Pain free, now 76. Also OMAD last 2 years. perfect meds. BMI 22. Except, you guessed it, high LDL, low TryGs, High HDL

@michaeltomkins6932 2 ай бұрын

I took glucosamine for years. Then I read in an arthritis charity’s magazine that it could cause dupuytren’s contracture. As my left little finger was becoming bent I stopped taking the supplement. The finger straightened. Over time a thickening of my right ring finger went away and I could wear a ring again.

@tallcedars2310 2 ай бұрын

Since February 2023 I have had extremly poor balance and fallen hard over 20 times due to ALS. Was fortunate to have gone carnivore almost 2 years ago. Previously, I broke bones 7 times; ribs 5 times, wrist, knee, while on SAD. Joints and bones are stronger on carnivore, at least to this point, and I recover quickly from bruises, cuts etc. I eat a fairly large amount of fat and collagen from pork and chicken.

@quaherway2941 Ай бұрын

Exactly the video I’ve been looking for over the past few months. I’m 48 and have had bad knees since my early 30s. They’ve always felt tight and squeaky (like old door hinges) and easily become painful when I get into certain positions-such as standing with my knees slightly bent, like when taking pictures for others. I started taking glucosamine and chondroitin, but after some years, I didn’t feel that the situation was improving at all. Still, I continued taking them. Fast forward to 2013, I decided to try OMAD (One Meal a Day) with clean keto. By day six, the tightness in my knees, which I had always felt, disappeared. While the pain hasn’t completely gone away, I can feel it improving. I now experience far fewer occurrences of knee pain, and when they do happen, the pain is less intense and recovers much faster. I strongly believe that glucosamine is only a placebo. However, like the video mentions, I should note that diabetes runs in my family (my dad and his mother). Despite this, I’m slim, skinny, and metabolically healthy. Currently, I’m following an OMAD keto-vore diet.

@NeyooxetuseiDreamer 2 ай бұрын

Thank you so much Dr Ben. I did a lot of research about Glucosamine for joint pain, and finally bought some but... after watching your video, I realized those promoting this joint support, make no reference to insulin resistance (which i have from eating good healthy organic carbs ie fruits vegetables). Another bottle of something going in the trash again. I appreciate your expertise. I went carnivore 2 years ago, and keto 7 years ago, but after 60 years old, my body just won't support healing that well, even though I have healed all four bodies this lifetime and the last body, the physical body focus since 2017.

@OldCatsLady 2 ай бұрын

You definitely are my Professor. I learn so much from you. I make notes like im in class

@susannahwhite7561 2 ай бұрын

Very good! Thankyou 😊

@tomtillman 2 ай бұрын

If I stop glucosamine, my joints start aching within a few days. I have noticed this multiple times. No placebo effect here.

@debbieb1482 2 ай бұрын

My experience also. I'm also insulin resistant and had already found this info on NIH, stopped taking it briefly and the pain was so bad I picked it up again. Magnesium also makes a huge difference in joint pain. Will drop glucosamine again see what else I can do. Defeat of insulin resistance is my #1 goal, trying to avoid my family's history of Parkinson's and dementia.

@rajashekari Ай бұрын

I had severe knee pain 15 years back. To the extent that more than one orthopaedic surgeon told me I should stop running and start swimming or cycling. Glucosamine immediately, and weight training over time, have provided over 90% relief and I am able to comfortably run now. I guess any metabolic negative is also offset by the metabolic benefit of running.

@Battery-kf4vu 2 ай бұрын

Acetyl glucosamine helps regenerate the myelin sheath of the nerves and also helps keep the tight junction in the gut. It's also said to be more effective than the other forms for the joints. So there are other positive things to consider.

@debbieb1482 2 ай бұрын

Interesting, thanks!

@TonganJedi 2 ай бұрын

Thanks for the info, Doc! It is appreciated.

@happynjoyousnfree 2 ай бұрын

I love that you think of this as a lecture. Takes me back to my BYU days 🙂HOLY CRAP this video!!! I take glucosamine at night along with my Metformin. I didn't know I was essentially cancelling out the Metformin! I mean maybe not totally.... but HOLY CRAP!!!

@tuyendo7409 2 ай бұрын

Very helpful information 💙

@hovareq6044 2 ай бұрын

I took glucosamine for at least 9 months. After 4 months of taking it i did a blood test, my cholesterol level was increased but yet was in the normal range but near to the borderline. At the sametime I noticed a slight weight gain which i thought was normal fir the winter season. But during the following 4 months the weight gain was very noticeable (about 5-6 kilos) so i decided to do another blood test, the result was not good, the cholesterol level went beyond the borderline, and even triglyceride level was worrying because i always had low triglyceride. So i stopped taking glucosamine which i can say that it helped me but not too much. Instead i started to take collagen type 2. In 1 week will be 4 months that I'm taking it, and i have to say that since last month I'm really feeling very well, almost no knee pain. In 1 one week i want to go for a blood test to see what's going on with my lipid panel levels.

@johnny7808 2 ай бұрын

way off topic but I would appreciate a video on why for some fit healthy people, trigs, AST, and ALT may increase on keto. I see posts like this in the LMHR group from time to time but no one seems to have cracked the code as to what's going on.

@aperture0 Ай бұрын

great video and also comments are very insightful

@aperture0 Ай бұрын

and subbed

@salutemetabolica1 2 ай бұрын

Please Professor Bikman offer us a lecture on glucagon! 🙏🏻🙏🏻🙏🏻

@Myfoodaddiction2024 2 ай бұрын

I saw you on another channel and you help me understand thank you 🙏🏼 💜

@earthangel2590 2 ай бұрын

Thank you!

@ngana8755 2 ай бұрын

Quick question: what are the effects of taking glucosamine with creatine, given that creatine absorption is helped by taking it with glucose? Is it better to take creatine with a glucose source such as carbohydrates or glucosamine?

@Dr_Boult 2 ай бұрын

interesting thanks. The metabolic impact made me wonder if the inconsistent effectiveness of glucosamine might actually be a function of the Metabolic status of the subjects. Do the papers actually measure things like IR and segment?

@stephenn3727 2 ай бұрын

Thank you sir!

@kerriking298 Ай бұрын

@benbikman Dr. Bikman, is there any similar (or different) response to insulin if a person takes D-Ribose as a supplement? ~~ as, in my guess, D-Ribose is some form of sugar. Thank you for all your teachings!

@jamesgordon8867 2 ай бұрын

Something is keeping my hands from getting worse, but joints are damaged. But they still work, so I will keep using this supplement with exercise, photobiomodulation, lower insulin levels and pray my joints function enough until God decides this life is not needed on this planet

@ladybird169 2 ай бұрын

You didn't mention if those studies were double blind? How they know that glucosamine was the cause, or just their metabolic condition progressing due to their diet?

@Always-xl9db 2 ай бұрын

Interesting. What about heart benefits? “reduced the risk of coronary heart disease by 37 percent among smokers, by 18 percent among former smokers and by 12 percent among those who had never smoked”. Also, this is by prescription in Europe, did u know. Probably because of these side effects but must be effective if it’s prescribed

@MarthaBurns-b2h Ай бұрын

High oxylate levels can also cause joint pain, knee pain, etc. 0:05

@robertwood9984 2 ай бұрын

Thank you.

@drhanafayyad4347 2 ай бұрын

If there are quite a few insulin-transporter doors on cells, that are not insulin-dependent, why then insulin resistant people have such a clinically significant manifestations as regards hyperglycemia while all other “ glucose doors” are available n freely open for Glucose entry?!

@drhanafayyad4347 2 ай бұрын

I mean “glucose-transporter” doors

@naomideleon8363 Ай бұрын

I'm soooo sad anytime i take any kind or brand of glucosamine..i immediately start itching feel dizzy and feel super high anxiety headaches and the feeling of panic! I couldnt take it anymore and a emergency room interntal medicine doctor told me he sees alpt of patients that are allergic to it ! I still cry about it because it has sooo many benefits and i really wanted it to work for me 😢😭😭💔💔💔

@drhanafayyad4347 2 ай бұрын

Does intake of chondroitin sulfate concomitantly with glucosamine at least partially impede the shift from glycolysis of cell metabolism, into the UDP… pathway,?!? Meaning how r they metabolized if adminstered together?

@dianelakata1308 2 ай бұрын

Gave Cosequin to my dog for years. Don’t really know if it was effective or not!!

@bluewaterwomen 2 ай бұрын

Ive never had any problem with joint pains and im 78. This is due to a healthy diet with low inflammation.

@TheMaaoow 2 ай бұрын

I tried taking a couple kinda of glucosamine and collagen, but they both caused glutamate toxicity! I also get mild symptoms from eating chinese take out thats high in msg.

@jobrown8146 2 ай бұрын

Thank you for sharing your experience. I developed glutamate intolerance after getting hooked on Pringles Sour Cream and Chive chips which contain MSG. It was so bad that I had several anaphalactic reactions and was intolerant to natural glutamates for several years after stopping the MSG. Looks like it wouldn't be a good idea for me to try it.

@onika700 2 ай бұрын

Does glycine do the same thing?

@franl9954 2 ай бұрын

Hi Ben, my parents (91 years old) take Lactulose to treat their constipation. Could lactulose cause insulin resistance? Thank you.

@WinningWithWarchild 2 ай бұрын

I have a FAT CELL question: If I'm losing weight/fat on the Carnivore diet currently, am I losing cells or just shrinking the fat cells I already have? Like, will I always have the same # of fat cells I have now or am I losing some while I'm losing weight? Thank you for your time.

@Shadow-bs1iu 2 ай бұрын

what about chondroitin supplementation

@laurelthompson6167 2 ай бұрын

how does the giant glucosamine molecule get thru the intestine and into the blood?

@terrifoster8986 2 ай бұрын

I was told by my doctor after a knee injury that I should take glucosamine. I took it for a few years, but it didn't seem to be doing anything. I stopped taking it and didn't notice any difference. So, for me, it was just a waste of money.

@debbieb1482 2 ай бұрын

Glucosamine made a difference for my dog, who couldn't walk without it, part of the reason I started taking it for my joint pain. It works for me but not worth the risk. I need to head down the carnivore road.

@paratrooper73 2 ай бұрын

Is it still "normal" to loose tons of hair during perimenopause, while being on carnivore/lion? I can not handle supplements and I can only handle beef, tallow and water. Anyone?

@roland6976 2 ай бұрын

I tried glucosamine and MSM. It did not help my knee pain. Hower, stretching resolved the issue.

@lauchlanguddy1004 2 ай бұрын

then glucosamine was never going to fix it

@meatdog 2 ай бұрын

I never take this useless supplement. Even veterinary research has shown this does NOTHING for our dogs joints. I feed my 6 dogs real meat only and they are getting old and still running cattle on the ranch. No glucosamine for them either. My great pyrenees is 13 years old. They usually die around 8 years. Thanks for this information.

@carlenekingery8860 2 ай бұрын

So glad you shared your experience with your dogs. Current dog food suppliers sucks.