Glutathione, Oxidative Stress and N-Acetylcysteine (NAC) in Psychiatric Disorders - Prof Berk

Professor Michael Berk is currently an NHMRC Senior Principal Research Fellow and is Alfred Deakin Chair of Psychiatry at Deakin University and Barwon Health, where he heads the IMPACT Strategic Research Centre. This video at the Psych Scene Symposium takes you through studies that have demonstrated that there is reduced glutathione in major psychiatric illness, i.e. Schizophrenia and Bipolar Disorder. Oxidative stress can alter redox status impacting on methionine synthase, gene transcription, and protein expression.
N-Acetylcysteine (NAC) has robust effects on neurogenesis and apoptosis, directly reverses mitochondrial dysfunction, potent anti-inflammatory effects, and indirect effects on dopamine and glutamate.
Take-home Points
• Glutathione, the brain’s primary antioxidant, is decreased in schizophrenia and increased by NAC.
• Altered epigenetic signaling through oxidative stress may explain the relationship between childhood stress and vulnerability to developing adult illnesses.
• C-reactive protein, interleukin-6, and TNF-[Symbol] are important immune markers.
Full article: psychscenehub.com/video/n-ace...

[@marijabu]

I began taking NAC for its immune-boosting during this COVID 19 pandemic. I found myself feeling especially well with improved mood and sense of well-being. I had been in a mild depression for months so I was curious as to why this was occurring. Videos such as this are giving me a wonderful insight into the great benefits of NAC. Thank you.

[@PsychiatrySimplified]

Marijane Bujold here is a review on nutritional supplements in psychiatry in general psychscenehub.com/psychinsights/nutritional-supplements-in-psychiatric-disorders-the-evidence-2/

[@TheReminderChannnel]

What dose do you take? Thank you 🙏

[@PsychiatrySimplified]

@@TheReminderChannnel NAC at 2-3 g/day provided a small-to-moderate benefit on depressive symptoms (SMD=0.37 p=0.001); however, more studies are necessary as data quality is low. Bipolar disorder : NAC at 2-3 g/day had a small effect size on functional impairment in patients with bipolar disorder (SMD=0.31; p=0.002); however, more studies are necessary as data quality is low. Schizophrenia: Adjunctive treatment with NAC had a moderate effect on total symptom scores (SMD=0.74; p=0.03) although there were indications of a high risk of publication bias. Please do discuss this with your doctor as this is not medical advice

[@TheReminderChannnel]

@@PsychiatrySimplified amazing! Thank you for such a concise response, much appreciated 🙏

[@christopherlancia7359]

what brand did you take

[@gregcooper7789]

This has done wonders for my brother-in-law with Alzheimer's the results have been wonderful!!! Everyone should know!

[@DarkoFitCoach]

What daily dosage for it niglet?

[@tiffanyharcz9718]

I’ve been taking this for 5 years for endo, my depression has become much more manageable. I mean, it’s incredible. I pray everyday that we win the fight to keep our right to use it.

[@jmatt98]

Buy it from Canada if it is banned

[@Jagharallt]

Endometriosis?

[@Testty]

I fought anxiety my whole life maybe even when i was 3-4 years old and i couldn't do anything about it and i didn't want to take medications. I tried every supplement (B vitamins, ashwagandha, vegetable powders, L-theanine, phenibut, chelators, keto, etc... i cant even name them all), but nothing worked. I recently started taking NAC and oh my god. I took 1000 mg first time. It started with an excited state feeling, like inner tremor but it wasn't unpleasant. It was like something was cleaning out of my system and i haven't felt it since then. After my first dose my anxiety is gone, i couldn't believe it, i never felt calm in my whole life. My muscle tenses are gone, chronic sinus congestion is better. Unfortunately i recently picked up an addiction (before NAC). After every dose of that addiction i feel great anxiety and depression but every time i take NAC it kills it and i feel calm again. Its saving my life.

[@charlieillingsworth9411]

Sounds great, glad you've found something! How long have you been taking it for?

[@Testty]

@@charlieillingsworth9411 i started last week and its doing wonders. It did wonder on the first day

[@simonemckee8840]

Where are you buying your NAC? I would like to try it...

[@ianpearson8976]

@@Testty placebo effect.

[@lilolmecj]

It has been 11 months, have you continued the NAC? I would love an update.

[@dreamstarworld1]

My family & I met a lady who had cancer and her daily dietetic regime was to maintain high levels of her glutathione... Now I also understand why my late daughter took NAC which caused her to function in spite of a ganglioglioma...The value of N-acetylcysteine as a precursor for great health and well-being cannot be underscored!!! Great lecture piece...

[@mrsam3236]

this lecture saved my life thank you

[@SavedbyGrace1157]

My son came down with Covid last Wednesday. Had high fevers Thursday too. My shipment from my uncles health food store came Thursday night. Gave him NAC and vitamin D, and zinc. By Friday morning he was totally fine. No fever, no runny nose which he had for weeks and no muscle aches ect. He has been perfect since. So blessed I found videos talking about NAC. Doctors need to be recommending this. Which they won’t Now my husband and I take it too.

[@Manchessollte421]

I could listen to Dr Berk talk all day, thanks for uploading. So much good info.

[@kilroy987]

And Vitamin D is important for glutathione production. Recent studies suggest proper glutathione levels really helps reduce the oxidative stresses that cause the more deadly COVID complications for people with comorbidities like hypertension.

[@stefanweilhartner4415]

it is all about inflammation. people with covid-19 die from inflammation. vitamin d modulates the cytokine storm. that means if you have a severe vitamin d deficiency there will be more inflammatory cytokines that are very destructive and you are likely to die by a factor of 10!!!! the other side is the protection from inflammation. and this is with glutathione. glutathione is made of three amino acids: glotamine, cysteine and glycine while glutamine is usually not a rate limiting factor. the other two are. so taking n-acetyl-cysteine and glycine is important. why supplementing? cystein is only in raw milk, eggs, meat and who beside rocky eats/drinks eggs raw? glycine is in the skin and joints/gelatine. not much in lean meat, who makes real bone broth and gulash?? this is why we have to supplement. it works very well. however with NAC or MSM i get stomack acid prpblems that i have to fix. taking it with sodium bicarbonate is better for my stomach

[@ahefner33]

@@stefanweilhartner4415 New research is showing endothelial dysfunction. Which Involves everything throughout your body. Yes inflammation plays a part in all or if not all but I don't believe from the papers I've seen it's inflammation totally.

[@PsychiatrySimplified]

@@ahefner33 you are correct. key mechanisms include hyperinflammation and hypercoagulability via endothelial dysfunction. We have covered it here in this article which focuses on neuropsychiatric manifestations. There is substantial evidence of anti phospholipid antibody production as well. psychscenehub.com/psychinsights/covid-19-and-the-brain-pathogenesis-and-neuropsychiatric-manifestations-of-sars-cov-2-cns-involvement/

[@jimtempleton4312]

@@PsychiatrySimplified sounds great

[@jimtempleton4312]

So if i take 500mg flaxseed oil with vit D3 4000iu and 150mcg K1,2 yes

[@debrajanzen6661]

Thanks for sharing all of this vital information. NAC worth a try.

[@bargaingrocery7012]

Also, based on what he is saying NAC prevents alzheimers, dementia, and the like. It would also help people who have had a concussion and other traumatic brain injuries.

[@RobertSpiller]

If one already has dementia, would it help to reverse it or control it? I have a few friends who have it, and I want to help.

[@wellbeingpromotor1157]

Lovely! Greetings from Romania!

[@sisterdianahlydiah_holistics]

Thank you for the information.

[@jimtempleton4312]

Yes Leslie New Prime Channel is Amazing ❤😆💪

[@tellingthetruth3726]

This is so helpfull to me.......

[@exploringdimensions4all853]

I've been taking 600 - 1000 mg. of NAC for two years. I was wondering where my OCD went. Now I know.

[@buzzybee4355]

Cool!!!

[@buzzybee4355]

All at once or divided dose? A.m. or pm?

[@exploringdimensions4all853]

@@buzzybee4355 All at once. Now, I'm taking 1000 mg. Am. I have heard it can cause trouble with sleeping if taken at night.

[@yesreally7438]

I'm just getting exposed to this info on NAC & ty for your comment! Do you take it every day?

[@exploringdimensions4all853]

@@yesreally7438 Absolutely!

[@jeffraybould5135]

Great video

[@melanied.8889]

Thank you.

[@irina8677]

Is that true that FDA removed NAC from the list of recommended supplements? And that Amazon removed NAC from their stores as a result? Is big tech now going to prohibit anything that helps improve people's health?

[@PsychiatrySimplified]

Yes that is true.

[@johnjones3332]

FDA claims the acetylated version of cystine an amino acid...(NAC) is a drug. and sent love letters to all major retailers. No one will make a supplement that can't be bought. there's now only a niche market for it and i wouldn't even touch it/ FDA banned tryptophan around the same time SSRIs were coming out.. look into that. NAC directly affects lung and the immune system so it like many other supplements have been pulled from the market by the FDA because average people were gaining this knowledge.

[@patsmith5947]

I will no longer purchase from amazon and I am also tired of Amazon selling fake knock off products.

[@artistrymindsstudios2531]

@@patsmith5947 Try Pure encapsulations, It's what Doctors and Medical Practitioners use to order their supply of vitamins/drugs. It's a very trusted brand backed by: Dr. Rondha Partick, Joe Rogan, and Dr. Sinclair.

[@johnchristopher20]

It repairs what a jab creates. They don’t want that.

[@williamiannucci2740]

OMG Thank you so much.

[@Moist_yet_Crispy]

I really wish we had the rest of the presentation.

[@PsychiatrySimplified]

Please see the rest of the lectures here. kzbin.info/aero/PLV0KZkVDyoOE9viTthAyka6_x8avYYdc-

[@lilolmecj]

This is very, very exciting, obviously anything that is not working properly at the mitochondrial level is not working properly on any level. Wish I had more lifetimes so I could be a researcher!

[@annacamila_]

Hey, if you want to be a researcher, why not? follow your dreams

[@jstreetjay8918]

Buddy you will have more lives. If you are unable to manifest this life cycle the mere sincerity you expressed toward it will help you manifest in a future life cycle. You are incarnating throughout the universe and this planet is known as one that needs help and souls to participate in purpose driven lifestyles. THE HIGHER BEINGS WHO HELP USE MANIFEST OR HELP THOSE WHO ARE SINCERE REAP WHAT THEY SOW ARE BEAUTIFUL. DD BELIEVE THAT

[@LemonChieff]

I suffer from a series of neurological and psychiatric disorders. Nine years ago, by mistake I once took 600mg of acetylcysteine a day when I was sad and whether through the placebo effect of from it's pharmacological profile I noticed that was doing better after a while and when I googled it I noticed that it was researched for psychiatric disorders. Although my experience is anecdotal I genuinely believe that there might be some misunderstood or even unknown mechanism of action that could be used for patient with psychiatric disorders.

[@PsychiatrySimplified]

Lemon Chief thank you for sharing your personal experience. That is very interesting.

[@tellingthetruth3726]

ViralTaco you’re quick.....

[@lakea.6218]

viraltaco Did/do you have amalgam fillings? Also, did your mom have them while pregnant with you?

[@MrCmt7278]

Its possible its reducing the toxicity of unbound copper, something that is seen in many disorders.

[@calklobuchar]

Hi, can you take glutahine if you are on an ssri like lexapro?

[@clintcarter]

Holy fack. How am I only coming across the incredible benefits of NAC now? 😳

[@tanyavandeventer3377]

Covid opened our eyes to many things 🤓

[@blidiascis8646]

Here I am 5 months later 🤪 I'll be late for my funeral 💪💪💪 #turtle

[@RedArrow73]

THEY. DON'T. WANT. YOU. TO. KNOW.

[@Cooliemasteroz]

NAC seems to help with Alzheimer's disease as well.

[@Mirha65]

I healed my husbond from manio depression with this and other suppliments

[@witkneemenyon5612]

What were other supplements

[@RobertSpiller]

Yes please share what other supplements do he take?

[@oibal60]

Am on 600mg NAC for COVID19. NAC interferes with the pathway to thrombosis.

[@PsychiatrySimplified]

See latest on COVID19. kzbin.info/www/bejne/oofXfXh8eJKpp7c

[@awle]

can you elaborate more? my mom has thrombosis and took the vax.. i tried my best..

[@MoneyStrategiesSOULutions]

@@awle hope that helped her! 🙏

[@jimtempleton4312]

Is it safe take 600mg capsule per day and does it matter if you only take it for a month or two or until summer

[@NzionNzion]

Wow!

[@sekolahbumi1023]

I have readt For produce glutathione.. NAC need glutama acid.. So i consume amino acid for gym....that has glutamat acid in compositions. Is my way right?

[@tomasnokechtesledger1786]

That's why SARS-COV-2 mess with infected behaviour. MEDCRAM 69 and Paul Cottrell.

[@detorahardi9567]

Medcram is the best youtube channel for covid-19 update. Watching Medcram give me relaxation during this pandemi.

[@stayfit57]

You know I started taking last 6 months. But Thomas Delauer says he doesn't like to take nac daily because he likes to create his own and it shuts down your own production that you aquire through your workouts

[@cosmichealth3907]

He is just a youtuber....not a scientist...you can take nac,gsh, vitc together for excellent results in terms of lung capacity,liver eye and heart' etc

[@MoneyStrategiesSOULutions]

What does he say to create your own?

[@treasuringpricelesstime5962]

In trials for endometriosis they took 600 mg 3x daily for 3 days a week only. The reason being, it's effectiveness can lessen if taken for prolonged periods. If anyone knows anything about how to properly take long term, please comment. Thank you.

[@bottlewaddle6677]

bump

[@cosmichealth3907]

This is not the only way...I am just telling you my experience with patients Long term use NAC might create mast cell activation....so one month on 5 to 7 days off. In between give either glutathione in lipo form or start with zinc and copper which produces SOD..so the antioxidant activity dosent diminish even though sod is second to glutathione

[@badmashan]

You can easily take it 4-5 days per week in a row with 2-3 days pause in a dose of 600mg-1000mg daily in one dose. This way of taking will not decrease long term uptake, and it can work perfectly fine for months.Every few months take 1 months total pause and its gonna work for many years. You are welcome ☺

[@jillphilips3788]

Please Share So Does it Work Curing all My Calluses for Years too 🕊❤️🙏🏻

[@NhungNguyen-kx8km]

can you tell me what you think about nutricos glutathione, I was planning to buy this product but saw some very bad reviews, that worries me Or can you recommend a reputable brand for me? please give me some advice, thank you

[@johnjones3332]

it's not acetylated glutathione, your stomach acid will destroy it. it's a waste of money. just eat foods rich in that amino acid like a nice red steak, some chicken breast, tuna, lean pork.

[@NhungNguyen-kx8km]

@@johnjones3332 thank you

[@Storiesfromthescriptures]

Doesn’t Black Seed oil help produce or has glutathione?

[@katherinejones2593]

Can you take glutithione instead of NAC I have issues with Nac supplement not glutithione

[@SR-hu7qr]

I just notice I dont crave for coffee eny more after taking NAC for two month

[@SufyMusic]

why is this unlisted?

[@kathleenmckenzie5766]

Does asea help with redox signaling

[@MaximC]

It's probably because heavy metal toxicity that we all are submitted to with the va-nes (mercury and aluminum). Some children/individuals manage to detoxify, those that can't get all sorts of health issues, from mental disorders to cognitive impairments.

[@MaximC]

I would have added au tism, but since it's taboo to put this word with the word "va-nes" in same sentence, plus it's heavily censored by KZbin and other platforms, I didn't include it in the original comment and I didn't write the two words normally because I don't want to risk the comment being ghost banned.

[@MaximC]

In other words - a lot if not most cases of mental illness are actually physical in nature. Not physical in terms of "brain chemistry balance", but physical in terms of heavy metal toxicity, oxidative stress, low glutathione, mutated MTHFR, etc.

[@420ROXY]

I see liquidized mucous in the toilet 2 days after taking NAC, IT WORKS!!

[@Tinyteacher1111]

What does that mean if that happens?

[@EldanSai]

Can you speak to the safety of NAC? I saw some research papers linking it to cancer growth, to be fair I also saw the opposite where it helped fight cancer off, so I'm pretty confused. It seems to have a huge potential taken together with Glycine

[@PsychiatrySimplified]

The jury is out re the harms and as you state there is an association but it is unclear if this is causal. However there is evidence of benefits in disorders such as OCD , mood disorders. Again this is not very strong on its own at moderate to severe levels of Illness but more as augmentation.

[@lilolmecj]

Is there research of using NAC to reduce muscle pain after exercise?

[@michaelhill5514]

My understanding is yes it can be of help in benefiting the body with different exercise workouts mp-body.com/articles-1/antioxidants-and-recovery-from-intense-exercise

[@DIAMONDM.]

MSM

[@katiehammond7845]

I've heard it's great for factor V leiden syndrome too

[@katiehammond7845]

My legs have been having theses weird spasms lately. I have increased my nac

[@PsychiatrySimplified]

@@katiehammond7845 there is an invitro study (but no trials yet showing benefits) - Results from invitro study - "We are able to demonstrate a significant decrease in the activity of coagulation factors II, VII, IX, and X with the addition of NAC. "

[@Leoji67]

Is there a link to the complete lecture?

[@PsychiatrySimplified]

Hi Please find the complete playlist here. kzbin.info/aero/PLV0KZkVDyoOE9viTthAyka6_x8avYYdc-

[@Leoji67]

@@PsychiatrySimplified Excellent, thank you!

[@weihnachtesn]

Are there any contrindications? What about medicine like Olanzapin for psychotic people, who take it?

[@PsychiatrySimplified]

Best to discuss this with the doctor. In general nac can be prescribed with olanzapine but specific caution may exist for patients. Contraindications and caution are listed on package inserts

[@jacewalton6677]

Why was the nac higher than control in the meth experiment

[@ilisvlad3134]

Can be used to treat ototoxicity induced by medication ? Have some one treat the tinnitus/dizzines with NAC ?

[@papinoo1159]

Do you take NAC with or without food? Thanks.

[@HaroldBrownJr]

I take 1000 mg every morning (started with 500mg). Over 3 months now. I don’t know if will help with Covid or not but I feel no different now than when I started taking it. Just FYI.

[@1dog915]

May be worth trying another brand, cheap supplements seem to be really inconsistent in their strength

[@rajibbasu5822]

Sir, can you suggest me a NAC supplement brand that organic and available in India

[@PsychiatrySimplified]

Rajib Basu please speak to the doctor and pharmacist. They would be able to assist

[@saiyanhead]

1mgdotcom, also learn to search/research.

[@Light4theWorldTV]

Please someone tell me what is the best format, liquid, powder, capsule? Which is best absorbed? What brand?

[@cosmichealth3907]

Setria glutathione lipo form

[@buzzybee4355]

@@cosmichealth3907 I just seen another you-tube that glutathione is not recommended. NAC is the pre-cursor to glutathione.

[@cosmichealth3907]

@@buzzybee4355 the issue with glutathione as a supplement is that it does not get absorbed...when you add nac with it gets well absorbed ,though not 100 percent...

[@yesreally7438]

I know Thorne is a high-quality/ reputable company - I'm just beginning to learn abt NAC however, so no experience w this yet. Biologically, things are usually better absorbed in liquid form than solid, idk if NAC is available in liquid though.

[@cosmichealth3907]

Nac is not about brand powder oil ...it's all about absorption..add vit c with msm to enhance abosorption and convert it into gsh

[@kellyofthehead]

I have M.E, severe burning in my legs (lactic acid) just from walking, definitely mito problems, ADHD, and I feel constantly in a state of fight or flight..... maybe this is worth a try!!

[@eyeswideopen7777]

Magnesium deficiency

[@kellyofthehead]

@@eyeswideopen7777 I take Magnesium daily 🤔

[@eyeswideopen7777]

@@kellyofthehead it worked for me. Are you Vit D deficient?

[@kellyofthehead]

@@eyeswideopen7777 not anymore, taking that also with K2, vit B complex, vit C, magnesium, b12 injections, fish oil and eating potassium rich foods. I'm at a loss, I feel worse than ever, the M.E is really kicking my butt 😢

[@eyeswideopen7777]

@@kellyofthehead it must be another issue

[@seed4147]

Is it safe to take nac before and after a surgery?

[@PsychiatrySimplified]

WillyWonkasLight we would recommend speaking to your doctor re that. Lots of considerations to take into account.

[@starbucksadmin7265]

should we take glutathione on empty stomach

[@giam1084]

i am residing in Germany and have recently bought glutathione (Actinovo) from the UK and now read in the folder ir is based in nanoparticles.... is it safe or should i throw it away?

[@locoman888]

Buy Gluthathione from NOW here in the states it is a very reputable company.

[@cosmichealth3907]

Nano is dangerous

[@margaretwansbone9413]

Steve K Scott has produced a glutathione that is swished 30 secs orally which goes directly into your system via nano technology (safe) and is immediately bio available I've had it since October and it is great

[@cosmichealth3907]

@@margaretwansbone9413 beware of nano...this word looks nano but has lot of hidden agenda

[@vijayahiremath9733]

Nano is very bad for health.

[@Byrial]

Glutamate would be the pre-cursor to GABA, right?

[@PsychiatrySimplified]

Håkon Martin Nilsen Bjerke yes glutamate gets converted to GABA by glutamate decarboxylase. This is an essential step to convert the excitatory glutamate to the inhibitory GABA

[@Byrial]

Right, thanks for clarifying. I studied GABA yesterday, repetition needed. Very interesting video. Do you consider NAC to have any dangers associated to it or is it safe to all consumers of all conditions?

[@PsychiatrySimplified]

Håkon Martin Nilsen Bjerke like all medications it can have side effects even though these are at milder end of spectrum. Because each individual is different it should always be discussed with your medical practitioner .

[@Byrial]

Ok, thanks

[@annettewilford7568]

Glutathione =NaC

[@Kid_Ikaris]

The pharma industry has largely been a intellectual property scam for 70 or so years. The new era of biotech firms I hope do a better job. If they do an incredible epoch of human progress awaits.

[@johnjones3332]

lol have you been paying attention?

[@Kid_Ikaris]

@@johnjones3332 Not closely to biotech, no. Why do you ask?

[@jillphilips3788]

How Come they Are Never able to get TO The ROOT OF ANY PROBLEMS. No More False Marketing Start There. Glyphosate Fluoride Pesticides Preservatives Metal Aluminum Lead Mercury GMO Radiation Aborted Babies RNA Animal RNA Food Colorings deodorants Roundup MSG Etc Etc And Products and Medicines and Bio Chemical Phycological Spiritual Warfares! And all Eugenics Manipulations and Weather Manipulations!!! Etc Etc Corporations Monopolies For Profits Not Cures . Psalms 33:12 Pry 3:5/6 1 Thessalonians 5:21 Prove and Test Everything For Love and Truths Discernments and Good Common Sense. Each New Day Never The Less. 🕊❤️🙏🏻

[@Not_all_as_it_seems]

would it work to eliminate pesticides stored in fatty cells of the brain and liver?

[@ashmac1397]

Pbx spray detox has the most studies to prove it safely removes pesticides and toxic heavy metals from the brain and body

[@MM-qp4pd]

Are there natural ways to increase glutathione beside taking pills and injections ?

[@amall7756]

Do you think NAC can helpe with gallstones problem?!!

[@PsychiatrySimplified]

This is an interesting question. Treatment of gallstones is outside this channel’s expertise: so with regards to clinical treatment please discuss this with your doctor as untreated gallstones can be associated with complications. From an academic point of view however - NAC has shown “ N-acetylcysteine significantly accelerates in vitro gallstone dissolution. We speculate that adjuvant therapy with an appropriate mucolytic agent may potentially increase the efficacy of clinical gallstone dissolution.” however as stated this is invitro - none the less an interesting hypothesis. A small clinical study in patients concluded - “We concluded that acetylcysteine can be used as a new agent for the direct dissolution of most types of gallstones in patients with cholelithiasis.”

[@amall7756]

@@PsychiatrySimplified many many thanks for replying.

[@marc5578]

Is NAC better than using a LypoSpheric Glutathione?

[@strawberryme08]

Nac is the precursor to creating L-lutathione

[@mikeanthony8699]

Why not take intramuscular glutathione?

[@locoman888]

Cost?

[@sacredneutral7304]

NAC and GLYCINE

[@alvidrez7956]

Nac dries me out . Wonder why

[@nizzy1057]

I wish i knew where to buy it, my psychiatrist swears by it but its not on amazon anymore so it freaks me out that the FDA is cracking down on it.

[@PsychiatrySimplified]

Yes Amazon has removed it. It's not classified as a nutraceutical anymore.

[@wren460]

Hey, no worries !!! You can still get it from many places. I bought a hell of a lot bottles a few weeks ago after reading all the news about NAC and the FDA. You can get NAC from nhc.com and also from lifeextension.com. Thank me later, you owe me a beer :)

[@nizzy1057]

@@wren460 no side effects on ur end?

[@wren460]

@@nizzy1057 zero

[@wgw2728]

Ebay

[@jimtempleton4312]

Gluathionine 1420mg liquid 1-2 shots per day or more ? its expensive

[@johnjones3332]

waste of money. stomach acid will destroy it. NAC is an acetylated version of the aminoacid cysteine - super precursor to Glutathione.

[@BillionaireDubaii]

I have metal rods in my spine. Can I take Nac?

[@PsychiatrySimplified]

No reason why that would interact. If In doubt always best to ask doctor or pharmacist.

[@BillionaireDubaii]

@@PsychiatrySimplified thanks 😊

[@findingnimo4707]

Sir can my father around 60yrs old "hvng diabetes" who has become very very irritable and depressed take Glutathione injection???

[@PsychiatrySimplified]

It is advisable to discuss this with his doctor as we can;t give advice.

[@michaelhill5514]

I agree alway discuss with health care provider before taking any supplements however many medical professionals are not educated to proper nutrition or supplements benefits or use I recommend he consult with a Naturopathic Dr. I use & make my own Liposomal NAC, Vit C & Glutathione it's much less expensive than injections or IV administration, you don't need Dr. , there's evidence it is more bioavailable than injection supplements, here's some info from NIH that may be informative: www.ncbi.nlm.nih.gov/pmc/articles/PMC6389332/ www.ncbi.nlm.nih.gov/pmc/articles/PMC4423164/

[@MarlaneM]

I would suggest supplementing with NAC. Glutathione will not cross the blood-brain barrier. My brother passed from diabetes and DVT. I believe he could have been saved. Please look into homocysteine levels. Supplement with NAC 1000mg, SOD super oxide dismutase, Caprylic Acid, Lugols Iodine, quercitin,

[@ashmac1397]

@@MarlaneM please could you send me any links concerning diabetes as my uncle has lost his sight and in bed every day

[@MarlaneM]

@@ashmac1397 Google “NAC Diabetes” and you’ll pull up a bunch of studies. I take 2-4 of Now brand NAC 1000 every day. Google “SOD Diabetes” and you’ll find a bunch of information. I take 2 KAL SOD 3000 every day. One of the most important life changing things I’ve added to my diet is lugols iodine. I had felt like I was dying for years and after taking the first dose of one drop in a glass of water I felt like I had come alive. My entire body felt alive! Read this article: iodineresearch.com/diabetes.html I take 2 to 3 drops of iodine in water on most days.

[@michaelhill5514]

Can you tell me why NAC is not being administered to treat COVI-19 illness esp. Acute Respiratory Distress Syndrome (ARDS)

[@annoyedtom9457]

Michael Hill from what I know, NAC works in reducing and clearing out mucus secretions (either allergic or pathological) in the bronchial and lung tissues. Whereas, ARDS is an alveolar level damage due to variable conditions that causes build up of inflammatory substances and fluid in the lung tissues. Two complete different situations.

[@wrestlemyk]

Check out ‘Medcram’ channel on KZbin. It’s run by an ICU Pulmonologist who currently treats COVID-19 patients. He discusses in detail N-Acetylcysteine (NAC) and it’s possible treatment for COVID-19 patients. It’s a very informative channel....well worth checking out.

[@dhandoreson240]

You may please learn it from kzbin.info/www/bejne/gWnOfIqdqKx8i5o

[@michaelhill5514]

@@annoyedtom9457 Yes I understand that NAC assist in reducing the viscosity & tenacious factors of ARDS in add I also understand it's a powerful antioxidant helping the body fight free radicals created by disease processes also I combine vitamin C with NAC when I make Liposomal NAC making it more bioavailable & significantly boosting its antioxidant properties

[@annoyedtom9457]

Michael Hill thank you for that valuable information. I’ll definitely read more about it :)

[@fondrees]

hundred years?

[@thebackbuddy748]

Could someone please tell us who this professional is??

[@PsychiatrySimplified]

Prof Michael Berk

[@thebackbuddy748]

@@PsychiatrySimplified thank you for the quick reply

[@iam6951]

Does Nacetyl cysteine reverses grey hair

[@prasanthmp500]

they say yes . i am also going to try .

[@MarlaneM]

There is evidence and studies that suggest SOD does. Super-oxide Dismutase.

[@azapp4761]

FOLIC ACID FOLIC ACID FOLIC ACID!! IT REGROWS HAIR AS WELL. I'M A WOMAN & NOW MUST SHAVE AS I'M GROWING A BEARD- MUSTACHE AND EVEN ON MY TEMPLES THERE IS A LOT OF HAIR. KNUCKLES ON HANDS & FEET NEED TO BE SHAVED!! NEVER HAD ANY OF THIS BEFORE. I TAKE THIS VERY CHEAP VITAMIN 3/DAY FOR 2 MOS. THEN 2/DAY WHEN MUCH GROWTH APPEARS. MY EYELASHES ITCH FROM GROWING IN! NOW I TAKE JUST 1 OR 2 2-3X WEEK FOR MAINTENANCE. AMAZING RESULTS IN JUST 3-4 MONTHS. MUST TAKE FAITHFULLY! YOU'LL BE AMAZED AT RESULTS!! CHEERS!😊

[@JesusIsGodsSelfie]

@@azapp4761 lol 😂 maybe you took too much ? ☺️ kindest regards 🌸

[@azapp4761]

@@JesusIsGodsSelfie been taking for years. I KNOW it works!

[@dreit899]

Help, when i take NAC i couldnt sleep. Why is that?

[@PsychiatrySimplified]

drei t while we can’t provide advice - Other nonspecific side-effects reported were headaches, skin rashes, elevated blood pressure, dry mouth, fatigue, muscle pains, insomnia, nasal congestion, runny nose, restlessness, and dizziness. Please discuss this with your doctor.

[@inetpathfinder5767]

Me too

[@followthewhiterabbit8561]

It's the opposite for me. I had insomnia for years and after taking NAC, I've had the best sleep I've had in years . Also, when I wake up, I feel refreshed, awake, a live and regenerated. Before I use to sleep 10-12 hours a day and still feel tired and lazy. This has improved my life tenfold.

[@henryhendrika5689]

@@followthewhiterabbit8561 do you take NAC at night before bed to help you sleep better?

[@followthewhiterabbit8561]

@@henryhendrika5689 yes, that is the other side effect i eat. i sustain a deeper REM sleep and i have frequent lucid dreams.

[@luciaojos]

They dont known B3

[@demotkt2357]

0:23 glutathione is antioxidant for brain

[@akreation]

There is reduced glutathione in people with schizophrenia 1:30

[@dissdad8744]

Is it true tha NAC can act as an chelator, washing out heavy metals from the tissue? This can be good, but also bad, since it will mobilize the heavy metals within the body.

[@ashmac1397]

Diss and dad look up the andy Cutler protocol on fb..this explains all your asking

[@bottlewaddle6677]

@@ashmac1397 can't find!

[@witkneemenyon5612]

Yes it can . In fact I know my friend who’s naturopathic doctor prescribed her a heavy metal cleanser that had 900 mg of Nac in it

[@delia7301]

Hi. Can I take Glutathione and NAC together or separately? Any advise would be great. Thanks

[@wgw2728]

There have been studies saying that taking glutathione directly is ineffective because it is destroyed in the stomach. You need to bypass that and find ways to help your own body produce it, like NAC.

[@delia7301]

@@wgw2728 thanks for taking time to respond! I will take your advise as this is still a learning path for me:).

[@wgw2728]

@@delia7301 Unfortunately the FDA is trying to take NAC off the shelves. Big Pharma isn't making $$ on it. Look on Ebay or smaller health food stores. I think it's only a matter of time before you'll need a prescription for it.

[@delia7301]

@@wgw2728 Thanks for the advise! I got mine from Thorne. I totally agree with you. We will soon be required to have a prescription for NAC and nebulizers as well.

[@fdimasn]

Glu oral just wasted ..

[@thinkbeforesaying244]

Would NAC help someone on the autism spectrum?

[@PsychiatrySimplified]

Please listen to Prof Berk’s video on NAC in autism kzbin.info/www/bejne/qWqXZq2oa7WSqNU

[@lilianfetters1381]

Can't get nac anymore

[@thinkbeforesaying244]

@@PsychiatrySimplified Thank you very much. That was helpful to know.

[@thinkbeforesaying244]

@@lilianfetters1381 I just ordered some on ebay. I'm in Australia.

[@witkneemenyon5612]

@@lilianfetters1381 oh yes you can 😏

[@johnjones3332]

and now it's banned. been using this to treat OCD and flem-breathing related problems for years. I'm screwed.

[@staycurious644]

You can still buy it in the US from specialist nootropics retailers, just not the big retailers like Amazon etc.

[@lillacoix9808]

Yes, I believe there's a gray area with the whole fda banning bullshit that will still allow for purchase of NAC from smaller and/or lesser known retailers and even a few big ones like iherb and eBay, just not Amazon. A lot of people using NAC probably don't realize this.

[@Storminlikeelnino]

I just bought in store at a Fruitful Yield

[@followthewhiterabbit8561]

I just bought 2 bottles on ebay.

[@lillacoix9808]

@@followthewhiterabbit8561 that's awesome.

[@kaufmanat1]

Is there an advantage of taking NAC, instead of just taking glutathione, which is what NAC is eventually converted to? I don't fully understand all this stuff.

[@nikitagaidach3962]

Yes.If you take Glutathione directly a really really really small part is going to be absorbed, that's why it's better to take it's precursor (NAC).

[@henryhendrika5689]

@@nikitagaidach3962 do we take NAC with empty stomach .

[@nikitagaidach3962]

@@henryhendrika5689 It's not necessary, but it does get absorbed better with an empty stomach.

[@witkneemenyon5612]

I’d take both tbh ! Nac will enhance the glutathione

[@MoneyStrategiesSOULutions]

@@nikitagaidach3962 it depends. Products out there now that are highly absorbable.

[@intuneorange]

Dr Alan Pressman

[@JohnSmith-oh5zp]

What about the animal studies of the cardiotoxic effects of NAC? Also, there was a study showing an increase in liver toxicity when taken during or directly after drinking alcohol.

[@michaelhill5514]

NAC can help rid the body of hangover effects: www.mdlinx.com/article/scientifically-proven-ways-to-get-over-a-hangover/lfc-4732 NAC has been shown to reduce cardiotoxicity remember some toxic conditions may be caused by free radical damage which NAC can help to resolve or even prevent: www.nutraingredients-usa.com/Article/2015/10/14/NAC-supplements-may-benefit-cardiovascular-health-Human-data

[@MarmaladeINFP]

I wouldn't advise taking NAC or any other supplement with a beer or shot of whiskey.

[@keving1774]

A lot of reviews said the supplements make you sick

[@lasetlivingstin7752]

You have to start off slow, work your way up...I started a month ago, now I have no bad feelings...

[@nadadenada319]

@@lasetlivingstin7752 lol

[@nadadenada319]

NAC Decreases glutamate, thats how helps for ocd and anxiety since these both are related to high limbic glutamate

[@lasetlivingstin7752]

@@nadadenada319 Do you take NAC?.. If so, can you give your experience?..

[@lasetlivingstin7752]

@@nadadenada319 What NAC helped or changed for you...

[@scottk1525]

Digs up single paper from the 30s.. "100 years ago we *knew* this" whoa, slow down there buddy. even in 2021 a single paper doesn't amount to much.

[@annap7678]

Some papers, as he suggests this one is, are groundbreaking. Most aren’t, but advance the scientific dialogue only a bit. He is saying that this one SHOULD have been groundbreaking but for some reason (perhaps as simple as timing issues or medical politics) did not get the attention or follow-up it deserved at the time. This paper is not the only one in this category.

[@scottk1525]

​@@annap7678 First of all, you're watering down his claims in order to make him seem more reasonable. He straight up announced that we "knew" this information in the 30s. That's what I take issue with. And nothing you said invalidates my point; said point being that a single paper does not demonstrate "knowledge." It was a working hypothesis at the time, and still is. Even today the evidence is nowhere near decisive. So to claim that we "knew" or even "know" any of this is invalid and deeply unscientific.

[@scottk1525]

@@tessalee6253 Sure, but also because science was in its infancy and because resources and biological knowledge were very limited.

[@msprabhakaran2102]

Nac makes fart smell more bad

[@bettyboop2468]

That sounds like a personal problem 🤢

[@SufyMusic]

why is this unlisted?

[@PsychiatrySimplified]

Frederick Bertram will make it public

[@SufyMusic]

@@PsychiatrySimplifiedIts most authoritative video on NAC for psych disorders out there unless I have missed others. I believe there was other ones before too