Glycosylation and Glycoproteins

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[@danabenjamin3864]

Wow I wish you were my professor. Something I was supposed to learn during the week you taught me in 12 minutes. Thank You. Not everyone has the ability to teach but you got that talent.

[@AKLECTURES]

Thank you so much for your kind words Dana!

[@tim47396]

What are you studying?

[@Daahlern]

This is the best, most concise and to the point presentation, I've ever seen

[@zidouri7956]

You are honestly a legend

[@kennethlopez6334]

If I would have discovered AK early in the semester my grade would have been much higher. Thank you so much.

[@alexisjones419]

I've never heard anything explained this clearly in my life!

[@irenecordero9775]

Mi profesor de la universidad nos ha mandado el video y he entendido todo mejor en 12 minutos que en 1 hora. THANK YOU

[@-..l]

Made more sense then my instructor and reading books. You are god-send thank you for this valuable information. Now I understand what Glycosylation actually is.

[@mariapayro2523]

Wow, best class video I've seen in my entire life. Thank you very much

[@smittywerbenjagermanjensen9281]

this was absolutely amazing, im researching hep b for a highschool internship at a biotech lab and i wanted to know more about the actual concepts we were exploring and this video was absolutely perfect. thank you so much this answered all of my questions (:

[@negarniknam3652]

It was awesome absolutely helpful, I have tried watching all the step 1 lectures none could help me to understand as much as I did after watching this tutorial!

[@daisywillis5982]

I am currently taking biochemistry and cell biology at the same, and it is kicking my butt. But you seem to have a video for every concept and topic that I am/have been confused about. Your videos are extremely helpful!

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you give people like me where proper education cannot be found a new hope, Thank you very much for your effort I hope i can repay you one day

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Much appreciated by humanity!

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clean resolution, I thought you were in my room

[@andreasolano3071]

Your videos are the best! Thank you for making them.

[@patiencechepkorir5596]

To remember where the linkages occur:;: En-(N)doplasmic reticulum...N linkage glycosylation g-OL-gi apparatus...(OL).. O-linkage glycosylation

[@Muuip]

Excellent presentation! Excellent teacher! Thank You, much appreciated!

[@TheMegaKidBoy]

Very compact with information and very clear to understand! Thanks man! :D

[@stephenodora4203]

Very good explanation of MBChB biochemistry I'm really amazed by this lecture

[@emmamerry6222]

In my 3rd year college exams and freaking out, this helped so much, thank youuu!

[@krokodilledertasche8412]

absolutly amazing! thank you very much for your efforts :) a real legend , pls keep on!

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Day by day I'm turning into a huge fan of yours sir! Thanks for all the awesome video lectures , it's helping me a lot .

[@mihirmakwana9012]

True💯🔥❤

[@jchae9820]

man ur the best actually... A LIFE SAVER

[@Sm1l3y805]

Thank You, very helpful! definitely helped me understand glycosylation

[@JKhan-ef4ri]

This lecture is priceless for me. God bless u, u r legend

[@RehamSalama98]

Thank you so much. Your videos have been helpful to me since high school and now that I'm a sophomore in college and I find your videos very clear and straight to the point which reinforces the concepts I learn at school. I have one question though, why is it only Asparagine that is capable of forming the -N linkage, aren't Glutamine & Arginine -NH2-containing amino acids as well?

[@amanimohammed2185]

YOU ARE THE BEST!!!! Thank you so much

[@sallyro9539]

God!! Amaaaaazing and clear! Thank youuuu soo much sir✨

[@xchg_107]

Very helpful, thank you!

[@rikwil21]

Super helpful, thank you!

[@pallavi07100]

amazing.. such a difficult topic explained so simplisticaly..

[@liewhaoyu1761]

Wow, this is the most wholesome content I've ever seen on youtube.

[@Muzee123]

I finally understood this topic after 6 years I only watch ur lectures now no need of big and heavy books 👍

[@yair4616]

you're the best

[@mirelabilali7394]

Omg so well explained, thank you so much!! My teacher left out so many important details that would have helped me understand this.

[@jernixlim302]

Really a big thank you i finally understood this topic ! please upload more lecture videos

[@nadimaarahimii4073]

👍.I found two video ak videos really helpful and also another channel biology and genetics just it is new and has made one video about DNA topology supercoiling concept it really helped me.

[@richswanger2042]

Thank you so much, keep that spirit

[@gengchengyang5338]

very good talk

[@piyushpreetomgogoi6218]

This video is life saving

[@luthfifadhlillah6487]

Clearly to the point! Like it, Keep it up :)

[@pkratra]

Very well explained.

[@petermerageas9710]

Question: Im looking at my BRS Biochemistry book and it says that both N-linked and O-linked bonds are both the ER and the Golgi. Why does the video say that O-Linked happens only in the Golgi?

[@user-se1jq4wp7f]

bravo thank you so much

[@prashantj50]

THANKS A LOT AK

[@isabelluo8752]

wonderful explanation

[@akandwanahoallan5252]

awesome video, all is perfect. thumbs up

[@Vishal5171]

Thanku sir .. love the way of explanation

[@nadaalmangosh873]

I really appreciate it❤

[@user-sy1rs8ep1d]

I appreciate your lecture, sir

[@358gin]

Thanks for the great video! Is it right to say that "a N-glycosidic bond is formed in one step"? (for a multiple choice question)

[@ilhemdr7220]

thank you sooo much ... it's a very helpful video

[@annie4880]

Excuse me, so the O-glycosylation is nothing but the "continuation" of the N-glycosylation opered by the Golgi apparatus?

[@witheredsky1255]

as one of the major significance of carbohydrate is protein modification, attachment of carbohydrates gives functionality to the proteins, so are those oligosaccharides used during protein modification, obtained from our diet? the glucose intake, does our cell polymerize the monosaccharide into oligosaccharide?

[@Jefftaylor2114]

this is brilliant

[@krishcielkalata3073]

you're so awesome!!!!

[@youssefmakram4913]

wow great explanation

[@MASKerAYD]

q: when the golgi complex modifies the proteins by adding carbohydrates through the o-glycosidic bond, it doesn't "modify" the work the ER already has done by changing the N-bonds to O-bonds right? By modify you mean it adds new o-bonds?

[@cooperdodd9788]

Does O-linked occur at the cis golgi?

[@Abhirawks]

Nicely explained

[@ehtx]

Well done

[@frodobilbo918]

thanks, was quite helpful. But sadly not enough. Can you make a video on the actual process of the formation of the N-glycosylation in detail? That would be awesome!

[@sumanagupta2452]

very helpful! you're lecture was actually too in depth, but the writing on the white board help me understand the general concepts, and the rest filled in the gaps. Thank you!!

[@abefromansausagekingofchic6480]

You're lucky if you thought this was too in-depth!

[@kiss45978]

very helpful !!!!! Thank you!!!

[@mr-wc3xq]

thank you so much

[@ranjeethabm7002]

Amazing sir 😊

[@derekcarter2645]

If the asparagine allows for glycosylation because of the amino group then could you do the same thing with glutamine since it also has an amino group? And then with regards to the other kind of glycosylation why wouldn't other amino acids like tyrosine, glutamate, and aspartate also work since they have hydroxyl groups available in their structures just like serine and threonine.

[@applewhite9403]

Thank u so much sir ,keep up the good work

[@orvaghazi9248]

manyyyy thanks ....I was wondering about how organic molecules become glycosylated inside cells .. so could you please wright me an explanation about it or could you tell me where can i find the answer please

[@hayaalmly6083]

Thank you for the nice explanation. Quick question that pertains to the conses seq.. Why the arbitrary X (AA) must not be proline?

[@lifeshortsostandtall]

Omgee you saved my life thank you so much, and waay better than Khan Academy. I mean, they're good, but anyway

[@Sorrskywalkerr]

omg, saved mine aswell

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lifeshortsostandtall is

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khan academy is for physiology but nothing else

[@pinkiekiss587]

@@gloriagmail3561 Bullshit, I learn from khan academy and get 90s in my exams at university. They are so thorough that it just sticks. Stop bitchin y'll.

[@w.almansori466]

"Legend"

[@gabriellayao2671]

thank you!!!

[@RohitPant04]

The cis face of a Golgi stack is the end of the organelle where substances enter from the endoplasmic reticulum for processing, while the trans face is where they exit in the form of smaller detached vesicles. Incase, anyone else was revising too!

[@mihirmakwana9012]

🔥😂💯

[@elliechaabi9753]

Thanks

[@user-hh1iw8jt8p]

Thank youuuu🙏❤️

[@vaibhavkumar8541]

Based on ncert..very nice

[@mrniceguy4277]

I guess there are to things that can be misintepreted. 1st, the formed protein doesn't just move to the Golgi complex. Instead, it is packed into a versicel and activly transported to there. 2nd, the transmembrane proteine are already formed into the membrane and then transportet as a vesicle to the Golgi or cell membrane. So they are not put into it later...

[@samiyanaaz5006]

Sir why X is any amino acid but not proline???

[@soheilza3244]

Isn't asparagine an amino acid ? So why should it be made by the ribosome of the endoplasmic reticulum... isn't the ribosome for making protein not the amino acids?

[@drumandball]

This is one of the only videos of yours that you dont sound angry in hahaha

[@yaralbrahem9762]

I have a child who suffers from this mutation, is there a cure?

[@StayExtraVirgin]

Keto Diet for the win ! Sugar Carbs in excess are the cause for inflammation and most diseases fasting is the best reset

[@BakrAli10]

Only asparagine can form a N-glycosidic linkage? What about glutamine? Glutamine has the exact same functional group so why it can’t form N-glycosidic linkage??

[@jawadal-dyab7253]

Applause!!

[@jenniferpaltiyan-bugtong8680]

Sir, may I know the references you used for this lecture? Thank you.

[@yannishamani1834]

Jen 01 your mom

[@ahmedpatel7220]

Maybe textbook of biochemistry thomas devlin

[@giselle8867]

I believe he uses the textbook by Berg, et al called Biochemistry. I say this because I have this textbook and use it as reference and notice sometimes his language is exactly the same as the book. It is also a very well regarded book for biochem.

[@wardalyasmeeb7035]

Thats helpful video

[@AKLECTURES]

Ward Alyasmeeb awesome

[@maleen5990]

Can more than one carbohydrates attach to s single protein ??

[@yikichong]

Malee N yes, sometime it is more than 2, 3 and more.

[@aprilhicks3474]

wow!

[@user-hr4jo2eu2b]

Have a good day productions ideas 😀

[@yuliakehayova3574]

Great video. However, collagen is glycosylated to form an O-glycan and that occurrs in the ER so that bit where you say O-linked glycosylation only occurrs in the Golgi apparatus is not 100% true.

[@rokayaahmad7617]

From master degree student's thank you

[@lelabb4110]

the GOAT of solving the unknown one pays thousands to schools to achieve ..do you erase the white board, thats painful to imagine!

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just wanted you to know that you saved my sorry ass thank uuuuuuu

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king

[@insafmarwatiah7945]

We need French translator please?!!

[@user-cv7ld6wj2u]

Thaaaaaaaaaaaaaaaaaaanks

[@doctorsdoctors5721]

👍👍👍

[@chongjingxuan2660]

Good lecture . However it’s a little bit uneasy for non native speaker of English . As sometimes you included some words that we don’t understand.

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I love you

[@mihirmakwana9012]

Love u too❤😍😍

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Can u take my place in the exam 😂