Guy with a mustache shouts about organic chemistry for 12 minutes and 28 seconds

Рет қаралды 1,754

Abdelhamid Khodja

Күн бұрын

Пікірлер: 31

@khansa1485 2 ай бұрын

why cant the cl from acid halide attack lithium of LTBA instead of O? i mean cl has more lone pairs than O?

@abdelhamidkhodja 2 ай бұрын

Great question. While you are right in identifying that Cl has more lone pairs than O, that's not the only reason that drives the Li-O bond formation. This is primarily because of the following three reasons: 1. Hard-Soft Acid-Base Principle: Li is a hard acid and prefers to bond with hard bases like O, rather than Cl which is a soft bases. Oxygen’s high electronegativity and charge density make it a stronger bond partner for lithium. Therefore, favoring the Li-O bond. 2. Bond Strength and Stability: In this context, the Li-O bond is stronger and more stable than a Li-Cl bond. The lone pairs from oxygen’s are more reactive and bound tightly. Whereas, chlorine's lone pairs are more diffused. This makes the lone pairs from oxygen more effective in forming strong bonds with lithium. 3. Steric and Electronic Factors: In the slides you can see the structure of LTBA which has a bulky tert-butoxy groups. This essentially makes oxygen atoms more readily accessible to lithium. Finally, chlorine, despite having more lone pairs, is less nucleophilic due to its larger size and lower charge density. I hope this answers your question! Let me know if there's anything else you need help with. Cheers.

@khansa1485 2 ай бұрын

@@abdelhamidkhodja thank you it helped! just one thing, i read somewhere that nucleophilic strength increases with the increase in size (kindly correct me if im wrong), so hows o more nucleophilic than cl? is it due to electronegativity or smth, sorry if im being dense

@abdelhamidkhodja 2 ай бұрын

@@khansa1485 While it is true that nucleophilic strength increases with size, especially when we are dealing with polar protic solvents where larger nucleophiles are less solvated and therefore more reactive. However, in this example, it is the specific reaction conditions that make O more nucleophilic than chlorine. O is more electronegative than Cl. The higher electron density on oxygen makes it a more reactive nucleophile, especially in polar aprotic solvents OR when forming bonds with hard acids like Li. You also mention how you read "that nucleophilic strength increases with the increase in size" - this concept is largely applicable in water/alcohols (polar protic solvents), where larger nucleophiles are less solvated and thus more nucleophilic. However, in the case of LTBA and acyl chlorides, the solvent environment and these specific reaction conditions make oxygen a more favorable nucleophile.

@khansa1485 2 ай бұрын

@@abdelhamidkhodja got it thank u sm!

@isaacmalik3714 2 ай бұрын

im in year 11 and chemistry is my passion, really enjoyed the video mate

@abdelhamidkhodja 2 ай бұрын

Thanks for the comment! Keep up the hard work and let me know if there's anything I can help you with. Cheers.

@prasanth_m7 2 ай бұрын

i was low key expecting an angry mustache guy rage against his students. I get something else.

@sezr3122 2 ай бұрын

Was so needed, I watched at work.

@MrGraphics 2 ай бұрын

Same here man, I work at Odoo and watched this on company time (I'm a fraud).

@sezr3122 2 ай бұрын

@@MrGraphics sounds familiar

@abdelhamidkhodja 2 ай бұрын

I'm sure the HR department would be thrilled to hear this

@talaterro 2 ай бұрын

Better than most professors out there 👌🏼

@amrabulhaj1454 2 ай бұрын

"I am going to have to remove this from the recording."

@daimsharif1615 2 ай бұрын

This cured my depression

@Brentnutso 2 ай бұрын

understand nothing but goes so hard

@abdelhamidkhodja 2 ай бұрын

Average student experience

@ahmadmansour3432 2 ай бұрын

9:13 attacks the lithium or aluminum professor?

@abdelhamidkhodja 2 ай бұрын

It's actually the electrons from water that go to the aluminum (not lithium), I misspoke during the lecture! Thanks for correcting me and sorry for the confusion.

@ahmadmansour3432 2 ай бұрын

@@abdelhamidkhodja no problem. You’re the best, professor!

@abdelhamidkhodja 2 ай бұрын

@@ahmadmansour3432 No problem! YOU are the best student!