Inflammation: Vascular events and leukocyte migration

#inflammation #inflammationpathology #inflammationprocess
Inflammation is fundamentally, a protective response of the body against any offending agent or tissue damage. It involves responses of the vascular tissues and leukocytes which help in getting rid of the primary cause of insult and necrotic cells or tissues resulting as a consequence of the insult.
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References and further reading:
💡Kumar V, Abbas AK, Fausto N, Aster JC. Robbins Basic Pathology. 10th ed. Elsevier; 2018.
💡Kumar V, Abbas AK, Fausto N, Aster JC. Robbins and Cotran - Pathologic Basis of Disease. 8th Edition. Saunders Elsevier; 2010.
💡Abbas AK, Litchman AH, Pillai S. Cellular and Molecular Immunology. 8th Edition. Saunders Elsevier; 2015.
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[@HackDentistry]

Correction at 3:28 - Vasodilation is caused by histamine and prostaglandin. Leukotrienes do not cause vasodilation, they rather cause vasoconstriction.

[@pranav6143]

Why macrophages dont come first,or why it takes time for the macrophages entry as compared to neutrophils

[@ayeshazubair3681]

@@pranav6143 because they are large in size so it's not easy to cross the membrane for macrophages.

[@EDD519]

@@ayeshazubair3681 ah yeah, what he said ?

[@203-liton4]

Leukotriens cause vasoconstriction and increases vascular permiability except leukotrien B4 that induces chemotaxis...right?

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explained the whole topic i learned in 1 hr class in 8 minutes

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This is so great after 3h trying to under and link info to each other’s this helped a lot to understand the Idea and steps

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Best video on KZbin on acute inflammation. Thank you so much for this

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Beautiful explanation and easy to follow animation. Thank you so much.

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[@HackDentistry]

We are glad our videos have been useful! Cheers!

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Informative & easier to understand

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Your videos are very informative and interactive as well. I've been watching your videos related to basic immunology concepts and it has been very helpful. Sadly I can see that there are not many videos centered on immunology as such like the complement system, hematopoiesis etc. It would be very helpful if you could upload such videos that give detailed insights on immunology. Hats off to your creativity and best efforts!! Looking forward to seeing more of such videos.

[@HackDentistry]

Thanks very much for your feedback. I would love to create more videos on immunology. Hopefully I would create many more when time permits.

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Good explanation,very helpful video

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[@HackDentistry]

Thank you so much! We also have a lot more resources on our website hackdentistry.com! You could check them out too. Cheers!

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Amazing animated video! . I have one query I have studied that macrophages already present in tissues are first line defence? . As u told in the video the neutrophils are released first

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Very glad it was helpful :)

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[@believer401]

I got question 2:28 "..These molecules are recognized by receptors in the leukocytes like macrophages and dendritic cells.." - How did macrophages and dedritic cells get into there in the first place? Aren't they supposed to be inside the blood vessel? Or I'm mistaken?

[@HackDentistry]

That is a great question! Dendritic cells here refer to "Langerhans cells" and these cells can be present in the epithelium and can move back and forth between the epithelium and the connective tissue. As for the macrophages, they are present in the tissues too and they are called histiocytes. Also understand that the body is always in a constant balance between inflammation and health.

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Sir; exudate is formed inside the interstium ....that form edema inside the tissue..please correct it sir 🤗

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Sir Pleas inform me that I have Auto immune disease Ankylosing spondlytis suffering from 2016 a lot of fluid and soft tissue Swealing in my knee so my point is that can chronic inflammation damage the body Like my knee

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Thanks very much for the feedback!

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[@HackDentistry]

Hello Sakshi. We provide notes exclusively on our website www.hackdentistry.com. Please check out our website.

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[@HackDentistry]

Artrage for illustration Filmora Wondershare for video editing

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All our videos are now premium content and are available on our website www.hackdentistry.com

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