Hemoglobin moves O2 and CO2 | Human anatomy and physiology | Health & Medicine | Khan Academy

Learn the two ways that oxygen moves from the lungs to the tissues, and the three ways that carbon dioxide returns from the tissues to the lungs. Rishi is a pediatric infectious disease physician and works at Khan Academy. Created by Rishi Desai.
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[@julianaminett7654]

You explained this so beautifully it makes me want to cry.... I've been freaking out about not understanding this, but now I do, so thank you!!!!!

[@khanacademymedicine]

Absolutely! I will get this done soon...

[@9-volt247]

Why can't you just reply to the user instead?

[@yaakovwaxman4807]

@@9-volt247 11 years later💀

[@khanacademymedicine]

Check out the video on the Bohr effect and Haldane effect. =)

[@thomaslapsley8145]

I don't know who did this video but, his presentation on this topic is one of the best I've heard. Good job.

[@arnitheking]

khan academy.. those guys are heroes :D

[@whatstheirname2486]

I learned this in class!..... But that took 2 months and this took 14 minutes

[@Kajal_tanwar_047]

That's because you worth that one month. It always feels like we don't know anything. But in reality our mind collects those little information that are easy to learn about that. That made us easy to learn it later. And it felt like we're reading it for the first time. But when we see all those things twice. We started thinking like yeah.. I think i know a bit about it.. But it just slipped off my head.. My way of reading something i 1st catches the things that are easy to memories.. And repeat them..and while repeating as revision i do recall those words or lines that i don't understand. And then i work on it. If it seems intresting as well as important. I just do not force my mind to attain 90% of concentration at each topic. But after a large break. I first pick up all those hard points. & lastly reexplain everything that i had learnt.

[@Miinoyoyo]

THANK U, Khan Academy! Ready for my medicine exam!!

[@courtneyadavis]

Another awesome video! I love the way you explain things...way more clear to me than in my textbook. Thanks!

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Thank you so much for all of your videos, you make everything so much easier to learn and understand !!!

[@ayushiohri4046]

This clarified many of my doubts. Thanks Khan Academy!!

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lola pa said it before me: you have no idea how helpful your videos are!!! I wish somebody could help you sometime, how you helped so many of us!

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I feel the same way. These videos summate a 55 minute lecture into 15 minutes of clear, succinct explanations. Thank you so much.

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I want to thank you so much for making it much easier to understand, you explain so much better than my teacher. Much LOVE!!

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OMG ! I am gonna to support you till my last breath

[@Hanna_C]

this was so helpful! thank-you

[@itisactuallymejp24]

a classic lucid explanation!✨️ Thankyou Khan academy!!

[@sanazmohamadian2263]

Awsome! Thank you so much!

[@jessicalv6442]

fantastic, beautiful, brilliant explaining!

[@madil2259]

thank you for uploading this and for the effort

[@nellyhoffman6194]

Dr RISHI thanks a lot bro

[@nellyjunsokka]

Excellent work guys!

[@letslivelife93]

Very helpful.. Thanks!

[@tayneilson]

This is how Khanacademy should be. I didn't have to play it on 2x speed this time.

[@LucasMok]

I did

[@persekarva6444]

But errors

[@diamondthundergold]

beautifully explained

[@ChantelJonesCIB]

Again ... than k you so much for this great video ... your the master! :-)

[@lolapa1329]

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[@vanessad2035]

Thank you! You explained it so well :)

[@alanananjyle]

wow, now i got it...very helpful...thank you so much..so easy to understand...:)

[@sumaiyahaque8461]

Life saver! Thank you.

[@user-cr3of3gs8p]

very very good and useful , THANKS!

[@emycroc3286]

Thank you so much! Saved my life!

[@MissAtiluj]

Amazing... :) Thank you!

[@TravelWithPreston]

In my text book it says that O2 binds with the heme group of the hemoglobin molecule and CO2 binds with the amino acids in the globin part of the hemoglobin molecule, therefore o2 and co2 do NOT compete.

[@nickau55]

really helpful specially when i am going to sit my as exam very soon and my teachers are still watching youtube during lesson

[@kalkidanberhanu7708]

The best explanation :)) I feel more confident about the mcat now

[@MrDominik2233]

very well explained ! :) Eventhough English isnt my mothertounge I could follow you easily. Helped me a lot

[@saad55279]

Thank you so much.

[@sidhantkamble3261]

Extremely helpful video ❤️

[@infern0127]

My teacher was harsh and put this on a question sheet for year 7s. This really helped. Thank you !

[@niznofan]

You´re amazing, I finally get it now :)

[@aena_]

Awesome video, thanks alot!

[@anjaliashok8513]

The video does explain the concept in a very detailed but concise manner.... The point about the chloride shift (Hamburger Phenomenon) could also have been included.....

[@mehreenm.k8361]

the best vedio in you tube good job

[@dhruvk7892]

Thanks. Great explanation

[@christianamalgwi2798]

Thank you, I am now getting it.

[@anam67]

very well explained thanks so much :)

[@brightfutureacademy7492]

this is great!

[@Marlencheeen]

thanks soooo much! awesome

[@samarthgill7566]

Does the blood from the thigh not go to the heart and then the pulmonary artery where it is transported to the lungs?

[@durrahmj8986]

actually.....great vid 😍😍

[@nelsonmandela2284]

thank you is very interesting

[@hajareid2213]

very useful thx

[@karlospowell5097]

Ready for my A&P II exam.

[@aemf1689]

Very nice videos. Hav u guys made any videos on ventilation perfusion mismatch in lungs especially discussing increased dead space due to thrombus in pulmonary artery. Can't understand.

[@mirav8221]

thank you so much! you're awesome :)

[@kamalanepal8404]

Thank you khan academy ready for my A&P exam

[@alexbarraza769]

Nice, concise

[@Spider1]

The Blueprint of Life and Wellness

[@rileyedwards1673]

very helpful

[@marcoviniciotafollamanzo1613]

Thanks for the videos, really well explained. What program are you using for this videos?

[@jigarbavishi7353]

Very good video khan acaddmy

[@jaafarmaazel369]

Thank you very much

[@m.shazainrashid1806]

Great job bro..........waiting for videos

[@Michelle-lw3ri]

you are absolutely amazing :)

[@shamsyr3762]

thanks !

[@jakirhossain8409]

Thank youuuuu!

[@abdoulnaeem8918]

Nyc nd helpful videos

[@klaymonkey9073]

I have a slightly off-track question for you about SpO2 vs SaO2 cuz i'm having trouble finding an answer: apparently both measurements can be read by a pulse oxymeter. However, is it true that SaO2 can only be read by blood sampling through an i-STAT reading. I'm a little confused.

[@georgevanasch7212]

Damn this guy is insane. What a great teacher

[@kittujasthi88]

loved the vid by the way

[@dorinfischer1798]

What happens with the chloride? HCO3 wont get out by himself, it will be an exchange with Cl. What about that?

[@kittujasthi88]

When protons competed for hb oxygen lost it ( At the thigh cells )and when oxygen competed for it, protons lost it ( Alveoli ). How is that possible and why ? Please explain. That curiosity burns me from inside.

[@MohamedKhaled-ue5ty]

Thank you

[@yu-gi-ohisaac9703]

you elaborate more on co2 and h20

[@kew8784]

hey can you do a video on the Intrinsic and Extrinsic Pathways of Coagulation?? :)

[@pacoaguilera7241]

what app are you using? great vid

[@viv.ola.ufficiale]

you're the best

[@steveneiger5284]

Khan, how can I give you feedback? Many videos have minor errors, e.g. H+ and CO2 do not bind to the same site as O2, so it doesn’t kick O2 off, but it binds somewhere else and lowers the O2 affinity of Hb. Also equations reverse in the lung because CO2 is being lowered, i.e. as it comes off of Hb, it lowers Hbs affinity to O2. Not that O2 coming aboard kicks off CO2.

[@jeanwandrag3527]

so the O2 does not get kicked out of the car...there is simply less room in the car for O2?

[@persekarva6444]

Incorrect analogy

[@risaface]

More like.. The more country kids (CO2) show up to the drive-in and hop in their friends' trucks (amino binding site), the less the rockers (O2) want to chill at the drive-in, so they jump out of their Nova's (heme binding site) and peace out. The more that leave, the more cowboys show up and visa versa, depending which side of town drive-in they go to (lungs vs. thigh/glutes etc).

[@sarahstubs3420]

Thank you for this! As I was listening it didn't seem quite right...

[@gayanbandara5166]

same question i do have

[@bluebagel8084]

The Seahawks should of run the ball

[@davidkwilsoni4669]

I might have to watch this video more 5 times

[@alexbarraza769]

I've got a question, the protons formed in the carbaminohemoglobin are they still binding to another molecules of hemoglobin or they're still bind with the COO-?

[@kungfu82able]

Rishi, I have a question: My anatomy textbook says that C02 doesn't bind to hemoglobin in the same area as O2 (the heme group). So, is it correct to say that CO2 "bumps off" O2 when it encounters oxyhemoglobin in systemic circulation?

[@nidamalik7550]

CO2 splits up in CO2- and H+. Then CO2- combines with Hb and H+ is released. i hope i am right.

[@fsharpau4925]

Audio tech comment only - Your voice level seems to be a bit too high for the system ie. The meter is in the red ; ) - and distorting. Respectfully.

[@oboyy]

Can hemoglobin bind to oxygen and carbon dioxide simultaneously?

[@aena_]

Yes man

[@z3sieb]

when the O2 competes for hB and forces the release of HCo3 and H+ in the RBC is that the Bohr effect? and when the H+ competes for hB, releasing O2, is that the Haldane effect?

[@roberthenderson3316]

😅. KHAN. ACADEMY Medicine. ". Rules. In. My. World 🌎🌍

[@brettbemis7857]

I didn't think H+ competed with oxygen because they bind at different sites on the Hemoglobin. Where does the H+ ions bind to on the hemoglobin? to the histidine? lysine? propionate group? I believe it may be the c-terminal histidine group but I am not sure. Could someone clarify?

[@kennygarcia102]

damn will i learn about proteins and acids in anatomy and phyisiology?

[@XxNolaChild504xX]

I think you are mistaken when CO2 binds with oxyhemoglobin, it forms just carboxylhemoglobin and O2, no H+ protons

[@jacksonbertone2801]

The reaction frees a hydrogen and the T state is stabilized by its uptake due to dimer/dimer ionic interactions

[@shivanimakode9997]

Yeah

[@sabashakeel9566]

wow

[@yaseenjanalchemist8026]

Sir how many molecules of co2 carried out by the hemoglobin. ?

[@venomsnap]

"Hemoglobin" is Spelt "HAEMOGLOBIN" :O

[@scubadiver6895]

+Joe Conville US vs British Spelling like color vs. colour.

[@boorene6535]

Where can i take a chemistry class as refresher ? So i can better understand human antomy D: im going to be RT but im WEAK in sience

[@Ravenwest19]

why oxygen binds to iron if iron 2+ and already binded to four nitrogens and one globin. How oxygen finds place in this complex substance?

[@XJ1MMYHX]

*haemoglobin.....

[@allisonzarandi1972]

Im having trouble understanding the bicarb, pCO2 system for clin chem can someone please explain? In respiratory acidosis, pCO2 is increased. So the compensatory effect is increased HCO3-. All of my notes say that kidneys retain bicarb. How does retention of bicarb increase bicarb?

[@annalizshy2865]

I'm stumped on that one too...if you've found out please tell me :)

[@carlacalabrese7120]

i love you

[@One1Raptor]

Great video! Does a increased overall CO2(and decreased pH) level from lung desease from e.g smoking, mean the affinity of the O2 in the lungs?