Genetic Testing, MTHFR & SIBO w/ Ben Lynch, ND

[@imm0rtalitypassi0n]

This is SO helpful. I have the MTHFR mutation (yes, I'm a half-Italian female), and 8 yrs ago a naturopath put me on methyl-folate. It worked wonders for about 2 yrs combined with my own addition of dark leafy greens just by luck. But then my health started to ebb and flow, and I began developing Hashimoto's- my antibodies are around 400 now, but started out slow. I was advised to give up dark leafy greens. I swear it made things worse, and there were long bouts of time where I couldn't afford my supplements and I swear there was some improvement. I've also suspected SIBO on and off for many years- and this video makes SOOOO much sense of my health history. Thank you.

[@universaltruth2025]

Really interesting.

[@meggi8048]

i hope you took more than just folate. did you take also multimineral and multivitamin? if you take just one you deplete others over time. so i say, take all and that one you need a bit more.

[@cmauro7912]

I sent my 23andme results to Genetics Life Hacking. I think it might be interesting to see if it also indicates you have the genes that put you at risk for Hashimoto plus there are articles in the site with ideas and supplements that help a person a lot of the time.

[@dez6278]

How are you doing now? Fyi, thyroid problems are tied to mthfr variants.

[@imm0rtalitypassi0n]

@dez6278 thanks for asking. And for others who were asking- I'm sorry I'm just seeing all this now. Well, on and off okay. My health is still in an ebb and flow very much tied to periods of financial struggle and thus increased stress and limited access to the stuff I need like supplements and detox pathway support such as regular hot yoga. And of course, when I'm very stressed, I slip back into eating sugary foods I normally avoid as a dysfunctional coping mechanism. Good quality supplements are pricey, and since my gut is still challenged when it comes to proper absorption- it does have an effect. I have 4 small thyroid nodules now, but they literally shrink or expand depending on my ability to lean into detox support pathways and lower stress levels. I try my best to do these things when broke, but it's much easier on paper than in real life. At least I'm still a lot healthier than a lot of people my age. (44) Summer's coming, so sweating will be cheaper and easier, haha. Saunas and specifically hot yoga help me dramatically. I've also recently added fresh ground black cumin seed daily and after about 3 weeks straight, I was able to measure a decrease in throat circumference. (I don't have noticeable enlargement to anyone but me and a Dr who is actively checking. So...still keeping things somewhat at bay.)

[@the_devilboy666]

One of the most valuable videos on KZbin for me. Life changing. Also I discovered this and my mutation from Dr. Berg videos. Thank you to all for this 🙏

[@bushhack]

Im not a health professional. However, I'm trying to understand everything ... great info, but this was thick today! Now I need to listen 14 times in order to get it into my own base comprehension. What I need now is this discussion broken up into multiple rehashing reviews so that I can connect dots in each review, move onto another review to do the same thing, and all this before I quit for the day. Dr Lynch seems to be working with a visual somewhere on a wall that he's memorized or updates regularly. This "map" is also something that would help if discussions like this were broken down into mini reviews and "dot-connecting' rehashes. Anyway, the data you see related and connected, Dr Lynch, is phenomenal how much of it can be conveyed if one who is new to it has the time. I reeeally want to understand the folate issues and chemistry. I messed someone up today telling them not to take so much folic acid and to switch to a folate instead. I really want to know everything now before opening my mouth again. But I don't have time and a resource I can pick up and put in my car when I drive, or read for 15 mins, or whatever simpler tool ... I just have to listen to this material 14+ times every two months or so.

[@Highintensityhealth]

Hi there Imhepilo, Learning is part of the process! I try to keep the content on this channel at a higher level (hence name High-Intensity Health). That said, you have the show notes and can also listen in iTunes as well: itunes.apple.com/us/podcast/159-ben-lynch-nd-gene-testing/id910048041?i=1000376702461&mt=2 All experts were once beginners! Mike

[@Highintensityhealth]

imchepilo- also, I forgot to mention that I often break up interviews into snippets and post on Facebook (Facebook.com/mikemutzelms) Thanks for tuning in, Mine

[@EnlightenFunctionalMedicine]

Check out SHEI. Seeking Health Educational Institute for learning more on this topic. seekinghealth.org/ They have annual conventions...one coming up in April. Worth the investment for sure. (coming from a health professional)

[@ninabutt8861]

agreed! But I love listening to Dr. Lynch even if it's over my head)

[@avaelizabeth4808]

Ve are but mere mortals ...

[@laureljohnson3416]

I ❤️ This doctor, he is a genius! Why don’t allopathis doctors follow him? Oh wait I just answered my own ? Its all about $s. I have never been a proponent for taking supplements long term. It’s finally nice to have validation of this, supplements, sure to correct an issue initially but get to the root cause, fix it and back off them on the “supplements”. I wish I could go to Dr Ben to optimize my health, Hashi, T2, who knows what else. None of my doctors here will address the root cause by looking at genetics, epigenetics or methylation. I have gone keto, which has helped with some inflation markers and cholesterol, but now BUN/urea and liver enzymes are off which were fine 3 months ago. 😪. It’s all a very slow balancing act which most doctors know nothing about. Very frustrating when the patient knows more than the doctor

[@dollyproductions1]

After researching MTHFR nearly all day, im glad i got to hear Bens take on it. I'm not going to bother doing the data mining test. Im just gonna treat as is and do a ton of leafy greens/lentils (rich in folate) and foods rich in b12. Because that's the treatment anyway! along with the other obvious lifestyle factors of course.

[@FredoCorleone]

The problems with lentils is that those destroy your gut lining. And the problem with leafy greens is the amount of iron which results toxic if you lack methylfolate.

[@dollyproductions1]

@@FredoCorleone I healed leaky gut eating lentils and greens! You're probably thinking about the lectins but you can get round that by preassure cooking. Not sure where you're getting your info from but eating greens isn't toxic. Iron needs vitamin c to be absorbed - which you get in the greens. See dr greger, Dr bernard, dr mcdougall, T Colin Cambell, pubmed studies - its a ll there

[@FredoCorleone]

@@dollyproductions1 If you have impaired methylation you probably have impaired liver too and that's where the problem with iron comes from.

[@ARTISTCHD1]

MY-STORY: I personally can talk all about myself, eating far too much food for many years of adult lifestyles. Perhaps overcompensating for the times that I was or went hungry, during my early boyhood days of youth. I learned to go hunting wild game and fishing for fresh foods. Overcoming the problem and taking good healthcare and happily healing. But, as time went on, I wasn't in a position to plant a greens garden and go hunting and fishing and crabbing on the lakes and ponds and ocean seashores, and piers. And my overall health began to deteriorate and decline drastically; due to daily dietary deficiencies!

[@edwinscherer]

Hi and THANK YOU BOTH for all these informative, comprehensive podcasts. They relate directly to a triple MTHFR defect I have and has expanded my horizon about looking at all the other metabolic pathways, enzymes, etc., that are interrelated instead of just supporting methylation. This is a great starting point. Thanks again!

[@_einodmilvado]

Wow this was God sent after yrs of having issues with my mthfr mutations, noone ever mentioned folinic acid to me ever. I found it last week.. methylfolate can give me issues unfortunately. Thank you! This is an amazing discussion blessings

[@TammyPerry]

At 33:56 an important question was answered for me, I think. And hopefully for others. Am I correct to think that: a) I should not drink alcohol, b) I probably experience SIBO c) I need leafy greens EVERY DAY. I have 1/2 variants (is that the right term?) in CBS, MTHFR C677T/A1298C, COMT, and MAO-A. I'm a tall, strong, healthy woman, good muscle structure, and great bone density at 51 yrs., so I'm obviously not adversely affected by this in those areas. However, I have had INTERMITTENT: severe depression, crazy heart palpitations, strong (not severe) fatigue, serious brain fog (not remembering my kids names and birthdates), migraines, hair loss, and very slow digestion (3 days (non-scientific beet test :) ). All of this is accompanied by alcohol intolerance (one small drink and I'm dizzy), which goes away when I feel better (above symptoms go away). Oh, I'm 51 so is menopause a factor?

[@Highintensityhealth]

Thanks for sharing, Tammy!

[@EconaelGaming]

The video is hard to follow for a lay person, but very interesting in understanding the relationship between folate, liver, bile and small bowel. Thanks!

[@splonkdesplonk]

Brilliant video, fills in some of the blanks I'm experiencing right now. Best educational channel for health by far! Well done Mike (and Ben, of course)

[@cmauro7912]

The MTHR variant is extremely common.

[@KK-gi3wt]

I am so grateful for this show, it is so well done. I love both of your approaches. Bless you both and your family's. Cant wait for my Book Dirty Genes.

[@leslielandberg5620]

I have SIBO and chronic fatigue and leafy greens are Death to me! Right up there with beans and other complex carbohydrates. All my symptoms come roaring back with one salad or helping of whole grains.. I’m sure you know a lot, but with this gene I have real problems digesting the toxins in vegetables and can only do simple carbs never complex ones. I stick to carnivore and fruits - np grains and veggies.

[@kochaoji1]

I just got my StrateGene report. I really like the diagrams that show the various cycles (folate cycle, methionine cycle, etc.). Your SNPs are color coded in the diagrams ("normal," wild, heterozygous, homozygous) so you can clearly see where you might have a problem *in* that particular cycle. So the SNP info is *not* isolated and meaningless, which is different from the other genetic reports I've purchased. The price is very reasonable compared to other reports, especially given the time and planning that went into it. (I'm not affiliated w/ the company!!!)

[@DrBenLynch]

thank you! :) Make sure you click the link to join the StrateGene Facebook group. It's an amazing place...

[@jenniferrobinson1269]

How can I get this test?

[@TheBeardedSandman]

Hmm... this gave me a lot to think about. I really need to get my genes tested to see what I have. Also interesting to think that maybe the reason why I'm having so many problems is because I tried to give up meat for so long, but my ancestors are from Ireland, Scotland, England, and Norway - green leafy vegetables weren't as prevalent in Ireland and Scotland way back in the day and they ate cabbage, onions, garlic, and parsnips; and Norwegians - they ate cabbage, beans, peas, apples, and spinach. So if I'm over here loading up on broccoli, brussel sprouts, kale, ripe bananas, and all the fruit I can get my hands on, I'M MUCKING UP THE WORKS! No wonder I have so many digestive issue. My genes never adapted to this style of eating. Meat and eggs are actually healthy for me because I get those vitamins and things that I would have gotten from the cruciferous veggies, but couldn't consume in large quantity because of all the damn sulfur!

[@kezzybear1968]

What about Dr William Walsh and his work about methylation etc. Have you looked at his work at the Walsh Institute? Would love you to interview him if you haven't already. Loved your interview with Alessandro.

[@megret1808]

Since taking both methylated B vitamins and methyl folate two things I’ve noticed. Hand-drying my hair used to result in a rain of hairs. That doesn’t happen now. Also, I’m having to cut my fingernails twice as often

[@dez6278]

What are the websites where you upload your snp's and get supplement recommendations for $35? Wasn't it you that said there are several? I have lots of ++ snp's and need help.

[@darshilbhavsar2798]

Hey, great video, that was a mindblowing SIBO revelation for me. I was wondering, would you or Dr. Lynch happen to have a link to that SIBO rat study mentioned ? I would be very interested in reading it ! Thank you!

[@Highintensityhealth]

Hi there, Breakthrough indeed. Thanks so much. There are quite a few studies out now on the topic: www.ncbi.nlm.nih.gov/pubmed/?term=%22SIBO+bile%22 Cheers, Mike

[@dinadabian4356]

Loved this!!! It's would be amazing if you had an interview on pregnancy supplements , genes etc

[@SuperKpill]

Is getting a SNP test the best starting point for people with health issues? I suspect slow comt for myself.

[@hahnahtaran9153]

this information is life changing, thank you so much (both of you) for all the amazing information.

[@mountainriverwellness9958]

Hi there... I have been diagnosed with an mthfr variant (A1298C - hope I remembered that correctly). Dr Lynch stated a prenatal should have methyl folate, folinic acid and choline. What prenatal vitamin would you recommend? Thank you.

[@DrBenLynch]

Great question - this article may help you - mthfr.net/prenatal-supplementation-optimizing-your-future-child/2012/01/20/ The specific prenatal I formulated and recommend is Optimal Prenatal - found here - www.seekinghealth.com/optimal-prenatal-240-capsules

[@dprice81]

I bought what I thought was a great b complex because it had all the active forms of the b vitamins but they are huge amount of the active B's and none of the storage or dna b's

[@ليلىليلى-ه9ح]

please I need some information about mthfr a1298c homozygous that my son have he 5 years old

[@kochaoji1]

Interesting info re: bile and SIBO. I spoke to a SIBO specialist recently who believes that many (if not most) cases of SIBO are caused by an autoimmune condition affecting the MMC in the small intestine, impairing its motility. This condition is caused by food poisoning and gastroenteritis. The antibodies to the food poisoning pathogens are what cause the paralysis of the MMC and can be cleared out of the body over the course of 5 to 10 years with treatment. I wonder how the whole bile angle ties into this, if at all. Are these two separate theories as to the underlying cause of SIBO, or are they somehow related? Many SIBO treatments focus on killing the bacterial overgrowth, with not enough attention paid to the underlying cause (poor motility).

[@Highintensityhealth]

kochaoji1 This is a fascinating theory! Thanks for sharing. Are you a practitioner? I'm curious to learn more about this. Thanks for sharing.

[@DrBenLynch]

I think there are a few reasons why one may have SIBO - not just one. Motility is a factor for sure. If one has slow motility, then I'd suspect they'd have poor bile flow as well.

[@sasha6159]

Does exist a test to check bile flow? Thank you

[@DrBenLynch]

yes - you can ask your doctor to check serum bile acids. This will show if they are getting in the blood - and if so - that's not right.

[@alexcatchpole]

Hello Mike . most vitamin B complex supplements in the UK have folic acid in. would you recommend finding other vit b supplements. recommendations for here in the UK.?

[@marygilson3490]

Thank you- this could be very helpful.

[@AdrianaJSC11]

This is so fascinating! Especially learning that too much folate can create side effects.. I didn't realize the rda is 400 mcg, so learning this really helps me. Is it ok to lower the dose of B's as well though? Because it seems they always come together as a b-complex. Is it healthy to also take extra B12?

[@cherylmcduff5388]

My son has vitiligo. Produces too much hydrogen peroxide. What gene tests should he have.

[@jenuine3611]

What happened at 41:51 with that swoosh of light coming in? Cool. By, the way - this is up there with one of my MOST favorite talks! Thank you!

[@thedaydreamer7972]

Hi Dr Ben, my comt is val/val (fast)? is sam_e helpful for me? what would you recommend I try? thank you

[@aslitur5785]

Hi Dr Lynch, amazing video and so informative thank you! I believe I have the MTFHR and also probably SIBO, but I am located in Istanbul, Turkey. The 23andme does not ship here, are there other tests that you may recommend, or I can get tested at a local lab, but not sure exactly what to ask for? Also by any chance, any doctors you've trained close to my location? Many thanks, so eye opening.

[@josiahculley9877]

I have it the best treatment for it is Metagenics - ceralin forte..

[@mmenold10]

who did he mention was a good source for doing ketogenic diet correctly?

[@DrBenLynch]

Alessandro Ferreti in the UK. Mike has done an interview with him as well.

[@Highintensityhealth]

Thanks for tuning in, Mallorie! Here's the episode with Alessandro Ferretti that Dr. Lynch was referring to: kzbin.info/www/bejne/q6TblqGNepeda5I I have a new interview with him that I"m posting on Wednesday of this week--it's really informative. Thanks, Mike

[@CarbageMan]

MTHFR Looks like it would be refused for a license plate. ;-)

[@lpi1]

can 11 mercury filled teeth effect your sips and receptor sites? Now all mercury has been taken out of mouth... last one out yesterday! I have MTFHR issues also

[@jasondames7210]

just got into this podcast and already love it!! Thank you so much for putting out quality information!! I love this!!

[@Highintensityhealth]

My pleasure, Jason. I'm grateful that you've found it helpful, Mike

[@jddavisism]

the things is your liver enzymes can vary so much throughout the day, i really dont think taking a set of tests once a year is an accurate reflection. what if you had a fatty meal the night before the tests. it could reflect the wrong results and give you the wrong impression

[@harrington90803]

Thank you for this video! What resources would you recommend to interpret my “raw data” from 23andMe to determine what polymorphisms I may have?

[@nutri.jordanoliveira]

Hi! Thanks for your amazing podcast!! What dosage do you recommend of bile for treating SIBO? (I take 100mg daily, but it doesn't have any effect on my SIBO)

[@DrBenLynch]

One has to address methylation dysfunction and all the reasons why it exists. It requires way more than just ox bile. Doses can't be recommended. You may find health professionals I've trained at www.seekinghealth.com

[@DrBenLynch]

I will mention that 100 mg is a low dose for most.

[@DDumbrille]

HI Dr. Lynch, just a quick question: You stated in the video that bile is acidic, but other sources say it's alkaline. "Bile is not acid. It's an alkaline fluid consisting of bile salts, bile pigments, cholesterol and lecithin. It is produced by the liver, stored in the gallbladder and released intermittently into the duodenum, the upper part of the small intestine, when needed to digest fat." ???

[@bushhack]

I bet within a few years we will find that the alkalosis/acidosis is a new science with mental, electrochemical, grounding and capacitance influences that greatly influence what the ph level does or does not show. I work with electronic information and the human body is way more complex in ph issues than nano science currently works with. It's a new frontier.

[@dprice81]

Can we take something else for gall bladder health? I've heard of taking taurine???

[@stephaniewilson5284]

I was told I had worst case scenario that 3 percent of the population have gene mutation and I cannot get ANY benefit from vegetables and foods that should provide me with Folate that I have to take L methyl Folate 15 grams seven days a week he also said my liver was extremely good that I have to take higher doses of medication then other people. This coming from my psychiatrist. Should I contact a regular doctor about this too? I also have Scitzo affective disorder and feel no happiness suffered from Anemia my whole life....and other issues. I was so shocked I didn't ask what gene or lack of a normal gene would create this he also mentioned an enzyme and another test in regards to others levels in my blood of something that started with an H.... Anyways I am nervous about simply taking the pill and not doing anything else with that treatment. Should I get a second opinion?

[@dez6278]

Did you ever find out anything?

[@hahnahtaran9153]

I have a question. I discovered I had gallbladder dysfunction through attempting keto, had been struggling with sibo for over a year prior. upon realizing that my sick and digestive issues were being derived from bile acid deficiency and low functioning gallbladder. I have been boggled with whether keto is a good choice of diet to correct these issues. I can't go back to high carb ( I became insulin resistant). it begs the question, is keto good for someone with these issues or should another approach be suggested? Or could a modified and tailored approach to keto be applied?

[@DrBenLynch]

modified keto is important. People are not getting enough fiber in their diet with keto often and this increases dysbiosis and slower transit times in the bowels leading to further dysbiosis. Definitely need to consume a ton of vegetables still - as Alessandro Ferretti discusses a lot

[@lauren8627]

Dr Berg is a good reference on this. He has ways to increase bladder/liver function.

[@vonitaesse4307]

Did I understand right that "improperly constructed ketogenic diets (aka Zero Carb Carnivore diet ? ) is not healthy?

[@wread1982]

Great video thank you guys. I have two double positive COMT's and ++MAOs and have had severe anxiety my whole life and insomnia for the last ten years and bouts of severe depression. Should I try sam-e? I have been waiting to get into KU intagrative medicine in December, I can't wait to feel better. Also I juice spinach in my brevel juicer to get folate, does the juicing process destroy any nutrients or should I just eat spinach raw or cooked? Thank you

[@DrBenLynch]

juicing doesn't destroy the folate. High heat can so just don't blend for long periods of time. If you cook spinach, steam it. Boiling in water pulls the folate into the water and you lose it. SAMe - you can try the SAMe test as I mentioned in the video - but if you get more anxious from it, then your methylation cycle is slowed and needs support. Lithium may be useful along with magnesium and B6.

[@wread1982]

Ok thank you very much sir!

[@skvirk2669]

@@DrBenLynch Dear Doc , I wonder how come folate 1mg + B12 put me into insomnia?

[@семьяКнязевых-в3х]

​@@DrBenLynch мне помог литий выйти из депрессии

[@91Stellaakasteky91]

what is name of facebook group?

[@kathleen1685]

I do not think I can go ketogenic. I have a slight genetic condition that has to do with breaking up fatty acids

[@Rocky7729]

So you have issues producing bile and lipase?

[@kathleen1685]

@@Rocky7729 I do not know. I just know that I have issues with feeling very cold. In the wintertime, I am only warm when I am moving. I cool down very quickly once I sit down.

[@Rocky7729]

@@kathleen1685 this sounds more like thyroid issue

[@raymondspagnuolo8222]

Excellent!

[@toneman8478]

What if you have egg intolerances??

[@orcuttcat]

Wow, some great advice here

[@eederoo]

@Angelique Moreno It's quercetine.

[@megja1812]

He’s a hard talker to understand he has that classic naturopathic talk of going round and round

[@theresageiger584]

so what do you take for it?

[@suedavis4502]

What is C-Bo? Or See Beau? Or whatever he is talking about at minute 27? This would be more helpful if you talked to the audience as if we are intelligent but not aware of all your terms. Thank you and I think I am getting the general idea. That is, that answers are not simple.

[@kaiorr6239]

Sue Davis sibo, small intestinal bacterial overgrowth

[@mariaazucenamendozagonzale4930]

I heard something about the sale of this data, 23 & me, I really hope not do that

[@anemicgoalhop495]

The Stratagene link is broken.

[@TheJust22az]

It always cracks me up when ppl use the word "right?" after a sentence as a way of convincing others to agree with them.

[@wearashirt]

Watching this since the more recent Ben Lynch video. Around 38:00. I have this feeling that the highest, highest big wigs spun the anti-vax movement, so when these movements come in (functional medicine, LDL-revisionism, folic acid revisionism, low carb), it's an uphill battle and lumping with the anti vax.

[@blackbirdsinging6264]

A huge thank you 😘this has given me a missing piece to my health problems and the associated diseases are everywhere in my family and no one has been tested! Its been a family disaster Ive been looking into since I got ill.Wow. Looking into getting tested re.ApoE allile status,ACE and MTHFR.We have cancer,strokes,female mortality typically by 60 years!,ideopathic epilepsy,autism,cardiomyopathy,gluten intolerance,dairy intolerance,diabetes( in the absence of obesity!),Great info.

[@mikep1106]

bile is not acidic

[@titanbuck7]

Please work on diction and clear pronunciation and talking speed to become more clearly understood.

[@Highintensityhealth]

This video is almost three years old BTW; here's a new one w/ Dr. Ben: kzbin.info/www/bejne/pZbPqYGentxsirM

[@PoppiesOfBlood]

what is the facebook page?

[@elsablue3646]

Hi! I have homozygous mthfr,cbs,comt, and many heterozygous. My problem is I have sibo,parasites,lyme,bartonella. I cannot get rid of toxins I am fighting constantly with parsley tincture,lemon water. How can I open the methylation pathway besides eating greens. Im desperate cant treat my infections because cant rid of toxins and no drs know what to do! Thank you.

[@dollyproductions1]

Dr Hulda Clark. She's an expert on parasite removal. She has a great website. Good luck

[@ollymounara605]

Binders should help to get the toxins out. I like modified citrus pectin. And sometimes I will take activated charcoal. Also I like humic and fulvic acid.

[@biancahotca3244]

Is this guy still alive?

[@ingodnito7372]

What is a snp?

[@farahsabz8468]

Gene mutation

[@AngelqueM]

What is quarsitin?

[@Rocky7729]

It’s a senolytic; meaning a compound that cleaves harmful molecules in your aging body.

[@ollymounara605]

Quercetine also helps with histamine. I have used it for years for my hayfever. Also it is a zinc ionophore which sents zinc into cells to prevent viruses from replication.

[@TitusAugust-l6n]

Wilson Frank Young Edward Rodriguez Mark

[@username604error5]

WoWzers

[@jddavisism]

also Mike i like your videos but you look like youve got carotenemia. Have you checked your palms and feet for orange calluses? you could be low in b12, classic hypothyroid symptomns and you could also have vitamin A gene dysfunctions so you cant process beta carotene properly

[@Highintensityhealth]

jddavisism it’s the light on this video.

[@jddavisism]

of course it is

[@ChinamaxCLONESAWS]

Don't know is all that was true ... at least today ... most of these oracles of BS give results valid for about a week ...