Histology of Brain tissue ( CNS ) :Shotgun Histology

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Histology of Brain tissue ( CNS ) : Shotgun Histology
the cerebral cortex appears to be less well-organized when viewed with a light microscope. Nonetheless, it is loosely stratified into layers containing scattered nuclei of both neurons and glial cells.
Neurons of the cerebral cortex are of varying shapes and sizes, but the most obvious are pyramidal cells. As the name implies, the cell body is shaped somewhat like a pyramid, with a large, branching dendrite extending from the apex of the pyramid toward the cortical surface, and with an axon extending downward from the base of the pyramid. In addition to pyramidal cells, other nuclei seen in these sections may belong to other neurons or to glial cells also present in the cortex. You may be able to see subtle differences in the distribution of cell types in rather loosely demarcated layers.
There are 6 classically recognized layers of the cortex:
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Outer plexiform (molecular) layer: sparse neurons and glia
Outer granular layer: small pyramidal and stellate neurons
Outer pyramidal layer: moderate-sized pyramidal neurons
Inner granular layer: densely packed stellate neurons (usually the numerous processes aren’t visible, but there are lots of nuclei reflecting the cell density)
Ganglionic or inner pyramidal layer: large pyramidal neurons
Multiform cell layer: a mixture of small pyramidal and stellate neurons
Pyramidal cells in layers III and V tend to be larger because their axons contribute to efferent projections that extend to other regions of the CNS -pyramidal neurons in layer V of motor cortices send projections all the way down to motor neurons in the spinal cord! Deep to the gray matter of the cerebral cortex is the white matter that conveys myelinated fibers between different parts of the cortex and other regions of the CNS.
#histologyofbrain #histologyofbraintissue #histologyofcns #shotgunhistology