How diet and lifestyle regulate longevity with Dr. Valter Longo and Dr. Rhonda Patrick

This episode is a spectacular round two podcast with Dr. Valter Longo. Dr. Longo is the current director of the longevity institute at the University of Southern California and also director of the Oncology and Longevity Program at the Institute of Molecular Oncology Foundation in Milan, Italy. Dr. Longo’s research focuses understanding the biological mechanisms that regulate the aging process, the role of fasting and diet in longevity and healthspan in humans as well as metabolic fasting therapies for the treatment of human age-related diseases, including those of autoimmune origin and cancer.
EPISODE LINKS:
Show notes and transcript: www.foundmyfitness.com/episod...
"The Longevity Diet" Book: amzn.to/2zvxz8n
Dr. Longo's faculty page: gero.usc.edu/faculty/longo/
ProLon FMD: www.prolonfmd.com/
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Full interview playlist: • Interviews
Clips playlist: • FoundMyFitness Clips
Chapters
00:00:00 - Introduction
00:01:00 - Defining fasting
00:04:48 - Caloric restriction in monkeys
00:06:40 - IGF-1 & mTOR
00:11:48 - Laron's syndrome
00:14:20 - Fasting in other species
00:21:25 - Cancer
00:30:44 - Fasting-mimicking diet
00:38:57 - "Yo-yo" diet
00:42:49 - Muscle mass
00:47:33 - Apoptosis
00:53:04 - Refeeding
00:56:02 - Biomarkers for health
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Thank you for watching!
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PODCAST:
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[@duudleDreamz]

Another fantastic interview from Rhonda Patrick. Highly recommended. The additional explanatory comments during the video are very helpful. Thank you Rhonda and Valter, your work is extremely important. The genuine unbiased search for underlying metabolic mechanisms is palpable in this interview and much appreciated in a world where this type of truthful attention to detail is rare.

[@cristinacampbell7372]

42 hours into my fast. Watching to keep up my mood.

[@methodtraining]

Thank you for having Valter on your show once again. This great Scientists information literally saved my life. My biomarkers ( blood pressure/cholesterol levels/etc) were absolutely out of control until I started doing his fasting mimicking diet and following diet advice. My doctor has called the change a “miracle.”

[@paulperez6167]

How did you do the diet?

[@sunshine87654]

@@paulperez6167 I also do his fasting mimicking diet as outlined in the book. I make it simple. The fist through the fifth of each month, for four months in a row now and will continue to do it each month until I reach optimal health. It brought my high blood pressure down the first round and I am gradually lowering my prediabetes glucose levels. I follow his longevity plan in combination with Dr. Fuhrman's nutritarian diet. I prefer nuts and seeds to olive oil. I also get adequate amounts of exercise each day.

[@paulperez6167]

@@sunshine87654 I love those G-BOMB's!

[@LenkaSaratoga]

“A miracle” diet

[@patriciagriffin1505]

Everything is a miracle until it happens again and again

[@FoundMyFitness]

Hey, guys! As usual, this episode has amazing show notes and transcript available at the website at foundmyfitness.com/episodes/valter-longo-2. A huge thanks to Dr. Valter Longo for coming on the podcast a second time! If you enjoy these episodes, you might be a nerd. Or, put another way, you're our kind of people! So why not support what you love and become a member of the community? Learn more about how you can setup a pay-what-you-can monthly supporting membership at foundmyfitness.com/crowdsponsor. *In this episode, we discuss...* • 00:01:00 - The problems with using non-specific terms like “intermittent fasting” and a general exploration of what each of the terms that describe types of dietary restriction means, whether we’re talking about intermittent fasting, caloric restriction, time-restricted eating or periodic prolonged fasting. The latter of which is a special focus of Dr. Longo. • 00:04:11 - What two seminal studies on chronic caloric restriction in primates from the 80s teach us about caloric restriction as a preventer of age-related disease, and how the effects of caloric restriction may actually be stronger when the diet that is being restricted is an unhealthy one - similar, in some ways, to the typical western diet. • 00:07:34 - How the shift between normal metabolism and what Dr. Longo refers to ketogenic mode is subject to individual variation and the type of restriction practiced. Of particular importance is the protein or essential amino acid consumption. • 00:08:06 - How the suppression of the IGF-1 pathway, typically a hallmark of prolonged fasting and caloric restriction studies and potentially needed for some of the benefits, may fail to be achieved in human caloric restricters that eat too much protein. • 00:09:34 - How certain macronutrients influence the insulin/IGF-1/growth hormone axis interact to modulate aging in many cell types. • 00:10:43 - How mice and humans who have growth hormone receptor deficiencies have low circulating IGF-1 - as little as 10% of normal levels - and have reduced risk of diseases like cancer, diabetes, and age-related cognitive decline, hinting at what future research might reveal about the beneficial effects of prolonged fasting and fasting-mimicking diets through the downstream effects of periodic deprival of growth-related factors. • 00:11:05 - How the growth hormone / IGF-1 axis got a big boost early on in scientific interest when it was revealed that mice that have either deficiency in growth hormone itself or the growth hormone receptor live up to 40% longer and how this is accomplished through what is essentially a delaying of the decrepitudes of old age. • 00:13:42 - The clever experiment design where human epithelial cells were incubated either in serum taken from controls or the serum taken from growth hormone receptor-deficient Laron’s patients showed that the reduction in growth factors ultimately lead to the cells manifesting qualities of cancer resistance, like fewer DNA breaks but an increase in cell death, which is also an important protection against cancer known as apoptosis. • 00:15:02 - The origins of what Dr. Longo calls the fasting-mimicking diet - a 5-day diet focused on recapitulating some of the benefits of prolonged fasting, like dramatic changes in metabolic biomarkers, but without some of the drawbacks like reduced compliance and other risks that can come with multiple days of grueling strict water fasting in large, heterogeneous populations. • 00:15:42 - How periodic prolonged fasting or the fasting-mimicking diet may be able to render cancer cells more vulnerable while conferring stress resistance to healthy cells, a quality known as differential stress resistance. This can happen because of the way fasting interferes with what is known as oncogenic signaling. Also refer to 00:25:22. • 00:21:41 - The mixed results associated with the use of the ketogenic diet in treatment of cancer and how some cancers seem to be hurt by the metabolic switch of utilizing ketone bodies, which creates oxidative stress from the use of mitochondria, while other cancers seem to be able to use ketones effectively as an energy source, potentially accelerating their growth. • 00:22:54 - Some of the early but promising pre-trial clinical anecdata suggesting potential complementary roles for the ketogenic diet and the fasting-mimicking diet (FMD) used in conjunction with conventional treatments like chemotherapy or radiotherapy for certain cancers like gliomas. • 00:28:05 - How oncologists might approach incorporating the fasting-mimicking diet, which is still seeking further clinical validation and approval, into their patients’ care (if they choose to). • 00:30:44 - In the context of aging, how the fasting mimicking diet has been shown to “reset” metabolism, driving down biomarkers associated with poor metabolic health, inflammation, and cardiovascular health. • 00:31:45 - How, in contrast to chronic caloric restriction, the fasting-mimicking diet seems to normalize biomarkers like blood pressure and fasting glucose rather than continuing to drive them down into ranges lower than might be considered healthy. • 00:34:09 - The prospect of using emerging ways of measuring aging objectively, such as through DNA methylation profiles, to tell whether or not an intervention like fasting is having an effect on aging as a whole. • 00:35:14 - How long the metabolic effects of the fasting-mimicking diet tend to stick around and how often Dr. Longo thinks the fasting-mimicking diet should be done for most people and what sort of factors influence that. • 00:38:33 - The fasting-mimicking diet as a boon for the psychology of weight loss where, due to its cyclical nature, adherents can enjoy potential benefits like the reduction of harmful fat known as visceral fat while sparing subcutaneous fat and lean mass, without completely overhauling all other areas of their life the rest of the time. • 00:40:09 - How the fasting-mimicking diet, due to the shortness of the interval, seems to avoid the deleterious and generally undesirable effect of slowing the metabolism down in the way so-called yo-yo diets seem to. • 00:44:24 - How fasting, through the shrinking and then re-expansion of whole systems like the liver, kidneys, heart, and immune cells may represent a type of whole-system renewal that originated as a three-billion-year-old self-repair mode that was only activated during periods of famine or inconsistent food availability, but might now be dormant in people living in a modern world of regular food intake. • 00:45:39 - How Dr. Longo’s group has shown that, in animal models of multiple sclerosis and pharmacologically-induced type 1 diabetes, several cycles of the fasting-mimicking diet is able to reverse disease and restore healthful function. This mechanism also may generalize to erasing other diseases of autoimmunity through the destruction of autoimmune immune cells that are essentially reset through fresh differentiation from progenitors untainted by autoimmunity. A very exciting area of continued inquiry! • 00:46:17 - How shorter fasts may fail to approach some of the effects of periodic fasting and the fasting-mimicking diet by failing to achieve adequate glycogen depletion and ketogenesis. • 00:53:04 - How clinical trials demonstrated that the effects of IGF-1 are probably context dependent, exhibiting a sort of “Goldilocks principle,” in which too much IGF-1 promotes cancer, but too little (as in the case of chronic, long-term caloric restriction) negatively affects the immune system. But the refeeding that follows fasting mimicking creates an environment that may be just right: it switches on IGF-1, promoting the regeneration of healthy cells, even restoring full organ systems. • 00:55:05 - The importance of adequate protein during the refeeding phase following prolonged fasting or the fasting-mimicking to promote proper growth signaling to restore systems that have been broken down. • 00:56:01 - Dr. Longo’s “top picks” for assessing biological age - markers a person can ask their doctor to measure to gauge how well they’re aging. • 00:59:05 - A sneak peek at what’s covered in Dr. Longo’s new book, The Longevity Diet. amzn.to/2zvxz8n

[@tgifford4]

Hi Rhonda, great interview. It would be interesting to find out the relationship between fasting and your microbiota, and also possibly using fasting to treat HLA-B27 syndromes.

[@nickfozouni8126]

Great to see you back Dr

[@TheBoydbeauford]

Tangentially related & feel free to delete if inappropriate - why do vegans appear to have lower white blood cell counts than the average omnivore? Having lead a vegan lifestyle for 8yrs, my wbc count is consistently lower than average, however the rest of my blood work suggests I'm otherwise fit & healthy & I am rarely sick. This appears consistent with the experience of many other vegans. Some suggest this may be due to a lower overall inflammatory response from a lower protein diet higher in anti-inflammatory whole plant foods?

[@vederchi]

I have a question for Dr. Patrick: I have been doing intermittent fasting daily for 14 months. Breakfast at 2:00PM and 2nd meal no later than 7:00-8:00PM (6 Hr window). My diet is pretty typical American and I try to avoid all sugar but can't avoid it completely. Do you recommend some prolonged fasting to be included? My weight is good (not obese) and I workout 3 days a week for 2 hours doing aerobic & resistance exercise. I'm 71 years old and in good health.

[@kiwibirbnico]

Found Valter on a Dutch TV satellite show from the Netherlands and Flanders of the Dutch speaking BVN live online show. This guy is very interesting !

[@AFH2522]

Doesn't mention anywhere in the title or description who the interviewer is. She's Dr Rhonda Patrick. A very knowledgeable person in the fasting field.

[@JustMe-999a]

It's her channel, Einstein

[@Dieblauesau]

@@JustMe-999a lol

[@ChristtheKing2011]

I fasted the day before each chemo treatment for 6 months 5 years ago. I have Leukemia and Non Hodgkins Lymphoma . I had 15 visible tumors in my neck to start with. One week after my first chemo treatment I had an exam and all of the tumors were not visible any more. The oncologist had never seen results like that before and I told him I fasted 24 hours before treatment. His response? Oh that's interesting and left it there. UNREAL! This is our current medical system for you. Nothing innovative or new except the latest chemo drug. They treat patients the way they learned in medical school many years before. Very sad.

[@leleiskindofcool]

Ask your doctor before you try it....I told my doctor that my knees are in so much pain I cannot run anymore, and his response was "why do you need to run?"

[@MsStack42]

I'd find a different doctor !

[@devorahtucker-fick5178]

Wow. Ditch that doctor!!

[@lyleburns8532]

LOL!

[@ringo_-]

14:26 they start talking about fasting

[@kari25nov]

Excellent! I just recommended Dr Valter Longo to the Nobel Institute ie as a candidate for The Nobel Price of Medicine

[@TheBoydbeauford]

This is fantastic. I've long been interested in Dr Longo's work. So awesome to have the current state of research on fasting & disease control summarized so clearly, & without unsubstantiated claims. The linked quoted papers are a great & useful resource in addition to the discussion. Thanks Rhonda.

[@KyHarvey71]

I have never seen a better informed, intelligent interviewer. All i can say is wow! So informative without being redundant.

[@kevinwang5202]

Very informative. Glad that Rhonda is here to make this guy comprehensible. The accent and rhythm of talking throws me off and despite how knowledgeable he actually is, he just sounds like he’s rambling

[@Drstephenstokes]

Never listen to physicians (and I am one!) for health advice use researchers... Physicians are always behind on information, always follow the scientists, these guys are researchers. I get ALL my info from the scientists, not the drug company reps.

[@ajc484]

So true. There’s just recently, like within the last ten or fifteen years at most, been a change of including a nutrition segment in medical coursework. Most physicians working today don’t have any nutrition training aside from what they may have pursued on their own time. Biochemistry might give you some idea of what nutrients do in the body but not knowing how to advise patients based on current nutritional studies is just unacceptable. I can’t tell you how many physicians have told my diabetic family members to eat 160g of carbohydrates per day. That is INSANE. Dietitians, strangely enough, have also given this advice to a couple people I know. For diabetics! I can’t imagine having to take that much insulin every day just to keep up with that recommendation. What in the world?! And god forbid you ask an oncologist about recent studies showing that certain cancers respond way better to therapies when the patient has a HFLC diet. You’ll get laughed out the door, even though these studies have shown amazing results in treatment efficacy.

[@cvrki7]

This is the most frustrating problem when dealing with health issues nowadays if you’re informed. Research is updating and the physician is quoting stuff from 20-30 years ago

[@Drstephenstokes]

@@ajc484 Yes I agree, you must become your own doctor and then use your MD to get the drugs or therapies you figure out that you want to use. Sad but true, because doctors continuing education hours are just controlled by the drug companies.

[@pdxorbust27]

All of my nutritional knowledge came from Dr. Andrew Weil, whom a group of highly regarded Drs. from the Mayo Clinic called “on the fringe” and laughed at me for following his advice. This was in the late 1990’s. A few years later, EVERYTHING he had been writing about...diet, processed food,mind body connection and inflammation were now in the news and main stream.

[@grantadamson3478]

So all physicians are stupid? And research done 20 years ago is irrelevant? I just spat out my green tea reading your comment.

[@chrisbigelow2458]

Awesome content! I love that you include the citations as real time overlays so the audience can follow along while you discuss the data.

[@rizumu1]

I can’t wait for Rhonda’s talk with David Sinclair. I’d love to get a round table with her + Longo + Sinclair.

[@davemcclure168]

Q: how often should you do extended fasting / FMD to maintain health benefits? @35:50 "once every 4 months" (if you're in good health / good shape) @38:06 "monthly if you're obese / have other risk factors" seems like the general advice should be to do extended 3-5 day fast 1x/month until you get into shape / "good health" and then quarterly thereafter. (also wasn't exactly clear how long the fasting needs to be, altho seems like 3 days minimum to activate autophagy; certainly ok after 5 days)

[@cryptoyaqui6812]

Thank you!!

[@Utsusemi]

so absolutely nothing but water? :v

[@nickdurrant4283]

@@Utsusemi HOW ON EARTH DO PEOPLE DO THIS? After like 12 hours I feel nauseous and faint.

[@asdfasdf154]

@@nickdurrant4283 I think you need electrolytes with water

[@avantar112]

@@nickdurrant4283 kek. i have not eaten in 6 days now.

[@casianacasiana]

Rhonda you are the best! been waiting for your return. thanknyou for bringing this topic to the cientific pop table. thank you for doing this for us normal people who dont have acces/ knowledge to grasp the meaning of these studies, becomes loud and clear through your interviews and interviewed

[@rebeccajlee]

Best interviews with Dr. Longo anywhere! Specially thankful for the onscreen excerpt of research highlights and terminology definitions. Thank yo so much Dr. Patrick.

[@dianetonacia2122]

I love the way she interviews

[@Trendle222]

Dr Valter looks much younger and better in this video than the one from couple years ago! He was probably tired or somthing the last time, he looks 10yrs younger here! BTW i have the Utmost respect for both of you , incredible interview with a renowned person in the field, i learned a lot

[@FoundMyFitness]

You're right... Vastly different lighting. Actually somewhat sub-optimal in both cases. The lighting kit is a pain in the neck to setup, but I think we're going to try to be more consistent with it.

[@Trendle222]

thats true, heck! i know under bad lighting i look old and good lighting i look super awesome! hehe , but seriously absolutely love your Video's Rhonda =)

[@dianaa8125]

I think it's the new hair style he adopted? His hair used to be more natural and fluffy and now he uses gel.

[@Pyriphlegeton]

I'm very happy to see one your interviews again. I hope you had and have a wonderful time with your child. :)

[@tripp8833]

Dr patrick, I'm a huge fan of your show, I really like how you put the scientific papers on the screen while he's talking about them. Makes it more informative and interesting

[@heathermilnes7744]

This is such important information for all of us. Thank you so much for posting this and to the two doctors in the discussion.

[@Kevin_Street]

Thank you for doing this fascinating interview! I'm really intrigued by what Dr. Longo said about how occasional fasting may activate a sort of self-repair mode for the body - and why we don't automatically fast when the body is damaged like we automatically get tired when we don't sleep.

[@WYLOEvelin]

Water only fast saved my life. I had a thrombosis and in a 7 days the thrombus melt away. Without blood thiner!

[@helyrambelo795]

Do you continue to fast?

[@mikeessary4925]

Rhonda you look amazing!!

[@Mercury1955]

Thanks for another video Dr Rhonda. I love them all.

[@Gigifun440]

Just discovered Dr. Longo about a month ago I love his studies and what he talks about and started listening to his audio book today love this information thank you!

[@almostmatt1tas]

How timely, I just ordered Dr. Longo's book. Thank you Dr. Patrick!! :)

[@craigburkhart1616]

Glad you are back, you should do an entire podcast on health during pregnancy. My wife would be very grateful :)

[@katiie7]

Craig Burkhart I second this! :)

[@tiredrummertube]

Great suggestion!

[@timetothrive1637]

Good to see you back Rhonda! And thankyou for my knowledge fix!

[@mariak5253]

Thank you for this wonderful interview.

[@mfahlers]

This is perhaps the most interesting interviews of the many i have viewed of Dr. Longo. I reproduced the exact combination of fats, proteins, and carbohydrates of the the Prolon diet (for less than $1.50 per day), and extended it to 6 days. I also decreased the calories for days 2 through 6 to 550, in order to ensure positive effects. Five days later during my yearly health screening at work my glucose level was 73, 16 points lower than the past 4 years. This change occurred even though I had eaten a plant based diet (with no processed food) for more than a decade.

[@maryandrews8155]

Would you be willing to share what you eat. I purchased the Prolon pack once but it is cost prohibitive for me to buy 4x per year. I'm trying to make my own like you but don't have it figured out yet.

[@mfahlers]

Happy to help out. I did a reduced calorie version based on his patent which showed a caloric range based on your body weight. Day 1: 4.5 to 7 calories per lb, Days 2 thru 5: 3 to 5 calories per lb. I also used more than a dozen different foods to maximize my nutrient intake. Day1: 2 oz bok choy, + 4 oz green cabbage + 4 oz red cabbage + 2 oz carrots + 2 oz celery + 1 oz kale, 1 oz spinach + 4 oz white sweet potato cooked in a pressure cooker for 15 minutes and blended with 2 oz cucumber + 1.5 tbs olive oil + 14 gms chia seeds + 30 gms flax seed + 14 gms sunflower seeds. This comes to 781 calories. Days2 thru 6: 4 oz green cabbage + 4 oz red cabbage + 2 oz carrots + 2 oz celery + 1 oz kale, 1 oz spinach + 4 oz white sweet potato cooked in a pressure cooker for 15 minutes and blended with 2 oz cucumber + 1 tbs olive oil + 30 gms flax seed. This comes to 521 calories. The cooking and flaxseed mask the strong taste of the cabbage. The weights all pertain to the raw vegetables (prior to cooking) and lower calorie numbers per body weight. I weighed 175 lbs at the start and 158 lbs at the end of my fast. Since the FMD used for cancer patients uses about 300 calories per day I suspect fewer calories are likely to encourage the fasting state. I determined this mix of foods using the SelfNutritionData website nutritiondata.self.com/. If you add these foods to the My Tracking function you can check the nutrient density of my food choices and the mix of fats, proteins, and carbohydrates. I spent hours ensuring a precise match while maximizing the nutrient mix and magnitude. Let me know if you have any more questions. Mark .

[@maryandrews8155]

mfahlers thank you so much for the info. I just completed my second FMD today. The first time I purchased Prolon. This time I tried to reproduce their recipes. First time I lost 5 lbs this time only 2. I am not doing it to loose weight but I want to make sure I am getting the benefits. I'm guessing I ate to much of my delicious cabbage soup and my mushroom leek soup. The recipe I created for my fasting mimicking diet mary mimicking kale crackers were delicious too! I will use the website you recommended for next month. I wish Dr Longbow would write a "recipe" book. Prolon is way to expensive to do regularly. thank you again. 👍🏼

[@mfahlers]

I lost 2.5 lb per day, which was a concern since my BMI was 20.5 at the start.

[@mfahlers]

@@g.s.5868 That is not the same thing as a nutrient Fasting Mimicking Diet. Eggs are 39% protein, about 4x more than the amount listed for the FMD patent, and they lack the nutrient density which is only possible through careful selection of nutrient dense vegetables, seeds, and nuts. An extremely high nutrient content provides protection from potentially negative health effects of a pure water fast.

[@viorelg9499]

One of the best videos I've seen.

[@oliv23_]

I sometimes almost felt like I shouldn't be listening to this conversation: it's like dropping in on two scientist collegues discussing super sharp knowledge in their field. Amazed that I get access to this kind of quality knowledge for free

[@incapaisa]

So the sweet spot for optimal health is pro long 5 day fast? Great Interview and hope one day you can have Dr. Jason Fung as a guest... Thank you Rhonda

[@billhooper6557]

Excited to find out about The Longevity Diet thank you both for all your hard work.

[@TheShai472]

Thank both of u bringing this valuable information for people who are suffering..

[@michaelonello1022]

BRILLIANT....! Thx to both of you.. I can only imagine where science will take us over the next ten years....

[@cih]

Thank you for new content!

[@iphone202020220]

Good timing on the video, Fasting for around 40 days with your methods, lost 25 pounds of fat which i did not know i had and gained lean muscle, I have to say thank you very much for these methods and diets. This is the best channel for all men and women, please promote your brand into bodybuilding so that the people who typically get misled gets a chance to see your content!

[@Tedrins]

Thanks to Rhonda, I'm now in my 2nd week of intermittent fasting (14/10). I feel great and have lost about 5 pounds and 1% BF. I feel like a teenager again in the mornings during the last few hours of my fast. I was super skinny and skipped a lot of meals when in High School. I also have good energy to do my morning runs before eating around 10:30 am. Hopefully, the cells in my body are benefitting as well as I feel

[@paulperez6167]

What do you eat to break your fast?

[@0ptimal]

@@paulperez6167 breakfast.

[@riccardosecci2637]

I love your podcasts 🙂

[@cesarcelis5482]

Very good video with lot of good information. Thank you!

[@ThePathOfEudaimonia]

Such a rich and fascinating subject.

[@topgamer8289]

Welcome back! Love your big brained videos.

[@jxg151]

Thanks, guys.

[@sarahmarzouq1935]

Thank you!

[@ffbpb666]

Love you! God bless you!

[@SiegfriedEmme]

It is sad he has to be careful what he states because of the FDA. I would listen to him before the FDA anyday

[@zimamgebremedhin3171]

I am so grateful that the universe brought me to your channel. I am now a new subscriber

[@11BDUBS]

Fabulous interview! I’ve been a huge fan of both Valter and Rhonda for 6 years since Valter’work on mice with MS

[@luciasamaras7767]

These interviews are exemplary! They push my non-clinical mind to integrate science in a manner that rewards my curiosity with very practical application from well-researched investigation. You guys are the new Carl Sagans - thank you!

[@MattDonaldsonLive]

Loved this! Will buy his book

[@ant9228]

This page is amazing

[@Venomenn]

Guys. This the Mekka of information on fasting, on the freaking whole KZbin. Watch the whole video!

[@omegawarlords]

Excellent interview.

[@sadmanmahdi8281]

I find your passion towards health science very attractive and arousing

[@elninonmg9397]

LOL! Go on, Sadman.

[@jakestevanja1304]

incredible quality video with the studies and citation edited, really made it amazing!!! what program was used to achieve this?

[@skydiver117]

excellent interview!!!

[@LP-it9jy]

great video thanks!

[@jguarino6029]

Dr. Patrick please make a video on ways to manage or heal ulcerative colitis / Crohns Disease. I would love to hear your perspective!

[@RoxanneJ]

Jeana Guarino stop eating grains! Also sugar. That will help.

[@VSS1]

I have seen heard of some benefits of a carnivore diet, have a look on meartrx.com

[@francisbertolini2590]

I want to go back to school and learn this. I'm in health care and I agree that Alopathic medicine has reached a wall in relation to treating chronic disease

[@indiabliss]

Thank you so much for this. The once a month 3-5 day fast is definitely the way forward for me.

[@victoriap2519]

Beautiful interview , substantial ! How low carb-high fat diet can be a challenge and it is so easy to fast with it. I have been on low carb, moderate amount protein, high fat for the last 3 and the half years. On IF for the last 2 and the half years, i eat 2 times a day and often i do one meal in 24 hrs. Could not be easier, tasty! Never feel hungry, do mot have to count calories really, i know it is lower than if i would be on high carb diet. I do not use sweetener for the last 2 years, we all love foods but your taste receptors change. Of coz in therapeutic ketosis you need to measure ketones against glucose

[@Pyriphlegeton]

Seems like I will be leading the notification squad today.

[@paranariver1720]

Dr. Longo sos un genio!!! Además que paciencia tiene para explicar de nuevo todo lo que ya dijo en su libro é outra entrevista. Un ídolo! Gracias.

[@FoundMyFitness]

Glad you enjoyed the episode! Have you considered helping to correct the subtitle translation for spanish? That would be amazing! kzbin.info_cs_panel?tab=2&c=UCWF8SqJVNlx-ctXbLswcTcA

[@marcmeup1]

Excellent! It just struck me that Dr. Longo is an example of nominative determinism. Haha.

[@romannavratilid]

Professor Snape... is that you?

[@branshatch6862]

Roman Navratil underrated comment.

[@philosophicalmonkachu7711]

"Always"_ Severus Snape

[@devorahtucker-fick5178]

I thought it was just me! 😂

[@DR-br5gb]

You can always trust someone who says, "I don't know"

[@billyramirezhealthybydesig5188]

I dont know about that

[@billyramirezhealthybydesig5188]

Jk

[@hnonline111]

So true, actually! Problem is, ignorant people usually do not even entertain that kind of thought, so those will actually think the opposite of what you said.

[@DR-br5gb]

@@hnonline111 You're exactly right. Dunning Kruger in full effect.

[@11BDUBS]

Question if I may?; Since atophagy , for all practical purpose's is "not measureable", can we say with certainty that it "tops out" or levels off at any particular time when fasting (3 day? 5day? more?) Thanks for all the incredible interviews! Rhonda's knowledge, insights and ability to "pace" the interviews put her among the very best! I've followed Valter closely for 5-6 years since reading about his work with mice with EAE; he is a true visionary who, after not being taken seriously for so long by the so called "experts" and KOL's, is begrudgingly making believers of his critics because the results of his studies show long term fasting is so obviously an incredibly powerful healing modality with mind-blowing potential! A true "Rock Star" Thanks again!

[@stuarttanner689]

Dear Dr. Rhonda can you please make a video on how to properly grow broccoli sprouts from start to finish, also including the best way to freeze/store them and then also how to cook them or when to eat them raw? That would be very helpful. Many people seem to not know the correct way to do this properly. Thank you. I hope you're well. x

[@spaceghost8995]

Plant them in dirt and water them.

[@jameshancock2489]

Great interview - Do you know how much NAC or Resveratrol it takes to replicate Rapamycin in terms of mTOR inhibition ? and if one was successful how long does a cycle last for, is this known/can it be measured ?

[@msepoche]

I am in round two of the fasting mimicking diet. It is hard, but worth it.

[@creative8569]

I can’t tell if she’s 42 or 22... bravo Dr. Rhonda 👏🏻

[@bluewizard2008]

Hi, Great video! Love your content. I was wondering if you could make a video on special nutrition for pregnancy and what does the latest science say. Thank you!

[@metabrand]

I'm confused. At 53:03 in the video, Dr. Patrick and Dr. Longo talk about the importance of consumption of Protein during the Re-Feeding Window to increase IGF1 and proliferate stem cells, but on Page 114 of Dr. Longo's book "The Longevity Diet", it says: "Day 6 - Transition diet For 24 hours following the end of the five-day FMD, patients should follow a diet based on complex carbohydrates (vegetables, cereals, pasta, rice, bread, fruit, etc.), and minimize the consumption of fish, meat, saturated fats, pastries, cheeses, milk, etc." So which is it? Is it better to consume complex carbohydrates or protein (or both) during the re-feeding day? What about bone broth? If we shouldn't eat fish or meat, should we eat some form of plant protein? Is protein powder OK? What is recommended? Appreciate any thoughts on this, because I want to make sure and maximize the effect of re-feeding during this short window.

[@KP-dd2ci]

Would love to know as well....but not surprised there wouldn't be any youtubers addressing this...Dr. Longo needs to speak to this inconsistency.

[@Optimizemore]

Please post here if you find an answer to this question.

[@EG-ku3hc]

metabrand he is talking about the first refeeding day to eat more carbs to ease out of the fast. but after that you add protein in for the building phase. The book is right!

[@tiredrummertube]

I guess I missed the part where it has been found that cancer can use ketone bodies. THX so much for these videos !

[@squarz]

I don't know. I did omad for almost an year and a half and some water fasts and I think the benefits of fasting are almost completely due to the fact that you stop eating shit. So I just started to eating only whole plant foods, avoid any possible refined food and low in proteins. And I feel this is better for me (I'm already too skinny to fast...)

[@mfahlers]

I eliminated all processed foods from my diet 30 years ago, and had increased my vegetable intake to 40 to 50 lbs per week and still suffered autoimmune diseases which continued worsening over time. Six days on my DIY FMD began reversing one of my autoimmune diseases, so I don't believe a healthy diet is a substitute for fasting.

[@lidianieves4386]

mfahlers Episode 7 is live: Learn About Autoimmunity & Detox, Essential Oils & Weight Loss. Make sure to watch it today here: bit.ly/hs-ais7

[@ceeweedsl]

One meal a day is not a five day fast. There may be good advantages for some people and none for others depending on metabolism and diet. But fasting is something all animals are built to do and it appears that it is an important phase. Judging prolonged fasts by the effect of 23 hour fasts is missing the boat. It's not the same and this is well explained here. So I wonder how you are experienced to decide that you can dismiss the long term benefits if you've never done it? And then, next, how do you determine when you got effects if your health is relatively ok?

[@ivanabeba]

this is the best thing on internet!

[@windu80]

Dr. Rhonda Patrick, it would be very interesting to hear your thoughts about PMGs (Protomorphogens) and its effects on autoimmune conditions. I just discovered that one, but not sure what to think of it...

[@bennguyen1313]

Regarding the difference between the FMD and Intermittent Fasting/Feeding (as described by Dr. Satchin Panda).. after how many hours of fasting (ex. 15:8 or 23:1) would there be adverse health effects like those mentioned in Dr. Longo's interview on the HIH podcast (gallstones, overall mortality, etc (30m12s mark))? Also, any theories as to why daily fasting would cause such issues? In the future, what might a fasting diet look like for cancer patients? 24-48 hours of fasting pre-chemotherapy, followed by a normal re-feeding immediately afterwards with a standard diet (50% Carbs, 25% protein, 25% fat)? keto diet (80% fat, 20% protein, 10% carbs)? Also, didn't see any notes for it.. is this the link to the research by Morgan Levine (and others) mentioned at the 57m52s mark? www.biorxiv.org/content/early/2018/07/05/363291 Is there any plans to make the $300 5-day ProLon boxed meals (800 calorie a day) more affordable for the general public, or is it the intended market hospitals and oncologist professionals?

[@henrikarboejensen812]

Victorious long life to all from Denmark. You know the place where something is rotten in the state of. Sorry, I am back to my serious self. Super interesting talk, thanks too much.

[@thomasfrye8996]

She looks fantastic. She is literally the poster child for intermittent fasting.

[@emanuelporic]

Ok, what should i eath after 5 days of fasting, while refiding? Should i eath just soups for 2-3 days, or how that whole thing goes from there? Does anyone know?

[@amyrorris569]

I’m curious, does valter include fruit in his realm of healthy carbs? Really respect ur work!!!!! Ty!!!!!

[@shanaabell6252]

Have you thought about putting simplified bullet points in the drop bar, or giving a simplified breakdown at the end of these videos? I research nutrition more than the average bear, as well as other scientific topics and I haven’t been able to understand a good amount of any of these types of interviews. It would be nice if you could help those of us who don’t know certain language and certain assumptions of knowledge we may not have. I run my own business and simply don’t have time to research enough of all these interviews to fully understand what’s going on. This is why I love Joe Rogan interviewing you, he breaks things down for us. I’d love it if you’d consider this, I’d gain a lot more from your videos and I suspect others may too. Thx! I donate to you via your webpage because I appreciate you!

[@thestugats]

Is there a connection between nrf2 pathway and vegfc connection to lymphedema and can they work together in promoting bennefits in treatment of the condition

[@Kevin-ey8pj]

Does anyone know what the rules of thumb are for exercise during the fasting period? It seems problematic to do intense exercise, but was it directly addressed by Dr Rhonda Patrick or Dr Longo?

[@Nilsosmar]

Dr. Longo mentions in this video that there's a food aversion problem among cancer patients (the patients come to associate the FMD with their chemotherapy, and are averse to eating the same foods again the next time they go in for chemo). As a result, he's developed several variations on the FMD. I hope he'll make those variations public at some point, if only through ProLon. (i.e., there could be several different ProLon kits, all of which provide the necessary macros). This would allow people who want to try the ProLong five day diet, to choose one that contains food they like better and/or aren't allergic to. Case in point: I've done several five day water fasts, and have thought about ordering the ProLong diet to see how it compares with water fasting. I haven't done so because I'm allergic to wheat and nuts, two items which are present in the FMD. A nut-free, grain-free version would make it possible for folks with allergies like mine, to try it. (I've also tried creating my own grain-free, nut-free version following the FMD's macros, but a packaged diet would be easier)

[@FoundMyFitness]

Seems pretty logical to me, Nils. I don't have any inside knowledge on this point, but I would suspect it would feed back into their kit at some point.

[@vyovy]

you can mimick the fast mimicking prolon diet yourself. You can check Longo's literature, it is not a trade secret what basically works and the macro ratios. Prolon is recommended for compliance/medical system reasons (getting docs to prescribe, getting a "medication" that the box seems like, ensuring that food is safe etc.). But Longo is still pretty clear that prolon is not necessary, just recommended and useful. I saw that the basic breakdown is 1000 calories on the first day, and 700 calories from day 2 to 5. The approximate macro breakdown is 50 percent fat, 40 percent carb, and 10 percent protein (or less). Basically, the food is not what induces the benefits, the lack of food induces the benefits - the ratio keeps protein low as if it is higher some benefits are lost (the body is not "tricked" into thinking it's in a fast) and carbs are kept lowish at that calorie count for the same reason and to induce ketosis. Anyway, look online - there is a fast mimicking mimicking diet that someone made, or you could make your own. Good luck.

[@megankellyhensley]

Keep these videos coming! It is helping empower me to educate myself and put me in control of my health. Thank you!

[@AlituraNaturals]

Hi! We LOVE your podcast! We would love to sponsor it if possible? Can't seem to find a contact form on your website. Please advise :) -Andy

[@stuarttanner689]

Dr. Rhonda is so warm and friendly and Dr. Valter has the emotional range of a grave stone!! Lol. I have his book and found it very interesting. Hopefully this interview will top up my knowledge. Dr. Patrick is there any chance you could do a podcast on IBS and IBD Please? I will be forever grateful. All the best

[@charly40fication]

Stuart Tanner haha yeah thought the same lol archetypical scientist I guess :D

[@cathybird9763]

Dr. Valter is ESL, so maybe his blunted affect is because he has to translate the English in his brain before he speaks.

[@tofujelly]

@@cathybird9763 good point!

[@emilyirizarry6365]

Very European

[@Dieblauesau]

I find it interesting that Rhonda Patrick said on Joe Rogan that she is following a ketogenic diet. I thought there was good research behind a plant based diet, as Longo says meat increases IGF-1.

[@mehi8145]

I started watching your videos since I was 15 years old. Vv interesting stuff!

[@AlmazulVortex]

Tarzan I was watching this channel even since I was in an spirit form waiting for incarnating.

[@BigBlueRabbit]

I started watching just before the initial Big Bang.

[@draganpetev4677]

It is mindblowing to me how the videos with the best information on the most important subjects in the world always have so little views, fewer likes and even fewer comments... All of this is evidence that people in general aren't interested in the stuff that really matters...

[@draganpetev4677]

@Phil Jermakian it's because people are dumb animals in general... Sad but true!

[@0ptimal]

So the insert at 47:45 about dietary restriction, says it can lower the immune system. So is 'restriction' a lower than maintenance level of calories per day? And if fasting, the normal way, you get all required calories but in a short window of time? Trying to identify the key differences between the two.

[@zivojinstevanovic5644]

what about fasting in people with hypertrigliceridemia ? do they have the same benefit or fasting is doing damage to them ?? given that fasting could make hypertrigliceridemia worse ? thanks for answering .

[@snuseren]

I have a theory on why the organs shrink while fasting. The body tries to save calories so it will shrink the organs for a lower calorie expenditure. Thanks for the podcast I am as we speak in a 36 hour water fast. Aiming for 5 days or more

[@thrainng]

I have arrhythmia, mostly due to scar tissue I think, and it has had very debilitating effects on my life for many years. Since January I've been doing fast mimicking diet (FMD) every month; 5 day process. I basically just eat a mix of rice and avocado for the period. I have had extremely good results where basically everything has gotten better. If you have arrhythmia I recommend trying it. I suppose you should ask your doctor beforehand though.

Is it AF

[@thrainng]

Chase Palmquist yes but also tachycardia sometimes. Everything more stable now.

[@easyacademy8110]

hi may i know what you eat in more detail on those 5 days please.