How do antidepressants work? - Neil R. Jeyasingam

Dig into the discovery of antidepressant drugs, how they work, and what we still don’t know about depression.
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In the 1950s, the discovery of two new drugs sparked what would become a multi-billion dollar market for antidepressants. Neither drug was intended to treat depression at all- many doctors and scientists believed psychotherapy was the only approach to treatment. Neil R. Jeyasingam details the decades-long journey that followed and how it revolutionized our understanding of depression.
Lesson by Neil R. Jeyasingam, directed by Skirmanta Jakaitė, Art Shot.
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[@mariaclara4480]

Alcohol and cigarettes addiction actually destroyed my life. I could remember several years ago after divorce with my wife which brought me into my disastrous journey on Alcohol and cigarettes. I suffered severe depression and mental disorder. Got diagnosed with cptsd. Not until a friend recommended me to psilocybin mushrooms treatment. Psilocybin treatment saved my life honestly. 8 years totally clean. Much respect to mother nature the great magic shrooms.

[@AlannaPhillips-fn3fd]

they saved you from death bud, lets be honest here. and mushrooms are one of the most amazing things on this planet i wish people would all realize. they could solve a lot of problems, more than just mental treatments, environmental clean up; the possibilities are endless with fungus.

[@teresamartim6173]

Can you help me with the reliable source. I'm 56 and have suffered for years with addiction, anxiety and severe ptsd, I got my panic attacks under control myself years ago and they have come back with a vengeance, I'm constantly trying to take full breaths but can't get the full satisfying breath out, it's absolutely crippling me, i live in Netherland. I don't know much about these mushrooms. Really need a reliable source!! Can't wait to get them

[@WilliamSok-ib1ms]

YES very sure of Dr.Burkeshroom. I have the same experience with anxiety, depression, PTSD and addiction and Mushrooms definitely made a huge huge difference to why am clean today

[@MichealDavid-lj8od]

100% agree I used to have Psychosis and paranoid thoughts like "people thinking about me talking about me etc. Very odd behavior after getting off Adderall from 7-16. Antidepressants at 18-29. 31 now. I took way too much, but took about 20g of Gold caps (Psilocybin containing mushroom) I analyzed my entire life. The emotions that came out helped me understand behavior etc more. Wont ever need to do it again because I'm happy and contempt forever, but I wish more people did this to alter their perception of reality. Would help with healing much trauma

[@umarmikailu-cj8qg]

How do I reach out to him? Is he on insta

[@VLJ23]

i love learning about random stuff so i can tell my parents about random things in the middle of a conversation

[@gabrielsalles8403]

It increases the levels of serotonin and dopamine on there brains so if you ask them something it's more likely they will give you what you want

[@nagarathnammats110]

Same I like learning random stuff but I don't like learning math

[@VLJ23]

@@gabrielsalles8403 confusion? i dont tell them stuff to get what i want its just telling them random stuff i learn on KZbin

[@gabrielsalles8403]

@@VLJ23 jk, I was just quiting my biology teacher, it's his excuse to teach us some random and unnecessary stuff

[@VLJ23]

@@gabrielsalles8403 ok

[@lilybird6868]

Was in therapy for three years and have been taking antidepressants for about nine months since experiencing a breakdown early this year. If you're reading this and feel like you need medication, please talk to your doctor about it. It's made my life liveable again.

[@MrGG-xc6sg]

Mind is tricky isn't it? Have you considered that maybe the pills didn't work on you, maybe you just thought they did? The feeling what you have when you know that things will get better is powerful thing.

[@aidanduffy7065]

@@MrGG-xc6sg nope. Look at the placebo trials. These are not mind over matter. They work, don’t know how but they work.

[@Sl33pyDaron]

You need jesus

[@nomyt0766]

Nah I'm good for another year might go to one when I'm old enough to go alone

[@chinchillainspace3624]

​@@aidanduffy7065 did you not just watch a video on how they work

[@Crystyna03]

I have just started my treatment and I can honestly say it's mind-blowing! I have been in therapy before but never had these results. For me, the most surprising part is not necessarily feeling good but the willingness to take risks, take decisions and make changes. Before this, I used to look around me and feel somehow trapped, like there was nothing I could do to change my situation, whereas not it seems as though my brain can find solutions.

[@MrGG-xc6sg]

That's it! When you think you are trapped you are just reinforcing the feeling/idea of being trapped. You need to think that anything is possible if you just put your mind in to it. Ones you got that you think that depression isn't real you put these walls over your mind that protect you from depression.

[@criss6806]

What are the pills called?

[@nini-he8uy]

@@MrGG-xc6sgyou’re weird

[@fkmyoutube]

"Asking for help isn't giving up, it's refusing to give up." - The Boy, the Mole, the Fox and the Horse -

[@jewelsoftheworld101]

Exactly..

[@sakuranovaryan9261]

Yeah giving up would be refusing to take help.. which I do unintentionally

[@forregom]

@MOHAMMAD EISA Bruh CRAUNCH!!d!!!ff!!

[@LEO-zp5jw]

I love that book! I'm glad someone finally mentioned it!

[@aloyperez2059]

@MOHAMMAD EISA troll

[@rossplendent]

"It is easier to say 'My tooth is aching' than to say 'My heart is broken.'" Tell that to the dentist I haven't visited in 8 years.

[@blueorangeade3357]

my dad hasn’t been to the dentiste in well over 5 years 😭🤟

[@icannotcomeupwithanything4609]

@@blueorangeade3357 My father hasn't visited the dentist for over 10 years..

[@murdersuicide]

@Ken Henderson what does that have to with anything

[@yourfriendlyneighborhoodcl4824]

@@murdersuicide hes a scammer

[@sillybrisko]

i havent been since i was 7 because i started getting severely depressed from bullying n im now 15 and i Still have not seen the dentist to

[@DonnHowes]

I suffered severe depression 20 years ago as a teenage. Got diagnosed with ADHD. Spent my whole life fighting ADHD. Not until my wife recommended me to psilocybin mushrooms treatment. Psilocybin treatment saved my life honestly. 8 years totally clean. Never thought I would be saying this about mushrooms.

[@Paul_Michael]

Can you help me with the reliable source 🙏. I'm 56 and have suffered for years with addiction, anxiety and severe ptsd, I got my panic attacks under control myself years ago and they have come back with a vengeance, I'm constantly trying to take full breaths but can't get the full satisfying breath out, it's absolutely crippling me, i live in Australia. I don't know much about these mushrooms. Really need a reliable source!! Can't wait to get them

[@SusanaGomez-mp8sk]

YES very sure of Dr.benfungi. I have the same experience with anxiety, depression, PTSD and addiction and Mushrooms definitely made a huge huge difference to why am clean today.

[@AlexanderMales-gh8bm]

How do I reach out to him? Is he on insta

[@AnnaRoth-pb8xv]

From my experience it really works excellently! It doesnt even need to be a full hit. With potent shrooms 2-3 small ones will still make a clear difference. It will be a few hour cosy rumbling moment around rest time, but afterwards its just calm and you feel amazing and gain your freedom. Psilocybin is different dudes, its the only "treatment" I would recommend to someone who genuinely wants to get better. There is no addiction, withdrawal, or negative side effects. It's just pure healing., far more effective than any anti-depressant. You can thank me later,

[@JesseJason-qc7ug]

Does he ship?

[@Mattrero]

This channel answers questions I never asked myself. Thanks!

[@trtotally]

Thank you for featuring mental health-related videos.

[@nagarathnammats110]

Ted ed hearted this comment So must reply

[@Competitive_Antagonist]

And for being so nuanced.

[@maxine9263]

@@toastycookies4703 sir why must you assume their indian

[@redmist6630]

ted ed finally figuring out us kids will only watch this stuff if its less than 5 minutes long

[@sriku1000]

A Calming Video On the Theory of Moving Emotions. Something as complex as you. You kzbin.info/www/bejne/Y6bIqZ2vadiKq5Y"

[@rimaoulhaj9910]

Treating my anxiety disorder and depression has improved my life so much... I can never stress it enough. Get help people. It's not your fault. Don't feel guilty. It's an illness like any other.

[@kaittlyn]

@@oryuji2610 going to therapy is a good idea :)

[@pieceofart5962]

@@oryuji2610 what is the thing that makes you scared of going to therapy?

[@bumblebeebrass164]

Thank you, watching this video now so I can figure out what’s wrong with me. Been in therapy for a month, I think it’s time

[@deniz8265]

i went to a psychiatrist a few days ago and started taking two antidepressants. now i am scared that maybe i dont have depression and i fooled myself and the psychiatrist. maybe i just couldnt handle the sadness everyone feels and i am making a big deal out of it.

[@sophiesleeps12]

@@deniz8265 hey hey hey, stop that. If you feel sad for no reason and it lasts a long time, you're depressed. And a psychiatrist wouldn't just prescribe an antidepressant if you weren't really sick

[@ianfoster9538]

This is the first time I haven't learned a lot I didn't already know from a TED video. It just made me really grateful I have great people like family and doctors around to help educate me, and not everyone gets that :)

[@MartinsDesign-cs9iq]

I suffered the borderline disorder for over 23 years, with so much anxiety not until I came across psilocybin mushrooms treatment. Psilocybin treatment actually saved my life honestly. 6 years totally clean. Never thought I would be saying this about mushrooms

[@olegkroitory304]

Microdosing helped me get out of the pit of my worst depressive episode, a three year long episode enough to start working on my mental health

[@GlobalVisa-pf9pt]

Can you help with the reliable source I would really appreciate it many people talk about mushrooms and psychedelics but nobody talks about where to get them. Very hard to get a reliable source here in Germany. Really need

[@cemalcanguzel3683]

He's Shane.myco

[@MaruErnekr]

The shroom experience stands as my most remarkable journey, an awe-inspiring encounter that left an indelible mark of amazement.

[@bestaneierflott1195]

He’s on insta?

[@User-mp4vq]

The art is so perfect, you can really see the sadness in the clients' faces. This is the reason I only watch Ted Eds animation. Thank you Ted-Ed

[@bryce7889]

I kind of think it missed the mark because depression is had by so many beaming and smiling people. Everyone gaslighted me when I said I was depressed because I “looked happy”.

[@User-mp4vq]

@@bryce7889 Wow, I am so sorry, there are so many different ways people deal with depression, and not every person is the same. I really like the animation because it is simple, but you're totally right.

[@Yokasyan]

Well, you can also watch kurzgesagt it is good too

[@User-mp4vq]

@@Yokasyan Really? Thank you for telling me, I love the birds.

[@getonthecrossanddontlookba5004]

Repent to Jesus Christ!!! ““Ask and it will be given to you; seek and you will find; knock and the door will be opened to you.” ‭‭Matthew‬ ‭7:7‬ ‭NIV‬‬

[@ivanmont]

Chemistry can be really complex and sometimes really scary. Much respect to those people who dedicate their lives doing scientific research so we can live a better life, at the end of the day they're the real life heroes.

[@vincentschmitt392]

they are criminals

[@ishaanbhanushali3665]

@@vincentschmitt392 and how are they criminals?

[@vincentschmitt392]

@@ishaanbhanushali3665 for instance by publishing fake results regarding the safety of some drugs. This is quite common.

[@naynay8anaynay747]

Even then, sometimes people get bad enough where they do end wanting to kill themselves. Although it isn’t correct, it’s what happens to some people. U can’t rlly argue abt it bc all ppl have free will

[@naynay8anaynay747]

I meant to reply to the comment below sry. My apolgies

[@sanuspg]

I love the graphics style in this animation. Also, thanks for this informative video. More than 15 years with depression, I'm on meds, and I've had a long therapy, both very helpful, but it still affects my life, and I still try to learn more about it.

[@mehakjan6996]

Are u ok now

[@anywallsocket]

Bro the monolith casting spiraling shadow on “we still have a ways to go” with “understanding” at the middle 🤯 Animation artistry 🤩

[@akiangel1864]

I took antidepressants for 8-9 months, it helped me, and i eventually healed as time went by. Im glad to have survive depression and saved from the attempt of suicide. Here's a smiley face for anyone reading this >> •ᴗ•

[@philip6502]

Some depression is situational...death of someone close to you, loss of job, physical health. It will usually go away on its own or with medical/counseling help. Some depression, like mine, needs constant care...in my case, medication. I'm fortunate in that after years of trying, I have found one that works with minimal side effects. Every individual needs to find what works for them, but unfortunately, many don't try or are unable to. It's not an easy life.

[@jazmin0511]

Thank you for sharing your experience. I pray I can say this too one day

[@thunderedsun203]

why do these depressed people comment have to be so sussy 💀

[@hussain0413]

@@thunderedsun203 it’s not sussy, if you were depressed you’d understand

[@lalrinliana5966]

@@philip6502 hello philip i wanna talk to you

[@angiep.7253]

My grandpa had depression and he committed suicide, I miss him so much. He did treatment and we thought he was improving, this illness is heartbreaking.

[@lilyjay8530]

I’m so sorry to hear that, may your grandpa Rest In Peace ❤️

[@acrendon952]

Im so sorry to hear that. I hope you get better soon

[@sarfarazahmad1760]

Suicide is self murder........ everything belongs to almighty God Allah...... So it is haram to commit suicide.....closeness to God makes you peace full

[@Lokitellus]

@@sarfarazahmad1760 yo7 shouldn’t say that because not everyone believes that stuff

[@Lokitellus]

@@sarfarazahmad1760 your welcome

[@garrettwidner6915]

It's not just psychotherapy and antidepressants, there are 3 methods for combatting depression and any doctor that doesn't explore the 3rd option is falling short. Lifestyle is the 3rd factor. If you're working 80 hours a week, living paycheck to paycheck, etc, you can't be happy. Some of this is beyond our control but you can't expect results if you give someone medication and therapy when they're in an impossible life situation.

[@lawxs9114]

Blame capitalism then you Become marxist

[@ghostlyxero9030]

I've been depressed for well over a decade and it started in my early childhood years. Finally getting diagnosed and given antidepressants for the last 2 years has definitely helped me improve my mental health. Antidepressants do not take away my depression and anxiety, but make me feel less overwhelmed and more motivated to improve through therapy. there is always another answer, and it may not be the first one, but it is out there. for everyone dealing with their battles in private, i see and recognize you, and you are worthy and so so valid and deserving of getting help.

[@user-dc4bl1cu2k]

I'd reccomend checking your diet. If you're consuming caffeine, sugars, alcohol etc. your chances of overcoming depression are low. Just maintain a healthy diet and avoid stuff like that.

[@supersnapp]

Sounds like a very ineffective drug.

[@voxifyszn2534]

​@Shaun Snapp it's sad how people need medication because they sad

[@goodnightmyprince6734]

​@@voxifyszn2534 depression is more than being sad

[@sakurakokoro1567]

Here's to all of us who take antidepressants to function normally and survive! You are not alone. You are all cherished and loved. ❤

[@EvelynL.1112]

Thanks

[@h2o_exe]

Thank you.

[@limprofile]

Used to take them for awhile. Im glad i dont need to depend on them for the time being now. But u all are awesome!

[@quaimaboylan5175]

i take citlopram

[@herbertgamwell5364]

Thank you! You’re not alone too ❤️ Together we all will reach our goals I hope so!

[@mohammedsaquibkhan2592]

<a href="#" class="seekto" data-time="265">4:25</a> simply put "Correlation doesn't imply causation" - Demon of Reason

[@sergiobarros2697]

- D. Hume

[@jewelsoftheworld101]

😮😍👍

[@manikantan4809]

Not simply put though.hard words

[@dextro2090]

I just want to point out how psychiatry always says something like: we have effective treatments for schizophrenia and serious mental illnesses, meanwhile, they don't even come close to understanding how they work; and you just need to get out and see the number of homeless in the streets; I mean they say we can treat it, while you just have to look at those patients and see that they are so-far from controlling the disease.

[@josemorgan8048]

correlation does imply causation;correlation does not equal causation.

[@leonielopes7586]

Love the animation in this video. Complemented the topic really well

[@LarthMedia]

I’ve been taking medication and seeing psychiatrists and/or psychologists for over a decade. Trialing through different meds can be extremely difficult, I’ve had some rough days to say the least. My advice to anyone dealing with similar issues would be to never give up. The sun will rise on the perceived eternal darkness you are going through. Much love ❤️.

[@grv91vr23]

Antidepressants are bad they disabled me

[@TristanSamuel]

This isn't related to the topic but I like how everyone looks like they have a bird for a head.

[@kwdmawdmwoa5668]

oyasumi punpun

[@_Hunar_]

Never watch this video before taking pills. 🔥

[@hahalord7294]

@@kwdmawdmwoa5668 Exactly what i thought

[@blopin2002]

Reminds me of Goodnight PunPun

[@kwdmawdmwoa5668]

@@hahalord7294 yeah i just finished it and i feel so empty inside now

[@shayarhashim7567]

I am on antidepressants and i am proud that i have face the reality and went to fix my life, please don’t be ashamed when you need help ♥️

[@kaynatnasar1564]

Same . finally took the step towards medication after suffering for 8 months

[@Zwerlijn]

Well said, sometimes you need a bit of help, i was on them for 7 years. Made a lot of lasting changes in that time and learned to love and respect myself above all else. Now off the meds since a year and even though life still throws difficulties at me at times its much easier to deal with them

[@shayarhashim7567]

@@kaynatnasar1564 I am very proud of you to take that step to live a better life now.

[@shayarhashim7567]

@@Zwerlijn That is really inspiring to hear, you have done so much to make your life better and i think you are now living better than that before 7 years ago, there is no shame for knowing that life could be better until you see the difference after you heal your mental diseases. Thanks for sharing! I am very proud of you.

[@loriescalera]

I am proud of you too. There is no one size fits all. I have seen a lot of suicide. I have seen a lot of mental anguish and illness. I, myself, will always try to improve myself when "I am AWARE" that something could be better. Its not easy, but I want to live and be creative, so I embrace struggles.

[@gastly2109]

It was very sweet to include an animal with the people who experienced depression in the video ! Very nice :)

[@elementalsteve9029]

I really loved the animation in this video. It matched the lesson really well.

[@mind7938]

it's my first time taking antidepressants and i've never felt this happy (?) in years !! i literally was so shocked when i realized why bad thoughts were being suppressed / weren't being processed further, i remembered i took an antidepressant earlier. it's still weeeeird. i'm also a chemistry major but i really stopped studying it a few days ago because i was so unmotivated and probably lost passion. but i slightly got motivated seeing the chemical compounds in this video. perhaps i wanna make people feel what i felt and help them too

[@NotAnti2]

Hello! It’s been 3 months since your comment was uploaded. Has everything been okay regarding the consumption of AD? I want to get on them but I’m worried it’ll make it worse, doing my research still. Hope all is well along w your passions and drives!

[@jones2277]

how long did it take for it to work for you?

[@myaaisha3147]

Yea it makes you smarter also and make you realize things you never did before. It’s a different perspective the way you see things. When you’re happier, you function better.

[@myaaisha3147]

I don’t take a dose everyday just whenever I’m in a bad mood

[@mind7938]

@@NotAnti2 hi! in my case, there have been no problems so far, really only benefits from the medication. i still take them everyday but my dose was halved recently. but of course we probably have drastically different cases and our response to the medicine would also be different. again, i don't think and feel i experienced negative effects from the medicine. while antidepressant dependence could be a concern, i personally haven't faced the problem, but i also think i really wouldn't as long as i abide by my psychiatrist's instructions. what i learned, however, is that antipdepressants really are only a part of "getting better." factors like lifestyle, mentality, and your surrounding environment are just as important. with that, i just wanna emphasize that antidepressants did help me, but i could still not improve when i still have problems with those other factors. what i do suggest is for you to visit a health professional and when you've received the proper medications and encounter any problems with it, you just have to tell them and they will make necessary adjustments. in my case, all visits had been a share of responses to the medication and adjustments in return.

[@xzyhavionwilliams5058]

Ted Ed is my antidepressant because whenever they show up I’m happy

[@kingsley.]

:o

[@pixelpancakes489]

That was smooth-

[@HunterSuper]

You are saying this for likes aren't you

[@CatHostage]

Yes, i need TedEd videos in order to get out of bed in the morning too

[@bernae1902]

Depression isn't not being happy.

[@RossBilly]

Psilocybin DMT, mushrooms and psychedelics, as a whole, have shown substantial promise as beneficial agents that can truly aid individuals grappling with mental health difficulties.

[@MilitaryStrong-vt2oe]

I totally agree! DMT, Psilocybin mushrooms and psychedelics in general have shown great potential in helping people with mental health issues. It's truly remarkable how effective they can be in treating depression and anxiety

[@DannyFellon]

Can you help with the reliable source I would really appreciate it. Many people talk about mushrooms and psychedelics but nobody talks about where to get them. Very hard to get a reliable source here in Italy. Really need!

[@ThomasUrah]

I can say Dr.Jaffet is the man for you....

[@DaveFarhat]

Dr. Jaffet has pure psychedelics products.

[@YundaGregg]

How can I reach out to him? Is he on instagram

[@hsaqib8995]

Thank you for sharing.

[@Munthegun]

Lied to myself for 15 years about depression. Even made specific doc visits for it and lied to them, leaving empty handed. Finally openly expressed my emotions and got on antidepressants and it was the single best decision I’d ever made. Literally life saving. I call it the logic pill. Life is wildly better three years later heavily thanks to starting them.

[@tabularasa9576]

Why did you lie about your depression?

[@angelit0es]

@@tabularasa9576 its embarrassing to receive sympathy or pity for some people its why i lied about self harm as well.

[@adelmograziano2506]

It was the opposite for me. I was having depression, but antidepressants destroyed me. I can't feel emotions and every aspect in my life is ruined. I suspect neurotoxicity. It's affecting thousands of people. I'm glad they helped you, but they can come with life ending consequences. There are alternativee cures for depression, but there's no cure for this condition.

[@SARCASMOOO]

Yeah the thing i find so difficult since i am on anti depressants is trying to explain what it is like and people tell me just do it anyways. Like thanks that helped so much.

[@jakuxsi]

Great video! I'm always annoyed when people say that depression is "just an imbalance of chemicals in the brain" when it's much, MUCH more complicated than that.

[@raph2550]

A personal example: what if the side effects of the antidepressants given to treat your depression create new problems in your life, which thus fuel your depression?

[@crazydragy4233]

To be fair, sadly that sort of thinking is the lesser of 2 evils at times...

[@Kier4n99]

Can you enlighten me? As that is pretty much what I think.

[@jimiplayscobo5877]

@@raph2550 Then you tell your doctor to prescribe a different script. What works for one may not work for you :-) Peace

[@raph2550]

@@jimiplayscobo5877 Yeah, sure, but that may take a long time =/

[@bartpeeters2029]

Brilliant and very valuable info done is a masterly fashion. Love the design too. Impressive.

[@allrounderalltime5838]

The animation in this video is outstanding ❤

[@bull3tride]

As a victim of the above mentioned I can truly say that I would have taken my life years ago if it was not for therapy and medication. Do not be afraid to ask for help. A life with untreated depression is no life at all.

[@crowdise499]

Ah so I have no life *Great*

[@Connorscarlos]

I am going to get on medication due to this, I am suffering every day now with physical symptoms manifesting. My family thinks I’m dramatic but I have had enough

[@tonyd.u.y7262]

@@Connorscarlos How are you feeling now? I tried therapy but that didn't really work. I'm think of taking medicine since I find myself getting closer to actually suicide.

[@MrGG-xc6sg]

@@tonyd.u.y7262 have you considered that your depression is caused by you life choises? Like if you change your life you wouldn't be depressed? Like you don't have the thing that drives you in your life. Ones i found that i have never felt better. So my advice for you stop thinking negatively go for runs, start working out (strong body equals strong mind), start new hobby, listen motivation speeches, get quality sleep, eat healthy and reduce time on phone.

[@sigmamale4147]

@@MrGG-xc6sg i agree 100%, life choices were very important for me

[@sid-2k1]

I liked how the pup was giving instructions to the scientists to prepare drugs for depression.

[@dylanparker130]

Haha, love this comment!

[@Tree_Lord]

Who better to create anti depressants than one of the most anti depressing animals.

[@ladygrinningsoul357]

So that's what the dog was doing.

[@htsgm]

@@heckerjr.7982 no

[@monicayami2298]

@@Tree_Lord love this haha

[@guidaribeiromap]

Excellent content. Thank you.

[@user-go6dp8bq8c]

Wow! The animation style looks realy interesting, animators did a great job

[@justsomeoneelse5942]

I haven’t even finished the video but the animation is so good...

[@praveensheelvant6061]

You haven't finished the video because you wanted to post the comment.

[@thecreatorofpc7929]

And so is the background music

[@Abstractor21]

I dont know why but it reminds me to Pathology 2

[@anxiousleighwaiting]

A quote fitting for this video: "If you don't have your own serotonin, store-bought it just fine."

[@Dosia142]

"but that doesn't mean seretonin deficiency is cause of depresion"

[@elenapashaeva1]

But it’s true what they’ve said - it doesn’t help everyone. Fluoxetine did nothing to help me with my depression. But helps to get absolutely hammered when you mix it with alcohol. And then you are becoming even more depressed. Changing my life, turning to God, doing good things for others - that is what really helped me.

[@drot13]

Abigail? :-)

[@juanignaciogregoratti8606]

@@Dosia142 😂

[@richardwalker8575]

I've struggled with depression for many years and had enough of anti-depressants and ready to try something different .

[@patriciawalker851]

`have you tried microdosing pills?

[@richardwalker8575]

@@patriciawalker851 `Can mushrooms/microdosing caps help for depression ??

[@patriciawalker851]

@@richardwalker8575 Yes

[@patriciawalker851]

@@richardwalker8575 Helped me alot

[@patriciawalker851]

@@richardwalker8575 \Willliamsmyco1/

[@AliceP.]

<a href="#" class="seekto" data-time="251">4:11</a> - <a href="#" class="seekto" data-time="268">4:28</a> this seems like quite an easy riddle to solve. Serotonin deficiency doesn't cause depression, the situation/pressure/life in which one finds itself in does, but serotonin acts as an artificial "glass half full" feeling that makes a person have the will to live and eventually face their issues

[@paintwithtihani9926]

You can dance or you can cry but still the sun will shine on you 🌻 all love to the fighters out there, you know who you are

[@itsbutterfai]

Thank uuu❤️

[@cameronukz]

I think a lot of people take them and expect to just feel better which doesn't happen. They just make your mood more stable so you can actually work on the issues that are making you depressed or anxious without feeling crippled by panic and stress.

[@MrGG-xc6sg]

True, like depression is always the symptom of something. People trust too much for pills to fix everything but at the end you are the only one who can fix your own mind.

[@s.o.s7180]

​@@MrGG-xc6sg definitely agree, i dont believe in the power of these pills. Something artificial wont help me, I prefer nature.

[@hartejas2853]

This is fun learning

[@MissKareeBaby331]

very helpful video

[@carlogaytan7010]

What I got from this is that we are pretty advanced in treating the symptoms. But I've rarely seen someone talk about curing this, nevertheless, preventing it in the first place.

[@ohioskane363]

Eliminate childhood poverty and abuse, eliminate sexism and racism, and in some cases choose different ancestors.

[@binita4672]

@@ohioskane363 wtf do u mean by change ancestors

[@KeanuG95]

@@binita4672 just change your great grandparents, how else?

[@ohioskane363]

@@binita4672 Having grandparents who have undergone trauma increases susceptibility to depression in the grandchildren. Not practical advice, of course. 😉

[@LaurennM360]

Mood disorders are hard to regulate. It’s not something you just cure. I would say we aren’t that advanced. Unfortunately like he said lots of people don’t respond to medicines, but there is still a lot of doctors who just want to throw medicine at the problem and not address other issues that could contribute. (Socioeconomic status, level of support groups, behavioral, nutrition, other disorders, etc.) I was on prozac as a teen for many years. It was seen as a catch all at the time. Now I see a psychiatrist and take different meds that are a little more helpful for me. But let me tell you there is SOOO much that contributes to depression and anxiety. (Vitamin D, anemia, thyroid issues, people around you, exercise, thought process, trauma, other mental disorders like ADHD, anorexia etc,) A lot of times it is a side effect of something else going on. 🤷🏼‍♀️ Mood is hard to quantify. So it’s also harder to study. Harder to treat. Not everyone experiences depression the same way. There isn’t an easy way to “cure” depression. It’s mostly about improving your level of daily functioning.

[@burhbruh1786]

Wow, huge props to whoever animated this. I loved the art style, the drawings, the characters, the aesthetics. EVERYTHING!

[@MrAndreisousa]

thanks for this video

[@cactusboris2042]

The animation is amazing 💜

[@sebastianc2222]

I like how we are still at a point of history where we don´t understand how some stuff works but we kinda just go along with it cause it works.

[@KikaJoye]

i feel like few years later or maybe when our generation will be old there will be more informations and maybe ad will be seen as damaging like it happened many times before with cigarettes, alcohol during pregnancy or so on when we were not aware about bad effects at all

[@RetroPlus]

Just remember that only 50 years ago they still performed lobotomies

[@aplus1080]

That's medical/scientific history in a nutshell

[@suaiedail]

Scientist are still not sure what the mechanism of action of acetaminophen/paracetamol is, one of the most used painkillers

[@astromessier]

We would know if the 2 trillion dollars we spend annually on the military were used for scientific research.

[@Ellie-jl3vk]

Don't let anybody talk you out of giving antidepressants a try if you need them. I avoided them for 5+ years and giving them a chance saved my life.

[@AndyCouch3000]

Same goes for psychedelics

[@juleslloyd9162]

I second this!

[@deshaunblackett4745]

Therapy and a friend is better than meds

[@Ellie-jl3vk]

@@deshaunblackett4745 Go away

[@Justanobodybro]

@@Ellie-jl3vk no just facts

[@nicolemills4795]

Great information!

[@GrantCopping-brown-bs2hw]

Very well done and ❤️felt applause for this video , I thought the way it was done by pictures & very nonjudgmental, I’ve been suffering Depression, anxiety, memory loss ( & probably bipolar ) for years ,& a lot of the ( & in layman’s terms) way things were told/ advised were excellent., 👍😎

[@ellet8529]

This makes me feel better, I've been on antidepressants since age 14, and now at age 22 I'm looking to make steps to come off them! It's nice to hear that there's hope that I won't need them again

[@lisahansson2605]

Check out Kelly Brogans book A mind of your own.

[@ellet8529]

@Warped Sounds TW suicide and self harm. I mean I was suicidal so I'm not sure what the doctor could have done - he sent me to counselling but the NHS provisions aren't great and so I fell through the cracks unfortunately. I came off them for a short time at the start of university but my self harm tendancies came back and so I requested to be put back on them. I'm in a much better place now than I was back then though. I don't know if I appreciate you saying it's a phase, I have good days and bad, and I expect that will continue through my lifetime, but hopefully I'm more well-equipped to deal with it. Hope this all makes sense!

[@citroken]

I loved the little dog keeping the person company throughout the video ❤️ Reminds me of my dog throughout my own journery

[@balladofthebroken7569]

Out of the 7 I tried, they don’t work for me & instead make me a walking NPC with no genuine raw emotion. Also, some of them (such as Zoloft) lower your risk assessment drastically which can produce disastrous results in certain individuals (James Holmes). Speaking for myself personally as someone with depression induced by generalized anxiety disorder & PTSD: I am not a fan. Working out, socializing with others, a stronger sleeping schedule, a productive day, etc. benefit me much more. Thank you for coming to my Ted Talk El fin

[@haydenskiez]

This is so interesting.

[@kerentan9446]

that guy holding up the "It's not your fault" billboard is my antidepressant

[@esma1456]

We need more videos of "There's a Poem for That" 🥺💜 You completely forgot that series..

[@tonykhang1984]

yes

[@treve.mp3]

YES! Seconded.

[@little_swallow]

Agreed

[@chocolatymilk2402]

I agreeee

[@eirenec.m.9496]

Definitely!

[@Queening]

I find studying the brain's chemical ratios and balances so interesting. It's so amazing we can give people special amounts and kinds of medication to balance out the brain.

[@jonathan1100]

This animation is beautiful.

[@sinkpisserpro]

The art and animation in this episode is absolutely gorgeous!

[@anotherone8941]

"we don't know what causes depression" tell that to parents who think if the world didn't explode you can't be depressed

[@nastya0987]

Its hard for people who never experienced depression to understand it, that doesnt mean they are bad people, it just means that they dont understand it. You cant be mad at a man not being to understand extend of pain women go through during birth giving. The common point needing to be delivered is that its an actual illness that has nothing to do with events one may be experiencing.

[@otundetchagala9560]

As someone who overcame depression by himself, I'd say if you aren't some sort of cripple, you really have no reason to be depressed.

[@leon3672]

Parents should be totally aware of mental illness beforehand, since they introduce their children to all suffering by giving birth and play a big role in their development stages

[@otundetchagala9560]

@Chilapa That sounds like a character flaw more than anything else. Being loved and loving in return isn't something that should make you extatic 24/7. I'd say you either lack appreciation/gratitude for the people you already have in your life, or you just don't really like them that much. I'd suggest reflecting on your own thoughts and feelings before jumping on the antidepressant train.

[@lanatureestlartdedieu9591]

@Chilapa I agree

[@lethalsands]

I just got prescribed prozac, thanks for the helpful video.

[@fxaman]

I'm glad to learn more about this. I've been stuggling with depression (undiagnosed, just how I would describe it) for the past eleven years and lately all I could thing of is suicide, so I'm going to start therapy next month and I have first appointment to psychiatrist at the end of this month. At this point, I'd give anything for an option to feel joy again. I hope combination of therapy and drugs might work for me. I'm losing hope, but we'll see.

[@tuanz8009]

I used to have anxiety disorder. Ever since taking antidepressant medication I feels like I just came back to life

[@zuzannakielar]

Samee

[@houseoffirebellytoads1439]

Which one are you on?

[@Empr.Palpatine]

Do these pills make you feel "Sedated" in any way? because i have considered antidepressants. But i am afraid that I won't be able to learn things as easy or concentrate as long as before.

[@juligarcia23]

@@Empr.Palpatine no, and if they do your psychiatrist will find a better drug for you

[@Empr.Palpatine]

@@juligarcia23 ok. Thank you :-)

[@tobymax10]

I just switched school and felt (still do a bit) depressed. I found working out to really help with it. It gives you a better body which feels nice, but you also feel great leaving the gym. Knowing that you put effort into improving your life feels good.

[@FredSlocombe]

I took Fluoxetine for a couple of years and it improved my mood to the point where I was remembering positive experiences from my childhood that I couldn't remember before. However, this was in the run-up to the Covid-19 pandemic. I was unable to modify my habits and make necessary social changes in my behavior.

[@alexaclaire8728]

I have PMDD. The fact you explain depression as a chemical imbalance just blew my mind! The drop in hormones right before menstruation makes a lot of sense it could inadvertent cause a chemical imbalance. I hope we find out more about this disease in my lifetime

[@ssff4066]

It is easier to say 'My tooth is aching' than to say 'My heart is broken." It has been 20 minutes and I am still thinking about this line. 😌 so perfect

[@ramanrendersrandomly]

Ted-Ed consistently churns out vids with different animation styles and I love it.

[@AbelardoGzz]

love this

[@livyrose002]

i was diagnosed with depression 3-4 years ago and have been on anti-depressants since. they saved my life man

[@isaac3521]

Hello, I'm loving this channel, a big hug from Brazil 🇧🇷

[@alexanderveritas]

Well, I’ve been using antidepressants for some time now and I can say that this particular video has undeniably shed more light about comprehending my actual condition.

[@edwardwrightlambert1608]

been battling anxiety, depression and insomnia but getting to meet *Healermanchris* on IG who sales DMT, Shrooms, LSDs and other psychedelic products. I have been effectively stable and relaxed, he ships discreetly worldwide 🚚

[@shyaaammeneen63]

Alexander, Detox the mind. Reduce negative thoughts. Your breath is directly related to your mind [brain] causing negative thoughts-anxiety. For a relaxed life sit on a chair, back erect, eyes closed, be still and observe the sensations of your incoming--outgoing breath at the entrance of the nostrils for around 5-10-15 minutes or more. Don’t fight with your thoughts. Slowly they will reduce and relax the mind. Deep inhalation-exhalation is not needed. Anytime of the day or night before sleep sit or lie down and observe your breath. Top priority is to be as still as possible as it reduces negative thoughts. Make this a lifetime daily habit to have a good life. Best wishes Shyaaam Sir. -Counsellor

[@Arya-db3yd]

As someone who's been taking fluoxetine for about 2 months now, i really appreciate this kind of video! i love understanding more about stuff like this...

[@sergeychekoev6377]

Share with me?

[@Arya-db3yd]

@@sergeychekoev6377 share what?

[@sergeychekoev6377]

@@Arya-db3yd In your comment, it is said that you have been taking Prozac for 2 months. In your comment, it is said that you have been taking Prozac for 2 months... So I say, share with me? I also started taking Prozac.

[@Bean-hm4ob]

​@Arya-db3yd I think he meant your experience

[@Shreksophonefan2018]

i really liked the people drawn here :D . looked so simple so i tried drawing one of the doctors. turns out drawing shadows are the bane of my existence

[@nxcrorat]

I struggle with depression amongst other things but since I had bad experiences with doctors it's becoming harder to trust them and their prescriptions, thank you for this video, it will definitely help me.

[@billycasper3351]

The articulation of the concept is top-notch.

[@nowhereallow]

Amazing video

[@greteohneh4503]

I absolutely wish i would have seen this video 3 years ago, when my therapist at that time wanted to treat me with anti depressants so badly. But i refused, because i was against something that would help my condition or get out of it but my own abilities . Now, i moved, stopped therapy, and lived through the worst weeks of depression, but have no access anymore to the meds.

[@chelsealouise2232]

the animation on this deserves an award

[@crispin9152]

Jumped onto this video very quickly. Not only do I work in medicine and have a good understanding of depression and SSRIs, I too suffer from depression and went through trial and error of trying many kinds of medications. I hope that in the near future, we can have a better understanding of it's causes, functions, and treatments as well as eliminate the stigma behind it. Thank you TED-Ed for spreading awareness through your massive following.

[@shyaaammeneen63]

Crispin, If depression affects physical health like nausea, upset stomach etc medication of a low dosage is needed but under guidance. Detox your mind. Reduce negative thoughts. Your breath is directly related to your mind [brain] causing negative thoughts-anxiety. For a relaxed life sit on a chair, back erect, eyes closed, be still and observe the sensations of your incoming--outgoing breath at the entrance of the nostrils for around 5-10-15 minutes or more. Don’t fight with your thoughts. Slowly they will reduce and relax the mind. Deep inhalation-exhalation is not needed. Anytime of the day or night before sleep sit or lie down and observe your breath. Be as still as possible as it reduces negative thoughts. Make this a lifetime daily habit to have a good life. Best wishes Shyaaam Sir. -Counsellor

[@jamminjamie1]

I really like animations on this one!

[@penguinsmalz3774]

I've been taking SSRIs for over a month and they work. I live in a toxic household so I don't have the support I need. My meds stabilize my mood. I can't feel the extreme of any emotion. I am an artist so my imagination has also decreased. I haven't had a mental breakdown or the shooting chest pains(anxiety) since. This is not something I'd do long term but until I can get out of here, these are a lifesaver.

[@baraadaher3800]

the animation is so damn good, I'd like to work with their team. keep the good job ted!

[@johnm.7611]

I was on Sertraline and Fluoxetine therapies to treat depression but none of them helped me recover. On the other hand, I had severe side effects such as weight gain, headaches, insomnia and nearly developing diabetes. Therefore, it was not worthy taking them. Unfortunately, depression is more complex and just antidepressants aren’t the answer to the problem. If a patient suffers from unresolved trauma, medicine won’t really help. That’s why talking therapy with a psychologist is mandatory.

[@meeshterious8644]

Sadly, the psychiatrist I went to has zero compassion for her patient and uses non-therapeutic communication approach. She does not even pay attention to what I am saying, just asking me sypmtoms from her checklist and prescribed medications. She was in a hurry maybe to be able to take in more patients. My intial session with her took only maybe less than 15 mins.

[@azusa004]

i love this art style and thank you I'm starting SSRI s tomorrow

[@KingBongBoon]

How was it.

[@m.f.richardson1602]

Thank you. Peace

[@user-xn4ru6ex2v]

Love these animations, reminds me of so many kids shows I used to watch, colour palette on point

[@seulgisjoy7439]

My childhood best friend I haven't seen in a while has depression now and she's in a psychological clinic... She's only 14. I found out last week when I visited her again. It's so heartbreaking to see the joyful smile vanishing from someone's face... She already told me a while back that she wasn't doing all that well and plans on going to therapy, I comforted her and reassured her that therapy will help and everything is gonna be Allright! But I didn't think it was this bad anyway... I feel guilty for not staying in touch. I'm so worried

[@nataliastead7221]

In my experience antidepressants made me feel nothing at all, they made me somewhat numb. Although I wasn’t in a state of sadness and having to deal with anxiety every day, it also stopped any excitement or happiness overall. I’m not on them anymore but they did help me overcome lots of things and I did see overall improvements

[@Am0ha]

I hope u told them it made u feel numb 😅

[@phillipsmith4485]

Yes they depress some brain functions and numb the emotions, good and bad. Overall not good at all except for a very brief time.Even then placebos are as effective, and love, support,care, financial help friends and relatives can do much more without side effects.

[@meeshterious8644]

Hi Natalia. Glad it helped you. May I know which antidepressant did you take and for how long? I am apprehensive about it’s side effects. It seems like it can create more problems than the benefit.

[@lilyblossom9438]

I actually take Prozac! It's more for anxiety than depression though. I remember first going on it about 5 years ago and the difference was night and day. Cool to hear the history behind it!

[@joshnorman7234]

I wish they also talked about the other classes of antidepressants, like SNRIs and atypical antidepressants- the ones I am on. Still, very informative and awesome!

[@rafael-rossi]

Just a fantastic video on an emergent issue. TED-Ed, you beautiful creator!

[@LazerAzxl]

So far Prozac has given me a fresh breath of life after so many years in the deepest darkest pits of depression. I would go over and over and over with myself trying and trying to find ways to break out of that abyss but nothing every seemed to remove the root cause. After years, I finally feel like a normal functioning human which blows my MIND. I never expected it to have such an immensely profound impact on my mental state or health, it was honestly incredibly stigmatized from my initial standpoint.

[@purplemismagius28]

Prozac is a miracle pill, I was constantly panicking and scared whenever I was alone; but when I started Prozac I suddenly was able to live to my true potential.

[@znrdn]

Meow meow 🐱

[@Serennekin]

what dosage are you at?

[@emberhermin52]

That makes sense. It made me feel so dead and numb when I was on it, but if you needed an emotional "deadening" effect...

[@purplemismagius28]

@@Serennekin I’m currently at 30 mg

[@phillipsmith4485]

Placebos work just as well to help you recover.