HOW DOES PARACETAMOL WORK?

[@chalie42]

Hi Jesse! I was wondering if you could tell me why they seem to buddy paracetamol up with a lot of other pain relieving drugs such as, Ibuprofen, Codeine, Diazepam or Tylenol.. this seems like pain-relief overkill

[@TheTravellingScientist]

Yeah absolutely! So pain relief drugs can often be more effective when used in conjunction with one another, and it gets pretty complicated! Tylenol is the American version of Paracetamol (Panadol), and when used in conjunction with ibuprofen, they work together to COX-BLOX pain by getting rid of the prostaglandins that cause pain and fever. Opiate drugs like morphine and codeine work directly on the nervous system to reduce pain signals all together. And Diazepam is a relaxant that is usually prescribed to calm you down and make you sleepy...maybe to sleep through the pain. I will have to make a video that discusses how various drugs interact together when they are used at the same time. Great Question Chalie!

[@justmavi7999]

The Travelling Scientist Well you already made the Cox blox joke, thanks. Now I don't need to.

[@dhebert111]

@@TheTravellingScientist Hey there, great video. I have CRPS and I've been treated by some of the best specialists around here. I'm like 10% of the gen pop that can't turn codeine into morphine which happens in the liver I think. The diazepam (valium) is the absolute best at releasing a spasm. They work better than any other muscle relaxer but only at small dosages. Certain Antidepressants help the analgesic work better, so most people with any chronic pain illness usually adds this to their regiment. Your videos are very informative so thank you.

[@TheTravellingScientist]

@@justmavi7999Somebody had to do it, haha!

[@TheTravellingScientist]

@@dhebert111 That is a very interesting and unfortunate case. I'm surprised that you need to take Antidepressants to treat pain, but I'm glad that you have found ways of treating your illness. Thanks for watching the videos buddy, keep in touch :)

[@aaronsimpson8329]

That cox block joke is so cheesy but i laughed out loud 😂

[@TheTravellingScientist]

Hey, it ain't easy bein cheesy ;) But I'm glad you liked it! Watch more of my videos for more awesome dad jokes :D

[@manavendrasingh3414]

He didn't even joke

[@dracula5205]

I had 104 F fever just took paracetamol and it dropped to 101 F I was curious to know how this drug ' paracetamol ' actually works . Great video

[@TheTravellingScientist]

Thanks for watching, I'm glad that you learnt something new!

[@saunakpodder10]

Watching this while having a fever lol

[@TheTravellingScientist]

Hope it helps you in some way :) Take care

[@stradegy3338]

Okay, I had to scroll down for paracetamol videos until I crossed this one, and knew it had to be legit. Thanks a bunch!

[@TheTravellingScientist]

Hey @XxUnknowNxX Buff thanks so much for finding my video and enjoying it legend, I hope it helped you out in some way. Feel free to check out some of my other videos around similar subjects :D

[@rohitkumarbehera9150]

Jesse Sir, I loved the way you told about the side effects of Paracetamol (i, e; about NAPQI and Ucler) , it helped me a lot for my assignment. I am a student of +2 second year😀

[@TheTravellingScientist]

@mami behera why thank you very much. I'm glad you enjoyed the video and learnt something. I hope you keep watching for more awesome Travelling Science Videos every single week :D

[@gorgeousclicks9809]

Thank you dear for sharing such a wonderful knowledge. We were searching the correct information and found here.

[@TheTravellingScientist]

Hey @Gorgeous Clicks thanks so much, I'm glad you enjoyed the video. I hope you subscribe and check out more of my epic videos every Science Sunday :)

[@gorgeousclicks9809]

@@TheTravellingScientist Yes, We have subscribed and wait for every new video. Thank You

[@howtomedicate]

Great channel! always loved your content! I just started myself to make medical videos! You were a great inspiration. It is so hard to get people to watch you content though, but I guess I just need to keep going. Anyways keep it up! Keep make me smarter, haha!

[@TheTravellingScientist]

Thank you my friend! I will continue to make educational and entertaining videos because it is my passion, whether people are watching or not! Keep it up yourself, lets do a video together one day :)

[@howtomedicate]

@@TheTravellingScientist sounds great! I would be up for it! Haha

[@beyondbackwater4933]

To me it's more fascinating to find out how paracetamol actually works is unknown than what I came looking for which is how it works.

[@elijahgardner8213]

Thank you Doctor Thor!

[@TheTravellingScientist]

Haha, thats what they call me! Cheers Elijah

[@rheyza4475]

DUDE! You are Legit! Loved your vid man, your doin everything right.

[@TheTravellingScientist]

Cheers legend, glad you like it. Plenty more good vids to come :)

[@bahartiaredogs3813]

i m not a doctor nor can explain in proper english but all i can say is this paracetamol put adverse effect on memories because i experiencing this

[@TheTravellingScientist]

It is possible that paracetamol could have some impact on the neurotransmitters in your brain like noradrenaline, which could alter your memory slightly. This is a rare but annoying side effect. I hope it doesn't affect you too severely

[@carrerab2418]

Just had a paracetamol after years. God bless them

[@TheTravellingScientist]

It is an amazing drug, no doubt! I hope you enjoyed the video

[@koushikaadhav5317]

How did they design If they don't know it's working ?

[@TheTravellingScientist]

That is a great question! So paracetamol was first synthesized over 140 years ago, so it was poorly understood, but it was recognized as an effective pain reliever. 140 years later and not much had changed, haha

[@ivan0kurnia]

@@TheTravellingScientist so did they have volunteers to trial the then unknown drug?

[@TheTravellingScientist]

@@ivan0kurnia Well decades ago when the drug was first produced, you didn't need volunteers. They would test drugs like these on prison inmates to work out any side effects. The prisoners had a choice, but they would get paid (minimally) to take novel drugs for testing unknown drugs like Paracetamol

[@ivan0kurnia]

@@TheTravellingScientist wow that's a damn hard life. but thanks to them we all can enjoy these treatments we never imagined at the time

[@garethduffy3083]

Thanks for this am a visual learner and this really helps me learn :-)

[@TheTravellingScientist]

That's awesome Gareth, glad it helped you. Fun fact, I am actually a written learner :D Anyway, thanks for watching, feel free to check out some of my other videos around similar topic :D Cheers legend!

[@khairulq7708]

My brain : i curious how Paracetamol works inside a body. Also My brain : yes...

[@antiversion0]

Ah shit, theres COX in me

[@TheTravellingScientist]

There is a lot of COX in all of us :D

[@dumm-edumders2690]

Finally An educational channel that has decent jokes

[@ronzbonz8218]

This was great, Thank you.

[@TheTravellingScientist]

Got your Instagram message, cheers legend! Keep in touch, and keep watching every Science Sunday!

[@nouraalturki2723]

Thank you very much that was helpful a lot

[@TheTravellingScientist]

I'm glad you enjoyed it, next weeks video will be about a similar drug, Ibuprofen. I hope you like that one too 😊

[@aasimshaikh9072]

Thanks! Jesse.

[@TheTravellingScientist]

No no @Aasim Shaikh thank you! Cheers for watching and commenting Legend!

[@actualdbondz]

Thor’s lookin a bit different recently

[@TheTravellingScientist]

I think he looks better on KZbin :D Thanks for watching legend!

[@jackd4]

Does paracetamol help mental pain in any way? Like if you felt anxious would taking it make you any less anxious?

[@TheTravellingScientist]

Great question! Paracetamol should have little effect on mental pain, it has a purely physical response. However, a reduction in pain would probably improve your mental state, thereby making you feel slightly more happy and less anxious. So indirectly I guess so. I wouldn't prescribe paracetamol for anxiety, but theoretically it could help in this manner. Thanks for getting in touch legend!

[@jackd4]

The Travelling Scientist ok thanks for answering my question I appreciate it

[@ladyriddle1984]

Great video thankyou

[@TheTravellingScientist]

Hey @Lady Riddle no worries, thanks so much for watching and commenting with an insightful question. I hope you check out some of my more recent videos and consider subscribing, cheers legend!

[@Thisisaweirdthing2makeusdo]

Who knew? Paracetamol was the OG cox blocker 🤓😆

[@TheTravellingScientist]

Right!? Paracetamol just COX blockin left right and centre!!! Haha, thanks for watching and commenting legend :D

[@Underground.Rabbit]

They just discovered the reason two years ago. Hypothesis was it had something to do with CANNABINOID RECEPTORS. AND THEY PROVED IT.

[@TheTravellingScientist]

Intriguing, let me look into this and report back...

[@BensLab]

Interesting! I had no idea...

[@TheTravellingScientist]

Crazy huh!? I think it's important to know HOW drugs actually work

[@niteshmurti]

why can't we just ask the person who invented paracetamol how it works?

[@TheTravellingScientist]

Hey @niteshmurti great idea...unfortunately he is dead haha. But even if he was alive, he did not understand how it worked either, he just knew that it was effective :) Thanks for watching and commenting my friend, I hope you check out some of my other videos

[@treemonster-xy7in44]

Loved the Breaking Bad bit 😄 & the video was helpful 👍

[@TheTravellingScientist]

Hey @treemonster 2222 thanks so much legend, I'm glad you enjoyed the video and got something out of it. I hope you check out some of my more recent videos, they get even better! Cheers for watching and commenting legend!

[@NightOwlGames]

ive been suffering for 2 days from a Razor blade stuck in my throat feeling, 8/10 PAIN-SCALE, its been super painful to swallow any food and drink i cant even sleep its soo painful! thats exactly what it feels like a Razor blade stuck in their! OUCH! i gave up, i took 2x 500mg paracitamol about 2 hours ago the pain is still there but heavily reduced i feel loads better than i did 3/10 painscale :O GREAT this is way more comfortable to cope with.

[@mansibhol6212]

Thanks a lot.. actually I'm new to this channel n I wanna know how does it works.. thanx for helping me out.. nice explanation.. I'm a student n I like it😁...

[@TheTravellingScientist]

Hey @Mansa Bhol, I'm glad you enjoyed the video and I hope you learned something interesting. I'm creating new videos every Science Sunday, keep watching and send me more comments and questions. Cheers legend!

[@knoxieman]

Brilliant 👍

[@nielsdaemen]

I've never taken any painkiller in my life

[@TheTravellingScientist]

Hey @Niels Daemen good for you, I’m glad you don’t need them! Cheers for watching and commenting Legend!

[@Vinko44]

Hi Jesse.I like this video very much.But I have a question.Can we control our pain receptors without medications?I mean that's how placebo efect works,right?

[@onedave_2992]

You lool like Thor. Don't know

[@TheTravellingScientist]

Haha thanks OneDave 23, I appreciate the compliment :D

[@onedave_2992]

The Travelling Scientist haha it's a bit weird no one else noticed haha, showed your pic to my sister and she said the same thing haha

[@TheTravellingScientist]

OneDave 23 Rad, well keep watching for more Thor, travel and science!

[@onedave_2992]

The Travelling Scientist More Thor that's funny wahaha. Maybe you can make a video how do they make seedless grapes or oranges and other seedless fruits. I'm always curious about it hehe

[@TheTravellingScientist]

OneDave 23 Great idea, I'll look into it and make a vid for you soon

[@onlyonSiMPLE]

awesome video :)

[@TheTravellingScientist]

Cheers legend, thank you for watching! What did you like about it?

[@insykothebear6986]

Hi Jesse! Little question: how can paracetamol block Prostaglandins production yet not be anti-inflammatory? Thank you!

[@TheTravellingScientist]

Excellent question @insyko the bear there are many different types of prostaglandins, and they have different effects. In general, they cause pain and inflammation, but some are more pain oriented, while others are more likely to promote swelling, redness, itchiness, etc. Paracetamol seems to have a stronger effect on the pain promoting prostaglandins...gee, try saying that out loud :D Thanks so much for watching and commenting legend!

[@insykothebear6986]

@@TheTravellingScientist Thank you very much!

[@raviprakashsah4355]

Who is here after a headache

[@TheTravellingScientist]

Hey @Ravi prakash Sah haha good point, thanks for watching. I hate headaches, but Paracetamol should help you out. Cheers for the comment legend!

[@squeaksc9671]

Just 👀 it..nice job😷😷👍

[@TheTravellingScientist]

Hey @squeaks C Thanks so much for watching, I hope you enjoyed the video and learned something interesting. Feel free to check out some of my other videos around similar subjects :D

[@harrylederman1679]

Thank you I haven't seen this before BUT because I've got a bad headache I'm watching this in the hopes that the paracetamol I have taken is in fact effective.>> is there any way you can talk about complementary medicines search is valerian & Willow bark as well? And easier any evidence dad herbal medicines are just as effective?

[@TheTravellingScientist]

The paracetamol SHOULD treat your headache! I am looking at making a video about more natural pain treatments, but in the meantime I can tell you that valerian is proven to help people sleep better, but not necessarily to reduce pain from headaches. Willow bark is what aspirin is made out of, and aspirin is great for treating headaches, but willow bark is not as effective, probably more of a placebo effect. Anyway, thanks for the questions and thanks for watching. Cheers legend :D

[@ladyriddle1984]

But why DO damaged cells release arachidonic acid?

[@TheTravellingScientist]

Hey @Lady Riddle great question, that's just a natural response that our cells do to protect our bodies from further damage, by warning the immune system and triggering inflammation to kill any pathogens and promote repair in the local area...does that make sense :)

[@ismrity1976]

Please describe about your scientist journey?

[@TheTravellingScientist]

Hey @Ismrity thanks for watching and reaching out! I studied science at The University of Melbourne in Australia, graduating with my honours, majoring in pharmacology. I also spent a year doing a research project on novel nanoparticle vaccine development, and another year working as a laboratory technician in an environmental laboratory. Currently I am conducting my own research via peer reviewed journals so I can focus on creating educational and entertaining content for my audience. Please consider joining our community :D bit.ly/3CaLQCM Cheers legend!

[@ismrity1976]

@@TheTravellingScientist Thank you so much for giving me a lot of information 🥰 I am also studying science by taking chemistry as major subject in my bachelor degree 🥰 your information is helpful to me🥰

[@garethduffy3083]

Quick question, am training in the pre-hospital environment and a paramedic mentioned that paracetamol and morphine make a good combination is there a reason for this is it to do with the cox 1,2, and 3 I know paracetamol is thought to work on the cox 3.

[@TheTravellingScientist]

Great question Gareth, I would have to assume that they make a good combination because they both reduce pain via different pathways. Morphine acts on opioid receptors to reduce pain signal transmission to the spinal cord, while paracetamol acts on Cox to reduce prostaglandin synthesis and inflammation overall. Together, they inhibit almost all pain in the body. Hope that makes sense, thanks for watching!

[@sohaalikhan795]

Is paracetamol addictive tho?

[@TheTravellingScientist]

The drug is not addictive, but if you are suffering from chronic pain, then the pain relief offered by paracetamol can be addictive. It is important to find proper pain solutions that simply covering up pain with a drug like paracetamol, ibuprofen or aspirin! Great question Soha!

[@shubham9672]

Is this reduces swelling or stop increase swelling If not please tell me alternatives for epdimitis swelling

[@TheTravellingScientist]

Hey @Shubham Agye great question. Paracetamol doesn't really reduce swelling. Ibuprofen would be a better temporary treatment in this case. I have actually made a video explaining why, check it out: kzbin.info/www/bejne/kHaZhZSbm7KtqsU However Epididymitis is usually caused by an STI, which would probably need to be treated with antibiotics. I am not a doctor...but you should probably see one ASAP. Good luck my friend

[@shubham9672]

@@TheTravellingScientist Thank you so much..... I am under doctors treatment.... He gave mi crocin that's why asked

[@davedave3520]

Can paracetamol reduce covid immune response? I took one after my shot to reduce side effects of the vaccine but now I'm worried if paracetamol will reduce my covid immune response. Is my body reacting the same with or without paracetamol?

[@TheTravellingScientist]

Hey @Dave Dave Paracetamol will have little effect on your immune responses. It works to reduce pain levels, it doesn't have a huge impact on how your immune cells respond to external stimuli so don't worry about that :) Cheers for watching and commenting Legend!

[@ireneug1855]

Can I take paracetamol to relief my period pain

[@tahanislel1007]

hi Jesse today my doc tell me that there is new research about paracetamol inhibit another enzyme called cox 3 ,what do U know about it ؟

[@TheTravellingScientist]

Great question! I didn't want to make the video too complicated, but there are 3 different COX enzymes, COX-1, 2 & 3. COX-1 is always produced by your cells, while COX-2 is only produced during periods of stress (injury or disease). COX-3 is a variant of COX-1, almost identical, but it is found mainly in the brain. It is thought that because paracetamol is able to cross the blood brain barrier, it could be acting on COX-3 in the brain to reduce the pain of a headache or similar...but this is still yet to be proven

[@lisamartin5215]

Hi. Can you please tell me what would be good to take to make me less anxious for flying please as I'm phobic and diazepam doesn't touch me. Pleeeease

[@TheTravellingScientist]

Hey @Lisa Martin I'm sorry to hear that. In all honesty, if you have a specific fear of flying, I would suggest speaking to a therapist about it. I have made several videos about general anxiety, feel free to check those out and maybe some supplementation could help you out! Magnesium for Anxiety: kzbin.info/www/bejne/e6KWapaGbKpqiM0 Vitamin B for Anxiety: kzbin.info/www/bejne/jZTcmmdnaZJ1hpY Zinc for Anxiety: kzbin.info/www/bejne/iqPXq4yBdthogc0 Good luck, let me know how you go. Cheers!

[@prateekgautam5514]

So, if fever is a natural response of our body to fight against any allergy or problem doesn't taking paracetamol puts us in danger for the long run? Like sure, it will take down my fever but it isn't gonna cure the root problem that caused the fever in the first place and now with paracetamol it also hindered my ability to treat that root cause as well.

[@jeremiah6182]

But we take it every 4 hours. How about that? I'm just a curious kid with a fever sir

[@ES-yc1tp]

cox blocks LMAO

[@wahegurujio4891]

hlo sir if one can ear10 peracetamol tablets at once.is it is harmful ? if harmful then what have to do to reduce effect of peracetamol

[@TheTravellingScientist]

Uhh...don't eat 10 paracetamol tablets at once, that would be very bad for your stomach and your liver! Only take 2 at a time...3 if you are a large hooman :)

[@claireajibola3287]

Just took 2 paracetamol, back is killing me...

[@DarrioDiago]

Dr Thor!

[@TheTravellingScientist]

That's what they call me 😉

[@DarrioDiago]

@@TheTravellingScientist Really? It's Awesome!

[@Sam-kv3iv]

He looks like the actor Heath ledger

[@jeromedeleon1226]

John McClane aka Bruce Willis should then see a doctor

[@TheTravellingScientist]

Haha, good point legend! Love those movies :D

[@ok-bd6zd]

Why my fever(headache, temp.) goes off after taking paracetamol If my temp. isn't high then it means that my body isn't fighting to infection. So, is it bad to take paracetamol in fever?

[@TheTravellingScientist]

Hey legend, did you watch the video? Paracetamol blocks arachadonic acid, thereby preventing the production of prostaglandins which would normally cause pain (headache) and fever (high temperature). "If my temp isn't high then it means that my body isn't fighting infection" is incorrect, that would suggest that this simple tablet is shutting down your immune system...which it isn't. Paracetamol helps us to deal with pain and fever, whether it is caused by an infection or an injury. Either way, our body still works to heal the infection or injury, but if we don't feel okay, we can take a paracetamol to help us through the pain. I hope that makes sense, thanks so much for watching and getting in touch :D

[@ok-bd6zd]

@@TheTravellingScientist thanks Soo much buddy I asked this because I have Corona Take care of yourself

[@ok-bd6zd]

@Anita Patel no I'm under 18

[@ok-bd6zd]

@Anita Patel Yes

[@omarnaif8674]

My wife is pregnant , is it okay to take it?

[@TheTravellingScientist]

Like Asprin and Ibuprofen, Paracetamol is able to cross the placenta. However it has not been shown to cause any adverse effects in pregnant women when the correct dosage is used. So yes, your wife should be fine to use paracetamol if she is in pain :)

[@kidoo1567]

Does it cure cold

[@TheTravellingScientist]

Hey @kidoo good question, paracetamol does NOT cure a common cold...or any disease really, but it can help manage pain, so if a cold is causing you pain, paracetamol can help you to feel better. Hope that helps, thanks so much for watching and commenting legend :D

[@kidoo1567]

@@TheTravellingScientist thanks

[@globalresearch2860]

good

[@TheTravellingScientist]

Thanks, I try my best!

[@youmo07]

Dos co.codmal work 😥😥I take 3 tablet at once with 3 ibrophen still have painful condition back and muscle

[@TheTravellingScientist]

Co-Codmal is a combination of codeine and paracetamol and is a more effective pain relief drug than paracetamol or aspirin. If you are taking this drug WITH Iburpofen and are still in pain, something is wrong. Chronic pain is a very common medical issue. I would recommend discussing the pain with your doctor and finding an appropriate treatment, perhaps you need some sort of massage, physiotherapy, a chiropractor or even some sort of surgery. Thanks for sharing Mahammed, good luck with your pain

[@youmo07]

Iam diabetic t1

[@handlenameonyoutube]

OK but some girls need to take it more than once a week for.... reasons 😬 lol thanks for the explanation!

[@TheTravellingScientist]

Oh totally, in certain situations people need paracetamol! I mean if you are taking it more than once per week...EVERY week, y'know? Anyway, thanks so much for watching, glad you enjoyed the video :D

[@rheyza4475]

Question: Do you know how I can test for DMT in plants and trees? Without costly lab equipment, you know, on the cheep.

[@TheTravellingScientist]

Unfortunately there is no way to measure concentrations of anything cheaply, and plant sources can very greatly dependent on the growth situation. The best thing you can do is to find a reference concentration and then roughly estimate using that reference knowledge. Does that make sense? Sorry I can't help more

[@rheyza4475]

Makes perfect sense, thanks doc.

[@sectionwhat8145]

what drugs u on 4 yers later? u on the mushroom hype?

[@TheTravellingScientist]

Hey @SECTION WHAT! Yeah man, I've made a few videos about mushrooms and other drugs. Check them out and let me know what you think :) kzbin.info/www/bejne/oqrHd5SHprJ1i5I

[@sebastianryan231]

I lost you at cox-block

[@TheTravellingScientist]

Because it was funny or because you didn't understand me?

[@bir504]

My mother eat 3 tablets of paracetamol what to do now..plz help me brother

[@TheTravellingScientist]

Bir 3 paracetamol at one time is okay, and would offer effective pain relief. Taking 3 paracetamol regularly is not healthy, it can be taxing on your liver, and she should see a doctor to find the cause of pain rather than keep taking the drug!

[@bir504]

The Travelling Scientist thankyou so much.. now she is fine😇

[@jasoncoleridge5872]

QUESTION: HOW DOES PARACETAMOL WORK? SHORT ANSWER: FUCK KNOWS!

[@TheTravellingScientist]

Yeah, but it does the job!

[@highvoltageplasma]

Liked for making me laugh.

[@TheTravellingScientist]

Hey @highvoltageplasma thanks so much for liking and commenting legend, what made you laugh? It was the COX BLOCKS joke...wasn't it... :D good to hear legend, hope you check out some of my newer videos, they get better!

[@highvoltageplasma]

@@TheTravellingScientist Yea it was the cox blocks joke. I study pharmacology too. You have a nice channel.

[@potatothekiller8906]

i just drank 6 paracetamol in the course of 2 days .... fuck

[@TheTravellingScientist]

6 paracetamol? You'll be fine!

[@TheTravellingScientist]

6 paracetamol? You'll be fine!

[@potatothekiller8906]

but i wanna die how many should i hit? @@TheTravellingScientist

[@TheTravellingScientist]

You should check out my video on antidepressants...and don't take paracetamol unless you have acute pain

[@azzaman171]

How to remember the Australian Schedule classification system with rhymes Schedule 1: Not in use (not used by anyone) Schedule 2: Pharmacy medicine (Can be bought by you) Schedule 3: Pharmacist Only Medicine (Pharmacy) Schedule 4: Prescription only medicine or prescription animal remedy (need a Doctor) Schedule 5: Caution (Caution Clive! Lame I know) Schedule 6: Poison (burn your bits) Schedule 7: Dangerous poison (will send you to heaven) Schedule 8: Controlled drug (DDA - Dangerous Drugs of Addiction) Schedule 9: Prohibited Substance (Do the time (jail)) Schedule 10: Substances of such danger to health as to warrant prohibition of sale, supply and use (Never again (allowed))

[@TheTravellingScientist]

That's really cool, thanks Dusk! So you rhyme the numbers with the final word of each description, clever. Did you create this mnemonic yourself?

[@azzaman171]

Yes, most of it just came to my head when I was learning about it for my job. Then I just filled in the blanks. I find it's easy to remember things when they rhyme and are funny.

[@TheTravellingScientist]

Dusk Kingdom Phylum Class Order Family Genus Species, Kids Playing Catch On Freeways Get Squashed 😂 my favourite mnemonic

[@azzaman171]

hahaa, that's a good one! I would never have remembered the order of that otherwise!

[@kevino4372]

Don't mix with alcohol.. really hurts your liver. Use ibruprofin instead for hangover.

[@TheTravellingScientist]

Hey @Kevin O great advice. I actually created a video all about the science of hangover cures, check it out here: kzbin.info/www/bejne/gYrNgKKMgd2nntE Cheers for watching and commenting Legend!

[@wisxper]

Hey Jesse wanna cook?

[@TheTravellingScientist]

Great line haha, thanks so much for watching legend!

[@austinofficial9679]

💪🏽💪🏽💪🏽

[@arpisworld4735]

How it actually works inside the body mechanism plz.

[@TheTravellingScientist]

So after you take paracetamol, it is quickly absorbed through your stomach wall into your blood stream, where it spreads out and binds to red blood cells. This carries the drug throughout the body where it interacts with cells, inhibiting COX to prevent prostaglandin synthesis and reduce pain levels. Paracetamol is eventually metabolised as it passes through the liver, then it is excreted by our body. Does that answer your question?

[@arpisworld4735]

Okay but exact mechanism how to stop transfer from COX to prostaglandin formation??

[@TheTravellingScientist]

That is what I referred to as the "COX-Block", and unfortunately the answer to your question is not certain. I would assume that paracetamol binds to the COX enzyme, inhibiting it's active site and preventing it from interacting with arachidonic acid to produce painful prostaglandins, but that is not certainly how it works...that is just a guess, nobody knows for certain how this drug works, that is a key point of this video. Crazy huh!?

[@Hansca]

Could this be the answer to why it doesn't work for pain managemen, because it's just a placebo? I've always considered that if someone has a pain that can be eased by the use of panadol then they never really had a pain. Honestly you might as well have a jelly bean. Or is it just me who is totally resistant to it?

[@TheTravellingScientist]

Several studies involving double blind testing have proven that paracetamol is more effective at reducing pain than a placebo. Your resistance could be due to a variety of factors, maybe you should take a higher dose, or maybe you have a unique version of the COX gene that isn't really affected by paracetamol. Try taking a different analgesic like aspirin, ibuprofen or codeine.

[@Hansca]

I do find limited effectiveness with aspirin, however as it's not recommended to be taken by gout sufferers, which alas I am, I steer clear of it . Ibuprofen works fairly well and voltaren is quite effective. Codeine was always a safe bet but now, of course, it's not readily available. I pretty much only use pain killers for the odd case of gout or bursitis. Thank you for your reply.

[@azzaman171]

Or maybe you don't have the liver enzymes to metabolise paracetamol like many asian people for example.

[@Hansca]

Interesting and possible, however I have recently found out from speaking with chemists that I am not in the minority. Apparently many people don't get any relief from paracetamol. This has been highlighted by the recent restrictions applied to the sale of codeine in Australia. I'm not of Asian descent. Thanks for your input.

[@TheTravellingScientist]

Dusk Some Asian people don't lack highly important digestive enzymes, they might just work a little differently

[@paulflint6254]

666 sub

[@TheTravellingScientist]

Cheers legend! Keep in touch :)