How Dopamine Agonists Improve Parkinson’s Symptoms | PD Medications, Purposes, and Mechanisms #6

[@rossmiles7169]

Thank you

[@parkinsonsdiseaseeducation]

You’re so welcome! Thanks for watching Ross.

[@stevesilia9175]

Is ok to take a SSRI when on dopamine agonists

[@parkinsonsdiseaseeducation]

I’d best leave that advice to the physicians. I’d ask your MD, DO, NP, or PA. I do not prescribe medication or offer specific medical advice on the channel.

[@DrJoshLanders]

Great information! Are these used more often than Selegiline and Entacapone? Which of the drugs listed in this video so you see prescribe the most?

[@parkinsonsdiseaseeducation]

Awesome! In my experience these tend to be prescribed more often than the MAO-B inhibitors like Selegiline and the COMT inhibitors like Entacapone. Almost univerally you’ll see Carbidopa/Levodopa prescribed with dopamine agonists as the disease progresses. Also, it’s more common to see dopamine agonists prescribed rather than C/L as a first line treatment. It’s rare to see mono-therapies such as MAO-B inhibitors or Amantadine as a first option before prescribing Levodopa, which in my opinion is a mistake as it’s more conservative to try to keep existing dopamine levels higher to manage symptoms than to pump the body full of chemically manufactured dopamine or dopamine agonists. I’ve seen folks reduce C/L or even completely eliminate it in some cases and go to Amantadine or MAO-B inhibitor and they do even better… Sometimes Carbidopa/Levodopa is over prescribed and at too high a level. It can be taken in much much lower doses earlier in the disease process and still manage symptoms well, but so often it’s at the higher levels of 10-100 or 25-200.

[@DrJoshLanders]

Thank you for taking me through that progression. That helps demystify it for me.@@parkinsonsdiseaseeducation

[@shaynadavidovhansonrealtor]

Need help finding a “Dopamine Agonist” that doesn’t have the side effects like C/L. What else is out there to stimulate Dopamine - without the mania, constipation and nightmares? Mucuna and B1 ( maybe not taking enough) don’t seem to be doing enough and the C/L causes other awful, debilitating ( nightmares, etc) side effects in my HWP.. But w/o the Dopamine Agonist, they aren’t as active and not wanting to do as much.. Anyone have experience w / Selegiline? Doing Mucuna, L-Dopa, L- Theanine and B1- but not making a dent yet. Am I not giving right iteration or dosage? Thanks in advance🙏🏽

[@parkinsonsdiseaseeducation]

Hey Shayna! First of all, we need to clarify terms. Dopamine agonists are not the same as C/L. C/L converts to dopamine in the brain while dopamine agonists stimulate dopamine receptors in the brain (they “act” like dopamine) and can help with symptoms that way. Have you seen all of the medication videos on the channel? Each type is detailed along with examples. Selegiline is an MAO-B inhibitor and is not a dopamine agonist or the same as C/L. Keep up the mucuna and B1, but it not likely that there is a way to avoid medication completely. I’m also sorry to report that they all have side effects, so be very discerning before making any changes. Better yet, don’t make changes unless a neurologist advises. Here’s more information on MAO-B inhibitors such as Selegiline: Managing Parkinson’s “Off Times” with MAO-B Inhibitors | PD Medications, Purposes, and Mechanisms #2 kzbin.info/www/bejne/iKvXdqCqn9qKaac

[@HansGruber006]

Yeh low dose Opiods will do the trick

[@parkinsonsdiseaseeducation]

Opioids? For managing PD symptoms?

[@HansGruber006]

@@parkinsonsdiseaseeducation Opiods up regauate dopermine, why not ?