How Insulin Gets Glucose Into a Cell

[@dannyholley]

Very elegantly explained. You're a fantastic teacher.

[@MissNadj86]

Daniel Holley he sure is.

[@hillsongirl1]

How can anyone give this a thumbs down! He summarised brilliantly a complex subject

[@ChantelJonesCIB]

You are a brilliant teacher ... what a great video! Thank you.

[@nida2192s]

This is really cool. Had to study this for a biology exam, and its a little bit complicated, so thank you for making it a lot easier to understand!

[@rebeccavaughn2387]

Thank You!! This helped me in my BioMed class. It was very informal and straight to the point, which helped me A LOT!

[@tinafagan3127]

by far the best easy-to-understand explanation of why exercise is so important for insulin resistance. thank you!!!!

[@gregbalteff1529]

BRIAN YOU ARE FANTASTIC...MAKE THESE ESOTERIC TOPICS VERY UNDERSTANDABLE !!THANK YOU

[@drsamialrumaih]

Easy , simple, great explanation Fantastic Thanks :)

[@olliedye5353]

got my exam tomorrow, i must've looked through so many videos on diabetes. none of which mentioned anything about GLUT 4!! i assumed glucose made its way through the insulin receptors once it had insulin connected to it like a funnell!! great video your a lifesaver!!!!!

[@senseisommo1989]

Although this was an excellent explanation I have to be a bit semantic on one small thing. Glucose itself isn't "toxic" - not literally, physiologically speaking at least. The reason why high glucose levels have adverse effects has to do with the principles of tonicity; i.e. when a high concentration of a solute exists in a certain location it will pull water towards it. (Incidentally this is why medics don't use 50% Dextrose solutions with diabetic patients anymore - because the concentration of the sugar was so high that after a few minutes of use it would begin to necrose the tissue around the IV site). At any rate it was an excellent explanation but I couldn't help myself in correcting that small piece at the end. Cheers!

[@realimagevanity2289]

you are right on the money.

[@alejandrasalazarojeda1818]

Thank you sooooo much!! I am from Peru and tomorrow I have my phisiology exam and this video has helped me a lot ! thanks again! U ROCK!

[@Academicresourceshaskey]

A good explanation of the Insulin pathway and function.

[@mexican4evaaaa]

I found this very helpful because I have to explain how insulin is used to get glucose into the cell in a project at school, thanks a lot.

[@brucetretter]

Excellent, straightforward explanation. Learned a lot very fast. Can't ask for anything better. Thanks very much!

[@HanneEmarie430]

I have to make a model of this process and I just found the missing explanation I needed to finish ! Thank you SO much .

[@stevehas1861]

Excellent explanation! The best I have ever heard

[@morarehm231]

I'm a student in Biomedical Sciences and this was so simple and clearly explained. Thank you so much!!!!

[@victimsofthe3784]

Dude great video, maybe the greatest simply video I have watched on meds.✌✌, Many thanks.

[@sunnisukumar]

Great diagram and explanation, all in a few mins. Kudos.

[@Clover913]

Does help me to understand the whole picture much better. Thank you so much!

[@ranjanpaudel698]

honest , to the point, and really helpful...thank u

[@lllholder]

Wow thanks!!! I am getting ready to take a pathophysiology test on this and you really made it easy to understand! thanks.

[@ytnx]

Very good, specially about why we say that excercise is good, you made it clear to me . Thanks

[@koopsjunta]

Great video, mate. This has helped simplify this concept BIG TIME. Many thanks.

[@Lengsel7]

Thanks for posting, and taking us past the basics of insulin. ...after watching this a few times, I'm wondering how the "exercise induced" glut-4 receptors work...how does exercise work to engage them?

[@VishalPendharkar]

Why does my blood sugar level increase to high levels after excercise?

[@GabbyLagemann]

Very easy explanation. Thanks.

[@surfchick]

Thank you so much for this! just spent hr trying to understand my lectures note and you just did it in five... THUMBS UP SUBSCRIBED

[@hippophile]

Very nice, and not a moment of time wasted! Cheers!

[@sinkalavernon2340]

Made my work so easy. Great Prof. Thank you so much. How do I get your videos?

[@jennipherchanda6266]

I have a presentation today and after watching this video I'm very confident 😊 and ready

[@wealth1ness]

How long does the exercise induced GLUT4 window last?

[@georgeolt654]

very smooth presentation = great mind !

[@sarahjane9517]

Really appreciate your overview on that!

[@user-jq9wz7ld7f]

you are a perfect teacher ♥️♥️♥️♥️♥️

[@christosioannides]

Great lesson! I had a question about GLUT4, can glucose leave the cell via GLUT4? In the absence of insulin, would the increased rate of glycogenolysis result in a greater cellular glucose output? Many thanks

[@simrankohli1310]

This is reallly well explained!!

[@samsalla2381]

GLUT 4 is always dependent on insulin to uptake glucose from what i know from text books. GLUT 1 is insulin independent. If you can give me the source of the information that exercise can induce glucose uptake into the cell without insulin, please post me a link. I really much would appreciate it.

[@arpitkhanna3039]

Very nice and clear concept

[@titantt1986]

Thank you so much, this video is really helping me to understanding about Glut4 Working.

[@filopride619]

Excellent explanation!

[@JeaneAdix]

Quick question: In the case of low insulin, can you offset the effects of diminished GLUT 4 activity at the cell membrane through exercise?

[@Mdoekosad]

Do the cells also open when after a hard workout?

[@pratitimishra2119]

It's a great video. Very helpful 😊

[@mymymy5926]

That is a really good explanation which helps me a lot, thank u so much

[@lotusforest]

Very helpful and easy to understand. Thank you!

[@omarmahmoudibraahim443]

brilliant teacher .... thank you

[@write2me471]

this is the best n da easiest way to understand. tqsm 4 da video

[@deepjyotidas2052]

Uploaded 9 years ago but still very helpful for many😃

[@Ormorelara]

I find this super helpful! Thanks for sharing.

[@Insanegirri]

You cleared my doubt sir ...thanku so much

[@lilycarrington5132]

excellent explanation, thanks for this!

[@delux2414]

Very good explanation thank you

[@PatrickLoobs]

Thank you!! Very clearly explained. I now understand what GLUT4 translocation means. :)

[@souravrout1365]

Thank You sir helped me lot in my studies

[@CodieOnline]

Really insightful and i know this video was posted years ago but I am interested in the physical activity aspect. You stated that if you are physically active then no insulin is needed for GLUT4 to transport glucose into the cells, how is that possible? I thought physical activity only increased insulin sensitivity, allowing less for the facilitated diffusion to occur, not that it doesn't need insulin at all. If anyone can help me understand, I would really appreciate it :)

[@rohitbanavath29]

thanx for the simplified explanation, really helped a lot....!!

[@kboone314]

lowers the blood sugar by triggering cells to accept glucose (blood sugar) into them for energy. sorry if this sounds basics but I am trying to understand this insulin, blood sugar, fat thing. If I knew was going to be fat in Bio class maybe this wouldn't be necessary. But Im learning thanks to Drs like you.

[@laurenanne2854]

Makes so much more sense!!! Thank you

[@carolinemikkelsen8516]

Thank you for simplifying!

[@austinpaliga3954]

Thanks dad

[@brookeprudente]

Austin Paliga lol

[@abigailcartagenas6705]

Thank you for a wonderful explanation!

[@joydeepchoudhury3479]

Sir ur explainations are fabulous keep on uploading videos

[@sweetpicklez]

Thank you, very simple helped me to grasp physiology concept.

[@simransingh7210]

beautifully explained

[@TheStormBreaker11]

how many pathways does insulin have ?

[@jhern3230]

Finally, I had to go through 6 videos b4 yours that explained GLUT 4

[@dophatdai3324]

wow, it's so easy explanation. thank you so much.

[@robertsiddique2948]

Very nice explanation keep it up

[@braydoncooper621]

How do you know your not producing enough insulin or the cell isn’t taking in glucose?

[@LeoTheLion811000]

Man you good! This is real helpful for me to know! I take the knowledge that I learn from you and help others..azz well azz myself! Thanks..Keep doing your thing!!!

[@kokakolika]

DR. Brian u just rocked my world!!! i think im in love

[@TrenaryJL]

Thanks. This is a helpful review.

[@stephanieu4634]

Thank you so much! Very well explained.

[@jrg305]

@Bennyhidef Any sort of muscle contraction will work to cause translocation of GLUT-4. Strength training will recruit more muscle fibers for a limited period of time whereas aerobic exercise will recruit fewer muscle fibers for an extended period of time. Both have their benefits. I'd prescribe aerobic exercise because it is easier and has more health benefits than strength training, but people like to look good too.

[@aeyannalucero902]

VERY helpful! Thank you!

[@JRivera176]

Very helpful. Thank you for posting!

[@peterlanephotography]

So how can we know where the problem is?

[@josesantiago9227]

Epic explanation in Lehman's terms!

[@va3692]

Great explination!! Thank you

[@youngfil]

Wow! great teaching!

[@bobcocampo]

How about Glucagon?

[@artathanbailey4874]

This was very helpful.

[@utooktoomuchman]

I did find this very helpful! Thank you sir

[@Dr_Dubey]

Very lucid and student friendly

[@postsilv71]

thank you very much!!...beautifully explained..

[@mohammadmehedihasan9193]

nice explanation sir

[@Darkmatter321]

Isn't Insulin resistance over saturated cells with Glucose just shutting out more Glucose?

[@theseventhsojourner1413]

Well done!

[@yogayantra]

Hi, can it happen that the insulin receptor is not working because the cell is already full with glucose? I forgot to say Thank you

[@affzor]

No, because if the glucose-levels in the cells are too high they will turn them into fatty acids and store them as fat in adipose tissue. That's how you get fat from Cola even though it contains zero fat.

[@amiramiaa]

it's 2018 ! thank you so much sir!

[@khalid4192]

You are a legend.

[@tamanasahibzada8808]

love it god bless u n thank u so much very great n clear explanation awesome just love n love it

[@sarahblissmorin4159]

Really helpful! Thank you!

[@cahuebm]

perfect!

[@wr3573]

That was really helpful, thank you!

[@liveshinestar]

yees! I finally undestood it! thanks, you explain very well

[@bungalowtomcat1]

thanks helps heaps. keep them coming, cheers

[@mrj8012]

Nice info to the point.....

[@godblessamerica0762]

Thank you