The Mechanism of Insulin Release by Pancreatic β-cells

[@normallochie7390]

This has the hardest intro I have ever seen

[@xaviermagnate]

EXTRAORDINARY on every level! Thank you for the incredible and erudite tutorial. Simply PERFECTION!

[@hafsa4901]

Thanks it helped me for my cell signaling exam .

[@olgakaldou1606]

Great video! Thank you for your efforts! I study for my physiology exams and that helped me understand and visualize the whole process! Looking forward to other videos!

[@obscuredoblivion444]

Im always so amazed how our body works.

[@tigerhillsupa]

your video has made the mechanism so simple! Compared to book reading , I would rather watch your video!

[@domenicafigueroa9230]

Just what I was looking for, thank you!!

[@MrAbhra26]

Very good explanation . It is clear to me now.

[@katefreedom9708]

Learned a lot beautiful explanation

[@noname-mm9of]

This video is pure quality

[@williewonka6694]

Excellent explanations of these mechanisms. Reviewed a couple of times to understand the K+ and Ca+2 gate operations on insulation release.

[@Velvet003]

Excellent explanation!

[@erikfermin1787]

very clear explanation thank you so much

[@weezy224]

very nice and well explained, thank you

[@imtinan7136]

Couldn’t be easier! Thank you so much

[@agnieszkapodraza3083]

Thank you so much ! Amazing work

[@mahuubao]

Excellent ... well done ...

[@mutuwamercyvivian5748]

All I needed to understand... thanks

[@angellahnkhoma2762]

Best explanation 🤗

[@malikoussama6378]

Well explained 👏 👏 👏

[@inglescomcremildo6803]

That's cool man. Thank you a bunch.

[@ShemMwangi-no8nz]

easily well understood

[@mahmuterzengin614]

Thanks a lot. Great video. Very nice explanation. I admire your job.

[@itsiremm]

THANK U SO MUCH😭💙

[@AmirTalipov]

great, thank you!

[@nynmlg2299]

Thank you!!

[@catherinesalim3173]

Thank you so much,

[@gordisspegel4159]

Thank you!

[@tasneemaburaiya6944]

This really helps to make the process very clear! I have master degree presentation and this really helped me. Can you please send me references for the figures you are explaining?? I will really appreciated Thank you :)

[@CatalystUniversity]

Thank you, and I'm glad it was helpful. I can't post files here, but if you type "lehninger insulin synthesis" into Google image search, you should find these images within the first 20 images in the results.

[@tasneemaburaiya6944]

@@CatalystUniversity can I have your email if I ever have a question about anything thats rlevant to this , . I will appreciate it . Thank you and Good night

[@saitdemir6677]

@@tasneemaburaiya6944 @Catalyst University she wants your email address give it to her :)

[@medicalscience1528]

What I really wanna know how beta cells detect or sense that there is glucose in blood ? Or glucose simply travel to beta cells by their own ? Please clear it. Thank you for video.

[@josephboronka1734]

✔👍 perhaps through the GLUT2 transporter?

[@pranjalipranjali2751]

extraordinarily well

[@leonidalekseyev3809]

Very helpful, thanks a lot! Could you resommend a good textbook or two on Biology?

[@odarissantos6538]

Around 5:36 you had mentioned that there is an increase in Potassium efflux. Did you mean Calcium Influx? I got a bit confused there.

[@carolineatalley2051]

I think that's what he'd meant

[@adelenemorrow8852]

Really appreciate your work! Thank you!

[@marisad4079]

so low insulin could be due to lack of calcium influx into the cells?

[@matthayden1979]

Will calcium rich food or calcium supplement help in regenerating beta cells?

[@medicalscience1528]

Liked and subscribed 👍🏻 :)

[@PRTube01]

So beta blockers block insulin and elevate blood glucose levels ?

[@iamliam6929]

hey man, idk if still relevant but... beta blockers have nothing to do with beta pancreatic cells (i understood that u linked these two)...beta blockers are antagonists of beta adrenergic receptors (beta1,2,3). Beta 2 receptor activation normally leads to glycogen breakdown in liver and glucagon release from alpha cell of pancreas (glucagon stimulates glucose synthesis) so therefore beta blockers can actually lower ur plasma glucose ...cheers

[@PRTube01]

@@iamliam6929 it is said that first gen beta blockers affects all types of beta cells in all types of tissue. So by taking beta blockers you might inhibit insulin also and will lead to high glucose in blood.

[@iamliam6929]

@@PRTube01 oh okay didnt know that :) i guess i need to dig deeper :) cheers !

[@PRTube01]

@@iamliam6929 Iam no expert either

[@stevenwoldesellasie4520]

And how is the release of calcium from the smooth ER regulated?

[@islamshihata4380]

Great

[@liutasx]

So not glucose, but ATP/energy status of beta cell causes to release insulin?

[@wakylaugh]

You need glucose to produce the ATP

[@liutasx]

@@wakylaugh Beta cells can use fatty and amino acids to produce ATP, not only glucose.

[@wakylaugh]

liutasx but he’s specifically talking about GLYCOLYSIS and GLUCOSE

[@iamliam6929]

@@liutasx hey idk if still relevant but, ...try to think this way , beta oxidation is not favoured in this kind of situation when u have a lot of glucose(a lot of potential energy) ..no need for further beta oxidation..i guess its a lot more complex than this but it makes sense :D

[@AdegbiteStephen-zz8bl]

Thanks you Dr Igudia on KZbin for all you do in my life and my family. I went for a test today after taking the medication i ordered from Dr Igudia and I tested diabetes’s negative. Thanks doctor I will keep letting the world know about your good work sir.

[@bio366geethasankar7]

🙏

[@crimpers5543]

wow that intro

[@moiez0192]

the intro killed me

[@stevenwoldesellasie4520]

Even if you have moderate inhibition of potassium channels, there must be a certain minimum amount of ATP concentration needed since depolarisation is a all or nothing mechanism.

[@zakirzak1494]

❤❤❤

[@granderondeproductions3286]

So, what part of this process gets broken if a person has type 1 diabetes?

[@granderondeproductions3286]

@Hemlock Cocktail I see. thank you for explaining that to me.

[@josephboronka1734]

Maybe the Insulin secretion is good enough 🤔, and the 3:44 body has all it needs , so it resists and glucose goes up , and the cell just produces more and more Insulin till it maximum out 😊

[@brabbit1692]

These cells are destroyed in T1D. None of this happens because there are no cells that contain insulin since the body destroyed them.

[@mo_nicole]

Can anyone tell me if the pancreas can suddenly stop producing insulin? I’m talking like over night or working hours? Or is it typically progressive? I’m sure many factors involved but just in general. Thank you.

[@danielvalentindominguezsal2275]

It's typically progressive

[@akashmajeed283]

❤

[@adammichaelmueller115]

You're the fuckin man!

[@fabikainz9255]

its GLUT1

[@ghaziturki9756]

🙏🙏🙏🙏🙏💜🧡💙💚❤️

[@dimphosarah2191]

😁

[@ohShittttYar]

Good but I'd really like to suggest to treat ur flu, its very disturbing Pardon

[@JubayerAlMahmud-IUB]

*in **5:35** you have made a mistake. ***

[@jamesscott5509]

J

[@loritaismaili2845]

It’s the GLUT1 and GLUT3 for pancreatic ß-cells, NOT GLUT2 :)

[@Chowanana]

Not true, GLUT1 is mainly expressed in RBC and GLUT3 in neurons and sperm. GLUT2 allows glucose intake into pancreatic beta cells and hepatocytes.

[@PavelMacek-s3b]

Super nice intro. However, the slurping forced me to stop watching. Nevertheless, I got the take home message

[@michellemaat2198]

I could not listen through your sniffing

[@dd10fc18]

learn to be grateful, these videos are free