How Medications Get Absorbed By Your Body

MEDICAL ANIMATION TRANSCRIPT: Medication absorption is the movement of a drug from its site of administration into the blood. Oral drugs enter the stomach where they either dissolve and pass through the cell membranes of epithelial cells lining the stomach or travel undissolved through the stomach to the small intestine, which is the most common site of absorption. Here, drugs dissolve and pass through the intestinal wall. Oral drugs then travel through the portal venous system to the liver, where they undergo the first pass effect. During this process, the liver metabolizes some of the drug, either inactivating it or excreting it into bile for elimination from the body. The remaining amount of active drug leaves the liver and reaches general circulation and target organs. If a drug is administered via intravenous injection, it passes directly into the bloodstream, thus bypassing absorption in the GI tract. If administered through intramuscular or subcutaneous injection, the drug enters either muscle or subcutaneous tissue, where it passes through gaps between cells into capillary walls and then into general circulation or target organs, also bypassing absorption in the GI tract. Bioavailability is the net amount of a dose of a drug that is actually absorbed into the bloodstream. The bioavailability of oral drugs is less than 100% because of the first pass effect of the liver. In contrast, the bioavailability of IV drugs is 100% because they are not exposed to the first pass effect of the liver. Different drug formulations alter bioavailability, because they are not absorbed at the same rate or to the same extent. For example, tablets dissolve at varying rates. Enteric coated drugs dissolve in the small intestine, not the stomach. Because gastric emptying time differs between individuals, absorption times also vary. Sustained release formulas contain tiny spheres that dissolve at different rates, resulting in a steady drug release throughout the day, but also resulting in variable absorption. Some factors affecting drug absorption are the rate of dissolution. Drugs that dissolve faster are absorbed faster. Surface area, since the lining of the small intestine has more surface area than the lining of the stomach, most drugs are absorbed faster in the small intestine. Blood flow, the greater the concentration gradient between the drug-filled stomach and the rapidly flowing drug-free blood, the faster the absorption. Lipid solubility, highly lipid soluble drugs pass through the phospholipids in the cell membrane more easily than drugs of low lipid solubility. And PH partitioning, absorption is faster when the difference between the PH at the site of administration and the PH of the plasma attracts more drug molecules to ionize in the plasma. ♪ [music] ♪
#MedicationAbsorption #DrugAbsorption #DrugMetabolism
ANM11011

[@adamdumsday]

I don’t know if the makers of this video will ever read this, but these videos are absolutely fantastic. Some audiences are curious, some are in the medical field wanting to clarify something, some take medications and want the background. Well done and keep making these 😀.

[@emmanuelolayimika5459]

I agree with you. The explanation is so simple and clear.

[@sowhitney]

well daid

[@coolpanda7132]

better than my medical college professor

[@shantanupandey2752]

Lagta to nahi hai laude ke to med college me hai

[@yytyyy5329]

Overused comment

[@sudarsanaraopitta4939]

always

[@LifeIsArt3908]

Better than any teacher 0:52 0:54

[@flowerflower8242]

Lol. Thank you

[@charnitawalker9493]

Was looking for a simple explanation and learned so much more. Excellent job! Please keep making these videos!

[@AZKhan-ft2bc]

I have my maths exam tomorrow but this was important

[@rasmokey4]

Fantastic explation for the Laymen!

[@jeslinemwansakanchule2842]

The most beautiful illustrative video I've ever seen

[@Algebrainiac]

I wish you could do a video on antidepressant withdrawal syndrome!! That would be awesome

[@BaoTran-ls7oy]

Great video. Hats of to the production team for such an informative and well designed animation!

[@mathsquared121]

You provide very interesting information related to our body with animation making it more understandable 😉 thank you nucleus medical media.

[@Jakesullyy]

i am currently taking ATT T.B medicines ... and this is most valuable and most knowledgeable video for me ❤🎉😊 thank you !

[@Vilas-qh8ri]

This channel content and animation is really very good keep it forwarded and more❤

[@codedaily365]

as always loved it. Make a video on how brain targeted drugs work eg: ADHD, antidepressant etc

[@storminnormin4651]

Fascinating 💊

[@jaybee608]

We needed to know this!👍👍

[@septianhung4565]

Keep making amazing videos 👍👍👍

[@Young_giants]

Love the content ❤❤

[@wolfdenranjeet]

Far better than my pharmacy classes 2007

[@waelfadlallah8939]

Great animation ❤

[@robertceliberti7175]

Very interesting. Wish I had a video like this in high school biology when I was young..

[@Alsab786]

Superb Presentation!

[@OceanSwimmer]

These videos should be required viewing for High School students. Everyone should understand these concepts.

[@gideonosei5631]

Thank You

[@asifalithaheem5390]

How injury effects body parts like testicles eyes please make videos

[@faisalazam358]

Brilliant

[@zakiagul-zt4bp]

I am going in medical college next year... I hope these videos will help me through out my journey...👍🦅😊

[@asifalithaheem5390]

Hi nucleus my wish is make the video about diabetic retinopathy

[@DeBlauweOlifant]

How does it know which organ to target?

[@luissingh4722]

Very informative for a Registered Nursing student. As I'm now trying to understand pharmacology

[@magretangel5242]

Thank you 🙏🙏🙏 Can you also make video about Benzos!

[@mohammedal-hammadi5085]

I love this channel! Thank you for your great efforts

[@rustomabdulrhman6326]

amazing

[@asifalithaheem5390]

How external stuck effects brain and there function nucleus please make videos ❤

[@SudeepAdhikari0611]

Thanks to Whole Nucleus Medical Team ❤

[@joyguruvlog6095]

Excellent video of Medical Sciences 😃😃 I am a medical aspirant 😃 and it's a very good video and informative for biology students😌

[@MissCandy350]

Excellent presentation 👏👏👏

[@okonh0wp]

graphics are awesome

[@Codduct]

Fascinating

[@Ishwarya865]

Insightful

[@OmhashemGebril-vx2ly]

Good job many thanks 😅😅😅😅😅😅😅❤❤❤❤❤❤❤❤❤❤❤❤❤

[@worldhealth86]

Nice Information ❤

[@Collection234]

Thanks ❤❤❤

[@nobleiyke3723]

Very educative

[@manojkumawat7006]

Best explanation, I request you to explain complete pharmacokinetics ❤❤

[@imhritan1722]

Really too much informative...🙏❤️

[@lerossolas1057]

Very good animation from a soon pharmacist💊

[@jayalakshmijayalakshmi9092]

Thank you 🙏very very helpful Video 😊 to NEET aspirant ☺.

[@Dandelion_flight]

Stomach can absorb things? I thought it is only for digestion?

[@Panacea9]

Even patterns you picked up on your own early on you don't recognize the same. They can be glared over and go unnoticed at the time until it is out of your system. You can look at every instance later in memory and find those same patterns again and wonder why they went unnoticed because they can seem obvious to you again.

[@aminaelidrissisospedra4943]

locura i love this video

[@mrjamesmonkey]

You missed sublingual meds but that's the only thing I votive find in this video but other than that great video

[@robnewman6101]

Understanding our bodies in the Future.

[@userAl9893]

I absolutely love modern medicine

[@Drzein22]

Awesome

[@eileenlocke7877]

Clever

[@HealthJourney101]

5:00 amazing 😮😮😮

[@djstarrjunkie]

Question: What happens with the route of medication IF you don't have a gallbladder?

[@chaoticmind04]

I was also wondering this too. I got my gallbladder removed July 2020

[@mamenggaluh8897]

after taking medications by having diarrhea i was curious of how the meds work. now i feel powered, buffed and stronger than ever after taking the meds

[@eileenlocke7877]

I allways wondered

[@theodoraethelnaadoduahammo5625]

awesome

[@blinknazira2571]

How about the "plastic"cover drug?

[@TheTechCguy]

Ahh, yes. How the body absorbs the GOOD drugs! 😆😎👍💊

[@indranildas5101]

Amezing wow 😲🎉

[@kevinjones4142]

Does taking powder like (BCs) hit you faster than a pill like Tylenol

[@brandonfarfan1978]

Wow!😃

[@taylorembach8559]

She forgot to add in how liquid form by mouth gets absorbed

[@Ayushpatil0701]

Cool ! 👀

[@allthings77oo]

Digestive system look after the basic necessity of the human body

[@sulaimonramon7622]

Just wow

[@celestinez9406]

Does it also apply to Vitamin supplements?

[@anirudhv2997]

How did people first knew this?

[@sudarsanaraopitta4939]

I am curious

[@Kratos....]

So theres an on going war through my circulatory system

[@sleepdeprived8]

nice pfp you got there

[@AKA-VV]

I have lexapro

[@7-7191]

What about under your tounge?

[@josephsesay5662]

Just like Chemical kinetics

[@OlisaPrice-qq1wm]

Cool cool

[@Duricas]

How does a medication _know_ to target its intended organ?

[@chaoticmind04]

I was always wondering this too. What happens if the medication needs to go to the brain? Example antidepressants and antipsychotics

[@justkorbii3180]

I was JUST thinking this

[@tinanewrozi7667]

@@chaoticmind04they are manufactured as “more fat soluble” drugs so they get absorbed less throughout the body and more in the brain since brain is just fat and fat soluble things can easily pass through their very strict membranes, also to add on that blood flow to brain is very rich too. This might not be 100% accurate but i think its this way i’m a med student

[@chaoticmind04]

@@tinanewrozi7667 thank you for the explanation I appreciate it 😁

[@Rahul-en3cl]

YAAR IN SABKI HINDI VIDEOS NHI MIL SAKTI 🤔🤔🥺❤

[@saro5463]

Imagine if some of red cells got into the tube

[@ethanjohnson995]

nothing would happen

[@ballaki]

👍

[@rakeshvelpula6804]

👍 👌

[@DillonRussell-rj4yj]

Except for Klonopin

[@xenstence]

dont do drugs kids

[@krishangopal8261]

❤❤❤

[@carinasacoor82]

🎯 Key Takeaways for quick navigation: Medication absorption involves the movement of drugs from the site of administration into the bloodstream. Oral drugs can dissolve in the stomach or travel undissolved to the small intestine for absorption. In the small intestine, drugs dissolve and pass through the intestinal wall, then enter the portal venous system to the liver for metabolism. The liver can metabolize and inactivate some drugs during the first pass effect. Intravenous injection bypasses GI tract absorption, providing 100% bioavailability. Intramuscular or subcutaneous injection also bypasses GI absorption by entering muscle or subcutaneous tissue. Bioavailability of oral drugs is less than 100% due to the first pass effect, while IV drugs have 100% bioavailability. Different drug formulations affect bioavailability, with varying rates and extents of absorption. Factors affecting drug absorption include dissolution rate, surface area, blood flow, lipid solubility, and pH partitioning. Made with HARPA AI

[@saitwoqfwuwuf-zx2ry]

802

[@sandertitus6245]

Bro forgot IO

[@A_person.who_is.most_at_peace]

ঈশ্বরের ক্ষমতা আমার সঙ্গে আছে কোন মেডিসিন লাগবে না বন্ধু

[@simplicitylost]

Okay, but what about rectal?

[@richanother673]

💔 please, type in Greta Thunberg connects climate, ecological, and health crisis...

[@manjulashivakumar259]

Please explain in kannada

[@sleepdeprived8]

ಔಷಧಗಳು ಹೊಟ್ಟೆಯಿಂದ ಹೀರಲ್ಪಡುತ್ತವೆ ನಂತರ ಅದು ಸಣ್ಣ ಕರುಳಿಗೆ ಹೋಗುತ್ತದೆ

[@heyimmexican5681]

So we just don’t got lungs

[@nickwilson9210]

Nm Kk

[@ugochukwuozigbo3276]

I wish you could make a vid on how painkillers like panadol and paracetamol works in the body🥲

[@Puppies_Are_Forever..Sia.]

Sia..🫀😍!

[@RajeshKumar-ft8yc]

Do you ever wonder what is the worlds first pill?

[@Jakesullyy]

i am currently taking ATT T.B medicines ... and this is most valuable and most knowledgeable video for me ❤🎉😊 thank you !

[@Drzein22]

Get well soon

[@piyushpathak1186]

Me watching it with 102°F fever

[@user-yc1vs5gc1w]

Me 103°F 🤒

[@dannyrichards-nb9sh]

❤❤❤