How Mitochondria Dysfunction causes Disease [Science Explained]

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Created with Biorender
Original Video: • Mitochondria - The Key...
References (Copy and Paste DOI into Search Engine):
[1] doi:10.1007/s00018-022-04604-8
[2] doi:10.1080/15548627.2021.1964887
[3] doi:10.1083/jcb.202006043
[4] doi:10.1002/alz.12683
[5] doi:10.1016/j.cmet.2020.06.019
[6] doi:10.1007/s13402-021-00623-y
[7] doi:10.3389/fcell.2022.841523
[8] doi:10.1038/s41433-020-1110-y
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#mitochondrialdisease #mitochondrialhealth

[@Chaotic313]

As a Star Trek NG junkie, I highly approve of any Picard peppering to flavor your science and further your "enterprise".😁

[@wheelofcheese100]

😂 as soon as I saw the name “Picard” that’s the first thing I thought of.

[@jmc8076]

And my generation the ST before but Jean-Luc Picard was one of the best. Edit: So was the Dr and Worf (of course.)

[@CraigHocker]

When listening to this what came to mind is this is focusing on just one of the roles that mitochondria play. It isn’t just an ATP generator. Mitochondria are not only the organelle for ATP production and signal transduction, but they can also maintain the redox state and calcium homeostasis, regulate programmed cell death, and perform bioenergetics metabolism, stem cells reprogramming, ageing-related responses, innate immunity, and biosynthesis.

[@littlevoice_11]

I'd be very interested to hear anything around metabolic issues and their link to neurological issues, MS and rheumatology as well as autoimmunity

[@sdunca4864]

While you are theoretical and academic- it is appreciated you break it down to the level you have. As an instructor in an allied/professional health program- your videos are excellent content to explain and assist other concepts I facilitate to students. Thank you. If you're ever my way- I owe you a cup of coffee or tea- Bravo!

[@littlevoice_11]

Do you plan to talk about the cannabinoid system and the evidence for/against CBD?

[@Bonbon53539]

Love this stuff! Thanks. I can follow most of it and appreciate the diagrams, models, and the bit of entertainment along the way.

[@veronicaheaney3464]

I’d watched the interview with Dr. Picard earlier but really appreciated your comments. It put some of what was said in perspective and confirmed others according to how I’d understood them earlier. Also, love the “connection” to Captain Picard and the Enterprise. Some of this research has a very futuristic and sci-fi feel about it. 😉 Perhaps that’s what attracts me!

[@zhilahaghbin4766]

Thanks Nick for the education you provide. Love your sense of humor.

[@Physionic]

Thank you

[@stephenwillis9571]

Thanks very much for this and since I have the conn - if we're looking at disease it would be fabulous to have a video on ER Stress at some point.

[@aliceclearmanphd984]

Posted 6 minutes ago; I'm delighted to see I am not the first to watch. Bravo, you science super star, you!❤

[@Physionic]

Thanks, Alice :)

[@MichaelMerritt]

How does someone with suspected mitochondrial dysfunction and upregulated MMP’s find help or even just find someone to run a test like Labcorp’s Vectra Panel? It seems like only researchers understand what sort of damage dysfunctional mitochondria can do as my labs generally appear “within range”.

[@brianstewart1685]

Very interesting topic.

[@reedreamer9518]

Good day and good Mitochondrial heath to all

[@catman4471]

Interesting little things, Mitochondria. My entire supplement stack is based around Mitochondrial health, including NMN, and my current experiments involve uPEMF, or unipolar pulsed electormagnetic fields. VDAC1, or the voltage dependent anion channel, is a protein responsible for communication between mitochondria and nucleus where ATP and Oxygen are exchanged. Communication across this channel can be increased 600 times using infra-redlight at a specific frequency, and even more when used synergystically with uPEMF. NASA developed an interesting unified pulse coil for use with a patent by Hossam Mohammed which describes the role of mitochondria in disease, where he postulates that most diseases can be 'cured' through this combination of upemf and IR.

[@nicktube3904]

If you had to choose to start, would you choose pemf or red light therapy? Or do you insist to do both?

[@catman4471]

@@nicktube3904 It doesn't really matter, Red light therapy is amazing on it's own plus it's less expensive. But PEMF is more fun as there are so many things you can with it including brain entrainment. You have a host of frequencies to play with and could even ue it to harmise water at different frequencies to see what effects it might have. But for longevity, I believe a frequency of 9.8hz activates development genes, those which are active during our growing years, and as mentioned combined with RLT it increases mitichondrial function phenomenally.

[@m4inline]

I love this channel.

[@mitchellgould2053]

I’d be curious to hear your take on Dr. Pinchas Cohen’s work on mitochondrial peptides and the possible pros and cons of supplementing them.

[@richardcottone6620]

I recently saw a post about vitamin D. I'd like to hear your take on this

[@Dan-dg9pi]

Interesting video. I admit I was surprised you sprung the "powerhouse of the cell" trope so early that I wasn't even ready to roll my eyes.

[@nicktube3904]

I have Q-fever chronic fatigue syndrome and doing vagus nerve stimulation. I want to ‘help’ my mitochondria would you recommend PEMF or Red light therapy?

[@richguev]

What’s your thought on CoQ10? I never hear anything bad about it.

[@abigaila7341]

What is your take on long term antacids or antibiotic consumption and its affect on the mitochondria? Even SSRIs

[@ResidualSelfImage]

From what I ve gather ... regular human cells are erythrocytes cells which via evolution integrated mitochondria organelles that burns a more energy efficient mode using glucose and triglycerides with oxygen. When a human cell becomes cancerous, the normal cellular metabolism using the mitochondria is bypassed and the cell burns glucose without oxygen which results in a high growth pattern. Each erythrocyte cell has hundreds if not thousands of mitochondria - and a specialized cell will have specialized mitochondria. As long as most of the population of mitochondria are functional then the cell will run normally. When mitochondria goes bad it is removed and recycled by the mitophagy process. Mitophagy like Autophagy occurs when the cells are operating under less stress and in a slowly burning triglycerides/fat mode called Ketosis. Mitophagy need working Lysosome organelles inside the cell to trash and recycle bad mitochondria to work. Ketosis or fat burning mode is contradicted by high insulin or high cortisol levels. When Autophagy is needed to trash and recycle the entire cell, a healthy Thymus gland is needed to produce enough Tcells.

[@pmfith]

Lee Know has great books describing the mitochondria in great detail.

[@dankurth4232]

Yet he failed to mention Methylene Blue and Taurine which are most important molecules for mitochondrial health. He mentions PQQ which also belongs to this small group of primarily important molecules

[@BK-dy8jk]

WELL, cell function is like a symphony and each instrument has to be playing perfectly to make sense. Dysfunction of any one piece can make the music sound terrible and that piece needs to be replaced or removed. Start with clean air, pure water, organic healthy food and then start replacing the instruments that are broken instruments. Senescent cells need to be removed.

[@user-wz9pu7ty9z]

Do mitochondrial uncuplers cause Slippage??

[@zimskasalamaa]

Question 1, if someone takes tmg with nmn, would it be too much to take glynac too, and should it be taken apart? Also b vitamin with all that? Question 2, is silica in pill coating safe? How much of it is contained in 1pill?

[@Young-Turk99]

Can you explain l-theanine vs l-threonate vs magnesium glycinate? As a 30yr sufferer of depression, anxiety, panic attacks, Im always looking for natural help in my management. But all of these have different claims, the same claims, one works on serotonin, one on gaba because it crosses the brain barrier, and nobody is clear how long these can be taken. Some say daily. Some say daily for 4 weeks on, 4 weeks off. Nobody is clear on when to take them except saying all help at night with sleep. What about in the morning for all day help? Thanks!

[@theshadow8008]

Impaired oxidative stress regulation?

[@ellgonzales6165]

So because of the slipage and then those molecules interacting with other molecules in cells that shouldnt have, which causes free radicals, would antioxidants like glynac/ just nac which turns into gluathiome assist with fixing the issue after slippage happens in the cells?

[@quinnjohnson4690]

I'm no expert and just learning about mitochondria and health, but my father died of glioblastoma last year within nine months of being diagnosed. Taking his age into account and how it cancer risks risé with advanced age, he also started seriously drinking at the end of his life to the point he got alcohol poisoning and was killing himself. He got glioblastoma shortly after. I constantly believe he eventually caused DNA and mitochondria dysfunction through his overload of drinking. Just a theory

[@Unsensitive]

Hey, picking nits is sometimes important.

[@jtier11]

Any update or review on Urolithin A?

[@Physionic]

It's finished. Releasing in 2-3 weeks.

[@TheReminderChannnel]

@@Physionic thank you for your video on urolithin A - nearly fell for the “hype” train from other sponsored KZbinrs - appreciate your work buddy 🙏

[@dankurth4232]

Nearly all metabolic diseases are caused by mitochondrial dysfunction. And most can be effectively treated by regaining effective proper mitochondrial function. And it’s not too hard to get this done.

[@conscious_choice]

So how?

[@dankurth4232]

@@conscious_choice PPQ, Q10, Methylene Blue (avoid taking any SSRIs together with MB) best info about MB by Prof. Francisco Gonzalez-Lima also on YT, Taurine, Niacin (always together with TMG) Niacin will provide you with NAD+ and all the other metabolic derivates of Niacin. Now, I think that’s enough information for … the beginning

[@Justin_JJ]

How

[@dankurth4232]

@@Justin_JJ Usually orally, i.e. you take the respective pills in your mouth and then swallow them with an appropriate amount of an appropriate liquid, e.g. water. I hope that was helpful

[@randallhesse5011]

​@@dankurth4232 Good information. Except for, it's PQQ. Not PPQ

[@rachelwhite438]

So NAD, motsC and ss-31 should help

[@ashleyparker1203]

Then could taking creatine while leading a sedentary lifestyle cause electron slippage and ROS because of it's involvement with ATP? OR do I need to buy your book so I have a better understanding of creatine?!😅

[@Physionic]

Creatine tends to improve mitochondrial health, actually. No need to buy the book.

[@helenahandkart1857]

Ooh, cheeky slippitty mitochondria.. Now I think I understand why some are calling sedentarism the new smoking.

[@alant383]

No mention is made of the effects of telomeres in the dysfunction and/or damage to mitochondria. Shortening of the telomeres in mitochondria cause dysfunction and/or death of mitochondria from my limited understanding. So I was surprised this is not mentioned anywhere.

[@Physionic]

Well, 1. that's a pretty niche mechanism - there about 1000 other mechanisms not mentioned, but unless I make videos 5 hours long, I'll always miss many video to video, and 2. telomeres are in nuclear DNA, not mitochondrial, so I don't know where you heard that information on telomeres in mitochondria, but that is at it's foundation incorrect.

[@alant383]

@@Physionic Thank you for that correction of my misunderstanding. But i would love to know and get some level of understanding of the relationship between how the aging (aka shortening) of telomeres affects dysfunction of mitochondria, if at all.

[@BossNerd]

Telomeres are nuclear so they probably do not affect mitochondria directly. However, most genes have migrated from the mitochondria to the nuclear genome(there are only 37 left and they are mostly tRNAs and ribosomal genes). It might be that some of those genes are related to the pathways involved in mitochondrial function - in fact it is almost certain or they would not have been in the mitochondria in the first place. If telomrere shortening affects genes in those related pathways I could see a link. You would have to study up on the specifics of telomere shortening. To add an interesting side-note it does appear most of the gene transfer to the nucleus may be from paternal mitochndria and it occurs quite frequently in evolutionary time frames.

[@randallhesse5011]

​​@@alant383 I often wonder what effect would beta glucans of the 1,3 - 1,6 or 1,3D strains have on telomeres.

[@joecaner]

Dr. Picard = mitochondrial power Capt. Picard = warp power Got it

[@isa-manuelaalbrecht2951]

Tests are done on mitos in Germany and Switzerland..how it comes that this doc tells us, no measurements..test available..😂😅😮

[@aniE1869]

Captain Picard would say "shut up Wesley!"

[@russel082581]

Trimethylglycine!! (betain)

[@lewis-mindscrambler987]

outro music is a little loud, might suggest dropping it a hair. as a headphone listener, it caught me off guard

[@BossNerd]

I would like to throw in a comment. Mitochondria appear central to everything because of their link to modern/western lifestyle. Mainly our diet and lack of exercise. If western populations ate 1200 calories a day and did moderate exercise mitochondria would not appear to be as important to health. I think we really push biochemical pathways associated with the mitochondria to their limits.

[@KasKade7]

Sorry, but eating 1200 calories daily is nuts long term. Your health will suffer and is dangerous.

[@BossNerd]

@@KasKade7 Not doing it currently - but did it for about a year and a half and my blood biochemistry normalized. I am only 145 lbs.

[@BossNerd]

@@KasKade7 Also, several studies show this was probably the norm over the long history of human kind. 1200 may not be optimal but it is what our bodies have evolved to "expect". A good low carb diet can easily be done - I've done it. Only positive benefits going from 220 to 140lbs. I do NOT think it is harmful at all. I wouldn't be a professional athlete and do it but as a sedentary person it is almost required if you want to keep from gaining weight.

[@vickyverma6852]

A 1200 calories diet may work, but in ways that you might not want it to. For example, you can fall down and pass away just trying to take a dump - no you, no disease.

[@carolbrenner3121]

Just did genetic test for Parkinson’s disease.

[@carolbrenner3121]

Parkinson’s Foundation is doing this for no charge. There are 4 types

[@davethe-bear9923]

NERD ON!

[@Shirukan0]

Picard, I mean joke of the year 😜

[@carole.ronning9318]

Please forgive me but this information is old news! We need to understand what we can fix.

[@Physionic]

You are forgiven.

[@lotfibouhedjeur]

Nick sounds nothing like he looks. 😂

[@Joe_Brig]

When did you get funny? Nice.

[@davidsullivan8362]

Capt Dr Picard 😐is an egg-head.

[@casta9172]

All the Glory to Jesus Christ ❤️ Almighty God,, who has created all of this complex system,, He's amazing 🙌🏼