How science can reverse aging - and why we’d want to

[@Blackmark52]

1:25 *"What this looks like is a rather terrifying graph."* Guess that is a matter of perspective. As a 70-year-old I want the last bit to go fast. The curve MUST be steep at the end, the steeper the better. Worrying about the length of the flat part is a waste of time when you start to realize how long you've lived.

[@TSutton]

Honestly Andrew these videos have the production value of a channel 100x your size, you have such an impressive clear and concise way of explaining complex topics. Give it a few months of producing more content like this and you’ll be at 15K subs I can guarantee! Keep it up!

[@DrAndrewSteele]

Thank you! I will keep at it so I hope you're right! :)

[@seasong7655]

I hope the medication is released soon. I don't want to live pratically forever without my parents.

[@raysonlogin]

Losing someone sucks! :(

[@mikewade1604]

Agreed, I love my parents.

[@aneki3394]

Dont worry, in 20 years, humanity will have some therapies to extend our lifes

[@nicholasaurus]

@@aneki3394 She said she doesn't want to live without her parents.

[@aneki3394]

@@nicholasaurus do you think her parents will die in 20 years?

[@MsYoutuebchen]

Like I’ve always said: I want to die as healthy as possible as late as possible.

[@therabbithat]

Yeah 20 years life extension just raises eyebrows. Even 5 extra years of health would be world changing. If the average age of all age related illnesses was 5 years later, or 10 years, or hell, 1 year! That's what is exciting, that why what's being researched is so exciting.

[@SilverFan21k]

This video deserves more views..... people need to appreciate this subject more compared to your Wordle one, etc.

[@DrAndrewSteele]

Fully agree, I make videos about fun stuff to try to get views for this kind of stuff! (Which I do also think is fun!)

[@thegoodlydragon7452]

I think that WHY we should cure aging is obvious. The real question is HOW to do it, and how we can hurry up to be in time for most of us who are around now!

[@DrAndrewSteele]

You might be surprised how many people aren’t sure about the why! I agree though, I hope these treatments are available ASAP. :)

[@andrewhobbs5268]

i agree i want this so i can save family pets and older relitives i dont want to lose them and we wont have to not if we cure ageing hope it happens sooner

[@CheriLyn-music]

Nooooo wayyyyy the book has arrived. Yesss i am sooo excited 🥳

[@DrAndrewSteele]

Woooooo :)

[@minapatel1737]

Just watched you on Sunday Brunch, I was captivated by you, you come across as a very important person, thank you for sharing this important topic with us, am looking to reading your book

[@DrAndrewSteele]

Thanks Mina! Hope you enjoy the book. :)

[@supernaturalawesome1]

At what age would you stop aging and how long until you die. Heart just stops, no getting old? Me: 25 Life Span: 1000 years

[@VOLightPortal]

Is there a source reference for that graph at 1:50

[@DrAndrewSteele]

Yes, my sources are always in the video description! In this case: Calculation of number of deaths caused by aging based on Human Mortality Database data. You can find a report explaining the calculations, and the code behind it, on GitHub: github.com/ajsteele/ageless

[@therabbithat]

If rabomycin is THE med (forgive my spelling? ) how long before there are generic forms?

[@SnikieViniciose]

Loved the video !!! If I may, I think the video would benefit from a few images/videos/clips to visualize a few of the cells, subjects, etc. I think it could keep the viewer implicated longer in the video, for a longer watch time.

[@SwampyPanda3]

How some deaths are categorised as caused by ageing and not diseases itself not related to ageing, or how do we know how much part ageing has played in deaths

[@pavelbaidurov228]

Like from Russia, I'm very optimistic about future innovations because if nothing will happen - social and medical sectors will collapse with a current demographics, also people live so long even today - children have no place to live, property is so costly for many, people in Japan and in Russia as well sometimes work&live with parents up to 35-40yo just to collect some money and live in their own house. After first million of ultra rich will use these new methods like epigeneric rollback/AGEs breakers/etc - it will be cheaper than a phone. Also to be 80 and look and feel 30-40 it will be ultra popular, it will be a market x10 bigger than current cosmetics. Also sound quite futuristic and new.

[@DonAlonzo]

I'm looking forward to reading your book!

[@DrAndrewSteele]

Thank you! Hope you enjoy it!

[@LiveForeverorDieTrying]

So excited to have my hands on the ARC Andrew. Thank you for spreading the good word!

[@DrAndrewSteele]

I hope you enjoy it! :)

[@LiveForeverorDieTrying]

@@DrAndrewSteele I've heard great things, I'm sure i will!

[@jacobdaboss8413]

Can't believe granny lost a dice roll she never lost at dice.

[@Ars-vb7tm]

I have been thinking the same from my 24 years to today in my 30s and over to have my grandmother longer 🙂

[@andrewhobbs5268]

A cure for ageing is somthing we should all want for us family pets and older relitives we can do this its just when for me

[@SebastianNiemann]

A great book! Thank you very much! A great overview of the whole field. Love it 🙏🖖

[@DrAndrewSteele]

Thanks very much, that's very kind :)

[@anon-il9qf]

@@DrAndrewSteele didn't you do a ted-x presentation? aren't you in the market for self promotion? tsk tsk, guess i now have a license to dismiss any single thing you put up online. pro tip: be less smug and less phoney online and maybe you'll make more friends and actually put up information that has good substance vs good packaging.

[@marianbadea369]

6:27 Ageing is only one thing... Oxidative stress caused by toxicity and other forms of stress. All the 10 on your list stem from this!

[@Danuxsy]

Great video Andrew.

[@classicrock1027]

Ok so I have 2 questions Can this med be like if you were 60 and you would take this would it be like you would look and feel 20 again (I’m not 60 tho lol) 2 : when do you think this med will be released

[@larubisco4074]

Still waiting for it in Argentina. Have a great year!

[@psiphisapiens]

Brilliant job!

[@samiraly07]

As I m watching you now on today show from INDIANA state I searched your name on KZbin and I m a new subscriber So happy to find your channel

[@DrAndrewSteele]

Thank you! Happy to be spreading the word in the US!

[@SlamminGraham]

Please save us, science.

[@aliimran8479]

Great video as always..

[@patrickjos8922]

Hello M.Steele we would like to hear you also talk about cryonics. There's no life extension strategy possible without it. Why it's so critical to fund,improve,advocate for cryonics? When science today says "nothing can be done so let's burn or bury this body"cryonics reply that we will pause the process to bring you to the future when science and technology hopefully could be able to revive you. By being alive means we can die at any moments,having the option of cryonics is crucial. There's a tremendous work to be done to put cryonics as a viable option for anybody who wish it.

[@lakestreet3951]

You’re so tense. Relax man. 🧘🏼‍♀️

[@DrAndrewSteele]

THIS COMMENT REALLY HELPED ME RELAX THANKS!!!!!

[@treeeva]

​@@DrAndrewSteele😂😂😂 Thanks for the chuckle.

[@megacodex2597]

death is unstopeble, and there is a reason why.

[@Cricketwcc1]

Can anybody please tell me , how can I buy this book in canada?

[@DrAndrewSteele]

It should be available in most bookshops in Canada! It’s coming on March 23rd. :)

[@conversascontroversas7384]

Cure aging please

[@andrewhobbs5268]

i agree with you iwant this so i can save family pets elderly relitives i dont want to lose them and we wont not unless we cure ageing hope it happens sooner than later

[@shivamrichhariya4343]

Very good Sar ,God bless you .

[@GrimDarkHalfOff]

Look this all sounds wonderful, but let's be honest the poor will never have access to these treatments even if they begin to exist in the future. Fix income inequality and the wealth gap then I'll care. When the future looks like everyone being long lived instead near immortal billionaires and street urchins who die in their 20s I'll support you. I think that's fair.

[@DrAndrewSteele]

I agree it’s only fair to support these ideas if there’s good access for everyone, not just the rich-and I think it’s very likely to be the case, or I wouldn’t be promoting it! I’ve got a full video on the way about this, and will also be releasing a free extra chapter of my book soon to go into more depth about the ethics of treating ageing. It’ll be available at ageless.link/ethics As a really quick summary: the treatments are unlikely to be that expensive (most drugs can be produced pretty cheaply once off-patent and, while more advanced treatments will probably cost more, the economic benefits of treating ageing will encourage governments to make sure they’re available to reduce healthcare costs overall); and billionaires don’t want to be the only people taking these drugs! The only way to be sure they work is huge clinical trials and reliable measures of biological age, which mean billionaires, even if they were being selfish, would support the development of an industry around this, rather that brewing their own risky bespoke cocktails in an underground lab. :)

[@GrimDarkHalfOff]

@@DrAndrewSteele thank you

[@AidanRatnage]

If we do solve all 10 hallmarks could immortality be plausible?

[@DrAndrewSteele]

I suspect after we solve these ten hallmarks we'll find more that aren't such a problem in current human lifespans, or we've just missed… But human biology is finite, so eventually I'm pretty confident we'll crack it. Immortality is going to be a tough nut to crack because there will still be buses to fall in front of, an infectious diseases, but we'd certainly live a lot healthier for longer!

[@AidanRatnage]

@@DrAndrewSteele I meant the sort of "soft immortality" like you'd need to be killed to die, but wouldn't naturally die.

[@DrAndrewSteele]

@@AidanRatnage If we really did cure ageing and make people's death rates the same as a young adult, we could perhaps get close. There are still a few 20- or 30-somethings who get cancer/have a heart attack etc, but it's obviously very rare. What I hope for is ‘biological immortality’-death rates that don’t depend on how long ago you were born. :)

[@DrOlegKulikov]

The main cause of aging is stiffening of the extracellular matrix (ECM). And it is not even in the list of hallmarks of aging! My big dislike to the video.

[@DrAndrewSteele]

It is actually! I list it as a sub-hallmark under ‘protein problems’ in Ageless-maybe you’d enjoy the book where I’ve got a bit more than 12 minutes to go into more detail. :)

[@DrOlegKulikov]

@@DrAndrewSteele Stiffening the ECM is the MAIN cause of aging. All the rest is a consequence of it. Even accumulation of trash in the ECM is going because macrophages cannot migrate through the stiff matrix amd eliminate the trash. So, if you don't understand it then I believe your book is a kind of trash that only mislead people.

[@DrAndrewSteele]

@@DrOlegKulikov I don’t think that’s fair. The ECM is certainly neglected as a cause of ageing, but to say it’s the main one is to misrepresent the science. Even the two two ECM ageing experts I interviewed for the book didn’t say it was the main cause of ageing! Perhaps you’d learn more by reading it that you think. :)

[@DrOlegKulikov]

@@DrAndrewSteele Wow. Did you just deleted my reply to you? It tells a lot about you as a scientist. Congratulations. I believe your book will have a commercial success in this clown world.

[@DrAndrewSteele]

@@DrOlegKulikov No, your reply is right there! See the full comment thread (if you clicked on the notification it sometimes only shows the latest comment)

[@RyanLawless]

It's interesting how aging and death are seen as inevitable results of life, but they're no more impossible to mitigate as deep sea or space exploration. It's all a matter of applying resources to the study of each with a corresponding redesign of how we view the process of aging and whether death represents more than just the cessation of cellular activities in living organisms.

[@iantroggs]

Meanwhile Intermittent Fasting Ketogenic Diet Fasted Cardio Simples

[@conversascontroversas7384]

Reverse aging and don't let die humanity please

[@howin9235]

Are u also biologist ?? U also physicist And how u write book so fast I think u 👽

[@leftysheppey]

Honestly, I'd rather die than live forever. Life is already long enough. Maybe that's just depression speaking though 😅

[@DrAndrewSteele]

It's not about living forever! It's about reducing disease, which is a huge source of depression in older people. :) Take care!

[@altargull]

Removing aginig doesn't mean you'll never die. It means you'll live much healthier and for as long as you want (or until you get in an accident)

[@andrerodrigomaitamedrano1338]

felicidades para los paises anglosajones , el resto del mundo nos iremos al diablo pero hey asi es el mundo

[@Portia620]

This guy is like more morbid an the virology dudes I watch!! lol

[@ruffryderprabhu6206]

I am poor pls give me it for free i badly want to know and learn abt this

[@DrAndrewSteele]

Request your local library order a copy :)

[@ruffryderprabhu6206]

@@DrAndrewSteele thanx sir

[@orhanmekic9292]

Andrew you should change the title of this video to "What kills 2/3 of all people and can we do some about it?"