Can ‘Blueprint’ make you biologically younger?

If you enjoyed this video, you might like my book: ageless.link/
I saw a Twitter thread about Bryan Johnson’s ‘Blueprint’, claiming that he’d made himself biologically younger with a highly optimised combination of diet, supplements and exercise. What could that mean? And should we all start chugging 25 pills a day to start on the Blueprint ourselves? Probably not…but the biology behind it is surprisingly interesting.
Chapters
00:00 A tweet goes viral
00:44 Getting ‘biologically younger’
01:23 NAD levels
03:09 Maximum heart rate
04:12 Epigenetic clocks
07:12 Step 1: the Blueprint diet
09:23 Step 2: ALL THE SUPPLEMENTS
11:43 Step 3: track progress
12:40 Conclusion
Sources and further reading
My book, Ageless: The new science of getting older without getting old , goes into far more depth about rapamycin, metformin and epigenetic clocks, and lots more! ageless.link/
Max Hertan’s extremely retweeted thread on Twitter: / 1595213398358171649
My thread in response: / 1595398429018312705
‘Age-predicted maximal heart rate revisited’ www.sciencedirect.com/science...
The ‘Horvath clock’ genomebiology.biomedcentral.c...
The ‘PhenoAge’ clock www.aging-us.com/article/1014...
Bryan Johnson’s Project Blueprint website blueprint.bryanjohnson.co/
Corrections:
01:26 I say a decrease in NAD levels, when I mean a decrease in ‘biological age’ which Bryan infers from an increase in NAD.
02:00 I say that Bryan takes NMN to increase his NAD levels when actually he uses a slightly different supplement called NR. The logic and issues with this are the same though.
03:08 Same mistake as NAD levels, but with maximum heart rate!
03:52 And again… D’oh! These are, of course, therefore shown as a decrease on the chart… And also, while a higher maximum heart rate is associated with youth, a lower resting heart rate is of course healthier (learn more in my video with Medlife Crisis here: • The most important num... ) so perhaps you can see how I got confused while recording!
I’ve corrected all this in the subtitles for the video.
And finally…
Follow me on Twitter / statto
Follow me on Instagram / andrewjsteele
Like my page on Facebook / drandrewsteele
Read my book, Ageless: The new science of getting older without getting old ageless.link/

[@quantumspark343]

So... if one wants to biohack his way to immortality, what do you suggest? What is the serious stuff out there, the experimental true stuff?

[@DrAndrewSteele]

I’d suggest campaigning for more funding for ageing biology. And, if you’re as rich as Bryan, directly funding clinical trials yourself. It might sound slightly weird but I honestly think this is the best piece of health advice-we don’t know enough about treatments right now to strongly support anything beyond the basics (diet, exercise, sleep) so the single biggest determinant of how long most of us live will be progress in this field. Check out my book at ageless.link/ and, once you know a bit more about why this field is so exciting, spread the word: tell your friends, contact your political representatives, etc. You can find out more about how to help, either by campaigning or donating directly to fund research, at ageless.link/help :)

[@ellisfrancisfarros3935]

You don't. We all will die eventually somehow. Don't be afraid about that but instead come to terms with it. Not trying to be nihilistic with this saying life has no meaning, it definitely does. God gave this for a reason and the time will come when He takes it away and we will have to give an account for all that we have done.

[@MemeB0MB]

@@ellisfrancisfarros3935 God doesn't exist

[@DD-DerU]

​@@ellisfrancisfarros3935 If people five hundred years ago had said "we are never going to fly, accept it" planes, helicopters etc. would not exist, we need people to break the mold of what is possible or impossible

[@ellisfrancisfarros3935]

@@DD-DerU Planes aren't related to our bodies right? We still aren't able to fly, it is only the vehicle that flies and we are on it. And it is impossible to not die from other causes like an accident or the sun becoming a red giant and engulfing the Earth. Even if we move to another planet, the universe will die at some point and we will too. Delaying when we die and playing God has no point.

[@Churro_Douglas]

Most people have more savings as they grow older, so by spending all of my money, I will become economically younger!

[@DrAndrewSteele]

Hahaha, yes! Which, incidentally, spending $60/day on food and $11/day on supplements like this guy will help with…

[@charismahornum-fries691]

There's a study in Denmark where they are testing senior former elite athletes who are not on any supplements, who are still fit and well, and who are actively doing sports in some capacity researching why they are how they are. My mom-in-law is in it, it's fascinating.

[@NataliaMeleg]

are there any research papers already done about this topic? would love to read them!

[@inuhundchien6041]

Being active keep you active? Who would have knowwwww

[@DrAndrewSteele]

Wow, sounds super-interesting! There’s a lot of debate about this, my favourite example of which is the observation that Olympians live longer than the rest of us-but it’s hard to work out whether they’re living longer because of all the training they’ve done, or they were able to do all that elite training because their bodies were unusually robust in the first place! Good luck to the researchers and your mum-in-law! :)

[@felixalexios]

​@@NataliaMeleg Don't trust a Danish study. They always rip off other countries' studies. The latest example from this year was that Danish doctors concluded that smoking increases the chances of mental illness. But this was already concluded by the Americans in 2017. (5 years ago) I have countless examples where our media says that Danes found out something and then you Google it in English and find out others did the same years ago lmao xd. If Denmark actually performs original research, it is often incredibly flawed, not peer-reviewed, and has all the characteristics of a bad scientific paper. A good recent example is Denmark choosing to ban Ashwagandha based on a poorly done study by Denmark. Addictive Wellness did a video 7 days ago completely obliterating that study and explaining why it was poorly done! Lastly, if you are still not convinced you shouldn't trust Danish studies then you only need to look at how bad our healthcare system is. The WHO places us among 3rd world countries while our Scandinavian neighbours Norway and Sweden are some of the best in the world.

[@felixalexios]

@@DrAndrewSteele ​ Don't trust a Danish study. They always rip off other countries' studies. The latest example from this year was that Danish doctors concluded that smoking increases the chances of mental illness. But this was already concluded by the Americans in 2017. (5 years ago) I have countless examples where our media says that Danes found out something and then you Google it in English and find out others did the same years ago lmao xd. If Denmark actually performs original research, it is often incredibly flawed, not peer-reviewed, and has all the characteristics of a bad scientific paper. A good recent example is Denmark choosing to ban Ashwagandha based on a poorly done study by Denmark. Addictive Wellness did a video 7 days ago completely obliterating that study and explaining why it was poorly done! Lastly, if you are still not convinced you shouldn't trust Danish studies then you only need to look at how bad our healthcare system is. The WHO places us among 3rd world countries while our Scandinavian neighbours Norway and Sweden are some of the best in the world.

[@suyang4505]

He forgot one more health advice, don’t be poor.

[@B0bbyV]

Conclusion: First of all, I'm not 100% sure that you mentioned that Bryan Johnson's "Blueprint" is completely FREE... None of the food or supplements and workouts are harmful. He improved biomarkers on every test taken. And even if he didn't "slowed" aging, which by the results he did. He improved his overall health. Which is in my opinion worth of credit and it's seen as a contribution to society and not just another marketing scheme...

[@DrAndrewSteele]

The website might be free, but it says on the lists on there what all this costs: $4000/year on supplements, and $16,000/year on food. This is way out of reach of most people, and they could get most of the benefit for essentially no money. They might even get more of the benefit if any of the supplements turn out to have negative health consequences!

[@Ibeatuphomelesspeople]

@@DrAndrewSteele idk what brands hes buying but black beans, vegetables, and pumpkin dont cost 16k a year man. Especially 2000 calories

[@maxintos1]

How exactly did he contribute to society? He improved his overall health by eating healthy and working out daily, but heavily attributes it to the expensive vitamins. There are plenty of influencers that already promote healthy eating, good sleep and working out to improve overall health without adding weird pseudoscience.

[@maxintos1]

​@@Ibeatuphomelesspeople He is just quoting the blueprint website

[@darkfieldcarnivore3928]

Just eating species appropriate food will do it. Our bodies will regenerate given the right substrate in sufficient quantities.

[@foxymuldar]

Someone your age can wait a few years but Im 75 so I started on Metformin recently and switched my diet to low sugar more veggies and less calories plus I haven't eaten any red meat in 40 years. That I believe has helped me a lot. I also bike ride 90/120 mins at least four or more days a week. That helps my heart rate and overall fitness. I also like to follow what Dr. David Sinclair says about antiaging. He's a big believer in some of the drugs you want to wait years before trying. I guess if I was a multi millionair I could afford all the supplements and tests Johnson is taking. Most of us cant.

[@mightbeanybody]

I am also 75 Clarence, I used to be a racing bikie now I run 6 days a week. I haven't eaten processed food, drunk alcohol etc. for 47 years. I also follow David and others and yes, the supplements do add up in cost, £300 last month, not easy on a pension but I want to hold ground long enough to benefit from the near future senolytics etc. I put my blood test results into an epigentic clock and it came out at 57, I'll take that!

[@04dram04]

Meat in general is a high oxidant. Much better to replace it with beans, nuts, seeds, and legumes. They are antioxidants. The number one cause of age related death is cholesterol blockages. Plant based diet has no cholesterol.

[@leotravel85]

@@04dram04 While plants can provide many health benefits when consumed as part of a balanced diet, there are also several disadvantages and dangers associated with plant consumption for humans, including: Allergies: Some people may be allergic to certain plants or plant-based products, which can cause adverse reactions ranging from mild to severe. Nutrient variability: The nutrient content of plants can vary greatly based on factors such as the soil they were grown in, the climate they were exposed to, and the time of harvest. Poor bioavailability: The nutrients in plants are not always easily absorbed by the human body, leading to low bioavailability of certain vitamins and minerals. Preparation method: The way in which a plant is prepared can greatly impact its nutrient content and overall safety as a food source. For example, cooking, boiling, or roasting certain plants can destroy certain nutrients or create harmful compounds. Contamination: Some plants can become contaminated with harmful substances such as heavy metals, chemicals, or pathogens, which can pose a health risk if consumed. Toxins: Certain plants contain toxins that can be harmful to humans if consumed in large quantities. For example, plants like rhubarb and cassava contain high levels of oxalates that can cause kidney damage. Pesticides: Many commercially grown plants are treated with pesticides, which can persist in the plant and pose a risk to human health if consumed in high quantities. Chemical additives: Some plants are treated with chemical additives to enhance their appearance, increase their shelf life, or prevent spoilage. These additives can pose a health risk if consumed in large quantities. Interactions with medications: Some plants can interact with certain medications and either increase or decrease their effectiveness. It's essential to be aware of these interactions and to talk to a healthcare provider before consuming plants while taking medication. These are just some of the potential drawbacks and dangers of plant consumption for humans.

[@mobilerevolution11]

Nothing wrong with red meat. You've been duped.

[@04dram04]

@@mobilerevolution11 No you have. Any meat has cholesterol that leads to the number one cause of death.

[@BuxStop]

If his aim is peak fitness and health for whatever age he is, he’s definitely won.

[@mattlopez9351]

Really good video, thank you for recording this!

[@flaviosalazar2998]

Lo interesante de blueprint es que pone sobre la mesa el cuestionamiento acerca de los hábitos que realmente pueden lograr "rejuvenecernos". Por otro lado , tu vídeo tiene mucho sentido... Hay manejos que podemos lograr con nuestro cuerpo que nos darán resultados en muy poco tiempo. Es importante que vayamos popularizando los hábitos que van en esa línea. Hoy en día tenemos acceso a mucha mejor alimentación e información nutricional que hace veinte años. Muy interesante tu vídeo , muchas gracias desde Chile 😀

[@fcpolitimisoara]

Remember you must refrain from nuts until Thursday :) great video! I recently stumbled across a paper on sulforaphane, and although it's not mentioned in Blueprint, it seems to be another item in the list of promising anti-aging (particularly neuroprotective in this case) compounds that need more testing. If you know any specifics on this, I'd love to hear them. Cheers!

[@DrAndrewSteele]

I need to read some more about that too! Apparently he gets it in his ‘BroccoMax’ supplement but I have to confess I didn’t look into it in much detail because I found the name too funny!

[@fcpolitimisoara]

@@DrAndrewSteele though admittedly funny, it makes sense since the main source of dietary sulforaphane is in cruciferous vegetables!

[@DrAndrewSteele]

@@fcpolitimisoara Ha, I knew the cruciferous vegetables were related, but I did not know that’s what they were called! Keeping up the standards in the comments section there…

[@Rr17user]

@@DrAndrewSteele Dr Rhonda Patrick (FoundMyFitness) is a big proponent of sulfuraphane via broccoli sprouts

[@minatotheshinobi907]

Dr Rhonda Patrick is worth a listen and watch reference Sulforaphane (Brocoli sprouts) and how best they are prepared / ingested.

[@aliimran8479]

Always love to see a new video from andrew

[@scottbarnett3566]

Eh Bryan feels well ahead of the curve relative to the traditional medical model. He is currently employing 20+ specialists - including many MDs to empirically determine and ascertain what metrics hold value. Bryan does talk about 1. Not being destructive to your body as an absolute baseline.

[@forestrunner8922]

You seem like you are having fun figuring this out...cool...! Bryan Johnson is very interesting and methodical I find it kind of fascinating also,

[@vidhoard]

So fascinating!!! Your channel will absolutely be over 1 mil subs soon!

[@DrAndrewSteele]

Thanks! Hope so :)

[@waynehedd]

...a year later.... 33k....

[@vidhoard]

@@waynehedd I think it's only due to upload consistency. The content is solid.

[@DaveTexas]

I guess I’m the opposite of this guy. I’ve had a chronic autoimmune disease since childhood. It seems to have caused me to age more rapidly than most people. I was diagnosed with osteoarthritis when I was about 35. I had a bad case of shingles at age 38. I had to have cataracts removed at age 44. Now, in my mid-50s, I walk with a cane due to balance issues and I sleep 11-14 hours per day. I’m essentially 30 years older than my biological age. Guess I should keep my eye on those drugs. I eat relatively well - lots of vegetables and nuts - but exercise is a problem for me due to neurological and severe pain issues. I get plenty of sleep, but it’s too much sleep. That’s a whole separate issue; we can’t figure out what his causing my fatigue. I don’t think I’ve ever had COVID, but some of my symptoms are consistent with post-viral fatigue syndrome, which can be caused by COVID as well as a bunch of other viruses. The main problem is that I live in the United States. I can’t afford the doctor appointments and treatments for these things anymore. Being unable to work much, I’m stuck in a poverty cycle - if I could work more, I might be able to afford the medical care that would help me feel well enough to work more. I’m apparently not sick enough to qualify for disability and Medicare (our socialized medical insurance program for the elderly and disabled), because I’ve been repeatedly turned down when I’ve applied for disability. I hate this country.

[@alaedinebenani5715]

We don't know each other but I hope you will break the circle and feel better soon!! 🙌💪✌

[@saketravuri8496]

you should save up and come to India , I've helped a lot Americans in similar situation get great healthcare at a tenth of American prices plus you can backpack and have fun. or volunteer in a place like Auroville if you don't have money

[@jeccdog7584]

good luck david

[@trisbane4086]

This might not be the answer you want to hear, but my suggestion is to move out of the United States. The country is poison. Every day massive companies spread unregulated chemicals into every product and the environment. The soil is devoid of nutrients, the farm animals are doped and unnatural. Some people don't end up having adverse reactions, but many do (autoimmune disorders). Move to Europe, or somewhere else. Go where the climate is good and the food tastes nice.

[@DaveTexas]

@@trisbane4086 oh, I’d move out of the U.S. right now if I could afford to. I’d love to live in a country with universal, single-payer healthcare. The problem is that I cannot afford to move. I need to live close to major medical facilities with all the specialists I see regularly. I only work part-time, but my job is so specialized and unusual that I would not be able to find another job like it - I am literally the only person in a metropolitan area of two million people who does what I do. Losing my income from that would mean I couldn’t afford to eat. I live rent-free with someone here, which I highly doubt I could replicate elsewhere. Essentially, I’m trapped.

[@juliedesnick7401]

It's impressive that Johnson is doing his Blueprint. But a deep dive into how evidence based it really is, is appreciated. I'm a fan of Dr. Michael Greger on nutrition.

[@RB-qu3bz]

I'm proud of him. And happy that he doing that and motivating others. And it's better than the ppl that doing nothing with their aging maybe he did a great marketing and all of that, but the fact that he open the mind of others It's what is important here

[@Thedemonseedsower]

Be careful not to open your mind too much, your brains will fall out.

[@FreedomPact]

Absolute quality video once again, mate 👏 My favourite KZbin channel and person to follow on social media. You’re the man!

[@DrAndrewSteele]

Thanks dude! You’re too kind!

[@knosis]

I really like your channel, brother. I found you through Dr. Rohin's channel and I am glad I did!

[@DrAndrewSteele]

Welcome from a fellow Rohin fan!

[@Maxxomatik]

Thank you very much for this video. It spared me watching the almost 2 hour long video of Bryan Johnson. I read "Ageless" as well. Great work Andrew Steele. Keep it up.

[@DrAndrewSteele]

Ha, glad to have saved you the time! And thanks for checking out my book. :D

[@MaxsMonthlyChallenge]

Hi, I am Max Hertan, said thread writer :) I'm just genuinely a big fan of Bryan Johnson and wanted to share my great experience with his Blueprint program. Appreciate the share and thoughts Andrew.

[@DrAndrewSteele]

Thanks for the comment Max and glad you enjoyed the video! Perhaps you’d consider sharing it or my Twitter thread twitter.com/statto/status/1595398429018312705 to your followers?

[@ludicrousfilms635]

@@DrAndrewSteele pwease give me followers Max 😢. I know I was mean but please please followers I need them

[@DrAndrewSteele]

@@ludicrousfilms635 LOL, no, I would like Max to share in order to correct the misinformation he spread to thousands of people.

[@ludicrousfilms635]

@@DrAndrewSteele there’s 100 things he should do to correct the “misinformation” he spread before sharing this video lol. Everything Bryan does is backed with data, meticulously changing things based on evidence. All he wants is to optimize his mind so he can make a difference in the world. He has more to lose than to gain from lying. Doesn’t seem like you put much effort into researching the topic of your video

[@DrAndrewSteele]

@@ludicrousfilms635 Apart from spending years working as a biologist and then writing a book on the biology of ageing? As I explain in the video, this advice is far from evidence-based-at best much of it is money-wasting, at worst it could be actively harmful to people’s health. I’m guessing this won’t be a particularly productive discussion given your attitude, but if you can point out any specific errors in the video, please do.

[@ny4nk0]

He doesn't just put on some moisturizer, he gets a fullbody IPL (laser) treatment EVERY. WEEK. That's insane! He also uses tretinoin, which has been shown to improve skin tone, texture, and fine lines. Anyone who does that, regardless of their diet, will have good looking skin!!

[@NathanSmith-ng4ve]

what is fullbody ipl and what is more important ipl or tretinoin?

[@ny4nk0]

@@NathanSmith-ng4ve IPL is a laser treatment you can get for a variety of skin concerns, it can target unwanted hair and discoloration (broken capillaries, sun spots, freckles, rosacea, etc). it costs hundreds of dollars for a single session on one body part, and you require multiple sessions to get the issue resolved. you'll generally get a clearer complexion with IPL. unfortunately it works better on lighter skin, because the laser targets the contrast of color. so for hair removal, it works best on dark hair on light skin. tretinoin is the only topical proven to reduce wrinkles (it is a prescription version of retinol), it can also smooth out the texture of your skin and make pores less visible, and is a very good treatment for acne. your skin will look healthier and younger with tretinoin, but it isn't as effective at treating discoloration. however tretinoin can cause irritation and sun sensitivity, so its important to go slowly and only use a pea sized amount at night, and wear sunscreen during the day. the very best thing you can do for your skin is wear sunscreen btw, sun causes the most damage.

[@robbylebotha]

But he doesn't have amazing skin. He looks like the average 45 year old skin.

[@Jsarson1976]

Tretinoin is absolutely amazing I had acne and bad skin all my life and I am 47 but it’s made me skin look a lot younger that it did do before.

[@ohnoitstony]

Still looks like a vampire 😅 maybe I’m completely wrong and my tastes in good looking skin are mixed up or something, but here is an interesting thought. Subconsciously I find him detracting and this is obviously no scientific though but we should know subconsciously what healthy should look like

[@chillynight201]

This video is very interesting and well made and I’m really surprised that it doesn’t have more views!

[@DrAndrewSteele]

Thank you!

[@LukeA1223]

This was a fantastic video, thanks!

[@DrAndrewSteele]

Glad you enjoyed it!

[@representado8751]

your humor is pure gold.

[@bondjane007]

They just wanted to thank you for your video I enjoyed listening to you speak and you make sense. I agree a lot of things that sound fancy and really it boils down to a lot of basic sleep eating organic healthy food and getting plenty of exercise.

[@giulio9476]

Man I really like your approach, finally a true scientist and a great man

[@DrAndrewSteele]

Thank you!

[@dianewalters5731]

I am thoroughly enjoying your videos. I subscribed awhile back when I viewed your Wordle video.

[@DrAndrewSteele]

Thank you! Come for the word games, stay for the ageing biology… :)

[@mike4088]

I am happy that Bryan is using himself as a Guinea pig for the rest of society. The hardest part of any new innovation is the research and creation of a prototype. After that the supply chain and manufacturing around the innovation needs to scale so the rest of us can enjoy it at a relatively cheap cost. I think he will eventually find something of worth that can be replicated for the masses. Good thing I'm much younger than him. By the time I'm his age I am sure we will have some significant advancement in the field.

[@maxintos1]

But he is not doing or adding any research. He is just taking vitamins that he or his team have found from existing research to potentially have positive effect on ageing. He is not funding any research or studies. Him taking experimental drugs does not help society. He is literally taking 100 pills a day, if his ageing is actually slowing down we would have no way of knowing which of the 100 drugs are causing it or if all 100 are useless and it's all just gym, good sleep and healthy food.

[@travv88]

I agree

[@FingerGunProductions]

This is not something new he is just doing what many rich people have done through history which is try to elongate life while not

[@broken_abi6973]

A study with sample size 1 is not very conclusive in this field of science. Let's not try to exaggerate the importance of this "study" over actual controlled trials.

[@mitchell10394]

In podcasts he’s been candid and shares that his goal is to extend his life and hopefully reach longevity escape velocity - while hopefully capturing useful data along the way. He cannot control how far the industry has come up to this point and is doing what he can to be around for (if) when we do reach that point

[@DrAndrewSteele]

He has hundreds of millions! He may not be able to ‘control’ the industry, but he could make a huge contribution to it.

[@ptegsotica5895]

ahhh yes ... the ol' "longevity escape velocity" trick! yes .. yes .. 😂😂😂

[@1peatler1]

he will most likely die under 100 his routine is pure autism and useless

[@fbulderin2415]

​@@DrAndrewSteele what do you call what he's currently doing and sharing the info for free if not helping the industry?

[@DrAndrewSteele]

@@fbulderin2415 He could do far more with $2m/year than an uncontrolled _n_ = 1 experiment, and from the publicity I’ve seen he’s making people think that longevity is some kooky thing billionaires do, which undermines the industry…

[@einszweiweltstein2574]

Thank you for an honest review

[@sgtbetter]

Hello Andrew, great video, very informative and easy to follow, thanks for breaking this down. I have a question, what is your belief and understanding concerning autophagy?

[@DrAndrewSteele]

Probably a bit too long for one KZbin comment!! But, to be far too brief, it does seem to be important for longevity, perhaps especially in the brain, and the links with dietary restriction and rapamycin are intriguing. For a lot more detail you might enjoy my book, _Ageless_ ageless.link :)

[@thecrazything95]

You are criminally underwatched for the production value!

[@DrAndrewSteele]

Thank you!

[@nathanlrobson1974]

Thanks Dr Steele, informative video as always. You mentioned spermidine again, last I heard was that supplements of it failed to raise spermidine levels in the blood. Are you still as optimistic about this particular compound?

[@DrAndrewSteele]

I’ve never been especially optimistic about spermidine! It does get a mention in Ageless but it’s one of many. :) Do you have a link to the research?

[@nathanlrobson1974]

@@DrAndrewSteele I haven't actually seen the research, but I watch Dr Brad Stanfield as well, and he recently did a video on supplements. He played a clip where Dr Richard Miller discussed his lab's findings, one of which was that.

[@DrAndrewSteele]

@@nathanlrobson1974 I’ll see if I can find it! Big fan of the ITP (obviously…) and also a Brad subscriber :)

[@waytogo11]

Good critique. The basic is the same. Good diet, sleep and exercise. The specifics of what works and what doesn't is what bryan is unearthing.

So, increasing your NAD level might be something like coloring your gray hair. The indicator of age decreases / vanishes, but it doesn't mean anything.

[@DrAndrewSteele]

Quite possibly! It may be more useful than hair dye, there’s still evidence to be gathered…but I’d certainly not bet on NAD specifically as results so far have been…mixed…

[@saketravuri8496]

@@DrAndrewSteele but I've seen many people get lots of energy because of them . I'm only worried about the cancer risk I'm 25 so I guess there is time

[@DrAndrewSteele]

@@saketravuri8496 Plus placebo effect… I’d definitely watch and wait if you’re 25!

[@georgehornsby2075]

By waxing off all of my body hair I have the biological equivalent amount as a baby, averaged out with my IQ and my prostate volume (which is the size of a 10 year old's thanks to an implausibly large amount of finasteride) I have an average biological age of 7, a far larger reduction than his! Where can I apply for my world record?

[@DrAndrewSteele]

Haha have you considered a long Twitter thread about this

[@ClassicStrategist]

🤣🤣🤣

[@Kiido11]

This should be top comment. Of the entirety of KZbin.

[@mightbeanybody]

No finasteride for me, too large an effect on my athletic performance. I am taking natural products and have a prostate artery embolization scheduled for March. Happy 8th birthday soon?

[@solesticia]

Lolllll

[@kylemurray8230]

I'm looking forward in what he is doing, see his markers over time..

[@Firstvgd]

Very well said, that's exactly what I said once I watch the blueprint, eat well, exercise, sleep ، relax and worry less, everyone can do it, you don't need $2 m to do it.

[@callmeperch]

I really appreciated this video! You broke everything down really well and communicated the concepts clearly with good editing and helpful graphics. Do you think it would be possible to add a reference sheet for this & future videos?

[@DrAndrewSteele]

Thanks, glad you enjoyed it! And good news: there are references in the video description. :) Hope they help!

[@DrAndrewSteele]

What aspect of the Blueprint would you be most interested to learn more about? Rapamycin and epigenetic clocks are probably top of my list for future videos, but let me know in the comments what you’d find most interesting! Also: dammit! Thanks to switched-on commenters for pointing out a few mistakes that snuck in because I made this video in a hurry back when this Twitter thread went viral! I say a decrease in NAD levels (at 1:26) and maximum heart rate (at 3:08 and 3:52). D’oh! I obviously meant a decrease in ‘biological age’ which Bryan infers from an increase in NAD and maximum HR (from 169 to 183 bpm, apparently), which is of course therefore shown as a decrease on the chart. And also, while a higher maximum heart rate is associated with youth, a lower resting heart rate is of course healthier (much more on that in a future video!) so perhaps you can see how I got confused while recording! I’ve corrected all this in the subtitles for the video. I also say that Bryan takes NMN to increase his NAD levels (02:00) when actually he uses a slightly different supplement called NR. The logic and issues with this are the same though! I’ve also corrected this in the subtitles. All this (and mistakes in any of my videos!) are listed in the Errata section in the video description.

[@fatboydim.7037]

DHEA has been mentioned by Dr David Sinclair as it reduced epi age by 2.5 years so that would be a good one to dig deeper into. I have read about Bryan Johnson before I think he wants to hit Longevity Escape Velocity before anyone else.

[@tomsekmanis]

Hi, I'm wondering whether we know if the PhenoAge epigenetic clock is, again, causative or correlative. Do we know what genes are influenced and are the changes in their expression linked with ageing symptoms? I've read that the environment can cause certain epigenetic responses, so is targeting a response in this metric a good goal? Would targeting this metric cause improvements, or is it just an indicator? Your video intrigued me, but I'm afraid I don't have the time in the middle of my exams to do the research myself, so if you are interested in video ideas here is something you could touch upon :D

[@DrAndrewSteele]

@@tomsekmanis Thanks for the question! The short answer is: I don’t think we know if it’s causative or correlative. The longer answer is…well, I should probably make a proper video about how they work and what they mean as you suggest. Definitely on the to-do list! And good luck with your exams :)

[@Dogo.R]

What makes no sense to me is that alot of these drugs have data behind them that is either "anti disease" or "reduced aging in mice". But with the first one, that isn't "anti aging" evidence. And with the second one, mice clearly don't age like us because they live drastically shorter. How can people think that mice aging is similar in mechanism to humans when they literally age at a drastically different rate. I mean if we were super similar aging wise and there was just a few little differences that completely ruined how long mice live for then those should be easy to fix? And if they can't be fixed, clearly the very impactful things will still remain, so how do they not completely invalidate the validity of mice lifespan change data?

[@frealixofficial]

really interesting would be establishing a formula for how to put the different markers together. How important is hearth, brain, skin age etc. Once you have the individual values, how do you come up with one coherent result, that is ideally not just averaging all individual biological clock.s

[@ok373737]

Excellent insights!

[@seif9923]

I came to that exact conclusion like you by just watching bryan's videos, and you mentioning that makes me think youre much more credible, definitely will subscribe and follow your content, don't sell out please like most of the popular wellness and anti aging "influencers"

[@pinkuho2419]

You mentioned that you prefer waiting an additional five years instead of taking the supplement immediately due to concerns about potential risks. However, would it make a difference if Bryan undergoes comprehensive organ and other related health checks to assess any negative effects caused by such supplements? It seems that in Bryan's case, the presence of a team monitoring his well-being would detect any adverse impacts and discontinue the supplement's use if necessary. Considering this scenario, does it still justify waiting five years over adopting such a method? Additionally, I would like to hear your thoughts on the future of research and the potential development of simulations or neural networks that could significantly speed up the generation of evidence compared to the current trial-based approach, which often takes years. While acknowledging that we have not yet reached that stage and it may take decades to achieve, do you believe it is feasible for such simulations or networks to replace traditional research in the future? I'm just a student so I'm sorry if I'm saying something terribly stupid :D.

[@DrAndrewSteele]

Great questions! The problem is, while Bryan does a lot of tests, we don’t have a good comprehensive measure of biological age yet, so we don’t know what his ‘improvements’ mean-or if they even are improvements. They can probably spot if he’s doing something that might be immediately dangerous to his health, but there’s no way to tell if a given supplement or practice is adding or subtracting a year from life expectancy. Given that he’s taking so many, they might cancel out, or interact negatively, in ways we can’t test for. And I hope AI will have a big role to play, but at the end of the day you always need training data so we’ll still need some experiments! Perhaps AI will one day be able to help by telling us which experiments would best improve our understanding though, and I imagine this will make huge advances in the next decade or two-so we should be collecting as much data as possible in advance in readiness IMO.

[@nineteenfortyeight6762]

He might be monitored, but by people who work for him, and he has a financial stake in lying.

[@KommentarSpaltenKrieger]

A very big problem I could see is that doing all these things at once doesn't help at all with knowing what works. Even if I just combine diet changes and exercise, improvements in weight, well-being etc. could be due to either one of these two or the two combined. If this anti-aging guy does experience some effects, the question is: due to which of these 100 components exactly?

[@DrAndrewSteele]

Totally agree. It’s _n_ = 1 subject but _m_ = loads of constantly changing interventions!

[@davidderidder2667]

Great critique

[@cinemantics231]

This is a fascinating area of inquiry, and one that I've grappled with since I was a kid. I've always looked far younger than my age. It troubled me greatly as a kid because peeps of my own age treated me as a "child" rather than an equal. Of course, now at 38 I can brag about it. Even today people think I am in my early 20s. But I did always wonder, does the fact that I look younger mean that my aging process is slower than usual? If so, what tests might I do to confirm my biological age. I've heard stuff about telomeres and all that, but apparently it's not conclusive or even advisable.

[@user-xd3rb1fm5z]

Do your relatives look younger too ?

[@cinemantics231]

@@user-xd3rb1fm5z Some of them, yes. My mother looks like she's in her early 40s even though she's 70 now. I also have a cousin sister who looks far younger than her actual age.

[@user-xd3rb1fm5z]

Thanks for yor answer. Have you and your mother and cousin the same diet and habits?And are they similar to Blue print project ?

[@cinemantics231]

@@user-xd3rb1fm5z No, in fact we have very different diets. I am a non-veg (mostly chicken) but eat plenty of fibrous vegies, low carbs. My mom is a vegetarian and eats lightly, my sister is also a vegetarian but has some food intolerances so follows a different diet. Both me and my mom do consume very few carbs and next to no sugar though.

[@cinemantics231]

I should add that our diets have been different over the years depending on where we were. However, our appearance has pretty much remained consistently younger than our actual ages since as far back as I can remember. So, I am not sure if it was only diet that's at work here, although it's probably an important factor.

[@samumedi]

Bryan Johnson: Shares his personal results and health journey for free. Doesn't promise anything. Andrew Steele: Creates a KZbin video analysis about a tweet from a third party without going to the actual source. Bryan Johnson: I don't know if this actually works 100%, but here are my results. Andrew Steele: I don't know. Despite all the available data, everything might be speculative. Proceeds to gaslight and tries to misdirect his arguments with logical fallacies and misquoting Bryan by undermining a tweet from someone who is totally unrelated to him.

[@Ninsidhe]

Yup- there’s always critics ready to raise some personal interest by misinterpreting and skewing the conversation. I’m a huge fan of Bryan and what he’s doing, he’s not selling anything, he’s releasing all the data for free and he’s using his own money to fund a large portion of Kernel because he believes it will help everyone in the long run. Compare this to what others aren’t doing while they feel entitled to critique….

[@SirTenenbaum]

All of Andrew Steele's criticisms are valid. There's not much value in an uncontrolled n = 1 experiment. We already know diet and exercise are important for health, so Bryan Johnson is wasting millions of dollars and not providing valuable information.

[@Blackfatrat]

@@SirTenenbaum If he does end up wasting millions, so? He's a billionaire, he can do whatever he wants. Better to spend it on trying to find ways to combat age than buying a Yacht lmao. And all Steele's arguments aren't valid, he based all of this on a twitter thread from a guy unrelated to Bryan. The fact that the twitter user is a marketer is pretty irrelevant to Bryans experiments, no?

[@SirTenenbaum]

@@Blackfatrat I'm sure Bryan means well, but his self-experimentation isn't sufficiently powered or controlled to produce meaningful insights. With a sample size of one and dozens of interventions simultaneously, we can't know with any certainty what's beneficial, neutral, or harmful. Just as biohacking is probably better than buying a yacht, helping fund powered/controlled clinical trials or investing in startups that intend to, is better than spending millions on self-experimentation if the goal is to advance longevity science.

[@estilusafter1239]

THANKS!! POR PONER SUBTÍTULOS EN ESPAÑOL❤❤❤❤

[@Elaba_]

Having a cat definitely changes the aging process of mice.

[@nineteenfortyeight6762]

Pretty sure the K he's addicted to isn't kittens.

[@lsd22252]

You talked about him taking NMN to boost his NAD level but I couldn't find it listed on the pages you showed on screen. I could only find NR morning/dinner which is an alternative older known NAD booster than NMN.

[@DrAndrewSteele]

I misspoke, it is indeed NR…I made a note in the pinned comment and description with the correction. :)

[@TheVanillebluete]

As far as I understand it , this is exactly it, he is basically providing himself as a testing platform...for his on interest and ours..and since ppl might want to know provides his results on a webpage

[@TitusManiera]

Bryan Johnson is not a doctor, and for that reason also, not all of his words are scientific language. Your opinion about ultrasound i do not share. You can measure so much age and health related factors with them. For example the contractility of the hearth, elasticity of the arteries, grade of arteriosclerosis and much more. David Sinclair states : If we don’ t do anything, we know how it will end for sure. For that reason i try similar procedures like Johnson, also because of my age (60). Some older people will not wait until aging is killing them. Younger can wait and do basic stuff (fasting, HIT training, nutrition , cold exposure and so on)

[@maziusclavo8021]

But you will die anyway and not be able go back to your younger sharp, vibrant and full of vitality self.

[@macea.mcdonald8820]

Man, you are so good at telling Bryan Johnson "you are an idiot" in a very nice way... I loved it.

[@AFSMG]

Pero Sinclari toma NAD para retrasar el envejecimiento. Es correcto?. Felicitaciones por su trabajo. Saludos cordiales . But Sinclari takes NAD to slow aging. It's right?. Congratulations on your work. Kind regards .

[@redberries8039]

Interesting to see the things he's left out of the Blueprin, telomerase activators for example

[@vjr6939]

Really good stuff, yes the “blueprint” is most likely a good way for the dude to make his next few 100mill. Rapamycin supplementation is for mTOR activation? Exercise activates that pathway as well as Leucine ingestion if i recall, Ill be honest I didn’t read up on the physiology of it, much like I don’t care to much about metformin either, since correct me if i am wrong, that is a pgc 1a activator just like ampk pathway activated during endurance exercise. Been a while since grad school, but from what i remember no drug was actually as effective from a systemic perspective on health and prevention as proper exercise and diet. In the case above, maybe i misunderstood rapa but that is the resistance training pathway activation without the other associated benefits of resistance training, much like metformin is to endurance exercise. Or am i wrong?

[@DrAndrewSteele]

Rapamycin is usually thought of as a ‘dietary restriction mimetic’ because it reduces mTOR activity and increases autophagy. Metformin is far more complicated, and I’m not sure anyone really knows everything it does-though, if it does boost longevity, the likely pathways are AMPK, effects on mitochondria, and perhaps effects on the microbiome too! If you want to learn more about this, I’ve got a book… :) ageless.link/

[@maziusclavo8021]

Yeah, hes obviously doing marketing but it looks like the guy of this video is reacting similarly to those people that Byan says that they respond it would be a dystopia if they conform to a system of "perfect" health. If he feels great and he can indeed live longer and bring interesting results wheres the problem?

[@Blackfatrat]

He's not selling any of these, he's posting his data for free and most of the supplements, exercise and food could easily be had for most people. Getting a less distracting bedroom is also possible for most people.

[@mattalex8701]

For sure he is doing in the correct mindset...the question is until where the impact can it apply using the interventions we have today? As far in my understanding,any lifestyle modification from now,won't make you break the maximum lifespan,we need more aggressive approach like gene therapy,blood transfusion,epigenetic reprogamming and so on. So these lifestyle modifications with the right supplements will surely improve healthpsan bringing somebody to 90 like a 70 but after this time,still some downward road happen and it's pretty certain at 100 that the person will be in a very bad state...

[@deyvismejia7529]

I find it funny that people are tying to correct you in the comments, an expert. Lol. I think some things to untangle are aging clock rates (different tissues can have different biological ages), longevity, biological ages (you discuss different measures), environment(such as diet, stress, radiation exposure, microbiota, exercise) and genetic factors (chromosomal abnormalities,genetic syndromes such as progeria etc). Otherwise people won’t really understand what one is talking about.

[@stargazerbird]

I watched his Blueprint videos and all the time thinking ‘What is he selling?’ He has click throughs for all those supplements and there is Kernel - his weird helmet. I am not sure about calorie restriction. I thought that was considered to have undesirable effects. His skincare is on point and all available on the market although the in office treatments are a few hundred a time. Everyone can get Tretinon, vit C serum and sunscreen though. I found his workout regime really interesting. Movements in there I hadn’t seen so I found it is a system from Knees Over Toes Guy and his mobility exercises are excellent and I am doing them now. He needs to do zone two cardio though and less gym work. HIIT three times a week is too much. I tried his food and love the nutty pudding. It’s very satiating and tasty. Adopted. The veg thing is nasty. He never explains why he is vegan and also says you might get better results with some animal foods. His hormones are crashing due to the calorie restriction and low body fat. I am guessing most chaps would not like the low test that results and taking ‘non feminising’ estrogen. Shame he has had no luck with his fundamental health issues like his heart, lungs and a worrying blood supply to the brain. I looked at his stack and there is stuff there that I tried once and got bad side effects from. I am very wary of supplements now. I do take NR as it’s the single one I feel a benefit from with zero side effects. Interesting stuff. Hope he gets progress on the health issues and keeps reporting. He’s still a marketing chap at heart though.

[@travv88]

I've only seen him promote one affiliate link for a product. All of those links on his Blueprint site for supplements are just normal Amazon links.

[@Lunarac]

Knee over toe stuff is great, buddy. Cool to see you mentioned it. You need a certain amount of body fat, as per sex and person there's a essential cap you need for hormone production besides the common other benefits of "fat", this is why doctors recommend to not get too thin and more studies have been dropped the past 10 years on this. I don't know about what kind of calorie restriction you mean, however fasting for example has benefits because of what it signals to your body and your body is depleting other "tanks" to stay functional, can be seen in s detox way, as well as that your body is more forced to repair, instead of replicate which in turn doesn't damage your telomeres on your dna. but yeah, stress also has a fucked up effect on your telomeres. Watch a Stanford lecture on some ape studies about this from R. Sapalsky

[@XSphynxForEvilX]

'we gotta wait guys' lol people have been waiting for so long my man.

[@BIDP-]

You remind me a lot of Steve Mould. great video!

[@DrAndrewSteele]

You should keep an eye out for a video later this week which may be relevant to this comment…

[@koningsbruggen]

Interesting video, I love this subject, thanks for sharing it. The primary concern with his approach imo aligns with Goodhart's Law: 'When a measure becomes a target, it ceases to be a good measure.' This seems relevant to some of your rebuttals. However, not all your arguments fully convince me. For instance, regarding NAD, you mention the lack of certainty about its benefits, despite its correlation with age. This doesn't necessarily discredit his hypothesis nor NAD its importance in various biological processes. Regarding heart rate, your comments seem contradictory. You acknowledge its correlation with age and improvements are made, but then question the possibility of increasing maximum heart rate. This needs clarification: either his data supports this improvement, or there are reasons to doubt his data, which you do not clearly articulate. Your explanation of the epigenetic clock is insightful, especially about the clinical relevance of the marker. However, in the worst case, provided the marker measures as suggested by the scientists who developed it, reducing biological age by a year while actually aging half a year is a significant result. Lastly, about Rapamycin: it's notable that its healthspan effects have been observed in various species beyond mice, including yeast, invertebrates, and rodents. Ongoing studies in primates and dogs also suggest benefits.

[@ninong7638]

Loved the video! P.S.: Would LOVE your take on AG1, I am sooo confused. Some people I really admire swear by it (Andrew Huberman), others I really trust say it's absolutely unnecessary and potentially dangerous. I suspect much of your audience is bombarded by AG1 ads as well, might be super interesting to hear your views! Anyway, thank you and greetings from Hamburg ;-)

[@massivedamage5677]

This was an interesting listen after watching some of the Blueprint vids.

[@jacobbailey5498]

What you don't seem to have understood is that "eat, sleep good and workout' is not useful advice, because it is so unspecific and taken as a platitude, that what is actually needed to help change people IS marketing that idea in a better way and being more specific and itemized about it. It has gotten me and many other people to start taking their health more seriously. The tracking element to it serves as well to gamify the process and make it addicting to do better for yourself.

[@Mi3940]

I am 42 and looks like I am in early 30s. In my entire family all mens at the same Patreon. It's GENETICS nothing else. If you have it. You have it. If you don't then there is no way if you can enhance it by any means😏✌️

[@gradysimpson3137]

Bryon has done the work and has developed a proven system for longevity.

[@maziusclavo8021]

Yes, because he states it himself that he feels much better and he is making all the tests and being compared with his son. He has that nutrition that is the most effective.

[@maziusclavo8021]

Problem is that hes misleading because hes not going neutralize aging radically. When you are 45 years old your body already is in a state of accelerated aging, which hes trying to mitigate.

[@ddextera]

NMN and or NR? The Blueprint website shows Bryan takes Nicotinamide Riboside 375mg (6 x wk), twice a day. -Curious where your statement that he takes NMN comes from. Do you have inside information not available to the rest of us? Do you use the names for the types of Niacin interchangeably? Thanks for any clarification.

[@DrAndrewSteele]

As mentioned in the video description, I misspoke-you’re quite right that he takes NR, not NMN. I made the video in a hurry when the Twitter thread went viral and a few minor errors crept in!

[@Jsarson1976]

I used to have fibro or I still do but have fixed it with suppliments and a 99.5 pant based diet with a tiny bit of fish. I am nearly 50 and can’t exercise due to issues but I walk 12 to 16 thousand steps a day and have removed all toxic chemicals from my diet and and products I put on my skin. Really good filtered water and not looking for anti ageing but it’s made me feel good. My Nan used to say you are what you eat and with all the cheap food around no wonder people have issues. Many though don’t see the coronation and actually what sugar and refined processed foods are doing to them slowly over the years. I am sure is shortens life but that is just my own opinion. I have the odd alcohol here and there so that’s what I need to sort out.

[@kylemurray8230]

I was in a wheelchair years ago with Fibro..A doctor put me on a paleo diet, with in four days my pain was gone..I gave up bread, and process foods.Every time I eat bread the pain starts coming back...I also bought an Infrerred Sauna, that really help with heart health, my good cholestrol went up. Helps with Brain fog and gets the blood flowing . I fell sick with FM in the 80's , some times in bed for three days, i was in so much pain.. I feel it is something in our food today, people in the 80's were falling sick..I had it for 16 years, then I met this doctor who put me on the paleo diet..I knew other people that went on the diet and there pain went away ...If you can't excercise ,sauna for heart health..I can bike 80klm now...I feel its' all in the food we eat, something there adding to our food..Soon as I start eating poorly like bread or fast food, I start falling sick again...

[@peterz53]

Thanks. Adam Antebi has shown, in mice, that low insulin raises Nmn (correlated with NAD+) and Akg. Riekelt. Houtkooper has shown that higher fitness levels in older people restored NAD+ to levels about 30 years younger. Janet Lord has shown that older exercisers (bikers) have much younger thymuses (sp?)and better immune function. My PhenoAge (by Morgan Levin's clock) is low 50s over last 2 years since I started tracking I'm 68 yo. Over last 10 years mostly vegan, exercise modestly daily (including 5 to 7 miles of walking). Stay mentally active. Time restricted eating last 8 years. Poor sleep though. Michael Lustgarten PhD Tufts U has done a lot of self quantification and uses PhenoAge as one key metric to gauge his progress which appears impressive, and routinely posts useful research,

[@cainen6355]

All this is true. Nothing he does we are really 100% sure is effective in humans, the thing is, that he does not claim that and what he does by his own words isn't about that. Johnson describes it essentially as an ongoing science experiment done on himself. He has his entire body monitored and essentially tries to optimize all of his different bodily markers, that at least could be associated with aging in some way. In that sense he is using his captial to contribute to the ongoing research on all of these potential anti aging drugs, supplements and routines. I think it is quite valuable.

[@elijahmitchell-hopmeier182]

While I don’t normally go into comment sections to try to detract from the knowledge of experts or try to go to bat for centimillionaires, I think Andrew misunderstands a few key points about blueprint. The first is that it is not a diet, or an exercise plan, or a supplement list, or even a sleep schedule, but a combination of all of those things. The other thing is that this is not as much as your average marketing plan from a millionaire to make more money it is a marketing plan chasing attention and there is a clear distinction there. Is there money on the line? Yes. Is it the focus? I don’t think so. From going through Brian’s work I would say that Brian’s lifestyle that he has created is more of an art project of sorts trying to explore the limits of what science *could* point to rather than to sell a set fad diet. Nothing about it is trying to be a fad diet. Then you might say to yourself, “but why all the viral marketing around the diet”. Well, that’s why you’re getting into it, right? He’s marketing the idea to get you hooked, but the diet isn’t everything. The actual plan is much much larger, and I think that point was conspicuously missed in Andrew’s assessment of Brian’s work. Let’s get back to my interpretation of this as an art project. I think there is some credence to it. Mainly, I think that the science obviously is not ready to fight aging, or even maintain good health for people, OR EVEN define what good health is. Not to put words or thoughts in anyone’s mouths, but I think the reality of this situation is that Brian is well aware of this and decided to answer all of these questions at once anyway. Are all of his metrics scientifically rigorous? No. But when the science is limited by not defining rigorous tests what options are there? By combining many scientifically non-rigorous tests it’s like Brian is making an art project of what future science could point to as optimal care for the body, but I think his interpretation of the scientific literature and showing what he is doing is far from trying to sell supplements to try to be just another fitness-influencer racketeer. I think Andrew is getting far too lost in the marketing of Brian’s work rather than what he is actually doing which is a lot more interesting and worth talking about. It’s a divorced dad making an extremely rigorously ordered collage of the scientific data and combining them into a theoretical continuation of what it could be if you combined them all. It’s impossible for it to be 100% scientific so I think Andrew misunderstands it by looking at it through that lens. It’s an extremely interesting divorced dad’s art project about what health could look like. Maybe I’m rambling too much, but I think my way of seeing Brian is a bit more precise of an analysis than Andrew’s and I think he missed a few points in his video analysis.

[@sulaiman7461]

just nailed it never though i would find another coffeezilla

[@scottbarnett3566]

You should interview Bryan. I’m sure he would come on!

[@galia.barkol]

Your voice is so important and rare :)

[@faisal-ca]

May be that is why they are working on converting NMN to a regulated drug. I do consume NMN every alternate day. Feels great.

[@lostinpa-dadenduro7555]

Like sand through the hourglass, so are the days of our lives. It’s good to look after your health. But no one knows for certain if they’re coming home on any given day. Brian can slow his aging but still slip in the tub. Life is strange like that.

[@davidgreen424]

Exactly, the irony is the longer you live the more likely you are to die from some random events, especially if you lead a active lifestyle.

[@maziusclavo8021]

Yeah but thats just a possibility that conforts your mind. Brian is happy and commited and he can be lucky and this process really make the difference to him.

[@luisvalero2118]

Good video! Just one thing, Bryan takes nicotinamide riboside instead of NMN in order to increase his NAD+ levels.

[@DrAndrewSteele]

Thanks for pointing that out! I made this quickly to make sure it came out while the Twitter thread was still hot and a few minor errors crept in as a result. :) I’ll add that to the errata in the video description!

[@luisvalero2118]

@@DrAndrewSteele thank you for your work Andrew! Your book is next on my reading list!

[@DrAndrewSteele]

@@luisvalero2118 Oh thank you, hope you enjoy it!

[@Slain42]

@AndrewSteele What do you think about Tony Robbins's new book Life force?

[@nullw8768]

On the Blueprint website the has a tiny, miniscule, itty-bitty sentence about his heart health. In that, aspects of his heart are "decades older" than his chrono age. "need to formulate a plan" I should think this would be one of the first places to put resources in to.

[@AndroidAquaponicsTech]

The body must be treated in its entirety for true anti aging to occur. Yes he should work on a heart health plan, but it is just as important to work on all other organs simultaneously.

[@vjr6939]

Great channel btw, proper spotting of bullshit! subbed.

[@DrAndrewSteele]

Thanks! :D

[@rikwilder8838]

I have a doctor's exam due in about a month (I'm 66) and I mean to ask about rapamycin. Does anyone have any idea as to whether doctors or other health practitioners are resistant to prescribing the compound to older, healthy individuals? Clearly, a number of people have added it into their routines and I'm curious to know if this is difficult to arrange.

[@RickLindstrom]

Most doctors would probably say “what is that?” or “but that is for organ transplant patients”. I’d consider bringing in some studies. Start by showing the dramatic mouse survival curves because those are incredible.

[@rikwilder8838]

@@RickLindstrom Thanks Rick!

[@redberries8039]

Bryan's doctor obliquely addressed the problem of lack of evidence for some of the supplements; he said with a sample size of 1 (Bryan) it's still possible to assess the efficacy of specific interventions because they have so much high frequency data measuring Bryan's health. I'm not sure I'm entirely convinced and I'm probably over-stretching his meaning, but there is mostlikey something in that.

[@DrAndrewSteele]

I think the problem with this logic is that they seem to be changing everything at once, so you don’t know which thing is having the effect on the very frequent measurements. It might be possible to do a ‘crossover trial’ where he starts and stops various things and watches for the effect, but it’s always so challenging with _n_ = 1 because it might just be that you’re having a bad month or whatever…

[@redberries8039]

@@DrAndrewSteele I hear you. He explicitly addressed that point. I think he said it was 'surprising' ( somewhere in the vid that lasts 1:44 min). If he he's been making the same measures daily for months and the std devs have been small, then the 'crossover' works maybe. It sounds dodgy but he's super smart, his boss is super smart and that's why I mentioned it.

[@maziusclavo8021]

@@redberries8039 He also said that when he makes changes he can see deviation reflected in the measurements.

[@nineteenfortyeight6762]

Well, that doctor is an ignorant ass. If N=1, you can measure N all day and guess what? Still 1.

[@James-mk8jp]

I don’t think there is a problem with the specificity of his protocol - it helps people to see what it really likes to be disciplined with diet, exercise, etc. to the extent that it prolongs life. Often people are dissuaded because of ambiguity and the effort required to figure out first steps.

[@DrAndrewSteele]

Or, from what I’ve heard from most normal people, it puts them off because it’s an overwhelming amount of specificity, work and money (likely for little additional effect).

[@James-mk8jp]

@@DrAndrewSteele Many things put many people off. That’s not some cosmic test of anything. Reducing a his protocol down to “just don’t eat crap and get some exercise” is missing the point. He’s trying to prove a strong point - that humans can live much different, much longer lives if you find “alignment” with your body. We often wonder why some species live as long as they do, and he wants to find out. It seems you want to shoot him down because 1) it’s easy 2) you have some credentials and people will listen to you and 3) people /want/ to hear that they don’t have to put this much in. It is certainly possible that humans are deeply misaligned with the systems that make them up, why knock someone down for doing science?

[@DrAndrewSteele]

@@James-mk8jp I knock him down because his efforts are discrediting the wider field, which has a far greater chance of helping people live much longer lives. We know diet, exercise and a few supplements won’t reliably get you to 100, let alone anything record-breaking. He’s wasting his money, and bringing more worthwhile things down with him.

[@James-mk8jp]

@@DrAndrewSteele How is he discrediting the field? Every ounce of his protocol is based on published science. He is not telling everyone that this is the protocol for their bodies - he is outlining a process that minimizes “self destructive behavior”. According to every known marker of aging, he is /not/ wasting his money. You can argue that these markers are flawed, but if that’s the case, there is no better indicator out there at the moment. He is strictly following evidence and a tight feedback loop that allows him to iterate on his routine with the best measurements we have. Where is the flaw in that?

[@maziusclavo8021]

@@DrAndrewSteele "likely for little aditional effect"

[@Hack3r91]

I take you're not impressed by David Sinclair's results with NMN suppementation *IN MICE* (yeah, I know...), why is that?

[@serenditymuse]

Cheating aging and death is a very good thing. The normal state of falling apart rapidly with merely more years on the planet is not remotely ok or good enough.

[@nellyevans7215]

What he can't change is his age! You are 50 years old you can't say you are 25 years old!

[@chestterfield]

So in summary, 'Blueprint' is just meticulously fitted for ones body daily routine. I would treat it more like art performance from the medical field than an actuall experiment. But it was still interesting to hear you talk about it.

[@kingplays5369]

12:20 But Blueprint is not Max Hertan‘s project but Bryan Johnson‘s so what does it matter what his profession is. Apart from that I really like your objective video and your elaborate view👍🏼

[@DrAndrewSteele]

Thanks! And yes, given the huge amount of media coverage Blueprint has since received on its own, I’m annoyed I made this off the back of a Twitter thread, hindsight eh :) (Wouldn’t change much scientifically though!)

[@johanvanwambeke723]

We don't know a lot of the things, that is why he is doing this and making it public. I make a comment because it feels a bit like you discredit the man. But he deserves a lot of praise just for researching and sharing this stuff. He's not saying - do it this way. He's saying, I did it this way, try measure and experiment with your own variations. So we can collectively learn.

[@DrAndrewSteele]

He is saying ‘do it this way’-and is launching Blueprint as a product so people can pay him to do so…

[@AlphaHealthYT]

Why is it better to wait?

[@agnesd6831]

that Brian Johnson is pretty much about marketing, I agree. I found out about him accidentally and I was quickly annoyed listening to his video where he was advertising a few products supposedly necessary for the management of good health.

[@user-tq3ud9zi7w]

As someone who has used NMN for two years I can tell you that this stuff absolutely works. I am disappointed in your passive aggressive and slightly condescending approach to what Blueprint is doing. The research is a valuable experiment that could lead to longer healthier lives for all of us, he is not trying to sell his findings and programme to anyone and makes all his info freely available. As a biologist I would think you would have been more supportive of what he is doing and trying to achieve since there are very few down sides.

[@DrAndrewSteele]

He’s launching a product to get the supplements delivered now so, alas, it seems not to be the pure, freely available science experiment it purported to be… And I don’t see it as a particularly valuable experiment in any case. It’s _n_ = 1, and he’s doing all the interventions at once so it’s not possible to know which are helping and which are just bystanders to the diet and exercise that’s probably driving by far the majority of the benefit!

[@anneis8319]

I agree with you and Bryan openly says that technology will advance and he will able to incorporate it as it comes in. I applaude his courage to be a human guinea pig on order to help others improve their health. I genuinely believe he is doing it for selfless purposes. Even the work he is doing with Kernal is interesting to 🙂

[@maziusclavo8021]

@@DrAndrewSteele But all summed up during many years the outcome is interesting to see.

[@bondjane007]

Well I think you might want to check he takes $111 pills a day. At least that's what I recall from one of the videos I watched about Brian Johnson. He's quite the phenomena! And seeing as he has all the money to do such a experiment on his own body well I'm eager to see what happens! I mean it's his life it's his body his money and he's sharing it with all of us and I like that! Know I can't do what he's doing because I don't have the money he has but I'm learning a lot from what he's doing.

[@oowatchoo]

Genetic predisposition to aging and certain diseases seems more important, of course you can reduce risks and maybe some local decay in your body in general but at a certain age those ‘bio hacks’ don’t play a significant role, at least how I see it. That is comparing the blueprint to a rather standard healthy routine, not baseline general health of the population, which is suboptimal anyway.

[@virginiapantoja8993]

i am a doctor... that is what it is; for now ... a joke. But it is important to do something for us to fullfil our souls after meditation. I liked very much what you said.

[@mdrageset]

well done.

[@autisticautumn7379]

I have an MSC in Biomedical Science I have never heard of bio fluids either .

[@lovelylora1700]

Wondering why he didn’t include fasting since it’s been shown to slow aging and increase longevity

[@Itzaofficiallyme]

He does fast.

[@AnitafromKilltime]

He does.