How To Inhibit CD38 As We Age | LPS Drives CD38 Expression | Prof Covarrubias Interview Series Ep5

[@ModernHealthspan]

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[@TheReminderChannnel]

Wow! Thank you, this is very beneficial 👌 LPS (endotoxin) has been linked to many, many other conditions. Apparently cooked white button mushrooms, raw carrot salads and aspirin (amongst other things) can reduce LPS (taken from Ray Peat’s works).

[@ModernHealthspan]

Hi thanks for sharing. That is really interesting as LPS certainly seems to increase with age.

[@jp7357]

The problem is that for us users measuring cd38 is next to impossible. Apigenin from parsley seems to be a good pre cursors … I suppose one could use intracellular nad+ , before and after to see if inhabiting cd38 allows nad- increase. Assuming that one’s nad+ is lowered by cd38 action in tje nad pathway.

[@dcjohnson2208]

I have hearing issues. It would be helpful if u would provide a summary screen at the end of your videos. Please do this.

[@cliffmode2000]

Use closed captions?

[@kwitseo]

@@cliffmode2000 The uploader needs to provide the captions as youtube will have the auto-generated captions.

[@dcjohnson2208]

Unfortunately auto generated captions have the same problem as I do. The speaker is wrongly interpreted.

[@kwitseo]

@@dcjohnson2208 Exactly. That's the reason why the uploader needs to provide the captions.

[@ModernHealthspan]

Hi DC, thanks for your comment and understand your concerns. We will look at how we can provide better captions.

[@gstlynx]

Well done as expected.

[@ModernHealthspan]

Hi Eugene, thanks for your support!

[@joshuagenes]

So will cryotherapy help reduce CD38? I have heard that it is used for locking in fat loss by reducing inflammation and changing the behavior of white blood cell so they do not inflame or try to repack on the fat.

[@ModernHealthspan]

Hi Joshua, thanks for your question. Cryotherapy is not something that I have looked into much. To me cryotherapy as a way to reduce inflammation (as in when used on an injury) makes more sense, as Dr. Covarrubias said, one of the ways to attack CD38 is to reduce the original source of inflammation.

[@joshuagenes]

@@ModernHealthspan Maybe some future video then. Thanks!

[@jaym9846]

So we should enjoy parsley, onions, and capers?

[@TheSocialSmilingMonkey]

elevated acidity plays a factor in profileritation of cd38 .

[@shirleyharold3887]

Very insightful, thank you!

[@ModernHealthspan]

Hi Shirley, thanks for your comment. I do hope that you found the video helpful.

[@ronm6585]

Thanks gentlemen.

[@ModernHealthspan]

Hi Ron, thanks!

[@josejr.8328]

A good section of the interview. 78c has potential to become a drug?

[@ModernHealthspan]

Hi Jose, thanks for your question. 78c does seem promising. At the moment it does not seem commercially available. I am not sure if anyone is trying to take it to clinical trial.

[@101rosebud]

Doesn't inhibiting CD38 reduce immunity?

[@sweetbon76]

A complete loss of CD38 function would impair the immune responses. But since CD38 levels increases with age, mouse studies suggests there are benefits to inhibit CD38. Also inhibitors like Apigenin and Quercetin are known flavonoids that are present in berries, fruit and greens like apples, onion and parsley. Should be safe to eat.

[@lawnmower11]

Good vid and have you seen Dr Brenna Osborne’s presentation on her mouse study for 1 year that found that cd38 reduction exacerbated premature aging, wondering your thoughts on her results? Thanks for the content; I’ve been supplementing with dried parsley flakes in recent months, not sure if to continue

[@ModernHealthspan]

Hi Falcon, Thanks for sharing. I had not seen that. I have found her video on KZbin and will have look.

[@lawnmower11]

@@ModernHealthspan It appears in her study that they completely eliminated CD 38 so perhaps the solution is to keep CD38 levels in check maybe with a reasonable amount of parsley flakes or apigenin rather than completely deleting CD 38 from the body

[@LTPottenger]

The cd38 seems to be used in some kind of macrophage repair process, so you can't just block it you have to address the root issue of senescent cells.

[@101rosebud]

How would you check desirable levels of CD38? What kind of test? What would those levels be? Would it be about checking inflammation such as in CRP levels? I don't want to even start this process until I know since it seems lowering cd38 can lower immunity.

[@101rosebud]

@@ModernHealthspan Did you look at her video yet? I made a comment on this thread about my concern about lowering immunity. How would you moderate the amount of supplementation to reap benefits without lowering immunity? See my comment below.

[@christopherellis2663]

That going thru PayPal is a pain. I have two accounts that I cannot use, so I don't want to use PayPal again

[@ModernHealthspan]

Hi Christopher, thanks for your thoughtfulness in letting us know. We are looking at other contribution plans!

[@bassathehelingmindcassa2341]

Can you use medical muchrooms ?

[@ModernHealthspan]

Hi Thanks for your question. I do see that some mushrooms do have anti-inflammatory capabilities and it would make sense that this would help.

[@littlevoice_11]

@@ModernHealthspan adaptogens herbs or mushrooms in particular?