How to Prevent Almost ALL Disease - The Medlife Crisis Podcast #1

[@DrAndrewSteele]

Thanks for having me round your garage, Dr Crisis! If we cure ageing, we can look forward to decades of extra healthy life to enjoy nearly-two-hour KZbin interviews.

[@ninjam77]

I saw this video and thought: "Huh I know that turtle". It's the same as on your books cover! Great to see two of my favorite channels covering medical topics collaborate.

[@DrAndrewSteele]

@@ninjam77 Ha, the tortoise is famous! You have great taste in KZbin channels :)

[@jamesgrover2005]

Great interesting information in this podcast😉 thanks for putting this out there guys. As for a billion causing 50% of the co2, an Oxfam report put it at the wealthiest 10%, more recently I've heard it's mostly the 1%, which when I see their lifestyle is really easy to believe.

[@Siderite]

Dr. Crisis! That felt really funny for some reason. "Hi, I'm Dr. Crisis. Friends call me Medlife"

[@MedlifeCrisis]

@@Siderite Please, Dr Crisis is my father! Call me Meddy

[@ShubhamBhushanCC]

Rohin's Facial Foliage Deserves a channel of it's own

[@Oberon4278]

He is INCREDIBLY proper.

[@GrumpyOldFart2]

ABSOLUTELY!

[@mothmaiden]

The man could sell beard oil, if this whole highly skilled, high demand, essential for life medical career thing doesn't work out.

[@MedlifeCrisis]

I think you will enjoy what I hope will be my next video...

[@ShubhamBhushanCC]

@@MedlifeCrisis Don't talk to me if it isn't another issue of the Old England Journal of Medicine

[@elizabethk3238]

Very informative and pleasurable interview. Thank you from a 76 year-old who lives a life of gratitude, pays attention to diet, exercise, (including taking the stairs from and to my 8th floor apartment), and who I let into my emotional space. I remain pain and meds-free, and feel this is the best time in my life so far.

[@squeakypistonproductions2228]

Your mothers prenatal environment and your dads epigenetics set you up for almost guaranteed success. Just because you are healthy doesn't mean you get full credit for being so. The opposite is true too. Most people who have terrible health were set up to fail for those same reasons.

[@Dihydrousoxide]

Timestamps / Chapters 0:00 Intro 5:37 Why you got into the anti-ageing field? 7:15 Ageing as a cause of death 9:18 What is ageing? 13:32 Hallmarks of Ageing - Senescent Cells 17:25 How do we target senescent cells? 20:10 What are telomeres? 22:40 How do we stop telomeres shortening? 26:00 Evolution optimised for reproduction, not ageing well - BOFFFs 33:54 Autophagy - cellular recycling 42:00 Testing of rapamycin - Effective Dose 45:35 Why don't we have human data on rapamycin? 46:24 Metformin - TAME trial monetary issues 49:04 What is Metformin? 52:50 How does Metformin work as an anti-ageing drug? 54:03 What therapies excite you at the moment? 58:39 Thoughts on Calorie restriction 1:04:53 Rhesus Monkey Diet Trials 1:08:14 Potential Therapies - theoretical mechanistic science 1:12:46 Amyloid Studies 1:17:20 Should we stop ageing? 1:31:29 Where do you see the anti-ageing field being in 2050? 1:43:03 Outro

[@DrAndrewSteele]

Not all heroes wear white coats Thanks for that public service!

[@MedlifeCrisis]

Thank you! I was travelling yesterday so couldn’t do it myself but I’m just going to use yours, much appreciated! 🙏🙏

[@missshroom5512]

There comes a time when gravity takes your butt and your triceps…overnight seemingly…around 50….when this starts to happen your not thinking of living another 150 years. There is a turning point in the psyche as well.

[@frankcastle1862]

Ok

[@Guilherme-nc5li]

1a@€22

[@samuelbrown9665]

Time-Stamp Breakdown of Facial Hair: 0:00 - Full Frontal Foliage 1:15 - Subtle Stubble 4:21 - Marvellous Moustache

[@KatrinaTapio]

these are the time stamps we really needed

[@therabbithat]

It's like eternal sunshine of a spotless mind

[@Rafi_Stern]

Wasn't that Borat with the moustache?

[@ethallial3217]

I thought it wasn't real 😅

[@JamesDecker7]

Not the hero we want; the hero we NEED.

[@Paul-dorsetuk]

Anyone else who's listened to the end will realise how brilliant this is!! The guy in the middle didn't say much though.

[@kevinbreslin5718]

Was driving. Now listening while parked against a tree.

[@XboneMalone]

One of the best roundabout ways of describing a crash I've ever seen!

[@karsuli]

Did you crash?!

[@fathurrochman2469]

Is the tree okay?

[@faye_isc]

is the CAR ok ??? 🤣🤣🤣🤣

[@sparkplug8763]

Is the guy in your trunk okay?

[@lukas4235]

Growing up I had a high opinion on all sorts of medical interventions. While studying chemistry and biochemistry, I got more and more disillusionised to what medicine is really capable of. Learning how finely tuned our bodies homeostasis works and following the medical news where common practices and medications are retracted on a regular basis because they don´t work after all, you really get more pessimistic. Rohin has a very realistic view on that, which I like.

[@katfoster845]

I think it's possible to go too far the other way and assume that no medications are effective or that exercise cures everything. When you have a body that misbehaves like mine, medications are needed to stay alive. I tend to have low blood pressure and I struggle with POTS. If I stand up too quickly, I faint. Obviously this isn't good. I take medication to boost my blood volume and raise my blood pressure so I don't faint. It's easy for doctors to default to diet and exercise as cure alls when they're absolutely not. The body tends to homeostasis, but sometimes our bodies just don't work in the way they need to.

[@Maakyo]

@@katfoster845 You’re not wrong in a certain sense, but I think the complexity of the situation is so beyond us because of how much tampering humans have done to their environments and their own bodies. I personally am diagnosed with a chronic illness, chron’s disease specifically, and for most of the time I’ve basically been told that my life is over, I will be on medication for the rest of my life and there’s nothing I can do about. Here’s a pamphlet on why vegetables and nuts are good for you. They gave me meds and I had a surgery to remove some intestine that was beyond repair, but after the fact I never got healthier. I wasn’t dying anymore, but the entire time they couldn’t tell me anything about the disease, why it happens, where it comes from etc. And I was so pissed throat they thought they could just give me some meds that seem to work without actually telling me why it works and why I should use it. I stopped listening to everything anyone would tell me and exclusively listed to what my body told me. Eventually I found a diet and exercise routine over the course of 10 years that was able to help me come back from this hell that I was told I had to live in. My point being that not all is set in stone, and while medication can be useful, I think it is used too much as a crutch to solve problems.

[@orngjce223]

@@Maakyo Multiple things can be true at the same time. It is totally possible that 1) you were not recommended enough diet and exercise and 2) Kat here was recommended too much diet and exercise.

[@orngjce223]

@@katfoster845 I think one of the biggest problems is that in many cases we legitimately cannot figure out what can and can't be dealt with using medication or lifestyle modifications, because we can't untangle the underlying disease process(es). Possibly the purest example of this problem that I can think of is the two types of diabetes. Type 1 diabetes is _only_ treatable with insulin, no amount of non-medical interventions will help. Type 2 diabetes is partially caused by this aging process, partially caused by this diet and exercise stuff, and giving insulin to these people would be completely missing the point. These both present clinically as diabetes, as a struggle to maintain blood sugar, and yet one is absolutely reliant on medical science and the other really needs to be treated with something that isn't a medicine at all. Now - what if we didn't know that the difference between type 1 and type 2 diabetes existed at all? Then we would be flailing around trying to give insulin to people who have no reason to be on a highly perishable injectable for the rest of their lives... and/or we could lose people to totally preventable consequences of type 1 diabetes because we would be too scared of having people dependent on a highly perishable injectable for the rest of their lives. All this is to say, it can be absolutely true that you cannot possibly be helped by anything short of vasopressins and Makyo needed to get away from medical science entirely, _at the same time._ I think about this a lot because I am somehow in both camps simultaneously. Specifically, I take several medications for my treatment-resistant depression (due to C-PTSD). I am absolutely reliant on a significant amount of tablets and pills... and one of them is a probiotic supplement. Let me repeat this: I take _probiotics_ for my _depression._ There's probably some gut-brain stuff going on there, but part of the most difficult symptoms for me is a lack of energy, and apparently improving my digestion helps with that part?? ...At the same time, if I am out of even _one_ of my actual prescribed psychiatric medications, I collapse entirely. So I can't stop relying on modern medicine either. Human bodies make no sense and this whole thing is a mess.

[@Maakyo]

@@orngjce223 I’m aware multiple possibilities exist. I’d be dead without medical intervention. My point is more that none of our collective knowledge is 100% true and that our contemporary standards for medicine and health are highly flawed and need reconsideration. They talked to me about my illness like they knew anything about it, but really there solution to my problems was a shot in the dark with a medication for which it’s primary purpose was not even related to the illness they were trying to heal inside me. I might not even have an illness I might just be ruined from America’s garbage health standards. It pissed me off and I want to be a force for good change in this regard.

[@ganondork7561]

The Nietzche mustache is making my day

[@gordslater]

There's nothing Nieizsche couldn't teach 'ya 'bout the raising of the wrist. Socrates, himself, was permanently pissed.

[@blindleader42]

@@gordslater John Stewart Mill, of his own free will, on half a pint of shandy was particularly ill.

[@DrAndrewSteele]

@@blindleader42 Plato, they say, could stick it away, half a crate of whisky every day

[@Confucius_Says...]

Nahhh, he looks more an Old Timey Bare Knuckle Boxer... 😂

[@michaelkalin2209]

the algorithm has been hiding this from me since its release, i think youtube hates podcasts now. great work as always! you never fail to cover interesting topics and bring up insightful questions, leaving me to rethink my career choice in chemistry. fascinating stuff.

[@Blehblehblehhowlongwillthisgo-]

Kids who watched Phineas and Ferb know exactly what an aglet was.

[@cohentheblue]

This is the kind of discussion that could possibly inspire someone, somewhere to make a breakthrough to improve our lives by orders of magnitude. Please continue creating videos like this. This was riveting.

[@therabbithat]

Podcasts are more frequently of this quality, i only discovered them recently, i thought they'd be like radio

[@sandwich2473]

It's always exciting to see a video from Rohin Let alone a video about a topic that's saturated with medbros and pedlers of sudoscientific nonsense _Let alone_ a video that's the length of an extendened documentary All the best things rolled into one That was a very very interesting watch/listen. I'm vaguely familiar with Andrew's stuff and hearing more from him is always good (I should really subscribe) The next 30 years look to be full of very interesting things in terms of medical science from the studies being done just now, to ones that could be done in the near future I like to think that I'll get to live to at least 120 years old but I'm very clued into how short one's natural life can be considering I live in Glasgow (a very depressing shout-out but it's one that's present in the minds of everyone I know haha) Very exciting and interesting Rohin should do more podcasts (if he can get the time)!

[@konbini2004]

*pseudo not sudo

[@DrAndrewSteele]

@@konbini2004 sudo science is where you force your computer to do your science for you (and thanks @Sandwich247, looking forward to hearing you’ve become a 120-year-old Glaswegian! PS you subscribed right)

[@Krunch2020]

Pseudo longevity science is much more palatable than the FAKE statin science from Merck. Why do I hate Merck? My mom was prescribed Vioxx and had a bad stroke. Fake data from Merck killing and maiming again and again. Who is selling snake oil? Rohin.

[@odedrim]

Fascinating conversation. Even when you got to a subject that I happen to know a lot about professionally (Alzheimer's), you covered it incredibly well and in an unbiased, balanced way. A treat to listen to.

[@sucim]

I know nothing about any of this so this is very reassuring to hear! For me it is quite rare that I find people talking in a knowledgable way about my field (computer science, AI) on the popular media

[@quantumpotential7639]

Turmeric powder taken with powder and pumping iron, while eating 'clean' prevents Alzteimers. Of course most professionals in the field refuse to acknowledge this simple truth because they themselves refuse to lead from the front and pump iron. If you're searching for a cure, then you just found it. Thanks

[@astilealavatica1404]

​@@sucimI want time with any AI, to request it seek out and delete all numbers related to evil people. Think it might improve Earth.

[@dawsongooch4194]

Hyped for some well evidenced, grounded conversation about longevity! I'd like to make it to the triple digits, and I'd like to hang out with my parents for a good portion of that time as well. Immortality would be nice, but another decade where I can spend quality time with family would be nice too :)

[@kellydalstok8900]

If that’s how you feel, you must still be relatively young, and you never had any horrible experiences in your life. Getting old may seem like a good thing, but only if people stop breeding at the incredible rate they do today.

[@jessip8654]

@@kellydalstok8900 uhhh...? Aren't birth rates in free fall worldwide? Also, people can work through trauma and still find happiness?

[@Homerow1]

​@@jessip8654Correct. And it has repeatedly been shown that increased quality of life (food, water, shelter safety, education, access to medical help) reduces birthrates greatly. So as more of the world experiences those listed things, the more the birthrate will even out.

[@ubororos]

Mustache is FABULOUS. If I were to select my family doctor based on a photo of the doctor, a person with this kind of mustache would get me as a client 100% of the time

[@quantumpotential7639]

How so?

[@georgeeliot2012]

Just like my maiden aunt, the testicle specialist.

[@rogerstone3068]

You have NO idea what's living in that jungle.

[@genier7829]

Very interesting to me, as the caregiver for my 97 yo mother. Bedbound and in hospice due to dementia, but very strong physically with better skin and vitals than most 50 yo. Her nurse said she did not know what would be the cause of death. Mom is forgetting how to swallow and therefore harder to feed, so that will probably be the cause , in my opinion.

[@charcoal8]

Omg, that's rough.

[@andrewharrison8436]

Yes, there are people whose body outlasts the mind and those where the mind outlasts the body - both are tragic.

[@SirTenenbaum]

@BIGFOOOOOT You're right that cognitive health is just as critical as physical health. The field also dedicates a lot of research on the brain and maintaining cognitive healthspan.

[@fireincarnation2]

You can get her a feeding tube or iv nutrition but i think most people want to pass naturally at that point

[@faye_isc]

UP UP UP !!

[@RoboLamp]

Focusing on the ageing process instead of what ageing risks causing reminds me of the saying "An ounce of prevention is worth a pound of cure"

[@skybluskyblueify]

This is more entertaining and cheerful and less dogmatic than I thought a video about anti-aging would be. I tend to avoid anti-aging videos because of my experience with them.

[@KH-tt3wv]

Describing an opossum as "a sort of cat-sized rat," is temarkably accurate 😂. Thanks for another fascinating and enlightening video!

[@unice5656]

I've had a Nebula subscription for over a year but I still watch 90% of the creators' videos on KZbin because there's no comment functionality on Nebula.

[@jonasheinicke11]

Same 🎉

[@nsjhdhdhdbhsudgvdydb7751]

as a teenager who recently got diagnosed with mitochondrial dna disease caused by spontaneous mutations (kearns sayre syndrome) this talk is very intresting. thanks for the video.

[@sheriwilliams8942]

Did you take Covid Vax?

[@nsjhdhdhdbhsudgvdydb7751]

@@sheriwilliams8942 my symptoms started before the pandemic. so no, its not related to the vaccine.

[@brianpratt3224]

Portraits of the two greatest doctors of all time in the background.

[@isakle8474]

This is very comforting, my life goal is trying and lerning everything the world has to offer but l've always dreaded the thought of not having enough time

[@jamesallen4165]

1:16:25 I literally, most genuinely burst out laughing. I love this interview - you talk about specific studies, the questions invite deep elaborate responses and you're funny... which coincidentally is what I look for in a partner.

[@onetime7408]

Lol.

[@blackbabychocobo7179]

The rizzler

[@MegaAdeny]

Oh my freaking god, FINALLY you do the thing you so obviously should and make a podcast. THANK you.

[@willfrank961]

The mustachioed wink at 16:59 really made my day :D

[@PinataOblongata]

In 2014, as a mature-aged student, I got my degree in Molecular Biology and Biomedical Science - largely due to people like Aubrey de Grey, who was only briefly mentioned at the end of the video. For a long time these ideas were seen as "fringe science" or not as scientific at all, so I think it might have been nice to pay some respects to those who fearlessly pioneered the whole concept of increasing life-span and health-span via biotechnology and serious research into both ageing mechanisms and potential interventions based on what we learn about those mechanisms. It's only been in the last few decades - literally as I grew from a teenager to an adult (now 43) that those pioneers forced the scientific community to take this field seriously. It's a major achievement by Nir Barzilai to have convinced the FDA to allow an interventional study that treats ageing itself, as they previously refused to classify ageing as a target pathology. Hopefully people interested in this stuff, who can now see serious discussions and papers on it in virtually any health-related sphere, realise the paradigm shift they are looking at and will undoubtedly benefit from.

[@Fomites]

Yes indeed.

[@InvertedGoblin]

I will definitely check out Nebula! The demonetization is just too random!

[@Jablicek]

Fascinating! An entertaining and informative overview of how anti-ageing keeps turning into "oops, it's cancer again!"

[@DrAndrewSteele]

Damn that cancer, it gets everywhere

[@ohjahohfrick9837]

Damn rebellious bastards.

[@garethbaus5471]

Cancer cells are immortal, so it isn't that surprising.

[@DrAndrewSteele]

@Blue Bee Late to spot this but this is a good pun

[@nohypocrisy]

the mind, the soul, idea, ignorance, arrogance, dream, stray, patience, fear, life, worker, success, graduation, power, festival, deception, i struggle with myself, use reason so you can live for yourself

[@monikagombkotoova2074]

I watched this on Nebula, I will watch again here. Such an interesting conversation. My husband says he wants to live 150 years, I need to show him this, and probably make him exercise more to get his heart rate down (as per Andrew's video).

[@therabbithat]

Exercise and some vegetables! Do they mention it in the video? Every single type of movement counts - get off the bus a stop early - vacuum - don't bulk buy milk so you have to walk to the local shop to get it - stairs (always try to live somewhere that has stairs if possible ) - think of things like say, someone who has an upstairs and downstairs bathroom, always using the upstairs one if you mostly live downstairs. Things like that where the habit is the version with a bit of movement so you don't even notice it. Obviously officially "exercise" is important too 😅

[@Unitedstatesian]

"Not doing something is a choice in itself." Best quote from @DrandrewSteele in this video. Another reason that doctors should start treating the individual patient and not just following "standard protocols." After almost three years with Long-Covid, I am constantly weighing interventions to reduce symptoms or "cure" the disease. It is amazing when I ask doctors for advice on "low-risk" interventions and they say "There are no RCTs for that treatment and your medical issue. Just wait (suffer) for 5, 10, 20 years for a proper treatment protocol." Luckily, there are some doctors willing to look at the early data or medical reasoning and help patients do controlled, low-risk, n=1 experiments. I have done many n=1 experiments so far that has led to large improvements! BTW. Have you done a video on Peter Attia and his stance on nicotine patches?

[@Unitedstatesian]

@@Sarandib22 I am not fully recovered yet either, but the path seems clear. If you only need a bump to get back to work I suggest looking into doing Yoga Nidra and brain training. There are lots of free videos out there and different books that can help... let me know if you want recommendations. There are also lots of recovery stories... Look at the ones from "Kyle" on KZbin. He gives a good simple rundown of how brain training helped him...and he is not selling anything 🙂

[@sietuuba]

@@Sarandib22 So many people out there need help with that it almost makes _me_ sick. @physicsgirl is one currently bedridden and I wish I knew what might, or who could help them.

[@Unitedstatesian]

@@Sarandib22 I am still at 75 or 80%. At this stage it becomes harder to rest and pace....since pushing a little lets you have an almost "normal" life. At this stage we still need to run at 80% energy use most days so we can recover well during sleep. The temptation to push and run at 105% keeps us stuck... in my opinion. Each person has different journeys.

[@levismith5169]

As a 21 year old prospective doctor I love your content so much. I fall in love with so many topics but medicine has been such a special love just because of how immense of a future I see for it. I know maths isn’t a big subject on your channel but I would love to see some content on the flaws of peoples capacity for diagnosis. I hope to see some sort of system that allows physicians themselves to input clinical signs and symptoms in and receive a chart of some sort going over the probability of possible illnesses and ways to cross off the more lethal prognoses. Complex probabilities are just a process that computers are way more adept at than humans.

[@markkalsbeek5883]

I think a big inpediment to this is just sheer data. A few years back my partner came down with a mysterious chronic illness, and I spent evening after evening trying to find datasets of all the diseases and symptoms and their relative rates of occurrence, but I could not find datasets that had this data. But for this to change I think the whole medical information pipeline has to be rebuilt from the ground up. Where GP's comprehensibly record all appearantly symptoms and ask after less obvious ones. Then as diagnoses roll in over time a true dataset can be built up than can be used to make a predictive model like you want. Maybe with improved natural language processing a lot of this could be extracted from current medical records, doctors notes, etc, but just the medical confidentiality aspect of it would make this very hard. In the end it took almost two years for my partner to get diagnosed with chronic fatigue syndrome, but this was more down to the stubborn headedness of the GP than anything else.

[@user-jw6yh4ev4n]

​@@markkalsbeek5883most GPs are pretty much useless when it comes to chronic conditions especially mental health

[@rationalskeptic1]

HOW do you not have over a million subscribers yet!? You’re so funny and so informative and fight against misinformation! The perfect trifecta!

[@arthurghahramanyan3279]

I opened this video and put my phone in the pocket, listening it as a podcast. I am happy I looked at the picture close to the end of the video, because in the other case I would have missed that gorgeous moustache

[@hellNo116]

If I didn't have exams I would be listening to this. sounds intersting. especially the politcal side of such problems.

[@keel0611]

good luck on your exams!

[@applegal3058]

I'll live, try to be healthy, and eventually grow old and die. That's just how it goes. Keep moving until I die, and try to enjoy the good things in life.

[@discursion]

A lot of us are used to 3-4 hours podcasts, so feel free to go at whatever length that feels necessary to cover all the most interesting aspects of a given topic!

[@Cheepchipsable]

Are "we"? I must have missed the poll.

[@ishudshutup]

Great talk with Dr. Steele. Would be awesome if you could make this a regular series with frequent updates from the age experts including Dr. Sinclair.

[@carlloeber]

It's amazing that I could understand you both so clearly.. especially your guest.. he spoke very rapidly quite rapidly but his diction was so perfect that I didn't even try and never missed the word..

[@sean..L]

I'm all for this type of bold-faced, utopian aim for science. Even if we can't become immortal we will certainly learn a lot more about The Human body.

[@sherlockmaverick]

Well, you finally got the podcast going! Watched it on Nebula already but came here for the podcast link! Could you give us an RSS feed as well?

[@karangupta4615]

This discussion makes me really hopeful but also a quick look at the current landscape of which communities have access to medicine makes this really worrying. The topic of the massive resource consumption inequality was brought up and if an anti ageing drug is developed it would surely be a really valuable product which might not be available to everyone further increasing the inequality.

[@189643478]

Rapamycin definitely isn't pence per dose. I've recently started taking it for aging and it costs in the pharmacy 3,6 euro per 1 mg tablet (because aging is not a recognized indication health insurance doesn't cover part of the cost).

[@therabbithat]

To manufacture it is pence per dose he said i think. So generic versions will be very cheap. Some drugs are genuinely expensive to produce and their price does not have the potential to ever drop below that (even if the government or insurance is the one paying that price, i.e. tax and premiums)

[@189643478]

@@therabbithat All sources seem to suggest that rapamycin's high price is due to the very low yield of its biosynthesis by Streptomyces hygroscopicus.

[@joyg2526]

Life expectancy is dropping in the US at least, partly due to the horrible healthcare "system" and the ever widening chasm of the wealth gap. People don't get paid enough to afford the terrible health insurance and even if you do have it, the quality is complete crap if you're not rich.

[@jagolago-bob]

The bad diet isn't helping, either. More and more processed foods.

[@RICDirector]

When you are broke, processed food is the least expensive and most available...and heaven help you if you've no way to cook or safely store uneaten food. Gained 150 lbs that way....

[@jagolago-bob]

@@RICDirector That's pretty sad when one is broke. I've been in that situation a few times. In Europe you can still eat on a pretty tight budget (maybe less than 3 Dollars per day), but you will definitely lose weight, so if you are a labourer it might not be enough energy.

[@TheSteinbitt]

On caloric restriction, I remember reading a short section on it in my pathology book around 2012, that (paraphrasing): “although it might increase lifespan somewhat, why would you deny yourself one of life’s greatest pleasures, only to be able to deny yourself these pleasures some more” or something to that effect, which I thought was very interesting perspective:)

[@secretname2670]

Not everyone likes to eat tasty stuff, sensory stimulation isn't the only way to be happy and enjoy living. It's like saying "although it could make you healthy why deny yourself cocaine only so you can deny yourself some more" What if i like fishing, or exercising or laughing or helping people?

[@TheSteinbitt]

@@secretname2670 Fishing, exercising and helping people increase metabolic demand and caloric requirements that will make you eat more and thus increase oxidative stress. You can’t get energy from cocaine so it’s not a good analogy.

[@secretname2670]

@@TheSteinbitt i have mentioned cocaine as a way to stimulate your senses to point out that not everyone does it the same way as you do (i hope). Also oxidation is not directly linked to aging, it's an effect of digestion and nutrition dispersal throught the body which is harmless to young people with healthy cells , little to no CRD and working epigenome. Time will tell if we'll reach that point of being healthy in this century, of what i'm skeptical just because we are moving blindly around vitamin B3 and it's sub-particles to suppliment what goes missing with aging, but not actually fixing the reason of aging. Time will tell

[@EpicMiniMeatwad]

@@TheSteinbitt It's an analogy because it insinuates that "You shouldn't quit X because it makes you feel good." "Why should I quit cocaine? I would be denied of life's greatest pleasure."

[@TheSteinbitt]

@@EpicMiniMeatwad Perhaps because cocaine isn’t essential for life😂

[@lilpixie25]

This was incredible! Moar!

[@elimik31]

Thanks for providing this as a proper podcast with an RSS Feed, which allowed me to comfortably listen to this while on a run, which helped with not getting to bad a conscience when listening.

[@Kotapises]

I've been waiting for one of my favourite youtubers to get nebula, glad to be able to support you!

[@kates-h3325]

why no mention of menopause and HRT? andropause?

[@Do-U-Know]

old guy who did stick around to hear you congratulate each other - I agree - it was a good job ! ... the dialogue between you works THX

[@solidhyrax]

That was a fascinating listen, I'm really liking Dr. Steele's optimism.

[@neru_d]

That podcast download link is a blessing. Medical podcast videos for life!

[@HardikMeel]

Damn Doc you are really pushing the 8 minute mark huh? Lol love your videos.

[@robertgarland5012]

Can we have more of these expert interviews? This was very informative!

[@Gribbo9999]

4:21 Owzat? Surely that's the top batsman of the Raja's XI c.1890?

[@TonyT-fz8od]

best video to date, we need more of this aging and age related disease videos so thank you so much

[@shydead1392]

I like this guy, like I really resonate with him. I feel we have a lot in common and want to pursue the same dreams. Also, I too have misplaced my pelvis and head, I wonder if science will ever solve that

[@ToriKo_]

Really enjoying this conversation so far, great job

[@ToriKo_]

Wow this was really enjoyable, the articulation at the Should We Stop Ageing Part 1:17:20 was really good

[@ToriKo_]

I would’ve liked this video 10+ times if it was possible

[@JayeCole]

Absolutely fascinating. I would love more episodes like this one. I loved that you challenged him with difficult questions - made for a much more compelling interview!

[@ZephyrCubic]

considering the theory surrounding calorie restriction leading to better outcomes, it could explain why we've seen a correlation with eat a lot of vegetables. A low calorie, largely indigestible (in the case of things like leaves) food that still fills you up, meaning its essentially just a method of fooling your hunger system into letting you eat less without making you feel bad, instead of some magical property of their nutrients

[@Juttutin]

Quite remarkably (to me) when I quit the corporate world and moved onto a bit of bush land, I changed from eating three times a day plus snacks, to eating just once a day without any intention to do so. If I don't have a drink in the evening, then I have no desire to eat any dinner, and fasting 23hrs a day requires no effort at all.

[@marieokamoto5803]

I’d never thought about aging as anything other than an unfortunate inconvenience of life. Lots to consider in this video. Thanks to Drs. Andrew and of course Rohin for the discussion. Thought provoking even if that mo was very distracting as I waited for it to launch its own channel.

[@DrAndrewSteele]

You’re very welcome, thanks for watching! Very happy to hear it offered a new perspective, that’s exactly what I’m trying to do. :) And I too am looking forward to subbing to MoustachelifeCrisis…

[@sajidhaniff01]

Thanks! Excellent discussion!

[@rothn2]

I wish Nebula would add comments. Forums have comments, why can't a major video platform?!

[@stealthymonk7734]

I was thinking of giving Nebula a try. No comments, you say? Ugh!

[@nawarelsabaa]

👏👏👏👏👏👏 Talk about starting on a strong foot! This has been one of the best interviews/discussions I have seen ever. Looking forward to more Medlife Crisis Podcast

[@reallyWyrd]

00:02:28: You are the first person who I have heard talking about longevity research that I won't immediately dismiss out of hand. (Obviously I am as yet unaware of your friend. who you will be talking to in this video/podcast.) I'm gonna go do other stuff now, but I will listen to or watch this soon.

[@janasteyer214]

Took me four days to watch all of it. Was too intrigued to forget about it in the mean time. Great video!

[@juliand.1147]

Assuming we actually find some drugs that generally slow aging / reverse aging, we might as a society consider putting those in our food. Something comparable is already done with iodized salt and of course vitamins in all sorts of products. I could even imagine that some plants could be genetically modified to add these components to the foods they produce. Something similar has been done with golden rice, which produces beta-carotene, a precursor of vitamin A. Edit: spelling

[@oakley6889]

This is what I needed, your voice is pretty nice to listen to, and giving me 2hrs of content to watch is great.

[@Undergroundcilia]

Any plans to release audio only versions on apple podcast? Either way, always enjoy your long form, in-depth content. Cheers

[@MedlifeCrisis]

I've submitted the stuff they ask for, just waiting to see if it goes through. Bit of a learning experience all this is!

[@oafkad]

This is an incredible video. So engaging! How we see life is going to VASTLY change once death is not a certainty. Everything changes immediately, I'm very excited and I hope I get to see it.

[@TheMoped]

I love the Phineas and Ferb reference with the aglets

[@Ryaninja]

Thank you for putting this in podcast form, I found it truly fascinating. I would say the only thing missing from the podcast was your fantastic moustache or any indicator that you were sporting one. Thankfully I came here to comment about how much I enjoyed the podcast, so I didn't miss out! I think I'm going to leave this playing at half speed while I go do something else for a few hours, just so you get some algorithmic love from youtube for the most excellent content.

[@aanchaallllllll]

0:08: 📚 The video discusses the science of longevity and challenges the misconception that it is only about making rich people live longer. 9:34: 🐢 The video discusses the concept of aging and the different rates of mortality in various animals, including those with negligible senescence like tortoises. 17:25: 🧬 Senescent cells, which can occur due to cell division or DNA damage, are a promising target for combating aging and cancer. 24:53: 🔬 Understanding the aging process and interventions is simpler than we think, as evolution primarily optimized for reproduction. 32:07: 📚 The video discusses the genetic legacy of animals with fast metabolism and quick mortality rates. 40:44: 🎙 The video discusses the story of rapamycin and the scientist Suren Sehgal. 48:28: 📊 The speaker expresses frustration at the lack of real-world data and government funding for aging research, despite the potential economic benefits. 55:53: 🔬 Teratomas are grotesque masses often found in women's uterus that can cause cancer and have a negative side effect on liver cells. 1:03:52: 🕒 The timing of meals may not have a significant impact on weight loss or aging process. 1:12:57: 😮 The discovery of amyloid plaque in Alzheimer's disease was initially overlooked due to lack of interest from the audience. 1:20:29: 🌍 The speaker discusses the United Nations' freely downloadable population data and the hypothetical scenario of canceling aging in 2025. 1:28:26: 👵🌍 The speaker advocates for public health and discusses the impact of smoking, drinking, and poor diet on aging and poverty. 1:36:42: 🧬 Gene therapy and stem cell therapy are already being used in clinics for rare diseases, and while we may not cure aging, we are likely to have advanced therapies available in the next 30 years. Recap by Tammy AI

[@TheSteinbitt]

Geoffrey West wrote a fantastic book on this very subject, called “scale”. There’s a very good interview with Sam Harris on it as well.

[@jrelevates1574]

You can do everything right and get hit by a bus. Live your life, in balance and enjoy it. I mean fully enjoy it. Thank you for great content, love.

[@yeetyeet7070]

putting that 4 minute ad break in the beginning really helped the views lol

[@faceonnailsdonehairdid]

Yay, you've just made my Thursday just that little bit more interesting with this upload. Love your videos and your dry sense of humour.

[@mophead-xk8dd]

To expand on what they said about dieting - losing weight is incredibly simple. If you don't eat, you'll lose weight. Something being simple, however, does not make it easy. Adherence is the most important factor in successful long-term weight loss, so that's what you should optimize for when choosing one.

[@garethbaus5471]

This.

[@jameshoey303]

Where is the skull off the skeleton? If it is a real skeleton it must be a child.....if its real...which I doubt did the person whom the skeleton belongs give permission to feature their skeleton in this vid...

[@ConfusedRambutan]

​​@@jameshoey303it's most likely not a real skeleton, although it would be pretty fucked up if it was.

[@n48_art]

I don’t really agree with that. Losing fat without losing muscle, keeping your metabolism fast and not ruining your digestion or mental health is a tight rope to walk. It may be simple in theory, but in execution it’s really quite complicated.

[@189643478]

Actually in C. elegans at least 7 different methods of calorie restriction have been tried. From bacterial dilution to medium without bacteria (axenic culture) to genetic mutants that have defects in eating (eat mutants). In all different feeding protocols the worms lived longer.

[@eternalfizzer]

Absolutely amazing - you roped me in to a topic I didn't think would interest me. Love the philosophical excursions.

[@_negentropy_]

This was the most sensible conversation I’ve heard on ageing yet. Thank you both! Andrew’s optimism is refreshing though I’m not super convinced that wealth redistribution and environmental degradation will be resolved before we start to see advances in…un-ageing? de-ageing? non-ageing? Probably bc, given the data mentioned, the latter seems heavily dependent on the financial grip of the former, and if history (and I would bet neuroscience) has taught us anything it’s that sickening levels of wealth shift perceptions of reality and entitlement inward rather than outward to benefit humanity. Also there is a subtle but important bias here that I don’t think was addressed in the arguments against anti-anti-ageing and that is this conversation is between two UK docs who experience the benefit of government subsidized healthcare. In the US there are longevity researchers clamouring to get ageing designated as a disease while, first of all, holding exclusive formulation patents to potential anti aging compounds (cha-ching), and second, in a country where medical insurance is already financially inaccessible to the non-diseased let alone any predisposition to disease (again, cha-ching). I appreciate that Andrew doesn’t like the phrasing of ageing as a disease, but this phrasing gets considerably more precarious and complicated in countries that do not have an accessible healthcare infrastructure.

[@jenkinseric2]

great to sit and listen to the two of you geek out. thank you

[@loolylooly81]

please keep both long videos and their podcasts ; you’re doing a great job ❤❤❤

[@charlieinsingapore]

I am an erudite and thoughtful person and I am delighted that you brought up the subject of fasting and OMAD with regard to autophagy after 59 minutes. Excellent discussion. I too want my fish and vegetable pellets. ;)

[@cryalowicki]

Please publish this in audio only podcast form!

[@suzannetitkemeyernlq]

Metformin helps with my asthma too. It's all good. But, sorry, born with asthma and it's unlikely that anti-aging anything will help that. Most of the severe asthmatics in my family die by 35. My aunt is 71 and I am 62, We're both here thanks to advances in the treatment of asthma. My asthma is a symptom of Mastocytosis.

[@zenrobotninja]

What a great interview. Well explained, interesting and funny. Love it

[@lis1752]

I love your video’s, thanks. Just a small rectification: teratoma’s are not found intrauterine, but in ovaries. Still often filled with hair, cartilage, teeth, etc.

[@tali055]

This is an awesome format, would love to see more of these!

[@sspaceforce]

over population is doubtfull for lots of reasons. I could agree that there is population density that has exceeded comfortable levels in certain areas, sure. But some places such as japan they have a population crisis because they do not have enough people being born for as many people that are dieing. And the result of that is entire towns are collapsing because they don't have the population to upkeep it. Top that off with the drop in first world countries of fertility. According to some ladies who deal with pregnant women they said still births have increased over 500-800% in just several years. they were talking how a drop in fertility and loss of life is not just bad, not just a desaster, but a catastropy. (yea probably screwed up some spelling here ) anyway have a good day.

[@ronaldgarrison8478]

I've been pondering an hypothesis (as old guys often do). Consider that, a century or two ago, the big killers were mostly infectious diseases, and they tended to kill mostly children in the first few years of life (obviously, many others, but just looking at the overall weight of stats). Around the middle of the 20th Century, accidents, cardiovascular disease, and cancer became more focal. Accidents have a major impact on about the second and third decades, once infections are reduced. In the US, I believe, heart disease mortality peaked in the Fifties. Globally, age-adjusted cancer deaths peaked about 30 years ago, and have started slowly dropping. (Certainly open to corrections, if you have sources.) Meanwhile, things like car safety, smoke detectors, and all manner of other things, have had an effect probably mostly for young adults, broadly speaking, but heart disease and cancer were causing a lot of premature death to those in middle age. So as time goes on, improvements in public health seem to have more of their effect for older age groups. So would it not be just part of an expected progression to see doing something about the core processes of aging as the next trend to surface? (I stopped short of calling this a "natural" progression because, obviously, none of this is exactly natural, is it?) The effects would accrue mostly to the oldest. Yes, I know that's a self-serving argument, if I've ever made one. Hey, that doesn't make it wrong.

[@notmyname327]

This was SO interesting! I didn't know about metformin, what an interesting result for a widely prescribed drug. This whole field is fascinating

[@Teetuetenmogli]

It did take me three sessions of watching but I made it to the end. Thanks Garden-Chairs your service is appreciated :)

[@d6d6d6d61]

I don't think people dislike the idea of anti-aging because they don't want Alzheimers cured. Rather the idea of being stuck another 50+ years in your current job (which most people dislike) and paying rents and trying to make ends meet even in the Western world is incredibly stressful. Of course the billionairs are pumped about living longer though

[@merrymachiavelli2041]

I've always found that a really odd way to think about lifespan. However suck-y life may be, aging and age-related diseases are likely to make it worse. There is always the potential for life to improve and if it really, really doesn't, suicide is an option, as dark as that may be. It's like disliking your house and so wishing it'd be seriously damaged in a flood. You aren't going to be happier as a result.

[@megsarna7429]

Yes right plus f humans could prolong lifespan for 200 years there would be so many other problems too. Many more murders, suicides. More & more food production is required.

[@garethbaus5471]

If you don't age as quickly you can work fewer hours since you don't need to save as much for retirement and the future medical bills aging causes which could drastically reduce the amount of stress you get from your job. Literally no quality of life improvements come from aging, and if you want to live a currently normal lifespan with a relatively normal retirement age while working just as much you could still live a much better quality life especially in the last few years up until to the point at which you choose to die

[@lijohnyoutube101]

If you dislike your job, get another one!

[@F3XT]

​@@merrymachiavelli2041the comment is talking more about systemic issues and individual feelings and you're speaking of a rationalization to justify anti-aging, but still keeping the individual feelings, you're saying the solution is for people to suicide instead of trying to solve the systemic issues, yall are putting 2 separate problems as one, aging and capitalism sucking, both need to be solved and both have very different solutions, and neither of them are solved by suicide or not wanting to live +50 years

[@diyeana]

I wouldn't like to live longer if I still have multiple joint osteoarthritis that started at 39 when I was a marathon runner, eating super healthy (mostly vegetables, fish, low fat meats, whole grain, reasonable calories), and generally taking great care of myself. I feel like my cells quickly self-destructed at that point and it's pretty much too late for me to have a good _quality_ of extended life.

[@therabbithat]

That's the one that is super unusual in young people, isn't it? Fran the engineer from Frans lab got that very young too and has it decades now. She found a lot of the doctors advice wasn't helpful because they'd only seen it in old people

[@19billdong96]

Just found a new addition, need more podcasts from you

[@kayleeson509]

The content is fascinating and the almost-dad-jokes are much loved. I say "almost-dad-jokes" because a proper dad joke includes having the chutzpah to not apologize for the dad joke. I know your kids are young so haven't quite grown into that yet. I look forward to seeing it.