HPLC vs UHPLC | Which One Should You Use?

A lot of vendors nowadays are pushing UHPLC and for some applications, it makes sense. However, what determines if you need a UHPLC and could your current HPLC do everything you need it to?
Are the benefits of UHPLC worth the upgrade and what applications would you use a UHPLC?
That's the question we will talk about in this video
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[@wahmfarad2719]

Dear sir you explained well..

[@ferhatoezsoenmez]

Good video :D

[@DavidYazdi1]

Thank you!

[@rpsly1873]

What is the difference in time to run a sample of Nicotimamide mononucleotide C11H15N2O8P on HPLC vs UHPLC?

[@DavidYazdi1]

Not much of a difference. You would typically use a small particle size column which should lead to sharper peaks.