What Is Psilocybin (Magic Mushrooms) & What Are Its Effects? | Dr. Andrew Huberman

Dr. Andrew Huberman discusses the chemical and structural similarities between psilocybin and serotonin, their effects on the brain, the specific role of the serotonin 2A receptor in psilocybin's actions, and its potential therapeutic benefits in treating mood disorders and inducing neuroplasticity.
Dr. Andrew Huberman is a tenured professor of neurobiology and ophthalmology at Stanford University School of Medicine and host of the Huberman Lab podcast.
Watch the full episode: • How Psilocybin Can Rew...
Show notes: www.hubermanlab.com/episode/h...
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[@tammyb8742]

I started microdosing 2 months ago and with the first dose I felt soooooo much better that I don't feel like I need therapy anymore. It was like the dark cloud that had been hanging over my head my entire life just evaporated. That doesn't mean I don't have bad days or that life is perfect now but it's so much better.

[@edunsavage]

just curious what your dose is like?

[@tammyb8742]

​@@edunsavagevery low: 0.03g or 30 mg every other day

[@Mohammadali_9999]

Do you have to keep using it?

[@janetesch9578]

What was your dosage?

[@francois9747]

dosage pls?

[@foodaddict2759]

Magic mushrooms literally saved my life No more additions No more depression No more anxiety & No more sertraline 🙏🍄❤️

[@debwest7071]

Where do you get these from? Guessing you're in the uk? I'm prescribed sertraline

[@hasnasoliman6722]

How did you use it? Full trip or microdosing? How did you get rid of SSRI? Is there any protocol you used or did you freestyle? Thanks in advance

[@ogwill1662]

Are you referring to this shrooms?

[@foodaddict2759]

@hasnasoliman6722 hey, Yes I starting microdosing psilocybin whilst very slowly tapering down on sertraline, until I completely stopped sertraline. I also take a heroic dose once a month . Its great 👍

[@zahidzazei8311]

@@foodaddict2759which species of mushroom do you take?

[@makaveli8979]

I stoped drinking, and eating crap food. I started sleeping better and being happy inside. All by eating magic mushrooms. No wonder they don't want us taking these. It would end soo many jobs and pharmaceuticals. 🎉

[@sangohanuchiha]

I absolutely agree with you

[@Eysc]

🎯 Key Takeaways for quick navigation: 00:02 🍄 *Psilocybin's Chemical Similarity to Serotonin* - Psilocybin, a tryptamine like serotonin, closely resembles serotonin in structure. - Serotonin, a neuromodulator, influences various neural activities, including mood, pleasure, and motivation. - The similarity between psilocybin and serotonin raises questions about why psilocybin induces specific experiences despite their structural likeness. 01:29 🧠 *Serotonin's Functions & Receptors* - Serotonin's diverse functions involve mood regulation, pleasure, motivation, and more. - Its impact on numerous serotonin receptors leads to a wide array of effects in the brain and body. - Understanding serotonin's role highlights the complexity of its influence on daily life and mental health. 04:24 🧩 *Psilocybin's Interaction with Serotonin 2A Receptor* - Psilocybin's specificity in binding to the serotonin 2A receptor drives its distinct effects. - Activation of serotonin 2A receptors triggers changes in neural circuitry, leading to mood improvements and relief from certain disorders. - The selectivity of psilocybin in targeting this receptor explains the excitement surrounding its therapeutic potential. 07:17 🔄 *Comparing Psilocybin and SSRIs* - Psilocybin's efficacy in treating depression surpasses that of SSRIs in some cases, sparking attention. - Contrasting outcomes between psilocybin and SSRIs underscore the importance of receptor specificity in their effects. - Understanding the selectivity of psilocybin for the serotonin 2A receptor elucidates its therapeutic potential compared to SSRIs.

[@anitahernandez1207]

The key takeaway is that science does not fully understand serotonin but since serotonin is also influenced by the gut, proper nutrition is the beginning of overall health, not a psychedelic that’s main purpose for many is to obtain a “trip” or to patent for profit 💊 🤑

[@ShadoCroc]

Thank you so much!

[@ShadoCroc]

​@@anitahernandez1207That's an opinion.

[@anitahernandez1207]

@@ShadoCroc research shows that psilocybin affects people differently. For example a physical injury produces a different chemical reaction even depression, especially if an injury goes untreated. It can put the body in a state of chronic stress. “Stress signalling is part of a cellular response to potentially harmful stimuli and thus is essentially involved in the process of synovitis” or other pain modalities. (NIH.gov) Psilocybin would need to become like a super computer to know how to interact with each individual’s stress signals, injuries or chronic pain. Behavioral therapy would be for a different type of depression but nutrition is still important for both.

[@user-yw9mw9hv8o]

Awesome episode. What's his background? The way he says ligand is funny to me as a chemist.

[@Neto37375]

Mushrooms played a pivotal role in my journey to conquer addiction, and l've never experienced a greater sense of self-control.

[@greatestofalltime4125]

I can honestly say psychedelics experience was probably one of the most profound and beautiful collection of moments I have ever had

[@BorisTonkikh-un1qe]

Meet this mycologist where I get my psychedelics from including shrooms, dmt, lsd and more >>>>>

[@BorisTonkikh-un1qe]

Pharmshrooms001 !!!

[@BorisTonkikh-un1qe]

On instagram ````

[@mr_green33]

i absolutely love when we discuss pharmocology. Escpecially the pharmocology of naturally occuring substances.

[@anitahernandez1207]

Cyanide and arsenic are also naturally occurring. Are you going to take those to get a trip? At least it’s not a Tide pod. 🤒 🧺 The synthetic version of vitamin B12 is derived from a form of cyanide. It’s a slow form of malnutrition. Pharmaceuticals are not always the smartest tool in the shed.

[@Getfromjude_shrumzonIG]

jude shrumz

[@Getfromjude_shrumzonIG]

On IG

[@Getfromjude_shrumzonIG]

Sells

[@JesusRaves]

great talk Andrew, what are the dosages that you speak of ? is this a once off dose or is it a micro dose on a routine basis?

[@spontaneousbootay]

In my experience, therapy is best done frequently for a few days, normal dose. Then give it a long break to reset tolerance. Minimum two weeks

[@katrina429]

He goes into detail about your questions on the full podcast about psilocybin

[@johnnyjoedillinger5254]

You had me at "lets talk about psilocybin". I'll take 4.

[@edunsavage]

very interesting video. With some of the recent research into the causes of Long Covid (which Ive been dealing with for 19 months) low levels of serotonin and cortisol in the gut are being looked at as a possible cause of some of the LC symptoms. I have done some micro dosing during this LC nightmare but perhaps its time to up the dose a bit. Any one else out there dealing with LC?

[@ashazkitchenandcrafts5143]

Tinnitus tremors pains but after COVID vaccination

[@jaynsilentboom]

Ive been out of my supply since early Feb. worst feeling in the world. It’s a hard crash like getting off of SSRIs. For someone like me who has many mental health challenges like major depression, anxiety, CPTSD. This is equivalent of getting off your meds. I feel so connected, alive, full of motivation, able to control impulse and hyperactivity. Moderate my diet, stick to my routines. Require less sleep and get so much more done, when I am micro-dosing. It’s a shame I have to wait for it to be legal. Alas. I’ll be regrowing my own supply again. There is nothing I’ve ever had (especially from the VA) that can compare to the terrific effects of microdosing. I’ve also macro dosed and got through some hefty trauma stuff. I can’t do therapy without it. The memories way too deep, and the trauma triggers send me into a spiral without them. So, north spore all in one bag, and inoculate the world for the win.

[@Scarlett_Ava]

@👉Crystal growstores That's the mycologist's page name.

[@Scarlett_Ava]

His on ln$ta, not website.

[@Scarlett_Ava]

I'll recommend you look up the mycologist for quality supplies and guide on dosage. They got the best stuffs

[@sethtenrec]

This is the problem with the authoritarian Christians who want to control everything you do.

[@ingridsara213]

Research has shown psilocybin to have great potent to treat a range of anxiety and behavioral disorder. -

[@Jordanmiths]

Mushrooms has been a God to me thanks to my buddy who has been guiding me through this experience

[@Jordanmiths]

Dude on Instagram

[@Jordanmiths]

@mycotinny

[@brettholowaty7250]

hey doc i was wondering if you could help me understand nicotine replacement pouches i live in canada and the ones that are available to me are called zonic they are like the zyn pouches in the usa my concern is that they say they are food safe and okay to swallow the biproduct of it witch is in your syliva i belive these to be hard on your liver and kidneys what do you think

[@JesusRaves]

hey there man im not an expert but i would not recommend swallowing that stuff. if you are experiencing this alot, chances are you arent doing it right or that it has been in your mouth too long. though i have forgotten them in for over an hour before and do not have any issue with the biproducts seeping into my mouth. try to keep it as dry as possible when its in

[@spontaneousbootay]

I was sooo sick before mushrooms lol

[@patrioticcanuck9930]

45 yr old male Developed daily Vagal Afib/ Daily MM 1g dosing has stopped afib completely I can’t find a single piece of information related to this

[@Stormy_Coyote]

I want to try Psilocybin, but I'm kind of afraid to. I've been struggling with alcoholism and depression for over a decade now, I'm so tired of feeling like crap all the time. I used to take anti-depressants, but they were 50/50, somedays I felt alright, others I felt worse than before. I also suffer from panic attacks.

[@FranciscaAham]

Best contact for all kinds of trips stuffs like dmt shrooms,acid,ayahuasca, edibles and many more also discretion delivery ...

[@ervinacadenamayonga]

I remember days my anxiety flew over the fence, weighed my options and there i found this dude who got the best strains of psilocybin and other psychs….

[@ervinacadenamayonga]

(They're on Telegrams & Instagrams?..

[@ervinacadenamayonga]

(They're on Telegrams & Instagrams?..

[@nickkurr4967]

shrooms made me feel really grateful for my sober state and that I dont really wanna go to far from it and id like to stick to the hippy drugs

[@ervinacadenamayonga]

I remember days my anxiety flew over the fence, weighed my options and there i found this dude who got the best strains of psilocybin and other psychs.

[@ervinacadenamayonga]

(They're on Telegrams & Instagrams?..

[@ervinacadenamayonga]

@PHILLSMYCO2, is the handle?.

[@PeterDeMarco-fk1ph]

Im micro dosing right now and its the ONLY medicine that has ever ever helped CPTSD 🍄💯🍄 Thank you! Calcium deficiency is the cause of all depression and parathyroid/thyroid in the throat right.

[@PeterDeMarco-fk1ph]

@iwilifred6471 yes please. I agree, the mushrooms are totally divine.

[@SonnyMoonie]

What is it that psilocybin does? Not how does it work, or what does it do to the brain. What effect does it have, that the person taking it experiences? You're just saying in this video that it may relieve depression, and may relieve obsessive compulsive disorder symptoms. Why then do you call it a "journey" to take it? How can there be something called a "journey" if there are no detectable experienced effects worth mentioning? If it "improves mood" how can a person tell that their mood is improved by it? What's the experienced effect?

[@Thaddeuslovesmusic]

This is only a 10 minute clip of a two hour discussion, so I suggest you check out that video

[@Azusadesuu]

Where i can buy magic mushrooms or psilocybin, im from Philippines btw I realy want to try this for my mental health

[@FranciscaAham]

Best contact for all kinds of trips stuffs like dmt shrooms,acid,ayahuasca, edibles and many more also discretion delivery...

[@FranciscaAham]

On Instagram or telegram ...

[@burjalmadre]

Is 200mg with a ~1.7% psilocybin concentration per day enough to change some depression? Have ANY effect on the brain? Does anyone know? Its what my capsules from a reputable supplier contain. It that enough or just wasting them at such a low dose? I just started, to see what it does for my severe depression. I'd love any opinions or tips? Maybe two capsules a day at that level?

[@slacker8727]

hi Andrew

[@caseyschmidt6532]

Hi

[@PanicInSectorFive]

6:53 what kind of doses?

[@Getfromjude_shrumzonIG]

jude shrumz

[@Getfromjude_shrumzonIG]

On IG

[@Getfromjude_shrumzonIG]

Sells

[@henkgroenewald7588]

Psilocybin saved my life

[@Jordanmiths]

Mushrooms has been a God to me thanks to my buddy who has been guiding me through this experience

[@Jordanmiths]

Dude on Instagram

[@Jordanmiths]

As mycotinny

[@michellewest3287]

Scammer on this thread be careful.

[@henkgroenewald7588]

@@michellewest3287 yep I ignore these fools

[@Meilikescats]

How to get them?

[@AliyuMusaAdamu-kh1qw]

I'll hook you up with this mycologist whose been my guide for some time. His got LSD, DMT, MDMA, MUSHROOMS, CHOCOLATE BARS, GUMMIES, ETC..

[@AliyuMusaAdamu-kh1qw]

@chaposhrooms..

[@mycommentmyopinion]

Depends on where you are. You can also just grow shrooms

[@michellewest3287]

Beware most people who share insta & telegram are scammers be careful!

[@freedomwarrior5241]

what about cat food?

[@jameswilliamson288]

Can we go on a field trip First class🍄🍄🍄🍄🍄🍄🍄🍄🍄🍄🍄🍄🍄🍄🍄🍄🍄🍄🍄🍄

[@mrs_Mccoy]

I got some psychedelic products from an online store

[@mrs_Mccoy]

from cruise_mycologist

[@emdr-willdavlin]

Talk about wearing sweatpants reverse for better sleep You put your feet in the bottom of the legs of sweatpants to sleep

[@drg6586]

Like a Sleeping bag for your legs? I guess it could help in winter for ppl with cold feet or circulation problems

[@flortortonesi2710]

Clickbait

[@BestOfTate23]

This was the most boring video on shrooms I've ever seen. Even your background was boring.

[@marsisflat]

today im so high it was fun to watch😮

[@BrainDev-qs7yl]

youtube celebrity doctors are the best

[@burjalmadre]

Is 200mg with a ~1.7% psilocybin concentration per day enough to change some depression? Have ANY effect on the brain? Does anyone know? Its what my capsules from a reputable supplier contain. It that enough or just wasting them at such a low dose? I just started, to see what it does for my severe depression. I'd love any opinions or tips? Maybe two capsules a day at that level?

[@ervinacadenamayonga]

I remember days my anxiety flew over the fence, weighed my options and there i found this dude who got the best strains of psilocybin and other psychs…

[@ervinacadenamayonga]

(They're on Telegrams & Instagrams?...

[@ervinacadenamayonga]

@PHILLSMYCO2, is the handle?….

[@burjalmadre]

@@ervinacadenamayonga wasnt quite looking for any random, stranger's handles haha, just any imput in the information and numbers I threw out from anyone who may have some knowledge or experience. I appreciate it tho