I'm Not Awake

Sing your way through the neurobiology of the sleep-wake cycle. To register for the NEI Congress, please visit nei.global/congress.
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[@noeldbs]

For those who wants to sing along: (I'M NOT AWAKE) (x3) Yeah i was in the dark Then the light came on Hit my RHT (I'M WIDE AWAKE) And histamine came on so strong (I'M WIDE AWAKE) Hypocretin from Hypothalamus Stimulated me (I'M WIDE AWAKE) And then the dream i had was gone Basal Forebrain Is what happened next Acetylcholine To the cortex PPT LDT Gush Acetylcholine On THALAMUS VTA will shiiiiiiine Dopamine levels get hiiiiiigh Norepinephrine cooooomes From locus coeruuuuliiiiii (I'M WIDE AWAKE) Oh no i'm not asleep Cause 5HT is up From raphe Nucleus (I'M WIDE AWAKE) It hits the basal forebrain WO-oh! (I'M WIDE AWAKE) 5HT will rush The hypothalamus Hypocretin hit (It goes down) And now it's sleepy time again (I'M NOT AWAKE) VLPO is Now on the scene (I'M NOT AWAKE) GABA is releeeeeeeeEeEeeeeased (I'M NOT AWAKE) It's getting hard to fight closing my eyes Wake circuit is no more (I'M NOT AWAKE) (I'M WIDE AWAKE) HYPOCRETIN: Orexin RHT: RetinoHypothalamic Tract VTA: Ventral Tegmental Area VLPO: Ventrolateral Preoptic Nucleus TMN: TuberoMammilary Nucleus LH: Lateral Hipotalamus RN: Raphe Nucleus LC: Locus Ceruleus PPT: PedunculoPontine Tegmental Nucleus LDT: LateroDorsal Tegmental Nucleus

[@oluyemimaryadebanjo7041]

Wow! This is the most beautiful piece I have seen on sleep-wake cycle anatomy/physiology. Thank you so much.

[@jeremiahbaker6396]

this video makes me feel proud to be a human. ironically when i had to memorise this i needed to get some coffee. and at the right moment was learning that caffein along with inhibiting the PDE 3 and 5 enzymes to prolong cyclic amp , it can also inhibit Adenosine. Adenosine promotes the activity of VPLO therefore give caffien ==> no adenosine ==> no vlpo ==> stay awake to study the recticular acitvating system . appreciate this video🙏

[@jeremiahbaker6396]

* VLPO - ventral lateral preoptic neucleus = found in anterior hypothalamus

[@enzyme20056]

The Psyc students are going to love this. I know I do.

[@adelmograziano2506]

Once would think that, but most psychiatrists are completely ignorant about this stuff. All they care about is their stupid serotonin theory that has been debunked many times.

[@Serrandipity]

I honestly think this might be the most amazing thing I've ever seen in my ilife

[@samimabubaker]

OMG this is amazing! I first thought I clicked the wrong link lol Thank you!

[@freyaelliott3173]

THIS IS AMAZING!! I LOVE IT! I'm a med student, and so this is SO useful and clear. (And such an great song/voice!) Much thanks

[@RSmith8]

Using this in the psychiatry system when I teach this at the med school. NEI is the best with these videos!!

[@privateprivate2421]

This is so great. However I still can't sleep. Lost my sleep drive altogether 1yr ago. Chronic insomnia for 26yrs. Now I'm learning about the brain to see if I can find out what's wrong with me.

[@Uneagle1]

That really sucks, have you had your vitamin D level and vitamin b12 checked? If they came back low, check out Dr. Gominak, she talks exactly about this. Most people who have insomnia have a depleted gut bacteria, because the gut bacteria that create the chemicals to make us sleep feed off of D from the sunshine. If it goes low insomnia happens. A D blood level over 40 ng/ml and B50 complex for 3 months usually fixes it for most people, but for the minority (if you've had insomnia for a really long time and need a lot of repairs) it may take longer and you may need to stay on a sleep medicine that helps whilst at the same time regrowing the gut bacteria responsible for health. It's a bit more complex than this but this is the general gist. You're missing neurotransmitters responsible for sleep, which the body naturally makes.

[@mizzy_xyounus171]

My forever best song 🎉

[@kumarkancharlapalli1131]

Video chesinavallaki shathakoti namaskaralu

[@taneestarcohen4278]

this is fantastic!!!!

[@oluwamayowasmith3558]

This is Amazing!!!! Please can I use this video on my IG page and credit you guys?

[@Book_Bird]

This is profoundly good.

[@alemulemma2317]

Awesome work! thank you very much for simplifying things to this level.

[@rekhary]

Good job!

[@elizabethdowning8028]

love it !!!!

[@carmelam.gutierrez338]

es lo mejor que vi

[@tealmcfarland1137]

thank you! this is awesome!

[@pegahmashayekhi2895]

Thank you!!! This is an awesome way to remember Wake-Sleep neurophysiology for my Sleep Medicine Boards!

[@thornyninethree]

nicely done!

[@AKnewbeats]

excellent!!

[@mariyajacob4107]

Really thankfull for the fantastic video it really help me a lot

[@adel2944]

dang so much education

[@zefmoonsun9474]

i have a systems neuroscience exam and you probably just saved my a**

[@fedexido]

best video ever

[@leowhogoestothedojo8523]

so why are doctors trying to prescribe or recommend melatonin, when its my VLPO not functioning to send me to sleep? how does melatonin affect the VLPO activation?

[@nesbertkagonda2447]

made my day haha

[@cbbhvjc]

Could never have predicted a music video about the flip-flop sleep-wake switch.

[@eIenaxx]

She is calling u!

[@MegaMissfitz]

Morning sarks.. ya not awake yet ???

[@ronypazavinoamhatuka7583]

people sufferings comin in to learn for to get some help and you singing?