Arnold Kriegstein (UCSF) 1: Outer Subventricular Zone Radial Glia Cells - Brain Development

[@soniccontrolclub2495]

Thank you for putting this very high technical context in plain language for me and affording all of us the opportunity to grow by understanding ourselves from within.

[@PaulDentith]

Thank you to yourself and team Dr. kriegstein. Very informative presentation.

[@juriwestendorf6548]

Thank you so much, Dr Kriegstein! The way you condense decades of work into one talk - INVALUABLE!

[@Han2000]

What an AMAZING class! Thank you so much Dr Arnold Kriegstein!

[@Gary_Texan_USA]

Excellent presentation of your collaborative work on brain development, thanks!

[@neuropsychologist]

Brilliant master class! Thank you Dr Kriegstein. Downloaded a lot of your research in this area, which I’m now reading. I struggled a bit with this topic, and your visuals and presentation helped enormously.

[@tyfoodsforthought]

That was really just incredible. You've all done very great and amazing work. Thank you so much for sharing, Dr. Kriegstein!

[@alejandrodominguezlago2964]

This is incredible. I will love to have a class like this in my university.

[@avidey7050]

astonish ! one of the most clearly explained for human brain development . One issue of clarification: Genes mentioned here is the are the Mitocondria Genes whose main function is to produce ATP (energy that the brain needs) ?

[@dabinjeong9560]

Thank you for sharing your pioneering research online. outer radial glial cells(oRGs) is very interesting, and I believe fully understanding its role in cortical development will unleash the secrets to a lot of human neurological disorders.

[@susannahhannaford353]

This is a fantastic talk, and I will assign it to my undergraduate neurobiology course the next time I teach it. Thanks so much for integrating the experimental methods and the (evolving) models that the experimental data allows you to build.

[@DavidMartinez-vo2cn]

Incredible talk, thank you so much! and congratulations for your wonderful research

[@venugopal-ir7hq]

Amazing videos that make clear of neurogenesis, thank you, sir

[@InquilineKea]

WOW, "supragranular layers (above layer 4) are dif in primates than other mammals - that's a great quote!!

[@coltonrobinson4255]

Fascinating work

[@drashokkumar9209]

Amazing and Excellent . But , I need to watch this video several times to absorb . One question -- what do we know about the effects of Fused chromosome 2 on human brain , especially the Cerebral Cortex ?

[@bupehara64]

This was amazing to watch. Thank you so much

[@abcxyz9852]

Thank you for the wonderful pictures!

[@guytelfer1353]

What's the similarity between the cerebral cortex and the small intestine? Possible transparent vessels considering the substances in a vessel gives the vessel its color

[@Claymor588]

Dr. Arnold Kriegstein and iBiology channel, thank you so much for this incredible lecture! Could you please answer my 2 questions? . - Could you please clarify, what is the difference between outer subvenrticular zone radial glia cells and basal progenitor cells(intermediate progenitors)? - When outer radial glia cells form their own fibres, does the VZ and ISVZ cells still contribute to the development of neurons, or they just self renew? Of course, with the exception that the VZ forms astrocytes. What does the ISVZ do then? Thanks in advance to everyone who found time for my question!

[@TheRockHardMan]

Hopefully this helps elucidate those questions. This is a very useful read to understand exactly what you're talking about. If you get too caught up on any portion in particular, the main takeaway that you're looking for can be found on figure 2 or figure 6. www.nature.com/articles/nn1172

[@Aleezah143]

Awesome video. Thanks

[@ianinaharms]

You're so good! I understand every word)) thanx!

[@wingsonthebus]

I had no idea the human brain had the most cortical neurons out of any brain. No idea. All this time going around thinking I was the big cheese for knowing cortical folding scales by a simple physical rule. Completely failed to know the cortical neurons thing. Thank you for this talk

[@wingsonthebus]

Big shoutout to my intermediate neural stem cells for going “lmao” and wilding, providing me with the lush, thick, neotenous cortex I use to crush my enemies today!

[@luisfernando-mm3jt]

I am a fan of your talks shaw one about stem cells year ago

[@mahuubao]

Excellent ... well done ...😀

[@timblackburn4052]

Very interesting then why adult stem cells should maintain their RGC cables into the olfactory bulb

[@cerenaseawell5753]

Thank you!

[@leostack8495]

I got parkinson now ill be 65 april.1 my syptons are getting harder to deal with quickly i have 3 children and devorced question what do you know about turning glieal cells of the brain into neurons human trials i was into cbs in my 4yr honorably dis charged duty at a young age 17 yrs

[@heyheyheyhey282]

Brilliant !

[@donnythedude8]

Incredible

[@KenJackson_US]

Indeed. I'm not medical, so I only understood a little of this. But it's fascinating. And it's really fascinating that people still think this level of complex function and hierarchy was not designed but came about by natural processes.

[@donnythedude8]

@@KenJackson_US I believe it was designed by natural processes

[@KenJackson_US]

Have you considered any math, @@donnythedude8? Even a relatively small chain of amino acids has an effectively infinite number of permutations. It would take trillions of unique mutations per second (across a population) nonstop for trillions of trillions of years to find a functional protein. Seriously. Experiment with the math yourself. Natural selection can't help because chains of amino acids don't have any benefit at all until they're very close to a functional protein.

[@donnythedude8]

@@KenJackson_US yeah the ones that get it right are able to pass it on. The thing I think youre missing here is the emense scope of time to be able go get it right

[@donnythedude8]

I mean. I'm not a phd but, once we get a functional protein right we just pass it on and move on to try getting the next one right.

[@WangtangLong-ce6ls]

Beatifu talk

[@jimeffinger6865]

mouth noise

[@Dr_Sri_Harsha_Guthikonda]

who the fuck did dislike this?. i told you ppl to comment why you disliked the vid?! or else what is is the point. criticism unless constructive is useless

[@ot8479]

!!!???

[@Dr_Sri_Harsha_Guthikonda]

@@ot8479 in the past , when there was an official dislike button! i used to ask why they have dislike the video.

[@jimeffinger6865]

Someone please explain how most of this happens in utero and in early childhood development... ALL WELL BEFORE reproduction is physiologically possible and how this complexity evolved over millions of years via natural selection. The paradox is that a random genetic process that requires a larger brain and skull in order to become successful could not be passed down through subjects who fail to thrive before they are old enough to reproduce. In order to pass down something beneficial, you need a burst of conveniently mutually beneficial random changes, or millions of very small yet inconsequential random benefits that do nothing to favor a species over millions of years of natural selection. (a doubly problematic paradox in the second case)

[@ifyoureadthisyoudi]

15:11 I object to the exclusion of monotremes from the dendrogram. Very interesting mammals, with platypuses having smooth brains and echidnas having very heavily gyrated ones.