Ruslan Medzhitov (Yale / HHMI) 1: Introduction to Inflammation

www.ibiology.org/immunology/i...
Ruslan Medzhitov provides an overview of the field of inflammation, outlines its role in pathology and homeostasis, and explains how Inflammation is generated.
Talk Overview:
Dr. Ruslan Medzhitov provides an overview of the field of inflammation and outlines its role in pathology and homeostasis. Medzhitov explains how Inflammation is generated when pathogens, allergens, or other perturbations are recognized by sensor cells that then release inflammatory mediators (cytokines and chemokines) to activate effector cells. Inflammation is then followed by a resolution phase that brings the system back to homeostasis.
Why do we experience fatigue and loss of appetite, as well as other symptoms when we get ill? Sometimes what we associate with a pathogenic response and illness is the effect of inflammation. In his second talk, Medzhitov outlines the symptoms that we often feel when we get sick, like the lack of appetite (anorexia), and unveils the molecular mechanisms that explain why we have evolved this way. In addition, he compares and contrasts how anorexia affects the outcome of bacterial and viral infections.
Speaker Biography:
Dr. Ruslan Medzhitov is a Sterling Professor of immunology at Yale School of Medicine and a Howard Hughes Medical Institute investigator. His laboratory studies the signals that initiate and control the process of inflammation, allergic reaction, and immune response. His laboratory also studies tissue biology, and the communication circuits that help to establish stable cellular communities within tissues.
Medzhitov earned his bachelor's in Biology from Tashkent State University, and pursued a doctorate degree in biochemistry at the Moscow State University (1993). Medzhitov was a graduate student during the profound economic crisis that followed the collapse of the Soviet Union, which prevented him from performing any experimental work during his graduate studies. Being unable to do any experimental work didn’t stop Medzhitov, who continued his studies by reading the scientific literature at the Library for Natural Sciences in Moscow, and attending lectures. There, he encountered his passion towards studying immunology after reading a paper by Dr. Charles Janeway, where he described his theories on how the immune system works. Medzhitov, fascinated by these theories, contacted Janeway and started a collaboration that shaped the rest of his career. In 1993, Medzhitov received a 3-month Unesco fellowship to study bioinformatics with Russell Doolittle at the University of California, San Diego. In 1994, he continued his postdoctoral training at Janeway’s lab.
For his scientific contributions, Medzhitov was elected member of the National Academy of Sciences (2010), and received the Shaw Prize in Life Science and Medicine (2011). Learn more about Medzhitov’s research at his lab website:
immunobiology.yale.edu/people/...

[@user-wy2nk9gs3o]

Руслан, какой ты у нас умничка! Горжусь тобой...удачи тебе по жизни и в работе!

[@alexiscao8749]

Thank you Dr.Medzhitov, this is the most conceptually clear, accurate and comprehensive introduction of the inflammatory processes

[@michaelb1785]

iBiology lecturers are so informative! I'm a little overwhelmed because there are so many incredible lecturers to choose from!

[@yesarieroksuz6964]

sizinle gurur duyuyorum..

[@naivelee8000]

Thanks for sharing this interesting lecture!

[@pedromajano1755]

Thank you very much Dr Medzhitov

[@alisalmeida]

A wonderful presentation from a great master. Thank you Dr Medzhitov.

[@ilmarinen79]

Clear and great presentation!

[@newharp8]

Thank you very much for this very elucidating introduction!

[@olgasukocheva1854]

It is a very good and easy for understanding lecture. Thank you, I will recommend it to my students.

[@FearIsaLiar]

Thanks for the lecture

[@dmajumdar2059]

Thank you so much for this! Keep it coming, iBiology! 🙂

[@davidbautistaqf]

What a great talk.

[@gregsilsbee8383]

Excellent!

[@saulinkya408]

Can the good doctor give us another elaborate talk on autoimmune diseases in the context of inflammation?...

[@yesarieroksuz6964]

Thank yo so much..

[@jlgarciagomez]

Now I have to see the second part...

[@mattbeckwith]

Brilliant

[@islamalais2891]

Sir may I get a reference for this work because I want to summarize it in a chart when my thesis, thank you in advance.

[@Naomi-it5gd]

hi

[@Helixx1]

Why is lymphocyte activation of macrophages necessary (third design) when macrophages can do this on their own (see first design)?

[@hraqhraq]

Because macrophages needs INF gamma to help them express the ROS enzymes that kills better the phagocytosed pathogens (especially viruses); so Lymphocytes act as the 2nd order sensors that helps the 2nd order effector cells for much stronger immune response if lesser levels are inadequate to handle the pathogens. Also Lymphocytes are also 1st order effector cells which will kill the pathogens but does not stop there without asking to escalate the system one more step up towards macrophages or plasma cells

[@helixx8332]

@@hraqhraq Thank you for the explanation.