Ruslan Medzhitov (Yale / HHMI) 2: Inflammation and Disease Tolerance: Surviving Acute Illness

[@ancientsage1969]

Thank You! I survived Listeria infection in 2016. Still not 100% back to health. Wasn't able to eat for more than 8 days... Glad to know why. My body was saving me naturally.

[@rhyothemisprinceps1617]

1:25 cost of inflammation and cost vs. benefit trade-off 4:01 sickness behaviors, includes loss of appetite - observed in all animals including insects 5:10 Decreased Food Intake After Listeria Infection - disease induced anorexia 6:32 Anorexia Protects Against Listeria Infection (survival rate) 7:43 Glucose is Sufficient for Lethality in Listeria Infection - even at only 2% of normal caloric intake 8:26 2DG (inhibits metabolism of glucose) increased survivorship (100% survival vs. 50% without 2DG) 9:06 Effects of Feeding on Sepsis Survival - sepsis model using lipopolysaccharide (LPS) injection - same results found for feeding, glucose and 2DG experiments 11:10 Effects of Glucose in LPS Sepsis is Independent of Magnitude of Inflammation 11:48 Mechanism for Glucose-mediated Death in Bacterial Inflammation - review of fasting metabolism - PPAR alpha, ketogenesis, FGF21 14:18 Glucose Supplementation Suppresses LPS-induced Lypolysis and Ketogenesis 15:09 PPAR alpha and Ketogenic Program are Required for Surviving Bacterial Inflammation - PPARa and FGF21 and necessary for survival 16:09 LPS sepsis induced oxidative stress in midbrain - incleased by glucose and decreased by 2DG ; increase in glucose uptake in midbrain shown on PET scan 16:53 Death from LPS sepsis is preceded by convulsions ; can anti-epileptics prevent death by LPS sepsis? 17:21 anti-epileptic drug valpoic acid rescues mice from LPS sepsis death, but not Keppra 17:44 Valproic acid protects / 2dg does not protect in PPAR alpla knockout mice 18:30 Summary of Part 1 - ketones and valproic acid acting as HDAC inhibitors 20:20 Critical Role of Glucose Maintenance in Bacterial Sepsis - too little glucose also causes increased mortality 21:28 How does Feeding Affect Viral Inflammation? - mouse model of influenza infection 22:24 Feeding is Protective in Influenza Infection 22:41 Glucose Partially Protects Against Mortality in Influenza Infection - *"the rest of the protection is provided by sodium"* 22:57 Inhibition of Glucose Utilization is Lethal in Influenza Infection - (inhibited by 2DG) 23:13 Inhibiting Glucose Does not Affect Lung Pathology in [flu] 23:47 Effect if Glucose Inhibition on [flu] Independent of [degree of] Inflammation and Viral Burden 24:20 Death from viral inflammation due to reduction in autonomic function; PET scan shows glucose preferentially taken up in brain stem 25:04 Viral Infection and ER (Endoplasmic Reticulum) Stress - UPR > CHOP (Ddit3) > apoptosis - lack of glucose for protein glycosylation can cause ER stress 26:35 Inhibition of Glucose Utilization in the Context of Viral Inflammation Induces CHOP in the Brain Stem - Poly(I:C) - mimics viral inflammation 27:09 CHOP Deficiency is Sufficient to Protect Against POLY(I:C) + 2DG Mortality 28:02 Summary Part II

[@maryodonnell5760]

thanks for saving me a half hour of my precious time which would have been wasted on the direction he takes here, he's not a genius

[@zakirzak1494]

Wow, thank you, it helped a lot to recollect the infos shared in the video.

[@ssmk100]

Great talk and the observations. A true genius of our generation.

[@jamiek6471]

вы для меня настоящее вдохновение!

[@norm1124]

I am not the great fan auf animal experiments. But this video definitly showed the gain of such studies. - Thanks for this very interesting lecture.

[@lou7572]

Great Ruslan!!

[@zakirzak1494]

Interesting video and informative. Thank you. It Showed the relationship of glucose , 2DG , ketogenesis and the link between seizures/ sepsis / evolutionary adaptations of infection.

[@AurobindVidyarthi]

Awesome lecture..!!

[@alexiscao8749]

Great lecture

[@AnkeetKumar]

Just awesome

[@0xoRial]

what about administering valporic acid + high glucose intake? it seems that this could help in both bacterial and viral infection

[@92JacobG]

So it is clear that during bacterial infection a ketogenic diet or fasting is prefered. But what about the viral infection? Is the best way to overcome it to consume a ketogenic diet with increased protein to allow the body to produce the additionally required glucose?

[@maryodonnell5760]

no, for many reasons - but I'm also aware of some 'genius' who tried it on his mom lol with predictable outcomes - where was this Yale professor during covid - hiding under a rock with all the others? There are some doctors had solutions, those solutions are still working, internet pretty silent on them eg Richard Bartlett with his nebulised budesonide, Dr Robin Armstrong who saved the nursing homes and the Peru team going strong since the beginning with the Nobel Prize Winning medication now referred to as 'horse paste'...

[@hdhddhdb2894]

S109

[@patrickcoin9457]

So "feed a cold, starve a fever"?

[@maryodonnell5760]

crazy, there's better solutions and sadly people already led astray in the comments applying keto to xyz, it's a fad