APOPTOSIS PART 1: Definition, Causes & Mechanism/Pathways

A series of video tutorials discussing the topics for undergraduates in Pathology
In this 1st part of Apoptosis tutorial , i have discussed Definition, Causes & Mechanism/Pathways
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• Definition of apoptosis
• Causes /conditions where apoptosis is seen
• Understand the mechanism of apoptosis
• Extrinsic pathway
• Intrinsic pathway
A pathway of cell death
Induced
By a tightly regulated suicide program
Found in 1972 John Kerr, Andrew H. Wyllie & Alastair Currie
Greek - mean "falling off" (like leaves falling from a tree)
Also referred to as programmed cell death
PHYSIOLOGICAL CONDITIONS
Embryogenesis
Involution of hormone dependent tissues
Menstruation, menopause, weaning
Loss of cells in proliferating cell populations
Bone marrow, thymus
Removal of self reactive lymphocytes
Death of inflammatory cells after their functions are over
PATHOLOGICAL CONDITIONS
Injured cells which cant be repaired
• DNA damage
• Misfolded protein accumulation
• Viral infections
• Duct obstructions
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Please watch: "WARBURG EFFECT: Hallmark of CANCER. What, Why & How?"
• NEOPLASIA 6: WARBURG E...
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[@Kyle0714]

I wish you taught pathology at my school. I had no idea that Caspase was a mashup of 3 different things, crazy!

[@TheSK1199]

Thank you sir. Reading robbins is so easy after watching your video

[@hritvikjain__3594]

I generally don’t comment of the educational videos on YT. But if I’m commenting, the shit is really awesome. I was so scared of Apoptosis, that i even decided to skip it for my exams. But after watching this video, the mechanism of apoptosis is very clear to me now. Thank you sir 🙏🏻.

[@ilovepathologyVijayPatho]

Hritvik Jain thanks 😊 glad you liked it 😊

[@sindynurafia4063]

im coming from country who dont use english as daily basis, so its difficult for me to listen and understanding something in english . you should turn on the subtitle, it would make me easier to understand. at least i can read it.

[@92soofiyanoushad8]

Sir, this vedio is really an exam capsule 😍.thank you

[@selvambigaig6541]

Awesome. Keep up the great work. A real boon for students.

[@criticaltruth5184]

awesome videos. love the details of the caspaces and the IAP family

[@17anandp86]

Such a wonderful class So easy to grasp the topic after hearing your class sir

[@kapilnath4059]

Precise Explanation sir . Thank you very much ..

[@doc599]

Ahhh.....such a detailed yet precised explanation

[@josetrujillo738]

I enjoy your lectures. I appreciate your very great ability to teach

[@narendrachaudhary609]

Wow..love it❣️ Such a good explanation in short time

[@rianacaeiro8711]

Very well explained, thankyou so much.

[@arvaoz6799]

Was very helpful! Thank you so much! :)

[@Artsylove4]

Thank you so so much sir for this tutorial ..❣️

[@venkateshwarlugangishetty8853]

Wowww,simply super 👏👏

[@lpangmeiphom1324]

Cleared my basic concept 🤘tq sir

[@pakapapita3104]

Thank you so much sir, I read Robbins only after watching your videos.

[@Artsylove4]

Me too

[@kidzstories2412]

Thank you sir easiest slide & explanations to follow 🙏🙏🙏

[@koolshakthi1985]

This is excellent. Thank you!

[@abhijityeole8462]

Awesome. Thank you soo much sir!

[@shameenabanu1143]

Thank u so much sir .....it is so. Much clear explanation ....

[@ananyagupta9730]

Thank you so much. I have much better understanding

[@janakignanan7793]

Thanks a lot :) This helped me alot for my degree :)

[@harshaharidas4786]

Thankuu very muchh sir Very helpful👍👍

[@DrDmitrii]

Thank you brother!

[@50divyaramesh77]

Excellent video which explains each and every point clearly😊please do more videos in all topics as possible.

[@piyumidissanayake6244]

great sir,thank you

[@samyu7925]

please make more videos like these sir🙏🙏🙏

[@shashishah7887]

could you please elaborate how the molecules on inner side of cell membrane got to be on the outside?because that's what caused phagocytosis...

[@anushabachchu1273]

Simple and super sir!

[@anaskp4667]

Love your classes

[@nandinimoorthy3163]

super great job

[@Baharaakbari]

Amazing thank u so much ☺️

[@tahiransari3917]

Very helpful sir

[@sabreenmodak7746]

Can i please know the name of the book that you've referred here?

[@TheSandeepkumar1991]

Thanks you sir..

[@benazirnowshath9002]

Could anyone give explanation more than this for apoptosis?! Really awesome sir🙌

[@HassanAli-zq3ml]

simple and clear

[@Joohi24]

Thank u sir for this lecture

[@phoolphool396]

Really helpful video

[@puneetsharma1134]

thankew sir.

[@hibakaleed387]

Please can I get this file I need to study it ?

[@polokocollen7072]

Thank you.

[@SMM-qp9ig]

Gorgeous way

[@13.tarunchandwani51]

Thank you sir

[@padmamahindravada]

Excellent video. very clear. Thank you sir

[@ilovepathologyVijayPatho]

Glad it was helpful!

[@JackT13]

I like the video but I thought apoptosomes were heptamers (7 sub-units)?

[@Rohit-fy4kl]

Sir which book you are following

[@21aparnamadhusoodanan94]

Thankyou sir❤️

[@shahnasshajahan529]

Thank you 💟😊

[@rutujamohite4890]

A Great Thank you

[@user-qk4hn5ce9x]

thank U 👍

[@vaisshnavi1257]

Smooth like butter 🧈🤌🫶💥💕💜💜💜💜💜💜💜💜

[@ilovepathologyVijayPatho]

Thank you 😊

[@shitalsurushe7496]

Thank you

[@nagamanigv8225]

Thank you sir nyc teach

[@suman-by7gt]

thanks so much

[@sebastianm.6875]

amazing

[@sainiksefteri7832]

how apoptotic factors are occurred and where? Due to WHAT?

[@fatahabdinur5383]

saved my life

[@anaskp4667]

Could you please share the ppt

[@abhi-wi2mj]

Explanation was very nice.

[@ilovepathologyVijayPatho]

Glad you liked it

[@chagalamukamorris4744]

Chagalamuka used this ❤

[@Daawonuurka]

Thank you From Somalia 🤒🥲

[@ikramshehzad6936]

Thanks 😊 sir which one book you following?? For better understanding of pathology

[@doc599]

Robbins pathology

[@zainabalradi2306]

you are a god

[@fatahabdinur5383]

ty bro

[@laurachueire4625]

perfect

[@imanehdjb402]

S'il vous plaît, quelqu'un me traduit les causes de l'apoptose en français

[@rosejasmine4214]

Very useful👍👍👍 thank you

[@user-wh1ev7gq6o]

H7

[@user-iw9ps3oj9l]

❤❤❤

[@pubsmedworld101]

Best teacher for pathology

[@ilovepathologyVijayPatho]

Thank you 😊

[@jaydeepchauhan7712]

sir this is the fantastic explanation, sir...can you please make a telegram channel for multiple choice questions practice,so that we can apply the knowledge of pathology

[@ilovepathologyVijayPatho]

Thanks so much :-) I think there is already a telegram channel for MCQs practice.. you can join that

[@jaydeepchauhan7712]

@@ilovepathologyVijayPatho can you mention the name ....plzz sir

[@ilovepathologyVijayPatho]

jaydeep chauhan "pathology UG Quiz😊"

[@saloniparekh8419]

This is so simple and easy to understand.R u from india?

[@ilovepathologyVijayPatho]

sanjana parekh thanks 😊 and Yes!

[@ursgp7]

❤

[@tejasgadekar6153]

👍

[@anaskp4667]

Sir

[@pavanjadhav5116]

Thank you sir....still I hate patho😭

[@ilovepathologyVijayPatho]

Wish I could make it interesting for you 😊

[@nativetexan6628]

I'm sure your video is very good, but I couldn't understand the words you were saying. I got a few words but your accent is so heavy that I just couldn't get it. I am so sorry.

[@pheonixheart5534]

💜💜💜🏌️‍♀️

[@ourvinesshahzad3931]

Thank you sir

[@abhi-wi2mj]

Thank you.

[@ilovepathologyVijayPatho]

You're welcome!

[@rikkigupta9546]

Thanks alot sir

[@ilovepathologyVijayPatho]

Most welcome