Apoptosis (Intrinsic, Extrinsic Pathways) vs. Necrosis

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[@DirtyMedicine]

Errata: perforin is the substance that creates the hole, Granzyne B is the substance that activates Caspase

[@Drmeira]

perforin creates holes for the granzyme to enter

[@simplehighlitestv1696]

I was just about to comments about that

[@ceciliakinawa9346]

Was just about to comment, otherwise very informative and concise. Thank you so much!

[@dramgcastillo]

I was goig to say that... perforin perforates... Granzymes, then enter the cell and go activate BAX... and so on

[@MohamedOsama-ny7ix]

promise im gonna support this channel once im done being broke

[@alfarouqelboom8465]

still broke??

[@bluejay8836]

Bcl stands for "B cell lymphoma" (just another way to remember that bcl = anti-apoptotic)

[@MultiNerve]

Didn't even make the connection lmao. Thank you for this

[@theonejackal89]

Not only do you explain it summed up in a simple way, but also you make it easier to remember! You've earned that like.

[@pacifist356ermek3]

thanks a lot u made my journey through USMLE whole way easier

[@drdoolittles6145]

You certainly have a way of making complicated processes a lot easier to understand 😊

[@vitezslavduda5224]

Mate, thank you so much for your work! I'm studying pharmacy and many of your videos are extremely helpful for my revision. Especially the ones focusing on pharmacology, so I'd definitely appreciate more of those. The mnemonics you use are amazing and helped me loads. So glad I found your channel. Keep up the good work :)

[@YellowBellow11]

Love it! My tutor recommended 👌🏽 y'all are both lifesavers.

[@FarrOutt1]

I am in MED school, I didn't understand this concept during Pathology Lecture but I manage to get it with this 15 mins video....Thankyou so much...

[@MultiNerve]

BAC or BAX has an "A" in it (duh,) which can stand for "Apoptosis" --> these cause apoptosis in the intrinsic pathway

[@aishahussein7927]

U made my life so much easier thank youuuu

[@pradipneupane9767]

Thank you for this information.

[@jacobhernandez953]

VERY HELPFUL thanks once again for these awesome videos

[@m.saadsultan2492]

awesome. May God bless u.

[@insidenumber0855]

It was so helpful thank you may god bless you 🙏🏼

[@namanshah2616]

Thanks for creating these videos

[@danielolojo6078]

This is just too amazing...

[@arileinkalra]

I guess the mnemonic could change to the "Toxic Perm on Granny" for extrinsic pathway!

[@afokujabi2394]

Thanks....really informative and helpful

[@maialaaeldin7126]

Extremely fast and perfect

[@frostedgraves6059]

Perforin forms pores on the cell membrane and then granzyme enters through the pores.

[@elenamarkova8815]

Thanks so much!

[@TahiraShaheeraShah]

Love your content !!

[@inaamulhassanjaffer8238]

Tahira Shaheera Shah love your channel!

[@TahiraShaheeraShah]

@@inaamulhassanjaffer8238 thankyou so much 😊😊

[@foreverxfall]

What about the specific caspases that are involved in the processes? For example, caspase 2, 8, 9 , 10 being initiator caspases But also caspase 9 being a key player in intrinsic apoptosis. On that note, it it important that we know the function of Apaf-1?

[@aaronkabwe3773]

God bless you 🙏

[@user-rn9pz6ht1j]

Thank you very much. It was very informative

[@degoldessie1826]

Excellent @dirty medicine, I like your Mnemonics

[@xaaboopinkly]

Thanks! ❤️

[@dr.reddyhoff]

perforin 'perforates', granzyme B enters. (big fan of your channel here :) )

[@kathleenadeshoga8415]

That's how I learned it

[@pinoy7tfc]

yeah thats how pathoma says it too and FA

[@danjbro]

I noticed that as well...

[@divyaslal8768]

Thank you✌️🥰

[@alikareem8591]

Thank u so much

[@jamesakien-nd9pm]

Its actually the perforins that make the pores while the Granzyme enters the cell cytoplasm to activate the caspas

[@fridaygames5710]

thanks so much

[@sweetmishoo190]

Very nice 👍 thanks

[@AbhishekSingh-sh8fj]

nice explanation sir

[@sandramulela9864]

Ur th best thanks so much

[@relambuyi]

❤❤❤ Thanks 🎉🎉🎉

[@ayaa32001]

Thanks a lot ♥️♥️♥️♥️♥️

[@alexkuradnov6462]

thank you bro

[@DrRomaMD]

Caspase nINe in intrinsic Caspase Eight in Extrinsic Thanks all for final caspase

[@sonya1500]

Those peumonics nearly made me perf thanks tho

[@nazihaallalou4989]

do the intrinsic and extrinsic pathways happen together? i mean, does the cell choose between the two pathways?

[@ominips7680]

You are awesome

[@user-ul2sd8yc3g]

Name : Dirty Medicine Job: life and time saver

[@doctorwish1681]

Please make a video of neurotransmitters brother!

[@Thedocpost]

Dude you're awesome

[@dr.hinamirza4094]

AMAZING 😉

[@francismaemates228]

Thank youuuuu

[@emilymacgregor4307]

amazing

[@jahanavikhanna2042]

Necrosis can be planned too. Something called as necroptosis.

[@SwetaSingh-rg7xu]

Sir! Your videos are marvellous, huge fan of yours, please make videos on high yield images on various systemic pathologies. please😚please😚 please😚 Loads of love from India.

[@dkdkdkd7450]

Nice

[@drpoya6851]

thank you a lut of

[@galwhostolethejag666]

so wierd i was studying this from robbins and your video just showed up on my youtube suggestions....coincidence? I think not...

[@DirtyMedicine]

nope i am a telepath and knew you wanted me to explain it better, so i did

[@user-jf6wx9el2v]

تخبلل وعليي ❤❤❤❤

[@ryoof9626]

suddenly i adore you grannnnyy🥰🥰🥰🥰

[@duyendiren7004]

Would you mind if I added the Vietnamese subtitle for your videos?

[@joshuabowman7210]

You never spoke about Butyrate and how it activates Apoptosis ?

[@malaynaskar924]

Please let me know about choline to be introduced in pregnancy & new born baby.

[@liyichen9317]

bcl-b cell lives-lymphoma

[@akhileshrathod1738]

Source book?

[@bryanflint8268]

Big Daddy Caspases, that's all he had to say for me to remember this forever.

[@bslaozora]

Not a US student and I have some genuine questions...No offense@@ Is that really enough for getting all the USMLE? I mean like, no need to know exactly which caspase (9, 8, 3...) and how 7 pairs of cytochrome C and APAF1 forming apoptosome, which cleaves procaspase 9 into its active form blablabla...(And other details I don't rmb/I didn't learn) Or these stuff are examined within the medical school so not on the USMLE?

[@markhorimam4778]

Dirty medicine nice videos Love it. 😙😙😚

[@markhorimam4778]

Yeah

[@GoodKnight5252]

I feel this video lacks a ton of info... Like liquefactive necrosis is found in the CNS and in the pancreas

[@mimi-nz7qe]

Thanks alot,,,hope I can clear usmle😅😅

[@michaelvalenzuela7723]

What happened to OMG OMT? Plz respond

[@bretw4754]

You're our only hope Dirty-wan Kenobi !!!

[@DirtyMedicine]

Those videos will no longer be featured on this channel. OMG OMT will eventually be relaunching on its own new website. No ETA yet

[@MichaelMValenzuela]

DirtyUSMLE if that could occur before my boards in June it would be much appreciated 🙏🏽

[@spencita]

Love uuuuu

[@rnhim2072]

toxic granny perfume?

[@YinYangx3]

it's apop-moses because it parts the C I'M SCREAMING 💀

[@tejaswineewazire2510]

I know right 😂

[@mikhail_fil]

soooo, BCL is broccoli because it extends life by preventing apoptosis? :) last question, whose life?

[@CorporaMedicina]

ask the med students the difference between necrosis, apoptosis and infarction... :-)

[@michaelgoldstein8516]

Just a pet peeve, but it's not a-pop-tosis. It's a-puh-tosis. The authors of the original paper that described and named apoptosis included a footnote for proper pronunciation, as it's from Greek. We don't say 'puh-neumonia' or 'puh-tosis.' But your videos are amazing. I'm currently using them to study for step 1, and I've gotten so many questions right on my qbank sessions because of these videos, I'm definitely going to join and support.

[@Be1smaht]

Necrosis follows inflammation

[@Rendezvous89]

Big Mistake in this lecture...... Perforins are only the channels for granzymes to enter into the cell and Granzymes activate Caspases; not the Perforins..............

[@Adele5554]

Thankyou so much, I could marry you.

[@MissCassie2001]

big daddy caspases XD

[@happymanali]

Didn’t know I had to be Christian to understand biology

[@tabithalewis5942]

omg Jesus google it... hahahahaha Facts

[@rihamibrahim1192]

amazing