Immune 59: Forks in the road: Th17 cells with Mandy McGeachy

[@lesfaby8997]

03:09 Mandy McGeachy bio 05:56 phD in Th17 regulatory T-cells autoimmune model of MS 06:45 postdoc in industry discussion of industry vs academia 14:12 industry impact on publications 21:04 What is a "chalk talk" 23:01 work at U of Pittsburg on IL-17 for example 30:41 how she decided to move to Cornell Links for this episode 36:10 Th17 cytokines in health and disease (Immunity) cd4 t-cells multiple functions 48:11 t-follicular helper cells 48:16 th17 cells involved in autoimmune diseases so is it bad or good similar to is a plant or a weed 53:41 fungal infection models 58:56 il17 use in IBD 59:12 il23 drives il17 as does additional cytokines il23 drives functions of th17 59:33 antibodies are used in treating autoimmunity but why not treat root cause patients may take years to get to the right doctor and trigger is long gone historic blood samples may help 1:12:56 comparing animal models of disease 1:18:10 you share the same microbiome with your pet 1:19:58 What she would have done if not science 1:21:57 How to make a contribution Audio Time stamps by Jolene. Thanks! background: t-follicular-helper-cells www.immunology.org/public-information/bitesized-immunology/cells/t-follicular-helper-cells GM-CSF: a role in immune and inflammatory reactions in the intestine www.ncbi.nlm.nih.gov/pmc/articles/PMC3291482/

[@stephanielangel335]

Thanks so much, Jolene!

[@lesfaby8997]

@@stephanielangel335 she does the audio timestamps but the youtube timestamps are done independently by Andria or me. The time offsets are different. Thank you for doing the show.

[@kettvektor8037]

Thanks a lot, 36 min until the actual discussion starts, wow. I would be frustrated by that time, so helpful to have timestamps!

[@stephanielangel335]

@@lesfaby8997 My sincere apologies, Les! I should have looked at who posted the time stamps but my eye caught the 'Audio Time stamps by Jolene'. Thank you for correcting my mistake and for your efforts posting the youtube time stamps.

[@lesfaby8997]

@@stephanielangel335 no apology needed. Like everyone, I have some friends and family that have autoimmune disorders so episodes like this one are salient.

[@parkinsons1970]

I love this episode a lot!! Thank you for the great conversation. Ms. McGeachy is like a magnet attracting great opportunities in her life!!

[@EnvironmentalCoffeehouse]

I really enjoyed this conversation. I loved working in academia so it was a really sweet listen. Your guests were fabulous Vincent👋🏽

[@sbartdbarcelona44]

Excellent episode. Enjoyed the conversation. Learned something. Many thanks.

[@lulitmelake7534]

What an enriching and complete information- thank you!!

[@fernie5128]

Thank you all for doing what you do! Go SCIENCE! Your Immune roadie in Minnesota.

[@tonaruch8623]

Crystal clear sound. Nice to see you together.

[@aliceobrien8390]

Just alice I love all the podcasts,look and listen to all every week have a great interest is all and love tham,always somthing to learn, the whole group are just lovely interesting people thanks all

[@1968Aristotle]

Is it true that the nicotine receptor blocks the covid receptor ?

[@frankkimitch5381]

24:53 🤣 Racaniello Black and Yellow. Classic 😂🙃

[@tonaruch8623]

Interesting to hear the psoriasis connection

[@jdawg-j2u]

Inspiring career story and great discussion, but as a lay person, what the hell does Aisle 17 mean? (This isn't a complaint, I love having discussions I need to reach to understand). This conversation was really difficult to follow.

[@stephanielangel335]

I'm sorry @jasonrivard, you're right we should have done a better job explaining! A 'T helper 17 cell' or a 'Th17 cell' is a type of immune cell in your body. It's named that because it is a cell produced in your thymus (they are called 'T cells' because of the T in thymus). They are called 'T helper' cells because they help B cells produce antibodies (and help other cells do other things). Finally, they are called 'T helper 17 cells' because they produce a molecule called IL-17 (also known as interleukin 17). What we know about Th17 cells is that they protect against viruses and bacteria, particularly at the mucosal and epithelial barriers. We also know that activation of these cells in the wrong way is linked to various autoimmune diseases. I hope this helped!