Intermediate-Risk: Do You Need Hormone Therapy With Radiation? |

Dose-Escalated Radiotherapy Alone or in Combination With Short-Term Androgen Deprivation for Intermediate-Risk Prostate Cancer: Results of a Phase III Multi-Institutional Trial: pubmed.ncbi.nlm.nih.gov/37104...
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0:39 Should hormone therapy always accompany radiation therapy?
6:24 Should age play a role in deciding whether or not to get short-term hormone therapy?
8:01 At what point does short-term hormone therapy become with the side effects?
9:55 Is it ever appropriate to delay hormone therapy after radiation?
11:32 Alex's conclusions
13:23 If you need more help
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[@sherwinmoscow9455]

My two cents: I am 70 yr old male, had Gleason 4+3, chose radiation (SBRT), and declined ADT. This is a very reassuring study!

[@robertpettigrew3862]

Had radiation and hormone therapy. Would never do hormone again. Side effects devastating

[@io3010]

I had PSA 13.5, Gleason 4 +3 7 in two cores, 3 + 3 6 in three cores all left side of the prostate. My Urologist and Oncologist suggested I receive 23 EBRT and LDR Brachytherapy with no ADT. I was very, very happy I didn't have to go through ADT, im 56 years old, 5 grandchildren, ride motorcycles, snowmobiles, love to walk and hike National parks with my wife and quality of life was my #1 goal with my treatment. So far so good, PSA after 8 months down to 2.5. Very few issues, just some urinary urgency at night. I had a friend who chose Prostate removal, he died 4 days after surgery from a blood clot. Im still not over this loss. Thanks, PCRI for all your help and advice and steering me toward radiation treatments!

[@jameshibbert9813]

At age 78, I have shocked my doctors by declining hormone therapy. Good news. I am still active and work physically most days of the week. This is good news to me as well.

[@artlautenbach5768]

I was diagnosed with a PSA of 37.2 and a PI RAD 5 tumor with 3 +4 Gleason Score early April last year at age 65. I started 6 months of hormone therapy with Lupron Depot on May 5th when they installed the Space Oar, and 28 sessions of external beam radiation to my prostate, seminal vesicles, and pelvic lymph nodes on May 22th. Treatment was successful. I found the hormone therapy to be wicked. Especially the hot flashes, and muscle and joint issues. But everything has gotten back to normal. The hot flashes subsided only in the last month, so the side effects of the 6 month injection lasted 11 months. I did 5 miles or greater of daily walking during my entire treatment and post treatment period.

[@charlesgair8608]

At 65 I Had Gleason 4+4 .I Refused Hormone Therapy Had 4 Weeks EBRT Then June 2023 I Had Permanent BRACHY Seed Implants. Last Minth My Oncologist Told Me PSA Is 0.6 And My Cancer Is Gone And Is No Longer Detectable.

[@Rickster6118]

These videos are so important ! 55 years old PSA was 69. Gleason 4+3 confined with possible ext. 1 HDR brachythearpy, 25 rounds of radiation and ADT orgovyx and zytiga. I'm at 6 months with the adt. 48 months was recommended. I agree that alot of information was missing when I started. It was layed out as a process. Side effects were not discussed on any of these processes. I value these videos because the stress of researching yourself is greatly reduced due to this kind of content. Thank yall for all you do!

[@John-the-Bass]

This is great information. I am 75. Four years ago I had radiation and two levels of hormone therapy. Enzalutamide & Zolodex. I did not tolerate the hormone therapy well. In short it was hell! Quality of life was very poor. I am still suffering the effects and I do not want to take anymore. I will accept any risk in the future. Thanks to you!

[@jamesvezina9886]

I am now age70 I had 8 months Lupron ADT & IMRT radiation 20 doses in 2023 The hormone therapy takes a long time to disappear I was told My PSA a month ago 0.32 was undetectable before with ADT I have a persistent soreness in my right foot When dx April 2023 I was 4+3=7 Stage 2C At the time no metastatic spread was found Thank you for educational videos God bless you in your work to help us PCa persons

[@TERRY-cb2ku]

Thanks so much for this video. My PSA is currently just above the normal range for my age. (5.56 is the highest it's ever been. Is currently 4.3) I have one 8mm lesion in the left central anterior region of my prostate shown on MRI scan. No other lesions are noted in the prostate, lymph glands or pelvic area. Haven't had biopsy yet, but I will get it done. Hoping for a clean slate or a Gleason 6 or a low 7. I'm almost 73 and can still function sexually. I might accept radiation therapy but I don't think I would want hormone therapy unless absolutely dire circumstances prevented other alternatives. I have watched dozens of these videos on different platforms, and this one is by far the best for information, updates and real hope for alternative treatments.

[@ricknowak4582]

This episode has confirmed by decision. Finally. I am going to get proton radiation with absolutely .... NO hormone treatments.!!!!!!! THANK YOU!!!

[@carladerenzy3674]

My PSA was 525 a year ago and now .2. I'm on two ADT's (Nubeqa and Orgovyx), and I just finished a Lutetium trial (6 infusions). Result is "significant reduction" in bone mets and no new lesions since April '23. My Oncologist seems determined to keep me on ADT's indefinitely, but I'm not prepared to live with the side effects for a great deal longer. They are, for me, mostly psychological, but also hot flashes. I'm 61.

[@davidbutler574]

Thank you so much! I had Gleason 7 (2 out of 12 specimens) treated with Proton Therapy. Highest PSA was 4.1. I refused ADT and my doctor was upset. I am glad I did.

[@rosecolored2024]

This is a great video. I am 73 years and I was a 4+3=7. I had a 3-month lupron shot on August 28th, 2023, and declined the second 3-month shot due to side effects. They were not horrendous but they were troublesome. They are now just about gone after 7 months.

[@valleus]

My prostate cancer was stage three. i did lupron with radiation. it was a rough ride but I think I did well. The radiation proctitus is no fun but Im using suppository steroids for the inflammation. I still find myself very emotional and I've been off the drug lupron for a year now. i get depression a lot. I do a little of walking . being outdoors and walking feels really good. I get a blood test every three months and I also get a stool test and so far there's no active cancer so that's a good thing. I live my life as best as I can.

[@longbowbill]

Im 58. Diagnosed at 56. 3 coress positive 1 core 3plus4 just 10 percent. I decided after much research and talking to many people to NOT have hormone therapy. I ultimately under weent 45 treatments of EBRT. Been a year since treatment, PSA continues to go down. Minimal side effects. I am very grateful of my choice.

[@clemchirpich4907]

Thanks for putting out this information. I received radiation and ADT (Lupron) previously. My quality of life suffered from ADT. I wish I could go back in time and change my decision. - I am working on improving my quality of life with new personnel. Thanks for your good work.

[@mikepatel7235]

Thank you Dr. Scholtz & Alex, as always great discussion and insights 😊

[@tomas6451]

I'm 61, i had Gleason 3+4 in one sample all contained and very small. Was lucky to go to Stanford and after many tests only needed 5 sessions of sbrt radiation. Now just dealing with fatigue in the afternoons, but no major side effects. All working normally too :)

[@cobia224...]

THANK YOU !! Timely info I needed.. I have an 8.1 PSA and a 3+3 Gleason.... 58 YO...I will be starting Radiation in a couple of weeks.....Glad I declined hormone therapy after seeing this...Thank you