Prostate Cancer and Androgen Deprivation Therapy

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University of California Television (UCTV)

Күн бұрын

As part of the 2024 Prostate Cancer Patient Conference, Dr. Eric Small reviews Androgen Deprivation Therapy, including choices of agents, side effects, considerations in timing, duration, intensity of therapy, and discusses interpretation of clinical trial results.
Recorded on 03/09/2024. [Show ID: 39756]
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Пікірлер: 39

@jimo50 3 ай бұрын

The doctor spends at least ten minutes describing how to lessen side effects with shorter ADT duration, intermittent ADT etc. At the end he is asked about exercise and says, 'we'll talk about it later'. That may be, but regardless it is typical of a doctor to make no mention of exercise in this type of presentation. Weight bearing exercise in particular is the single greatest intervention for ADT side effects by far. Far more important than the pharmacological elements he describes. Good luck finding a MO who will do more than gloss over the critical importance of exercise.

@jcolumbiap 2 ай бұрын

I will never forget the doctor telling me to get ready for death. Four months later I ran the 100th running of the Boston marathon. That was in November of 1995. I’m still running!

@jimo50 2 ай бұрын

@@jcolumbiap A great lesson for all of us! If a doctor tells you how long you have to live, shake his hand and say good luck, exit.

@Neworldisordered 3 ай бұрын

There are things worse than death.

@larryparis925 4 ай бұрын

Thank you for sharing this.

@robwells230 4 ай бұрын

How do you explain why long term ADT results in a two year reduction in overall long term survival??? Or is this a big secret that big pharma doesn't want exposed.

@jimo50 3 ай бұрын

ADT is hard on the body no question. It exacerbates every co morbidity and health issue. It shouldn't be given to most men, unless they are committed to exercising more and eating less. The average older man is not fit to withstand it. That's why they get picked off so much.

@janetw9430 3 ай бұрын

ADT puts men at risk for osteoarthritis, heart attacks.

@toma7744 2 ай бұрын

ADT is a joke.... mainstream medicine is a s c a m

@robwells230 Ай бұрын

And ADT CASTRATION causes severe brain fog, memory loss, diabetes, cardiovascular disease, permanent penile and testicular atrophy Plus a long list of other horrific side effects. ADT longer than 18 months results in two years reduction of overall survival. Big pharma doesn't want us to know the truth about their deadly TOXINS

@robwells230 15 күн бұрын

And diabetes, permanent penile atrophy, severe brain fog, memory loss, hot flashes, loss of libido and loss of orgasms, anemia, muscle loss, frailty, fatal fracture, and a high risk of permanent or partial castration. .After 18 months or more of ADT CASTRATION, 75 percent of all men WILL NOT RECOVER THEIR TESTOSTERONE LEVELS EVEN AFTER A MEDIAN TIME OF FIVE YEARS. Up to twenty percent of older men will not recover their testosterone levels above CASTRATE LEVEL and remain castrated FOREVER

@robwells230 4 ай бұрын

How do you do intermittent ADT CASTRATION when the original ADT term leaves the patient with sub- castrate level of testosterone?? Maybe that's the case for Orgovyx daily pills, but men are reporting that even that medication leaves then with castrate levels for many months.

@jimo50 3 ай бұрын

Everyone is different. Patient age, time on ADT, baseline testosterone at diagnosis and overall health greatly affect T recovery. Some men recover theirs within weeks after stopping Orgovyx. Even recovery from Lupron can be 3-5 months. Sometimes longer. Others never recover beyond castrate levels or slightly above. They don't know until they try. Always worth a shot.

@robwells230 Ай бұрын

@jimo50 But it is unethical, unprofessional, and criminal to coerce, deceive, extort and intimidate men into ADT CASTRATION without full disclosure about the horrific quality of life destroying and life shortening side effects and that ADT can result in long term or permanent CASTRATION???

@jimo50 Ай бұрын

@@robwells230 I agree completely that men should be told thoroughly about the risks in detail. I also am quite aware that many do not. It’s criminal, irresponsible. At the same time, for many men ADT delays time to metastasis, controls the disease and extends life that could otherwise be a very painful process. The quality of such a life may seem torturous to you, but not to someone who’s facing such a difficult decline.

@johnd3890 Ай бұрын

@@robwells230 Exactly this. NO ONE told me I would be anorgasmic for LIFE with ADT. Just that "some guys have a reduced libido." I still get aroused and have sex with my spouse but I can NEVER again finish. If I had the courage I would end my life but I'm a big coward so I continue on and pretend to be happy when I'm just a shell of my former self.

@robwells230 15 күн бұрын

@@jimo50 After 18 months or more of ADT CASTRATION, 75 percent of all men WILL NOT RECOVER THEIR TESTOSTERONE LEVELS EVEN AFTER A MEDIAN TIME OF FIVE YEARS.

@bell1095 3 ай бұрын

Are Prostate cancer cells, that do produce their own testosteron, targeted by ADT ?

@RH-xd3nx 4 ай бұрын

What about men with naturally low testosterone sub 200. And have aggressive pc ...how good is adt then ?

@jimo50 3 ай бұрын

Very good. The lower the better. Under 10ng/Dl is standard today.

@unapologetic7900 2 ай бұрын

@@jimo50 Why is it that in the phase of life when Testosterone is highest, the incidence of PC is lowest, and the phase of life where Testosterone is lowest, the incidence of PC is highest? Maybe there is more to this than we know (or are being told). I trust big Pharma less than ever after 2020.

@maxstyle3286 3 ай бұрын

I am aged 66 . My PSA is 4.1 The MRI prostate w wo contrast RAD showed 4 and the biopsy report from 12 samples showed one RA , biopsy 3+3 and one RMPZ biopsy 4+3 . The bone scan showed no spread . Am i considered as Intermediate Risk Prostate Cancer ? Should i do Radiation therapy with or without hormone therapy ?

@EdMaldo-me8gn 2 ай бұрын

you ok with active survilliioence . I am 3 ans 4 and been on AS for 4 year. I have same conditions than you.

@NoFaithNoPain 2 ай бұрын

No hormones or only one month. Radiation in 7 factions get an mri linac if possible. Dendritic cell therapy a good option don’t monitor and wait. Act now

@Pegasus384 16 күн бұрын

Those are good stats. 💪 Enjoy life and don’t check your PSA for 2 years

@jabster58 4 ай бұрын

Instead of taking away the testosterone... block the testosterone input on the cancer cell..we need ai bad..humans are to slow

@jimo50 3 ай бұрын

Drugs which do just that have been around for 15 years. They are called second line anti androgens. They sometimes work well alone, more often both are needed. We don't need AI as much as humans to stop calling each other slow. Especially the brilliant minds working on this stuff every day.

@jabster58 3 ай бұрын

@@jimo50 humans Are slow compared to AI.. It saved humans a billion years on folding proteins..that's a hard cold fact. Alpha fold 3 will save us a 100 years on new drugs.

@johnmchale8308 2 ай бұрын

yep block the receptor site

@johnd3890 Ай бұрын

Doctors don't mention a 2013 study showing that 100% of men who have ADT lose the ability to have an orgasm. This happened to me. ADT ruined me for life. Don't let it happen to you.