Introduction to Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

Now that we've covered some basics regarding drug nomenclature, drug administration, and the ways they move through and interact with the body, it's time to dive into a survey of specific drugs so we can learn about as many as we can. Let's start with a class that everyone is familiar with. These are nonsteroidal anti-inflammatory drugs, or NSAIDs for short. These include aspirin, ibuprofen, and some of the most commonly used over-the-counter drugs. What do they do? How do they work? It all has to do with some things called COX enzymes, so let's get a closer look now!
Script by Chris Hofmann
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[@agent_w.]

dave thankyou for your consistent effort to spread scientific knowledge to a wider audience. you’re a legend. we need more people like you!

[@backstreetfan2887]

I always regretted not getting around to taking a pharmacology class in college. In fact I even was considering going to pharmacy school, but life happened instead. Now I get to find out what I missed out on😁

[@backstreetfan2887]

@@EdwardHowton awesome, thanks 👍

[@adamnovosad189]

Thanks Dave. Your videos helped me so much in writing my thesis about NSAIDs and paracetamol.

[@brittanyjacobson5199]

Very nice, thanks, excited to see this series continue!

[@konradpanduram4576]

Not bad, not bad at all, as a seasoned nurse, I've lost count how often I still have to explain the basics to patients and co-workers.

[@fathemasultana1295]

I just love the way you explain. Thank you much professor.

[@titonsaha799]

Thanks Prof. Dave for making things easier to understand. You are really Genius.. Take love 💙

[@vegatronld]

Grate information Dave.

[@musiqal333]

Wow, I wish I learned pharmacology from you in medical school. I like this video. Thumbs up!

[@YouMockMe]

This is what got me into Chemistry / Pharmacology!!!!

[@jc7159]

you are a life saver Dave, your videos are awesome!!!

[@spideymcgee4718]

Thank you for the info.

[@robertgrey1377]

Hot damn, I love NSAIDs!

[@thomasneal9291]

@@PDMSAcademy don't tell me who to love!

[@ofejiroefejene6833]

Very simple and straight forward

[@glennpearson9348]

Excellent summary on NSAIDs and how they work. Thanks again, Professor Dave. Keep up the great work!

[@upanddownfact5453]

Thank for covering the pharmacy topic

[@SittingDuc]

For people outside the US: * Acetylsalicylic Acid = Asprin (a brand formerly owned by Beyer and surrendered as war reparations, so genericised and often just called Asprin) * Ibuprofen = once patented by "Neurofen" outside the USA, main ingredient in Neurofen, Brofen, Advil, and Motrin (never heard of it) * Naproxen = main ingredient in Aleve (never heard of it) and Naprogesic (from Beyer, available in New Zealand) Interestingly, none of these brands contain Paracetamol (acetaminophen), which suggests it is not an NSAID, so I will have to wait for the video on that one.

[@naynay3174]

Excellent explanation thank you so much 🙏🥰

[@thegardener3650]

Great video! Thanks you!:)

[@meera6153]

It was so helpful thank you🥺🥺💗

[@markmalinowski5951]

I always enjoy when people ask "how does the Advil find where it hurts?" and I want to send them this but their brains might explode.

[@dogwalker666]

Thats easy the nano bots are pre programmed by NASA, lol

[@markmalinowski5951]

@@dogwalker666 But you have to drink the GMO milk to activate them so we're in the clear.

[@dogwalker666]

@@markmalinowski5951 ahh good, I don't want any of that scary pasteurised poison.

[@db3536]

Professor Dave, I would like to see you cover multiple sclerosis medication. Thanks

[@mujib4466]

Thank you

[@berenaybekin2829]

Thanks professor. I'm watching you from Turkey. Thank you

[@Spaceinvader2424]

Hey i was wondering if you would ever do a herpotolgy

[@user-fb3oh2kp4w]

Please can make a video for an explanation of antihistamines 🙏

[@spideymcgee4718]

What would you define as "prolonged usage"?

[@janedy101]

professor dave ur so smart

[@konradpanduram4576]

You don't use Metamizol over there? Serious question.

[@skylarstevens5056]

Meloxicam did something to my stomach. I think it gave me diverticulitis and blood tests showed an impact on my kidneys.

[@drawyrral]

Advil put me in the hospital for a week with two holes in my stomach.

[@spideymcgee4718]

That's probably why my stomach feels weird. I have a herniated c3 on my neck and I take about 600mg of ibuprofen almost every day. I have recently been using kratom for the pain and inflammation to get away from them.

[@drawyrral]

@@spideymcgee4718 I have herniated c3 and c5 and I now take Tylenol 3 for it. Ibuprofen rips the lining from my gi tract and it ends up in the toilet.

[@dogwalker666]

Aspirin does that to me, paracetamol has no effect at all positive or negative, Ibuprofen works fine with no side effects.

[@ObjectiveZoomer]

Quit taking too much

[@drawyrral]

@@ObjectiveZoomer I don't take it at all. If I took it, I would throw up my stomach lining.

[@Suitswonderland]

125mg of Naproxen (I split it down from 250mg) caused me to wake up needing to throw up, I hate NSAID's, I wish I had better tolerance towards them because arthritis during the cold months (Which is most of the time in Scotland) is just a pain with limited solutions.

[@starlight8554]

I’m gonna count watching this as revision

[@mearionet]

Is there any reason to not always resort to taking a painkillers like Ibuprofen/Nurofen whenever experiencing a slight headache?

[@naynay3174]

Yes. It inhibits COX-1 which protects the mucosal lining in our gut. So, no protection = potential GI problems (stomach upset, even ulcers w/prolonged use)

[@stormingsharks]

Is it true that the reason why acetylsalicylic acid and other NSAIDs 'accumulate at the sight of inflammation' is because the pH is too low everywhere else before it hits the blood stream? As in the drug deprotonates mainly in the bloodstream because our blood's pH is much lower (at that point before everywhere else the drug passes through), thus allowing for equilibrium to occur between acid and its conjugate base... I think? I could have sworn I read something in my o-chem textbook that went down something down those lines.

[@ProfessorDaveExplains]

the next one is on aspirin so stay tuned!

[@Ugly_German_Truths]

Can you please try to make the break between the AN and the Algesic more audible, Dave? It is not an anal drug, but a drug against (an) pain (alges...) You wouldn't pronounce "an algorhythim anal gorythm", would you?

[@slouch186]

i don't understand anything about pharmacology but it's interesting nonetheless

[@uncleanunicorn4571]

I don't know Dave, i might just go with homeopathic onion water.

[@backstreetfan2887]

Lol

[@jbirdmax]

Helps avoid the potential spread of “good” hormonal dispersal between two bodies as the smell on the breath of the user is repulsive. No? 😮💨🤢 😂😂😂

[@mikeuk666]

can we get a new debunk of Pierre-Marie Robitaille

[@ProfessorDaveExplains]

The one was more than enough.

[@mikeuk666]

@@ProfessorDaveExplains any more flat earth videos or Kent Hovind?

[@ProfessorDaveExplains]

Nah, moving on to bigger fish!

[@mikeuk666]

@@ProfessorDaveExplains oh interesting, keep up the great work

[@thomasneal9291]

@@ProfessorDaveExplains egads you don't mean... ANTIVAXXERS??? *dramatic dark music plays* well, if you do one on antivax any time in the next 3 months, it would be more than appropriate and helpful methinks, given the current state of things.

[@drum4416]

That thumbnail looks similar to Northern Ireland

[@manlypomeranian4261]

COX enzymes ❤

[@fiddle_n]

For me, "prolonged" usage of NSAIDs was 2 days. Yes, it took 2 days for this drug to fuck my stomach up. No ulcers, thankfully, but a lifetime of GERD and stomach discomfort.

[@backstreetfan2887]

still not the buchner funnel buchner

[@abhishekshyam3427]

1 view 10 likes 🤩

[@MisterRorschach90]

Wonder if anyone has ever made a nerdy joke about cox digital cable or internet and Advil.

[@cateatingchezburger4267]

I dont understand a lot about how flat earthers think. Is our land mass siting in a snow globe with a flat terrain. They admit to everything above is a sphere. It may be 100km away. I dont understand. So snow globe theort?

[@fukpoeslaw3613]

why is sales for NSAIDs expected to grow almost two thirds in only seven years? oh, eight structural classes of 'm. maybe I mean aspirin and the likes.

[@gameofbros4728]

So every time I take Advil I’m scaring cocks away? Makes sense

[@smashsisters6936]

I'm the first

[@nils-ph3zs]

JEA DRUGS

[@nils-ph3zs]

First

[@shoogaibrahem4752]

Hey, can you get me something to eat?

[@backstreetfan2887]

No. I can't. I am sorry.

[@shoogaibrahem4752]

@@backstreetfan2887 I want you to help me with the exam.

[@backstreetfan2887]

@@shoogaibrahem4752 Well, I better be studying for my own exam today, but it is not on pharmacology, it is on psychology. Good luck to you!

[@shoogaibrahem4752]

@@backstreetfan2887 You can't help me, please, I don't want to study with you, I want you to help me with my exam answers when I'm studying for a nurse.

[@SaeedNeamati]

Dave please check your email

[@adamhassan7031]

Hey Dave the earth isn't flat or round It's the matrix

[@tushargadge567]

Pls avoid trade names, generic names and therapeutic conditions in next videos. It promotes self medication in public, which can be dangerous. Thanks.

[@dogwalker666]

Especially as they are American brand names.

[@tushargadge567]

@@dogwalker666 yes

[@ProfessorDaveExplains]

If I were to avoid both trade names and generic names, no one would have a clue which drugs I was talking about. Laypeople don't know chemical nomenclature.

[@dogwalker666]

@@ProfessorDaveExplains general names are better at least I can look them up in the B.P. but trade names should be avoided. When I tore the tendons in my elbow fencing I was prescribed Diclofenac and paracetamol, that's when I discovered what NSAID was.

[@tushargadge567]

@@ProfessorDaveExplains I understand As a healthcare Professional I would appreciate it if we stick to chemical names & mechanism of its action. Or if you feel its necessary to use generic names, please cover side effects, contraindications, drug interactions and over dosage too.

[@fernsader9261]

Don’t get too into pharmacology and medicine, you might get faced with seeing all the bs

[@ProfessorDaveExplains]

You need this content more than anyone so you can get rid of the ridiculous narrative you've been fed.