Pharmacodynamics: Mechanisms of Drug Action

Now that we know how drugs move through the body to reach their target, what happens once they get there? By what mechanisms can drugs interact with target proteins to elicit a particular cellular response, and by extension a physiological effect? Let's take a closer look at this now!
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[@Guidus125]

Great video! But you mention that an antagonist leaves a receptor inactive, which is not entirely correct. An antagonist does not block the activity of the receptor but instead blocks the activity of another agonist, partial agonist or inverse agonist. An antagonist still allows 'constitutive' activity, meaning that a receptor still has baseline activity when an antagonist is bound (the baseline activity is equal to the activity the receptor would have if nothing were bound to it) Because of this, an antagonist can in some cases increase the activity of a receptor, for example when it antagonizes an inverse agonist (since inverse agonists reduce receptor activity even below its baseline activity)

[@Jay-lq8ly]

Great video !! Thank you 😊

[@cassa6474]

someone please help I still dont understand, why would you only want to find 50% maximum effect wouldn't you want to find 100% maximum effect??

[@DrHongsPharmacyClassroom]

Hi Professor Dave! Your education video is very good! I am amazed at how you approach the Pharmacology topic. It is not an easy topic to explain even for full-time faculties at universities! Well done! Keep up the good work!

[@tcunero]

Pretty good overview. My job is to run bioassays on these types of drugs and these graphs are what I look at all day. Good explanation!

[@hoooty87]

I'm 35 years old, love science but never went to post secondary for anything scientific. This is my 4th series I've watched so far from Dave and want to watch and learn from all of them. Even things I know nothing about but still can learn even at 35.

[@jakeblake8851]

I admire your inquisitive nature, it makes me feel guilty for leaning these because i have to lol

[@marutinandansingh3546]

Thanks for making video on pharmacology Please make more video on pharmacology and medicinal chemistry if you have time then only otherwise no need to worry just do your work accordingly

[@tglong98]

Just found your pharmacology lectures...great for my nursing class.Thanks so much.

[@In0god0we0trust]

2:00 Oooh... I see. Facilitator drugs just activate natural cell physiology by introducing appropriate molecules, and the cells do the rest. It's kind of like CRISPR technology.

[@yaayorke8980]

I really love and appreciate the way you lecture you make it easier to understand but please if you can slow down a little it will also do much

[@sccm100]

I'm loving it these new biochemistry videos

[@_snehaaha_]

You are very clear and to the point which is exactly what I needed! Keep up the good work :')💕

[@kamogelotladi1187]

how do you know everything

[@skipinkoreaable]

I am guessing that he was born smart, asked a lot of questions and studied very hard. Love him or hate him, he is legitimately very clever.

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[@chipoart]

I started studing degree in pharmacy and mr dave you have helped me many times without fail. thank you😊😊

[@kaustubhken]

Dear Sir please tell us how hydroxy chloroquine works against corona virus

[@antyspi4466]

The problem is that nobody really knows if it does at all work against SARS-Cov-2. Hydroxychloroquine is used against malaria (not caused by a virus) and against autoimmune diseases. In vitro tests against SARS-Cov-2 indicated positive results, but the so far limited tests with actual patients yielded only mixed or non conclusive results (humans are after all not simple cell colonies in dishes). Further studies are currently under way. Hydroxychlorine can however have severe side effects.

[@kaustubhken]

@@antyspi4466 india is forced to supply Hydroxychloroquine to US

[@warlordofvideogameglitches]

With many viruses that we have came across like yellow fever these viruses weren't effective with hydroxychloroquine. It's the reason why we require blind clinical trials with placebo to understand many of things about how it works against covid 19. But we can't do this in a slow pace because of a pandemic so some scientist are somewhat bending some rules to ensure that these drugs get to people on time. because if we did it the other way it might take 10 years for one drug or vaccine.

[@JuanMUbeda]

Very clear explanation for those of us who are not familiar with the pharmacopoeia

[@NurseJuliaEzeji]

Just had this lecture today decided to run here for more tips! 🤗

[@sohayla.4]

You know dr Dave that I'm a Level 5 Mpharm degree student and I am using your videos to understand most of the topics, and I have been following you since I was in high school when I totally depended on your videos to understand calculus and chemistry, and I wish sir if you could expand your videos in pharmaceutical studies more to make it easier for pharmacy students

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i want to see your long hair again

[@Yousefmmohammed]

Can u please do a tutorial about cell adhesion molecules??

[@Asmaiq]

Thank you.. I share and utilize your lectures with my class...You did a wonderful job...

[@maxruphio5515]

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[@isabellabaabiineh439]

Great piece, very understanding

[@gloriadaniels9320]

I have a question..please answer me: why response is better correlated with drug exposure than with dose

[@Omprakash-fd2pc]

Dave sir which country are you from??

[@ProfessorDaveExplains]

USA

[@veronaademaj1230]

Can you write down the video what do you say, please? Because I don't know English very well and I want to translate it.

[@kassandrachan5268]

At 5:55, “covalent bonds are not necessarily required for binding to be irreversible” does that mean there are other bonds/interactions between the antagonist and receptor that can also be irreversible? If so, what are they?

[@ProfessorDaveExplains]

i think even just electrostatic interactions, if numerous and strong enough, are sufficient to make binding irreversible

[@cyh0422]

Also, I think there are certain types of molecules that can interact with receptors to cause a change in the shape of the receptor, thus making the binding irreversible.

[@MalakMalak-nl1zb]

@@ProfessorDaveExplains hi dr i need help

[@raghadbarjas7257]

Very helpful thank you so much ☺️

[@lis2596]

awesome! he really knows how to explain.

[@Ahmad38761]

More than perfect!!! awesome. Thank you is not enough!!!!

[@rubidelahoz8591]

So, efficacy is the ability of a drug to produce a more intense response, as its concentration is increased?

[@samuelserrykamara8648]

Thank you very much but I want to know why stones don't enter the appendix

[@tbac2432]

Professor I love all your videos. Yes some I scratch my head because I do not understand but I do go to your play list and start from the first one. But I have a question for you, How do you do the videos with out moving your hands? All I ever hear is all Italians always talk with their hands. I am kidding sir. I had to. My son was watching this video and said dad this professor is a fake Italian because he is not talking with his hand like you do.

[@silly2717]

Can you please make a video on long divison please im in 4th grade and i rlly need help :(

[@ProfessorDaveExplains]

i did that! check my mathematics playlist

[@silly2717]

@@ProfessorDaveExplains oh ok thx

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Hie Professor Dave . Thank you so much❤.

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Not sure if it’s the way he talks or the pictures in the presentation but it’s working for me 👍

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INCREDIBLY HELPFUL!!!!!

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First

[@shmatan]

Do one of drugaddiction aswell

[@ProfessorDaveExplains]

check my biopsychology series for that one!

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Sure is

[@alreadymarked]

Professor Dave, I wonder what are your degrees?

[@ProfessorDaveExplains]

BA chemistry, MA science education

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Haha...so good man. I love your pedagogy!!

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[@tasneembadier6790]

I had a hard time understanding this topic, but after watching the video I discovered that the topic is easy. Thank you very much

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am glad i found this video on time

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Will you upload More vedios, Please

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Awesome ! Thank you...

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[@Mariiiam]

Continue the series please :)

[@busobubutamirat]

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[@tariqhassan3046]

Thank you

[@ghitaderraz9101]

Professor Dave did u cancel these series?

[@ProfessorDaveExplains]

no i'm planning more right now!

[@graceusa3942]

These are the best teaching. Where can I see more of your teaching about pharmacology. 😭

[@ProfessorDaveExplains]

check out my pharmacology playlist

[@graceusa3942]

@@ProfessorDaveExplains Professor Dave, there are only five under your pharmacology playlist. I watched all of them. Do you have any other videos explaining drug classes? Thank you so much for your wonderful teachings. I love your explanation. They are the best on the youtube.

[@ProfessorDaveExplains]

I just hired a writer to expand the playlist, I'll be doing a ton more real soon!

[@graceusa3942]

@@ProfessorDaveExplainsThank you so much, Professor Dave. I searched everywhere on youtube and found out your teachings are the best. I will be looking forward to seeing more from you. I am saluting to you.

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second

[@celloivan]

We want moreeeeeee, pleaseeee

[@ProfessorDaveExplains]

don't worry it's coming soon!

[@drams8710]

Do you post any video on membership..?

[@babarazamsucks]

First!

[@thehandsomenipple3623]

Super helpful for my internship running assays at a biotech firm. I’m gonna be needing to look at graphs like these all day, so I better fuckin understand em

[@thehandsomenipple3623]

you never fucking fail me professor dave ur such a great guy for all subjects got me through physics and all sorts of other stuff i love ur astronomy playlist like i just love u man u have a good heart