Investigating second-line therapeutic options in hepatocellular carcinoma

Mara Persano, MD, University Hospital of Cagliari, Cagliari, Italy, discusses a retrospective study investigating lenvatinib versus sorafenib as a second-line therapy in patients with hepatocellular carcinoma (HCC) who progressed on atezolizumab plus bevacizumab. Multivariate analysis revealed lenvatinib to be superior than sorafenib, with better overall survival (OS) rates. There is no difference in progression-free survival (PFS) and objective response rate in patients treated with lenvatinib or sorafenib after first line therapy. This interview took place at 2024 European Society for Medical Oncology (ESMO) Gastrointestinal Cancers Annual Congress in Munich, Germany.
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