Ion Channel Selectivity: K+ Channel

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[@wynsday]

This also explains why sodium channels are much larger than potassium channels! More carbonyls are required to dehydrate sodium in comparison to potassium! Thank you so much for this video - it explained so much for me :)

[@layalalkhatib9694]

Thank you so much this is very helpful and what i love about your explanation is that you repeat the the information more than one time in different ways which makes the idea much easier ❤️

[@sung-wookher4381]

GOLDEN THANK YOU SO MUCH!

[@elizawilson199]

Thanks for this video!!! This is really helpful!

[@texastexas4541]

Excellent video, dude! Thank you!

[@satinderjit4]

This was very helpful!

[@juandiegodistefano335]

This video is a lifesaver

[@user-im8ou6ei3u]

the best explanation!!!!!!

[@darshandhanajkar5018]

Nice and simple Explanation...Thank u so much..Much appreciated

[@shenkathirraj]

Thank you! Your explanation was really helpful!

[@JosieGleeson]

This was really helpful, thank you!

[@MohitKumar-br3nm]

Josie Gleeson yes u r right

[@amalsalim-6562]

Sooo helpful thanx a lot ❤️❤️❤️

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Thank you!

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[@ngc-ho1xd]

That was awesome!

[@CatalystUniversity]

Thank you!

[@gurralamohankumar5838]

Thank u so muchhhhh

[@FaryalKhan-cx7kd]

Thank u soo much sir

[@IBTSaiyadaIqraKamil]

BRAVO wowwww thank you sir

[@eliasndaru9722]

Very useful video

[@zena8421]

You really save me♥♥♥thank u soo much❤

[@CatalystUniversity]

Glad this helped you!

[@applepie3639]

Holy f this helped me so much thanks a lot!

[@CatalystUniversity]

Thank you!

[@error_in_the_matrix4473]

thanks

[@khokhasadiq8040]

very helpful

[@grvever1575]

How many K+ ions can fit in the channel at one time? Can the K+ ions share the association with Carbonyl groups or can a carbonyl group only interact with 1 K+ at a time?

[@isaachester8475]

Question: Why is the opening so much larger on the inside than out? Why not just have the small opening the whole way through? Is it so that only one water cage can fit in order to orient the K ion correctly? Another question is, if there were an ion with similar radius and water cage geometry, it should fit through, right?

[@raychiu9735]

So it is backbom carbonyle that dehydrate the potassium?

[@trippleacemanflipper]

This is better than Tanks!

[@CatalystUniversity]

Thank you!

[@ozgeylmaz4106]

Thank you very helpful. But still can't visualize what exactly causes the conformational change for the openning of the channel.

[@mrjeevan5]

I think this channel is always open. Basically with ion channels you can have two types, gated channels or leak channels. Gated channels open due to a specific stimulus such as difference in membrane potential for voltage gated channels or ligand binding e.g. acetylcholine binding to Na+ channels in neurones which is therefore a ligand gated channels. Now you can have voltage gated K+ channels, but I think the one being shown here in the video is a leak channel. Its called a leak channel because is has no "gate" i.e. its not like the gated channels which open and close. In leak channels the aqueous pore is continuously open so K+ can "leak" out of the cell as it doesn't need to bind. Obviously K+ will stop diffusing out of the cell once the chemical and electrical gradients balance, but the leak channel doesn't provide a barrier to K+ movement, eventually it is the chemical and electrical gradients made by K+ movement which creates no net flow in diffusion.

[@ozgeylmaz4106]

@@mrjeevan5 good point thank you.

[@mawman9733]

Hydrated Sodium is larger than Hydrated Potassium though..?

[@amerakhaled4105]

Why is the cell membrane 100 times more permeable to potassium than sodium?

[@yandosan]

I think 1000 times is a better estimate

[@SubhanKhan-i3m]

😢❤

[@fungi42021]

Toke off