Voltage gated Na channels

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This brief video tutorial briefly discusses voltage-gated sodium channels:
0:00​​. Introduction
0:14. Structure (activation gate and inactivation gate)
1:09. Three conformational states:
- 1:24. 1. Closed
- 2:30. 2. Open
- 3:54. 3. Inactive (refractory period)
6:51. Where are voltage-gated sodium channels found?
7:24. In-a-Nutshell
7:30​​. Acknowledgements

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The clearest video covering this topic. Thanks

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[@ilikokherodinashvili2499]

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[@shesaidsomething1]

This is a great description of the voltage-gated sodium ion channels at the axon hillock and the subsequent propagation of the action potential down the axon. However, at 2:38 you explain the depolarization of the cell from -70mV. That depolarization is a result of the ligand-gated sodium channels opening when the excitatory neurotransmitters bind to it, allowing sodium (Na+) to enter the cell (making it less negative). That is how the cell actually reaches threshold, going from -70mV to -55mV (at which point the voltage-gated sodium channels open). You can find that description here. kzbin.info/www/bejne/eJO4lIqYqbudipY I do appreciate your videos and if I am incorrect please correct me. Thank you!

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[@TheNotedAnatomist]

No problem 😊

[@drewrobinson36]

Are there leaky channels that re-polarize the cell membrane as well?

[@moamel2486]

Thank you I have a question is the inactivation gate also voltage dependent or it’s somehow positively charged so that when the potential difference reverses and reach positive 30 inside the cell it will repel the inactivation gate and causes it to close Or all what I said is wrong But if it’s charged then why when the inactivation gate is closed it will not open no matter how strong stimulation is

[@TheNotedAnatomist]

The Na gate opens, inactivates and turns to the closed state all based upon the voltage of the membrane.

[@KD-um3sv]

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[@capgains]

So the gates open by the voltages?

[@TheNotedAnatomist]

Yes, in the membrane potential reaches a certain level the gates open and then they close when they reach another level

[@capgains]

@@TheNotedAnatomist so the charge of electrons causes pressure (voltage) which mechanically open gate?

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[@pawankumarmaddhesiya9272]

Nice

[@TheNotedAnatomist]

Thanks