Is Muscle Hyperplasia Real? (Science Explained)

[@Yupppi]

I love bringing on professionals in the field and scientists who aren't in the same media bubble as certain science communicators in fitness world. Casual viewers like me would never hear these names who are important in the fields otherwise, or get takes from a perspective of someone who has been working in the topic for potentially decades. I started weightlifting to damage my muscles for hyperplasia. Hitting the quads with a barbell a lot, getting bruises and stuff surely will grow it. Once I even dropped a 20 kg plate on my toe to grow it.

[@seaofseeof]

There might be another way to infer whether or not humans experience muscular hyperplasia, using methods from evolutionary biology/paleontology: phylogenetic bracketing, it allows you to statistically infer the likelihood that a taxon possesses a specific trait based on what (closely and distantly) related taxa possess. Basically, if hypothetically every other organism with muscle tissue experiences hyperplasia, including chimpanzees, the likelihood that humans were the only extant species to have lost this feature would be so astronomically small that it's far more reasonable to conclude that we do experience it, than that we don't.

[@willemjohannes9007]

I’m curious why we’d assume that hyperplasia doesn’t occur in humans if it’s been observed in animals. Even if it’s not a big mediator of growth, wouldn’t the baseline assumption be that it does happen, unless we find evidence to the contrary?

[@wizzelhoart]

not just animals, mammals more specifically

[@med_ayhem_benabda]

Same thought

[@qwertmom]

Because science is seriously stupid (sometimes). A 10 yr old could make the same assumption but that professor from the story in the vid simply said no because SCIENCE

[@colintidwell8902]

It seems absolutely insane to me that species as different as cats and quails both experience muscle hyperplasia from resistance and stretching protocols and yet somehow we assume humans are different. Why? Do we have any reason to think human skeletal muscle development is so wildly different? To me, the null hypothesis should be that it does occur in humans, since it seems to occur in all of the different species we’ve studied (animals as different as birds and as similar as other mammals).

[@greglnuckols]

Yeah, that's the way I tend to view it. Like, I'd understand a high degree of skepticism if it has just been observed in birds (birds' muscle fibers are different in several ways, mainly owing to the fact that the energy cost of flight is in order of magnitude greater than anything land mammals do), or if it had just been observed in the context of extreme stretching protocols. But, since it's also been observed in multiple mammalian species, and even when using protocols that mimic "normal" resistance training relatively well, I think it's fairly reasonable to assume that it can occur in humans as well.

[@ArnovanWyk-q2j]

I am inclined to agree with you, but I think the skepticism comes from digging through all those cadavers, they have a pretty clear picture of what they'll find with regards to bones, muscles and organs and it seems for the most part that even the higher fiber counts did not ultimately result in visible change to the muscle groups so it leads them down the path of defining abnormal or "significant" change and using this as a measurement - it doesn't make sense that we would not grow more fibers but it would probably come at the cost of some extreme trauma if it would be "significant" . . . the other argument is that many animals can regrow teeth, we cant, regrow hair where we go bold etc. ultimately I'm rooting for your argument.

[@RainbowFishSaysHello]

They taught a cat to pump iron?

[@Mostlypeaceful896]

Ooh fancy name. Where do I inject it?

[@WeighedWilson]

You have to download it.

[@bennconner1195]

Cats can add muscle real easily because they’ve evolved to maintain muscle while living a sedentary lifestyle.

[@gokukakarot1855]

Maybe those Seal Rows and Reverse Nordic Curls we added will add some fibers!!!

[@samuelhofmann2481]

god damn this has quite a few implications i might start experimenting with training very heavy for only ecentrics maybe i could make entire training blocks only training that way

[@zachdowdell583]

Why not just look at a pair of deceased twins, where one lifted weights and the other did some other form of exercise (or was mostly sedentary)?

[@RyanMcDonnough]

Great stuff

[@mcwillip]

Have we seen muscle hyperplasia in pigs?

[@hackelite01]

Have you looked into deactivation of the myostatin gene?

[@utubebrowseupload]

Well done episode milo, i liked how you interviewed the scientist and put it in the video, it gets kinda dry listening to you speaking the way you do sometimes. Especially when you try to sound too academic. Good stuff.

[@rajasmasala]

Good point ! I just noticed how smooth the pacing was after you pointed it out

[@jdabramson]

Thank you

[@danielbukovsky9517]

What about GH and resistence training?

[@danielstarr9037]

He said “Dragon Ball” as opposed to DBZ, is he a real og? Were you digging into DB manga as a youngster? These are also questions that need answers

[@scottlepsch]

Is there something that only muscle fibers would absorb when repairing? Wouldn't it be neat if you could make them stick out like celery fibers when it absorbs colored dye?

[@ksefchik]

Has anyone ever told you how awkward camera 2 feels? Can we like get the camera moved back and at a higher angle? Just for kicks for a video or two?

[@Jotto999]

Are there any animals confirmed to have NO hyperplasia? If not, then it seems strange that humans woube the only ones, on priors.

[@rooftopmadrid2402]

As long as my muscle gets bigger when training, I don’t care if it’s because my fibers get bigger or because I create more fibers. Just grow!!

[@brandonyoung4910]

Sick wheels bro

[@EricTMillerFL]

Hello sir. I have more wisdom than intelligence, so forgive my medical ignorance to the science as it applies here. Thanks first of all for vastly opening my eyes to scientific terminology that applies to my belief and application towards my training. Ignorantly I have rehabbed multiple injuries without any medical direction, I believe in my case I have experienced muscular hyperplasia. In reference to scientific application for proof. Idk about actual biopsies or on paper measurement.. but isn’t there a similar phenomena within the Muay Thai community. The body adapting to repeated micro fractures, and developing new bone density, and calcification. I wouldn’t doubt that the surrounding musculature would do the same. Tendons, ligaments etc. I wouldn’t be surprised if the meninges themselves were more dense than a normal subject. I’m sure that strength and density play a huge part in the restructure, but these examples to me would be a clear situation of damage that: if hyperplasia occurs in adult humans, it would occur. Thanks for your continued work and sharing with the community. You have provided immense knowledge that has helped me beyond measure. 🙏🏼

[@Christian-tw3sp]

This guy has been watching genetic beast

[@wdadwawdadawdwdwa4133]

Is there any evidence for hgh intluencing hyperplasia ?

[@soonahero]

Zygote to baby?

[@ozzy6162]

Kevin says that if hyperplasia does happen in resistance training then it's under extreme conditions. So why has there been no studies comparing two groups of bodybuilders, one group on anabolic steroids and the other natural, at the beginning and end of several months of training ? Several such studies may indicate whether Kevin's hunch is right - hopefully despite the problems mentioned in checking if hyperplasia has actually occurred in humans.

[@Yupppi]

There might be few reasons. Like why there is no research on anabolic steroid users.

[@ArnovanWyk-q2j]

Dr Wolf, have they looked at tissue density along with circumference? I would point at training along with things like TMG that have been observed to increase muscle density - that could be a sign?

[@CharlesOffdensen]

What if I am punching my muscles during exercise? Say I am doing reverse Nordic curls and I am using my hands to punch my quads?

[@ozzy6162]

Milo - have you asked King Nuckols 👑 whether he will agree to the production of Stronger By Science t-shirts & sweatshirts? You promised to ask earlier this year. I can't understand why this isn't already being done. Selling t-shirts etc., is a good revenue stream - come on Greg it's the 21st century.

[@mysticmarval]

What do you think about the use of a Neubie with training using it at high intensities inconjuction with the training techniques and methods?

[@moneymaker-ju1mq]

i think dr milo wolf needs some occlusion training

[@Gustaveitorland]

Yo, Milo, I've been going around some science based channels asking for somethign (if anyone will do some brief insight on this) I have hypermobility with EDS and when I train weights and things overall seems to be "different" (like ranges of motions and stuff). I saw progres in my current first year of traning (6xW), but my joints are pretty fagile even though my ranges of motion are kinda mad (plus the problem of joint stabilization). Question is : Is there any relatable source for traning with EDS? What should I have to consider ? Can you explain in detail (if possible) info that I might not know ( because I have almost no info except my own experience) on a video? or at least some key things that I have to consider Example of joints issues : I started benchpressing ike only the bar 20kg. Now almost 1year I can do it with 80kg BUT depending on how stressed (mentally) I'm because some times both of my shoulders dislocate (or my wrists) so I have to perform most of my excercises with very small (to my proportion) weights and lots of reps (20 or more) because sometimes just a lilbit more of weight I feel the joint close to dislocate or just it does. So also knowing which type of exercises I can perform (that needs less stabilization) are good. (dumbbell chest press sucks for me, but barbell is ok, machine sucks because I have 0 range of motion (for my issue)

[@Gustaveitorland]

Also consider that I've went the hipertrophy route because I need "better muscles" because I basically live in pain 24/7

[@Yupppi]

I'm not sure if this is the same, but there's a medical doctor on KZbin doing comedy but also educating with the stage/channel name Dr. Glaucomflecken. They do a podcast with his wife and one of the episodes was with a doctor on something like this, her wife has it and they discussed it in length. So maybe you can find some sources/names that would help through that. The wife mentioned how it was borderline impossible to find information on it until she met the doctor in question.

[@Gustaveitorland]

@@Yupppi thanks

[@gokukakarot1855]

For the algorithm

[@TheHybrid350]

Great

[@alixagaf]

That is, it makes sense to periodically arrange heavy workouts when the muscles hurt for a week. At best, this will cause hyperplasia, at worst a slight hypertrophy (compared to the one I could get from 3 workouts in a week)

[@robertseavor4304]

Alternatively, stop being obsessed with the size of your muscles. It's not healthy. Increase strength and endurance.

[@choosetolivefree]

Its a passion, not obsession. Anyone who is passionate about it will approach it with a fire inside

[@Yupppi]

Funny you say that when a very reliable way to increase strength is increasing the muscle size. And how endurance exercising seems to be an easy method to overdo exercising up to injuries or issues.

[@robertseavor4304]

@@choosetolivefree If you're passionate about what you look like it's an obsession.

[@robertseavor4304]

@@Yupppi Your inability to understand simple statements is annoying. Bugger off and admire your reflection. And keep on being a pussy.

[@choosetolivefree]

@@robertseavor4304 I'm not passionate about what I look like. I'm passionate about pushing my body to it's limits. I'm passionate about being energetic and strong. I'm passionate about respecting my body, and giving it all the love I can. Call it an obsession if you want. It's the healthiest and most satisfying obsession I've ever chosen.

[@Leonidas-eu9bb]

True Overload eccentric do it. But it's not that what you think. It's practically very difficult and dangerous. True eccentric overload leads by definition to injury! It's for example jumping down a box with a relative heavy barbell on your back. 😮

[@471444a]

Those animal studies are insanely unethical jesus Christ. 😢

[@davorzdralo8000]

You know that lab animals are euthanized in the end anyway, right?

[@hellrrrr7751]

Actually first :)

[@gerym341]

Congratulations

[@servethesongs]

nerd

[@rafael_ellanios2708]

Train every muscle x3 per week 10 sets per muscle per workout? Rest 1-2 min between sets? Sets 5-50 close to failure 1-2 ???????

[@taylorhillard4868]

?????????? Indeed. That about sums up the sentiments i feel every morning looking in the mirror.

[@servethesongs]

Thats way too many sets and typically counter productive

[@quantifiablyqorrect2905]

Push yourself and be consistent is all one needs

[@davorzdralo8000]

Way too many sets for 3x per week. Either split that up over more days, or lower the volume.

[@taylorhillard4868]

@@quantifiablyqorrect2905 haha. Good one

[@royalchamp]

2nd

[@servethesongs]

You owe us 14 minutes of our life back

[@dyl923gonz7]

why

[@peterfarr9591]

He provides free educational content on KZbin and you think you are owed anything?

[@DILFDylF]

I'll give you the best 14 minutes of your life

[@quantifiablyqorrect2905]

Why are scientists doing studies on animal muscle growth.....what a waste of time and money and attention....

[@glenoh88]

Ok, are you volunteering for experiments? Let’s ignore the exercise crap, let’s just use you for life saving interventions. You want to be the first live animal to test any potential life saving cancer treatments?

[@The_Patbey]

Why would it be a waste? There's not a big difference between animals' muscles and humans' muscles.

[@glenoh88]

@@The_Patbey there kinda is. A rats lifespan is way shorter than a human…cancer growth rates and effects of drugs on rats vs humans is not really known. Their metabolism seems faster than ours. But we can’t ethically test on humans…just some simple example of differences.

[@The_Patbey]

@@glenoh88 Sure, I'm not saying there's no differences, I'm simply saying that the general mechanisms in our bodies are relatively the same, compared to other animals. If you only knew what human muscles looked like, and inspected some other animal's muscles (obviously not something like a jelly fish of course), you'd still be able to recognize it's a muscle and see plenty of similiarities

[@greglnuckols]

Virtually everything we know about mechanisms of muscular adaptation originated with animal research. You can do studies much faster, for a way lower cost, with DRAMATICALLY better controls. It would be a much bigger waste of time and money to not do animal studies.

[@thatsit7933]

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