Is This About To Revolutionize Antidepressants?

[@SciShow]

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[@patsonical]

Love the technical terminology of "cheapo" EEGs and "swanky" EEGs

[@CrimsonCat87]

The true swanky ones use gold electrodes! So fancy

[@abydosianchulac2]

Whoa, I was a subject for EMBARC back in 2013. Glad to know they've finally gotten their data together.

[@nicholsonastrid]

I appreciate the use of "machine learning" as opposed to "AI", it's quite annoying to see the two so often conflated

[@Th3Shrike]

Problem is now everyone just replace "smart" branding to ai. Its not a smart bulb now, its a light bulb with ✨️ai✨️

[@conlon4332]

Are they not the same thing? Like, if a computer can learn, is it not artificially intelligent? I thought anything that teaches programs with data sets, in oppose to simply programing everything they do, is AI.

[@nicholsonastrid]

@@conlon4332 AI is a very specific term used to describe a computer so advanced that it gains sapience, machine learning is a much more broad term describing an algorithm that can iterate and change itself. the difference is that machine learning is real.

[@NNTorious]

​@@conlon4332 Machine learning is algorithmic. It gets a feed of specific information and does a specific thing for it. AI is basically provided a data set and they're able to make their own answers. Machine learning: you leave everyday at 6 do you want an alarm AI: you leave at 6 everyday do you want me to go into your email and sort through which ones I find most interesting and summarize them.

[@kewakl8891]

@@conlon4332 machine learning is a BRANCH OF AI ya know, like rectangles to squares not every rectangle is a square, not every AI is machine learning

[@anabelleharvey9342]

It was always the most frustrating thing in dealing with depression: getting the meds right and cutting out all the noise and subjectivity out of the results. Hopefully neuroscience can bring harder data points to the process in the future.

[@WingedAsarath]

Sertraline, now we've worked out the correct dosage, has given me my life back. No more intrusive thoughts, no more panic attacks, no more sudden breakdowns. In my case there seems to be a genetic component, due to a family history of anxiety issues and Parkinson's, and me also having ADHD and Restless Leg Syndrome (the latter three are all linked to issues with Dopamine production in the brain). Also, for the conspiracy nutters: I only went on meds after years of therapy failed. And I'm British so my meds are covered by the NHS and I only pay £9 every two months. No 'big pharma' in this case.

[@BeautifulBeansCheese]

Sertraline has helped me out super much too

[@3800S1]

I have RLS that comes and goes. I have had a very bad time with all psychotropic drugs, SSRIs the worst of all for me. I was misdiagnosis with drug resistant depression and was put on some rare combo of hard core stuff after reacting very badly with nearly all classes of ADs and it helped with the RLS initially as a side bonus, but I became dependant on the drugs pretty quickly and the RLS came back worse than I ever had it plus other odd and rare side effects. So upon tapering off and quitting I got severe and disabling withdrawal that are still on going nearly 3 years on, and the RLS has been quite bad and then I have periods it goes away completely. I recently learned that I most likely on the ASD and that explains a lot of the odd neurological quirks I have had over the years that come and go to change into something else.

[@craigpardy6204]

It was some of the worst few months of my life trying to come off setraline. I was having blackouts in work and I only sleep an average of 4 hours a night now. Be careful and don't stay on them for too long.

[@rlud304]

⁠​⁠@@craigpardy6204If a med is helping why would you get off it? That makes no sense

[@craigpardy6204]

@@rlud304 it wasn't helping at all, that's why. Also no doctor should be leaving you on this medication indefinitely. And there are also bad doctors who push medication regardless if it helps or not.

[@Anon1694]

5 months into Lexapro, and I feel balanced. I can finally have an easier time practicing meditation, and an easier time observing my emotions.

[@auditoryeden]

For those who've been around the whole carousel of antidepressants without relief, it can be useful to talk to your doctor about mixing different meds. I was on Pristiq, then Viibryd, then Effexor, then Lexapro, then back to Viibryd, then Wellbutrin... until finally I was placed on a Viibryd/Wellbutrin combo and got my life back after almost ten years. Neither worked by itself, but together it was like magic. Brains are super weird. It's important not to mix meds without a doctor's supervision, though, because of serotonin syndrome and other fun issues.

[@stax6092]

I think for something like this 60% is pretty damn high considering all the variables in any individual with depression, so this group study is great news to me as someone who suffers and has been from pill to pill because of depression. That being said, I have been through it for such along time I have narrowed down a lot of it myself through trial and error. I was even one of the first people to be on experimental medication from Mcmaster University and their early psychological study days. It may be meaningless for me now, but I do hope this study makes the future more bearable for people with depression and they don't have to go through the very chaotic experimentation I did. Good luck to all you out there suffering, it may not be much, but I hope anything lessens your pain even a bit.

[@hannahnfvideos1043]

I said the same thing! 60% is fantastic especially when you’ve wasted so much time trying and trying different meds. I was lucky in that I was started on Lexapro and it worked the first time at the first dose tried, however, I have a friend who has tried over 20 different antidepressants and been to at least 6 different psychiatrists and still has no relief from her depression. I wonder if something like this had been available, if she would have saved a lot of time not trying meds that probably wouldn’t work. She’s now trying ketamine which has great promise for others so crossing my fingers she will finally have some relief.

[@larrywalsh9939]

My doctor put me on Prozac for severe depression, but as it turns out, taking Prozac has not fixed the climate crisis, paid my mortgage, or made the bulk of humanity any less shockingly stupid. Maybe I need to up my dosage.

[@chrisdsouza8685]

😊

[@rlud304]

The bulk of humanity is not stupid. The bulk of Americans are stupid. There are like these whole other countries that exist that are Not the US. But as an American you probably don’t know that

[@jaimerivera4332]

Thank you for a REAL comment. This video hurts my soul. So much effort to create things that solve problems we create for each other.

[@rlud304]

@@jaimerivera4332 What are you blathering on about? Do you have an actual point?

[@jaimerivera4332]

it was included in the comment. Sorry you missed it. Have a good day! @@rlud304

[@SpaghettioRegrettio]

GURL. Ive been on 4 different antidepressants over the last 8 years and each one don’t even TOUCH my depression (But they really alleviate my anxiety which is cool). However, every time i have changed my meds it’s almost like the doctor wants me to shut up and get on with it. So i would LOVE some sort of scan to make this process more streamlined.

[@Canadian_Skeptic]

I'm curious about how one would qualify for this test. There are so many factors to consider, such as environmental, genetic and chemical imbalances. We don't always have the choice or ability to change the environment, so I hope the screening process is thorough. In some cases, counselling can change a person's perspective. There are no simple solutions. I truly hope it helps to maximize the effectiveness of medication for those who have no other option. A positive outlook is healthy, but skepticism promotes advancement.

[@Plantbliss]

About 5 years ago I got genetic testing done to see which antidepressant worked best for me. It turns out in all the years I’d taken these types of drugs I’d never been prescribed one that benefited me. The correct med plus weed and I have my life back. Hopefully this is cheaper. Though the testing I had is much cheaper now itself.

[@morg630]

How would I go about seeking that sort of test? I've been on so many different antidepressants and none of them have really worked, and I'm getting desperate for a solution :P

[@bjdefilippo447]

@@morg630 That's been my experience also. Crossing fingers I can try this, as depression runs in my family.

[@harmonicaveronica]

​@@morg630do you have an EAP (employee assistance program) through work? Lots of people have them and have no idea, especially at large companies. If you aren't sure, ask whoever coordinates employee benefits in HR! You may also be able to access one via your spouse's work too if you're married. Basically they provide short term counseling on all kinds of stuff, and I bet they'd be able to help you find a therapist that offers it near you. You might also be interested in enrolling in a study on psilocybin - you can find studies at clinicaltrials(for)gov. It's not approved yet, but therapist-supervised shrooms have some really promising results for treating depression so far

[@Plantbliss]

@@morg630 my primary care doctor suggested it. But the company that did it is called GeneSight Psychotropic.

[@alice88wa]

I too would love to know more about this. Can you share the name of the test? Was it covered by insurance? Is it a third party private company? Do you go thru your doctor or thru the company? How much did it cost, when you got it done? Was it only for antidepressants or was it a broader spectrum test?

[@LikeEmmaWithaT]

As a person who can't take SSRIs, I really hope these studies expand to classes of drugs. Bc omg that would be game changing

[@dextro2090]

Why can u not take SSRI?

[@3800S1]

@@dextro2090 Probably adverse reactions, I can't take any psychotropic drugs whatsoever and have high probability of permenant neurological injury from trying these drugs for that exact reason.

[@FenrirAldebrand]

Same here! They give me serotonin syndrome! So I'm on Vyvanse for my ADHD. Literally the only ADHD med that doesn't put me to sleep.

[@MachFiveFalcon]

Same! I have OCD which caused me to be depressed, and therapy has done a lot more for me than SSRIs ever did.

[@TomSaysStuff]

This would be great. My experience with Setraline was really poor. Night terrors/sweats and constant exhaustion was not a fun 3 month "lets see how it goes" experience.

[@LibraryAce]

What a crap doctor. You shouldn't have had to go through 3 months when it was obvious it was doing far more harm than good.

[@astralb.2647]

SSRIs haven't worked for me. Now I'm on a NINE MONTH waiting list to see a psychiatrist to discuss possible changes. And like... Idk if I have that long in me. Between depression, anxiety, chronic pain, and rapidly declining physical health, I'm kind of hanging on by a thread. 9 months is just way too long.

[@missashleymacmacmac]

i’ve been there - i waited 13mths for an appt that wasn’t even covered by insurance. the time passes anyway

[@redbloodedbutterfly]

I'm in Illinois, USA. May I ask where you live where the wait is 9 months?!?! Is it the lack of psychiatrists accepting new patients, that your health insurance only covers a few providers, you being physically unable to get to another psychiatrist, etc? Depending on the reason for the absurd wait, I recommend contacting your health insurance to find out what other psychiatrists are in-network. Then call each of them, verify that they take your insurance, and ask if they're accepting new patients. If the appointment date is still far out, ask to be put on a cancellation list. Call places that are hard to get to and ask if they do Zoom appointments. (My psychiatrist does Zoom appointments.) If that still doesn't work, talk to your current doctors. Your primary care doctors *might* be willing to help with mental health meds if you explain that you have no other option. You can also try contacting mental health non-profits in your area to see what they suggest.

[@astralb.2647]

@redbloodedbutterfly Thanks for your comment, and your tips. I had the luck to be accepted for an intake in a city 30 miles away. I am just finalising my permit for the use of a wheelchair taxi! Hope it'll go somewhere positive!

[@redbloodedbutterfly]

@@astralb.2647 Does that mean you already had your intake appointment? I hope you're able to get your permit quickly, so you can travel more easily.

[@astralb.2647]

@@redbloodedbutterfly appointment is in two weeks :)

[@Anson120]

I have trd and after 30 med trials I settled on high dose Venelafxine. It just helps a couple of my symptoms. I also use another "controversial" substance. I am still bad ,but it is truly saving my life. It helps my extreme anhedoina around 40% ,and that is huge for me. It starts with a K shhhhhhhhh lol

[@poetz123]

There are no narcs here, you can say kokaine. No one will judge you

[@LB-ge8ih]

Was your K administered through infusion, or through nasal spray? My insurance covered the inhaled version, but it didn’t do much of anything for me. Of course the injected version is still not covered…

[@poetz123]

@@LB-ge8ih you can't inject kokaine, you snort it

[@phelan8385]

​@@poetz123they're talking about k3tamíne 😂

[@poetz123]

@@phelan8385 yes I know lol, I was joking

[@MrQwint22]

As someone who recently discovered he's been taking the wrong antidepressant for two decades, it makes me happy to know that, hopefully, others won't have to go through that whole process in the future. (To be clear I don't really blame my doctor for the situation, I was in high school when I started and likely lacked the self awareness to asses things.)

[@gorawesome1]

I wish gene sequencing was mentioned as an alternative already in use by psychiatrists in the US to personalize medication for depression, anxiety, etc

[@IridiumGaming]

Gene Testing doesn't indicate how well an antidepressant will work, though. It only tests how well your body will metabolize the drug in question. Some tests do include like 3 or 4 mutations you may have in your receptors, aside from the metabolic bit, but those tend to have little scientific literature backing those up

[@happycowsfromwyo]

@@IridiumGaming Ya I would know. I did this testing and the only anti-depressant that was in the "green" column was Pristiq...6 months later, I ended up in a mental hospital. I've been on 20+ different meds in the last 10 years. This test did nothing for me.

[@aliengeo]

Yeah, I'm also in the 20+ club, and unfortunately my experience with genetic testing was not inspiring. The medication class that causes me severe neurological problems was listed as "green," as was almost everything else. The one yellow, which I'd already taken, wasn't even worse than the greens!

[@StormTheSquid]

The problem a lot of you are seeing is this: It's not 100% accurate. It can't guarantee you'll have positive effects, or any effects. It's just better than pure trial and error for a majority of people, because you then have a starting point.

[@dothedo3667]

They're pretty garbage.

[@BardovBacchus]

Having tried most RSSI inhibitors, I have been wanting this test for a long, long time

[@flateo334]

do you mean SSRI?

[@BardovBacchus]

Whatever TF they are called, @@flateo334.

[@wtice4632]

But have you tried improving yourself?

[@BardovBacchus]

Like Yoga, meditation, breathing exercises..? @@wtice4632 I have a therapist. Thanks for your concern

[@KY_CPA]

I recommend asking your Dr for a genetic test for medications. My psych office did and it's made a HUGE difference. Decades of bouncing around and now over a decade on the same one

[@deetlebee]

I'm on med number 13 so this would be really cool. I know a few places sell DNA-tests that claim to be able to predict side-effects of meds to help narrow the list down, but from what I've seen it is inconsistent at best...things get better all the time though. Hopefully this is another avenue doctors can use in the future.

[@TheColorsInGreyLife]

This was something I was talking about for ages after going through 2 years of finding no help with meds! I'm glad they are finally able to start with some more information to help them recommend meds that might help from the start

[@christianavance9124]

It would be nice if there was a similar process for ensuring that the diagnosis is accurate 1st. Often a med doesn't work because the diagnosis needs to be adjusted. I've actually had multiple professionals offended by my original diagnosis as it wasn't even in the same class of issues I actually have. I've also had a friend medicated for a diagnosis she showed no signs of but her father and 1/4 brothers had (it's also more common in males) the standard medication that was also started at way too high of a dosage basically put her body into a near comatose state and would have killed her if she had continued it. I was given the same med at its lowest dosage for a different diagnosis and it activated an auto-immune response.

[@TheZinmo]

I was finally diagnose of bipolar disorder (the one kind without much mania if any) after 20 years of more or less working treatment of the severe depressive (bipolar) episodes as regular depression. It did not really work, treatment against bipolar finally did.

[@Camrographer]

As someone with chronic depression this new technology will be much appreciated.

[@CyntaxEraNZ]

Love this. I spent 30+ years on different antidepressants targeting serotonin with little effect. Shifting from an SSRI to an SNRI (serotonin and norepinephrine reuptake inhibitor) had only slightly better results, but was only when I started on the NDRI (norepinephrine and dopamine) I'm on now that I've noticed a much bigger difference. Friends had previously suggested I get tested for ADHD as another friend who shares a lot of similar behaviours with me was recently diagnosed. Turns out that the NDRI I'm on now is also used (off-label) as a non-stimulant ADHD medication, so sounds like these studies could also be useful in assisting in the diagnosing of other neurological conditions.

[@caroljo420]

SSRIs saved my life. Nothing worked before that. I got Prozac when it first came out, and it was amazing!!!

[@markae0]

SSRIs ruined my life

[@tamfuwing1]

You're lucky. Especially since the makers of Prozac lied about the efficacy of the drug originally.

[@chrisweaving5307]

I came off antidepressants 3 days ago (low dose) and I am starting Med school in September, this is a very exciting and curious topic to pop up on my feed! Thank you!

[@KY_CPA]

My psych did genetic testing after decades of having to switch every couple years. Turns out the only meds I had a low likelihood of responding to were antidepressants. Once we got on one of the good matches, I've not had to switch meds in over a decade now. I HIGHLY recommend the genetic testing!

[@NezuChan]

I tried genetic testing and it only succeeded in putting me on something that failed miserably. It did sort of reinforce what I thought all along though, most, if not all antidepressants do not work for me. I am currently treating my depression without meds at the moment. I am happy that it was able to help you out though!

[@Plantbliss]

Agreed! I did that testing too . I had tried so many. If it’s possible to get the test it’s so worth it. If you’ve tried half a dozen you start thinking they’re all the same or you’re just broken. So it’s worth it for sure

[@htopherollem649]

​@@NezuChanhave you, by any chance, experienced a brain injury (from concussion to TBI) ? this can cause you to have altered brain chemistry and be the reason why a variety of medications do not work for you (in the ways they predominantly work for others)

[@NezuChan]

@@htopherollem649 Doctors think I may have had a brain injury, but nothing showed on scans after a medical emergency with prescription drugs. (Non opioid, non narcotic.) This occurred after my testing, however. I have a formal ADHD diagnosis and I may or may not be on the autism spectrum, so I wonder if that might affect things.

[@EddieTheH]

​@@htopherollem649 Concussion *is* a TBI...

[@CistudeSuisse]

Crazy, I'm in the middle of the trials of new antidepressants right now. What a video full of hope to get rid of the uncomfortable and sometimes painful and long process to find the right molecule.

[@GhostsOfThings]

If this could become a thing that would be absolutely amazing. My first trial with SSRIs was so bad that I can't bring myself to try another one. If something like this could narrow down options rather than the "I don't know maybe try this one?" system that's happening right now, that would totally change the game and give me some confidence to try again.

[@ajchapeliere]

This is really promising and I hope it can be expanded on. It would be good for everyone involved to take some of the guesswork out of medication options for mental illness. Being anxious about trying to find the right anxiety treatment is four layers of stress too many and no, I have no idea where the extra layers came from.

[@firelunamoon]

These sorts of developments are SO needed in psychiatry. Hope we begin to see more effective, accessible interventions for psychiatric conditions enter the clinic.

[@deiterp3912]

Psychiatrists really need to start using these kinds of technology. Right now, psychiatry is generally a field of educated guessing.

[@dawsie]

I must be one of the most luckiest person alive then, I did not go through all of that when first placed on my meds, I was on them for 7 years when they stopped working and had to be switched to a new drug, again they work great, the only problem was it stifled my creative side so much, but once my body had been on the new meds I noticed a difference, I was more creative and wanting to do my artwork again after almost 8 years, the new meds are working and I’m finally designing again.

[@DaveSomething]

SSRI makes me feel like I'm dying... doesn't help me with depression. so the "learn to live with it!" is the treatment I'm still on.

[@Finvaara]

There are still other classes of antidepressants. Giving up is the only thing certain to never work.

[@__-pl3jg]

I've tried/researched so many psychoactive substances I could be a doctor by now. Hands down the best was Psilocybin mushrooms and DGL licorice. NOT a macro dose. Just a small microdose in the morning before heading out to work. Cannabis makes you forget your problems but Psilocybin changes your brains function in a way that allows the user to think themselves out of the problem. It makes you smarter and the DGL licorice enhances the effect significantly.

[@Giggjsjwhdicm]

It took me somewhere between 5-7 tries to find the right medicine, SSRIs did not work for me either, but an SNRI did. It took forever but it's so worth it!

[@piddlydiddly]

@@Finvaara NHS gps will only prescribe very few (ssri/snri/mirtazapine) without constant psychiatry input, which is only generally given to people with significant diagnosis (scizophrenia, bipolar etc).

[@Psilomuscimol]

I take kratom. It's addictive though. The withdrawals are nothing compared to the brain zaps from stopping antidepressants cold turkey(you should taper)

[@Erik-pu4mj]

Left off on bupropion and escitalopram half a decade ago, gave up on finding a working med for years, and recently returned to the slog with escitalopram. What I'd give to find something that just... did something helpful.

[@DFSJR1203]

Psychiatrist I have seen for depression have tried me on more medicines than I can remember. All of the medicines that have been given to me over the years caused a deepening of my depression. I am afraid to see another doctor as I have had such bad luck with psychiatric medications.

[@liamfoxy]

Might be time to try more experimental treatment like ketamine therapy or psylosibin

[@elizabetha8565]

I wish they would do a video on NMN it's been a life saver for me!

[@GovilGirl]

Currently, the "try this for a few month and let's see" approach has an efficacy of less than 20% so a 60% efficacy is really high! My experience was with genettssting and although symptoms seemed like a SRI was needed, labs pointed to a SNRI. That genetic report nailed it perfectly and the drug it selected (by eliminating others) provided massive improvement with little to no side effects.

[@lomalanni]

I'm very lucky in the sense that the first SSRI I ever tried worked decently for me. I've had to up my dosage a few times, but I'm still on good ol' fluoxetine.

[@izzyxblades]

My psychiatrist got it right the first time, and I know that's not normal. It is really tough when the person and their doctor has to keep trying different ones

[@Ilix42]

Hey, I take Escitalopram, but I always call it generic for Lexapro because I can remember that more consistently.

[@thingamabitch]

If I had previous testing, I wouldn't have post-SSRI syndrome right now.

[@kyesickhead7008]

I love how much time, this is gonna take to reach my country.

[@undrhil]

I think there's Merit in continuing to trial different flavors of the same class, as you put it, since some people might react differently to the different flavors of the same class. And if none of the flavors work then you can Branch out to the other classes in the testing.

[@ianlewis4383]

Went through a rough period with debilitating anxiety/panic attacks and lexapro (escitalopram) was a lifesaver. It’s a big commitment since the “come up” period for it is a month, making it hard to “try out” like video alludes to, but once it stabilized I could actually function again.

[@KarynPeterson]

It took about 14 years to get the right antidepressants for me, after so much trial and error and not finding the right one. Turns out I needed more than one. I hope this can lead to people getting the right meds sooner on a broad scale!

[@bjdefilippo447]

They were doing some experimentation with SPECT scans about 15 years back to aid in psychiatric interventions. I'm intrigued by the new ideas.

[@gregsettle9725]

Sixty percent is huge for a study IF results can be reproduced in a larger group. Insurance might even pay for the EEG if it means not paying for a run of drugs for testing.

[@KatV1Beta]

I went through 5 other antidepressants before getting on trintellix- its been a life changer

[@sooperchiz]

If not done so already, we could go one step further and do trials of psychiatric drugs on "mini brains." They are currently heavily regulated and are specific developed cortical regions rather than full-fledged human brains. Perhaps we could target the drugs in neural areas key to depression/other psych disorders as well the regions likely to experience drug side effects for better evaluations. Since the "mini brains" are based on human DNA, maybe DNA trials of similar matches between patient and experiment could prove insight into which symptoms get activated by the disorder and which drugs may be more compatible in each patient/similar patients.

[@beirirangu]

Even 60% is LEAGUES better than the 20-30% most seem to be at

[@xellos305]

Fascinating I love the concept!

[@mikamekaze]

As someone who has been struggling with the weaning process of getting off an antidepressant that gave me the extremely rare side effect of very, very bad withdraw symptoms... This is so insanely promising.

[@masonmontgomery5025]

I have the exact same problem, you are not alone.

[@iceman5413]

After over 2years of being on a very strong anti-depressant, it actually lead to more issues. They didn't tell me that I'd become reliant on them. I tried for months to slowly wean off. It got bad and I didn't think I could do it. I finally had enough and quit cold turkey. Went through a couple of weeks of bad withdrawals. My mom stayed with me for the first few days. Now I always ask about becoming addicted before I take any meds.

[@Lara-rj5fi]

It's not rare, even tho they say it is. Ive had the same just trying to get to a lower dose.

[@reilley26]

This would be great but I remember learning about using brain scans for diagnosing different psych issues years ago and that still isn't a common practice in diagnosing.

[@angedejeudi]

I'm skeptical of this, compared with the blood test that was being tested, since so much of people's complaints isn't from it not working on their depression, but the side effects being considered not tolerable.

[@soapygrape777]

I am praying for this.

[@_____alyptic]

This is interesting, switching from Sertraline to Escitalopram now :O

[@erinbailey4631]

I have a spreadsheet of 17 antidepressants that doctors have tried. We even did a metabolic dna panel to see what my body would absorb the best. A quicker and leaner process would have been helpful. I’m stable now, but those last 9 years of struggle was a lot, and I’m one of the lucky ones.

[@liamfoxy]

Amazingly i did get mine right the first time, just had to up the dosage once. Sertreline. Unfortunately after 2 years it suddenly caused horrible acid reflux, so i had to switch to venlafaxine

[@snakedoga97]

My very first try on an antidepressant was effexor and oh my god i was a whole new person. It took my food cravings away, it gave me more of an ability to focus, i was able to wake up in the morning before my alarm clock and was ready to take on the world, and at like 11pm i was drowsy and actually falling asleep and my mind wasnt racing all night long. I was on it for 9 days and ive never felt so good before. I had a pupilary reaction and my eyes were rapidly dilating and constricting and i couldnt focus my vision and it looked like i was going to pass out even though i felt fine. I was very difficult to do my job in the ER with this... So i stopped it and have now been on Wellbutrin for over a year. My emotions are definitely better managed but i keep being told wellbutrin does better in combination with something. I need to try to get in with a psychiatrist instead of just my pcp...i just wish i could get back on effexor 😂😂😂

[@matir1225]

Finally an episode about my meds! :)

[@3800S1]

Any chance of a video about antidepressant and related drug discontinuation syndrome and long haul variants such as protracted withdrawal syndrome? Basically the flip side of these meds that leave some people far worse post drug than they were prior to starting them. There is also a similar condition where people have neurological injury from an adverse reaction as oppose to having injury from the withdrawal itself. As one of those people, it would be good counter balance video to inform of the risks and consequences of these common drugs that are very often overlooked or not recognised.

[@robinsmith5442]

Back in the 1990's I was started on Zoloft and it was like night and day. It quit working after a few years, possibly after it went generic.

[@Psilomuscimol]

It has nothing to do with being generic. Your body gets used to drugs. Generic drugs are held to the same standards by the fda.

[@LindaVernon]

​@zechrussell4938 In Canada a generic my be different in effectiveness from the original (brand name) by 10% plus or minus. In psychiatric meds that can actually be a substantial difference. Even more so in medications for epilepsy. Even if your epilepsy is well controlled on a generic, the pharmacist will ensure that your prescription refill is the SAME generic manufacturer.

[@robinsmith5442]

@@LindaVernon thank you! I just wonder how much the inactive part of the drug changes things.

[@roxyiconoclast]

@@robinsmith5442 Studies of thyroid generics have shown the “excipient” ingredients actually do make a difference in effectiveness. I’ll bet it’s the same for other meds.

[@LindaVernon]

@@robinsmith5442 Sorry, missed your reply. About those ingredients I have no idea. :( I wish you well in finding something effective. 🙂

[@rickseiden1]

I've been on meds for decades. What scares me is that your body gets used to the meds you're taking, and you have to increase the dose, then your body gets used to that and you have to increase the dose. Eventually, you're taking the maximum dose, and have to switch medication.

[@MichaelDeHaven]

That does stink when/if it happens. But if you can get a second acceptable medication you can switch for 3 to 6 months. Usually after that time you can go back to the primary with its efficacy restored again. At least this works in my case with my neurologist. Best of luck.

[@haleyes98]

Yup! I was on antidepressants by the time I was 12 (it worked amazingly) and I am now fully treatment-resistant at 25. The last options left for me are MAOIs and electroconvulsive therapy because literally every outpatient treatment and pill (ADs & off-label meds) on the market. We desperately need more treatment options besides traditional antidepressants because our cases are far from unique.

[@Sandy33569]

@@haleyes98Have you looked into Ketamine/Spravato? I think that’s a newer option that’s alternative.

[@craigpardy6204]

​@@haleyes98I tried everything and the only thing that helped me was micro-dosing mushrooms for 6 months, now I'm off all the meds and I feel a 100 times better. I won't leave any website names here because there are far too many bots doing that here already but do a little searching and you can find grow kits cheap and simple to use.. Best of luck.

[@HamMack600]

The three month trial and error method is exactly how neurologists try to find migraine medicines as well. Migraine patients even use anticonvulsants and antidepressants occasionally. This solution could help us as well.

[@GunmadMadman]

Weird, I was just told to “start taking this” and it was never brought up again.

[@Magnymbus]

The first Psychiatrist I saw had me try four different arbitrary feeling meds before I stopped going... My current psychiatrist, on my first appointment, after a lengthy conversation about what problems prompted me to seek a psychiatrist again, she said something like "Well, no wonder the meds aren't working, kid! That's not just depression and anxiety, my friend. It sounds to me like you've been dealing with ADHD some cyclothymic comorbidity this whole effing time!"... She was not wrong... She has such a very "let's look at the evidence and interrogate the symptoms" approach. She's a private practice, and for some reason insurance companies don't want to book her, so it doesn't come cheap, but she was willing to spread payments out over however long until the followup appointment.

[@levnzt6949]

hi, please fix the source (canbind) also checking the other sources I don't really understand where you make the jump from predicting which SSRI was being used to what SSRI will be effective for a given person. There have been no studies into that direction yet and it would require explanation. Btw, the actual accuracy numbers were 64%, not "over 60%" This is a big difference if the placebo-group has been measured with an accuracy of already 49% Yet more arguably , specificity instead of accuracy percentage could be the bigger factor here since the algorythm should also determine the correct SSRI instead of "any" SSRI , especially with the proclaimed future use, so I wonder why you didn't mention it. Additional details left out: participants size was was 125 for Can-Bind and 105 for EMBARC (The studies themselves were much bigger but only these participants have been included for the language model because specific SSRI taken and other reasons) Yes, it's "just" youtube info-content but I remember that scishow content didn't "simple it down" as much in the past. Leaving out participant numbers and rounding data-values (over 60%...) are not scientific behaviours you should aim to maintain. I'm keep your content in high regard, so I'd really love to continue watching scishow in the future as well

[@frostblade42]

Oxford comma would have been really nice. I thought you were saying sertraline was essentially a placebo.

[@parkershaw3753]

That wouldn't be an Oxford comma. An Oxford comma is for a list of three or more things. It would have been clearer if they had said "either sertraline or a placebo" but adding a comma would make it even more confusing.

[@frostblade42]

@@parkershaw3753 ooooh See. I still hadn't understood it. Thank you. I thought it was all 3. But you're right. It's one OR the other.

[@nivoset]

This seems like a brilliant use of machine learning and also using the 'non swanky' machine to just be insanely useful

[@Ladypuppy510]

Omg. I need your shirt.

[@bbbenj]

Thanks.

[@lightningwingdragon]

I luckily enough was able to get mine on the first try and it's worked for me Not trying to quote but I guess I was one of the very lucky few and I feel very lucky

[@maxblast8210]

Good to know that they might find one that works for me the day before I die of old age.

[@nicholasheimann4629]

St John's wort works well; just be careful about its bad interactions with certain drugs.

[@tamfuwing1]

It's not properly regulated and can make depression much worse. Stay away.

[@nicholasheimann4629]

@@tamfuwing1 In 1st world countries like the U.S. there are standardized supplements read the bottle and make sure to have a washout period of other drugs you might be on first. In combination with lifestyle changes that reduce stress and the implementation of certain psychological techniques, it can actually cure depression in a matter of months. For some people, they only need to take it twice a day for 3-4 months and they have long-term remission from depression. This is for regular depression rather than bipolar or whatnot so study it out first.

[@johntouchet7178]

About DNA/RNA. How does a gene for hair or feathers know where to produce its protrusions?

[@whisper3856]

I miraculously had my first antidepressant work great for me. Hope this works well and gets better. Even a 1/2 chance is much better than the literal dice roll it is rn.

[@jeanjaz]

I was put on a low dose of an anti-depressant to treat PTSD. Later, for a different reason, my doctor wanted me to take a test that mapped some of my DNA. It was somewhat expensive and Medicare wouldn't cover it, but I decided to do it anyway. It took awhile for the results to come back but it turned out to be worth it. I turned out I was talking the wrong anti-depressant for my chemistry, plus there were some other suppleness I needed to be taking. (Something to do with Folic acid.) My doctors can make better suggestions for my treatments based on these DNA results. I'm sorry I don't know the technical side of this test or it's application to my health. Maybe someone more knowledgeable can comment on it or you can ask your doctor.

[@gamingnerdgirlz]

60% is still a good base line start. i use Wellbutrin and Sertraline. i can say both are great together for me. i have train another before this and the side effect of heat flashes was often. these drugs are generic and less side effects. i am happy they work. its like i am normal again and not thinking negative and joy-less.

[@memyself12345]

I have been depressed my entire life so I can’t tell if an anti depressant is working. It’s only when I stop when I realize that when I was taking it I might have been slightly less depressed. But the difference is never enough to know whether something is working

[@CrimsonCat87]

@3:33 - Chris Hope got a good picture! Narration fits the image, too - this is "swanky", 64-lead EEG. Standard is 32 leads. 64 and 128 is for fancy pants science studies.

[@NotSoNormal1987]

I wish I could have had this when looking for the right medication combo for me. It took over a year to get it right. But I have bipolar disorder with depression that is hard to treat, I get seasonal depression, i've got an anxiety disorder, and there's adhd to top it off with. Figuring out what is right for me was very hard. And it involved a hospital stay when my meds were being adjusted. Fun times.

[@Danielle_1234]

The reason there is so much trial and error is because there are multiple kinds of depression. When one can identify the exact type of depression they have, curing it becomes somewhat easy. The difficulty is in identifying exactly what kind one has, because symptoms can overlap. It's not obvious without a deep and sometimes lengthy inspection exactly what the issue is. Most difficult to solve medical problems work this way. E.g. type 2 diabetes has multiple genetic precursors. Some people get insulin resistance from eating certain kinds of fats. Others get insulin resistance from eating certain proteins. When one gets a genetic test they can identify exactly what kind they have and can use that knowledge to increase their insulin sensitivity so they can safely eat carbs again. It's not just psychological issues nor is it physiological, any challenge that has multiple causes is difficult to solve.

[@rlud304]

What are you blathering with your nonsensical word salad?🤦🏻‍♀️

[@sora15151SomethingAppropriate]

I'm very fortunate and actually got the a medication that works really well for me on my first try!

[@johndemeritt3460]

I'm curious about MRI studies of depressed people's brains. Does anyone know about such studies?

[@anthonyshiels9273]

A few years ago I was prescribed an antidepressant for my anxiety issues. It did absolutely nothing for my anxiety but the side effects were not so pleasant, muscle pain and stiffness in my joints. Anxiety disorder is NOT depression.

[@badmonkey244]

Every time I get distracted by that absolutely awesome flamingo shirt, no matter how interesting the topic is 😅

[@archerelms]

Not only did I not get the meds right on the first try, even with a blood test, I think was the FOURTH one that stuck. Thankfully I even found another one that worked after that, and it works even better! But it's more expensive, my insurance doesn't like it...

[@grahamrankin4725]

I went thru several antidepressants. However, it was because of which particular drug was on the formulary of my insurance.

[@Qaos]

Would this be able to detect susceptibility to serotonin syndrome? Because that's likely what caused my seizure with my first antidepressants

[@chasewebb4377]

I was actually lucky enough to find my med combo with my first try. My health professional used a dna test

[@rlud304]

That’s not a thing🙄

[@chasewebb4377]

@@rlud304 ... what's not a thing?

[@OMGitsGODx]

I lucked out and got my happy pills right the first time. Literally a week in and it was like a light switched on and all of a sudden, everything was just... happier.

[@zeyata-cicero-herron4608]

There's a game from 2015 about a man going in for a scan to get help with his head; it didn't go well for that man.

[@aspidoscelis]

A pessimist might suggest that our lengthy "keep trying different antidepressants until you find the right one" process is just a way of dragging it out long enough that people improve on their own. It's a version of the multiple comparisons problem from statistics-something always has a significant relationship to [x] if you try enough somethings.

[@aspidoscelis]

In other words, it's not clear that there is something there for machine learning to learn-that the "find the right one" therapeutic model is based in reality to start with.

[@Sprinklgrl]

Can you run an already taken EEG through the same algorithms?

[@petra1995]

...I actually found the right antidepressant for my anxiety right away 😅

[@ompalompalompa2041]

What about the new magnetic treatment that seem to work on many people with chronic depression?

[@MikiM89]

everyone should know about the work of Apollo Neuro!

[@MossyBear]

genesight is right here, I wish we would make that more widely available

[@roxyiconoclast]

Also there’s at least one other test, Clarity.