Isaac PILLS Ranked by USEFULNESS

[@samba1one531]

I don't think I've ever used a "somethings wrong" pill in combat. I pick it up from a room clear, use it, and never find one for the rest of the run.

[@dannacoleman5189]

Or that becomes the only pill you find 😭

[@pedroking2262]

You know it's your lucky day when you can use the explosive diarrhea or something's wrong pill

[@envandrare]

I used it in combat once. A fatty enemy walk a bit slower and that's it. It dried up.

[@electric_6323]

i thought you were just gonna rank the pills by their colour 😭🙏

[@AnotherMattPlayingIsaac]

LMAO

[@JaxontheOkay]

that red and speckled one TOPS

[@schizopenguin]

​@@JaxontheOkaynah dude that ones always like a tears down or amnesia, f tier pill fr

[@chorizord6974]

Double blue f tier

[@NurseryDBD]

new video idea

[@AxelJohannAmazeen]

Matt: “I can’t even think of a scenario where a range down pill would be useful *_Monstro’s Lung users:_*

[@Victinitotodilepro]

also haemo if the range is alr too high

[@aurum678]

@@Victinitotodilepro when you're fighting beast and your range is so high it hits the moon instead

[@rijsmiddel8765]

If 'I Found Pills' is -4, 'Paralysis' should be. They both, essentially, do absolutely nothing.

[@greenagoo]

Paralysis can actively fuck you up if you just grab it and use it in a hostile room like a dummy because it hasn't been identified yet.

[@vaporizer200]

it activates echo chamber, both are good

[@yanik5480]

paralysis is a lot more annoying because if you use it in a hostile room it screws you over and if you’re outside one then it just wastes time

[@stupidman5735]

same with retro vision

[@Krocakyle]

Both give black hearts with false phd.

[@nathanieljones8043]

Is pretty fly underrated i have never heard of someone saying that it isn't the best pill as long as it does something.

[@AnotherMattPlayingIsaac]

I feel like everyone knows it's good but no one talks about it

[@JJroks543]

@@AnotherMattPlayingIsaac I feel like that's because 1. A lot of people skip pills and 2. Pretty Fly isn't the most common pill, so people probably aren't seeing just how good it can be.

[@scramble76]

6:36 you could argue that i found pills has use with placebo and book of virtues since the charge will only be 1

[@Boonetube27]

9:25 could’ve ranked the stat down pills in terms of usefulness with false phd? Like shotspeed down is a take even without false phd, but I’d never take a tears down for almost any reason.

[@HermanTheWolf]

Now rank all pills (including horse pills) by how cool the narrarator says them

[@XDTheEmoticon]

We getting pill-pilled with this one 🗣️🔥💯

[@AnotherMattPlayingIsaac]

i'm pill pilled all the time 🗣️🔥

[@thelegendaryrat]

I've taken range down pills before when I have arced shots (haemolacria, ipecac) and have been happy to see them because range is kinda annoying on both, but yeah it's annoying most of the time

[@PJsutnop]

Note on the drowzy pill: unlike stop watch it seems to also slow down the player, which is usually fine except there are some effects in the game that can't be slowed. For example, I used this againt hush once and were literally unable to run away from the tear pillars at the end, as they aren't slowed down

[@julienmaret1877]

I dont get why bomb are key is neutral. It may not be that impactfull but it's not rare to have a ton of usless bombs if you get stompy or can break the rocks/walls with your tears, or have a ton of useless keys because of paper clip or money talks. In all the cases where your generation/need ratio of keys and bombs is not the same the pill is usefull.

[@denalpha4056]

So... Good pills, good and bad pills are bad? That was really worth almost an hour of watching

[@dorianshrv6967]

Yeah like is the next video ranking floor by their difficulty and putting the last floors in the most difficult tier lmao

[@massivemansbiggestplan]

You asked

[@updownbanana]

literally one of the first things he does is rank a bad pill as useful because it has actual utility

[@CartoDarko]

if you think it's dumb then you're dumb for sitting through it my guy 😂

[@thisguyisfine1512]

pill maxing

[@matt.w]

Stoic Stick moment

[@alsenddrake7764]

Tears Down - you may cry, but youll do it slower

[@serafimbarbu7711]

Shot speed up synergizes well with Proptosis. Even though the game says "short range mega tears" it's actually the amount of time spent in air which decreases the damage. It's the opposite of Krampus charcoal.

[@Raii_Chu]

Okay, I subscribed because of the Subscribe-Pill being so very useful

[@Chuckle_44]

There is a very niche scenario when a tears up pill could be bad when going for data-miner rig

[@dannacoleman5189]

Explain please?

[@deringjosuegarcia1531]

They didn't explain

[@monstergamer5467]

@@dannacoleman5189when you go into the negatives in tear rate with data miner, it will loop back around and give you max tears instead

[@dlp6567]

​@@dannacoleman5189 Dataminer is so utterly unhinged that, if you are immensely lucky, it can make you tear stat go so low it literally UNDERFLOWS ingame and rolls from the lowest tear rate (0) to the HIGHEST (120). So yeah, if you are able to endure the immaculate 0.12 tears gameplay for 3 floors, this miracle MIGHT just happen to you.

[@dannacoleman5189]

@@dlp6567 makes sense

[@Bob_the_awoken_one]

The only thing good about the I found pills pill is the "I FOUND PILLZ!!!!1!!!!!!¡!!!1!!!!!!!"

[@JimBob-vg2og]

Didn’t know what Gulp did after hundreds and hours playing, thanks 😂

[@heeblybeebly]

hematemisis can spawn different hearts in super secret rooms (like the eternal heart/black/bone heart ones) thats pretty good

[@Samb11-vk2bh]

Ah yes, my favourite pill: Of

[@AnotherMattPlayingIsaac]

c l i c k b a i t e d

[@tiernanbonnar4212]

I mean, there is a scenario where getting more tear rate is bad, but it’s an item, not a pill.

[@Fsmit_uwu]

Can you do a video ranking all transformations the video may be short but it may be a good guide for players who are new to the game

[@KerranJast1337]

Friends till the end is actually a more consistently good version of infested? with no enemies, since it guarantees 3 flies, and repentance changed it so that blue flies and blue spiders deal the same damage to enemies. Loved the graphics you did for the video!

[@serafimbarbu7711]

I'm excited can help when farming loot in the arcade, it can also help after clearing all the floor and farming IV bag from donation machine. That's why the game says it's "neutral".

[@NagaTheOctopus]

Range down is very useful specifically on forgotten and Tforg because they never fixed the bone

[@AnotherMattPlayingIsaac]

yeaaa but there are just too many ifs for it to be good for any reason lol. IF you're playing forgotten, IF you have too much range like its wayy to specific so its just bad 99.999% of the time lmao

[@azula5646]

​@@AnotherMattPlayingIsaacI'd still say range down is -3 instead of -4 because there's still *a* way to benefit from it, and if you can't benefit from it, range is still the least useful stat

[@Sugarman96]

@@AnotherMattPlayingIsaac I regularly get too much range if I'm playing Forgotten, and I have to consciously watch my range stat, I don't know if it's _that_ specific.

[@AnotherMattPlayingIsaac]

@@Sugarman96 just stop picking up the range ups lmao

[@Sugarman96]

@@AnotherMattPlayingIsaac But picking up the items makes me happy

[@prism_protector128]

As an Azazel main, Range Up should be top of the list. i love popping those pills.

[@amymialee]

Had a run where I kept getting absurd amounts of health ups and I had to spam Health Down to be able to use soul hearts lmao

[@DOOM_glazer]

No clue wtf the items I had were but I recently had a run where every 2 to 3 rooms I was getting a heart container and literally couldn't ever get soul hearts

[@costcoRBLX]

@@DOOM_glazerbinge eater real

[@bigdumpygaming]

pillcels seething over cardchads

[@raymaikeru]

As someone who played keyboard and controller.. Ima be real there are moments where I want a Speed Down Pill. However, this is only if I'm playing keyboard. The difference? If playing with controller, you can slightly nudge the left stick to make Isaac move more slowly, potentially acting like a "fine tune" dodge option, especially whenever I'm dealing with Hush. Keyboard? You got no way to "walk", only run. Having only one speed, and having a high speed, can make it tough to dodge barrages of projectiles. So for me I try to keep a balanced speed, like 0.9 to 1.5. The moment I go over it on keyboard, I am just BEGGING for a Speed Down pill to make it easier to control.

[@noxthedremoralord2683]

The only times I say “Yeah range down!” Is when my forgotten run has a much range the bone’s bit is is super disjointed

[@Tymbee]

Shot Speed Down is actually super useful in a few cases. If you get an item like something like Trisagion, Tech X, or Godhead, it can directly increase your damage. It also makes homing shot effects more reliable. Honestly, if I reveal an early Shot Speed Down on Basement 1 or 2, I'll try to go Angel deals just because of all the potential synergies and homing items.

[@DOOM_glazer]

Also trisagion

[@Krebboi42]

Range down can be a life saver on T. Forgotten.

[@Ventii128]

I'd personally put luck up at +3 because unlike something like tears there is no cap and a ton of items have positive stuff with luck now

[@catcatharsismusic]

The thing about pills is that i never pop them in hostile rooms, so a lot of the offensive ones mean nothing

[@alexlorius]

Finally, the drug tier list

[@yeahyeah5338]

One downside for tears up is t-lilith if her tear rate is too high it's much harder to slap with gello

[@Damonnanashi]

Man, that Mario Paint music is really taking me back. Fantastic music choice.

[@Krocakyle]

Bad gas can knock back tears. Basically a parry pill.

[@mrmechpunch4653]

Range down is useful for a few scenarios. One of the few you mention is ipecac, but also hemolachria and dr.fetus. (also there is a chance for a synergy with Infested and card against humanity. Altho I understand that relying on a low chance gimmick is not the way to play issac.)

[@firegamingsuppp3592]

I've used lemon party for offense at floor one AND THAT MOFO MONSTRO GOT MELTED

[@The_Deep_Blue]

7:17 why does it mention zits? maybe i'm misremembering but there are no zits on his face it's only the hair 9:23 if you have monstro's lung you'll have a wider spread so you may enjoy that sidegrade

[@Belutsy]

range down can be specially usefull when playing the forgoten mostly becausae if you get too much range your meelee starts way further than your hitbox leaving blind spots right in front of u

[@aHamBroth]

I once got so many size down pills and items (like binky) that I was smaller than a fly and the true challenge of the run became picking up items bc my hit box was so small

[@gumbarius]

The I Found Pills placement is so funny, because you are basically saying nothing is worse than a slightly negative effect

[@lilchromie]

Range down is very useful if you are playing forgotten (especially t forgotten) and accidentally fuck up your range stat

[@----nobody-----]

and with monstros lung

[@muppymup3962]

Got a hot take, some of the stats down pills have a use. With false phd i love seeing a range down or a speed down. Health downs are great if im the lost but thats rare.

[@JaxontheOkay]

29:10 correction, spiders now do the same damage as friendly flies. why they changed this, i don't know. i felt it was balanced well considering spiders have worse mobility and are rarer but oh well

[@Vinnus0824]

I'm pretty sure that pretty fly is also permanent, so that's even better.

[@QUANTUM-_-]

8:37 does this deal damage to the boss thats like. Made out of flyes and has a like. A fake face? Idk its name

[@maigidraggnel20]

I can say bombs are keys can work a little bit in rigging, but maybe just a little

[@V-O-I-D64]

26:01 counter argument, Card Against Humanity

[@HexanTronic]

I think you forgot Horse Pills. Maybe a separate Tier list?

[@vandakarabeyan899]

9:20 the only time im like “yay!range down” is when im forgotten or have spirit sword and have WAY too much range and i can barely do any danage

[@jayyh_01]

28:42 i didnt even know what the filter did until today. after god knows how many years, i thought it was a gore filter. idk why its a setting but

[@S_yIvie]

12:18 I am ecstatic when Im playing as the Lost and accidentally picket up blind fire mind

[@deusphage9149]

Range Down is good if you fuck up your Forgotten or Spirit Sword range

[@deusphage9149]

Edmund please for the love of God make range affect swung weapons logically and not move the hurtbox 2 miles away from the weapon

[@timeparadox999]

worst feeling pill of all time is bombs are key on tainted blue baby. your bomb count becomes nothing because you don't have bombs, and your key count becomes zero because you don't have bombs

[@ViIvaNunner]

i feel like theres a case to be made for most if not all of the stat downs in negative never want to be at least a ring up from never want - if i have no other pocket consumable thats worth bringing with me usually i hold on to stat down pills if i can find them just for the small chance i find phd; lucky foot; virgo or false phd its a minor thing but to me i wouldnt call them completely skippable never wanting them; since the potential to convert them is pretty nice if you got nothing else to hold onto

[@cptspan1sh]

range down pill is good with monstro's lung, so it deserves a -3 at least

[@blueresonant5788]

Don’t forget, health down can help balance your health if you have too many heart containers and are unable to take soul hearts to protect your deal chance

[@scor-chii1671]

If you have an item like trisigon or Tech X a shot speed down pill is basically a Damage Up I hate getting shot speed ups with items like that

[@AzazelAlice]

I would argue some of the stat down pills are good if you have false phd, so at least they should be at -2 or -3, not -4

[@HexanTronic]

There is some situations where Tears Up would be bad. Some that come to mind are IPECAC, as well as Doctor Fetus.

[@victorkao1472]

9:23 range down pills are good with monstro’s lung. I’d argue also ipecac and haemo too. Too much range with melee characters especially like t forgotten is bad as well

[@cuteanimegrill151]

Speed down is sometimes usefull because I hate too much speed, at 2.0 it is hard to dodge

[@McDouble-op6il]

9:25 head trauma challenge more damage in little area

[@chigchog]

i got 600 hours on isaac and never realised there was more than one infested haha. I always just popped them and thought nothing of it.

[@RichConnerGMN]

please use something for nearest neighbor upscaling so sprites don't look blurry

[@jadeharIey]

Damn that clickbait worked wonders I really clicked to find out why golden pills were bottom tier 😭😭😭

[@jordandillardthememeboi]

Imagine this scenario, You're playing as The Lost or Tainted lost you have a godly run and you go in the curse room but, Oh No you got hit in there you're now going to die and lose this amazing run but you remember Oh Yeah I have a Telepills you use it and now you saved the run

[@fredohonius]

24:00 I have not played much of the game, but where does the hitbox stay then if you get bigger? Near the legs or near the head? Also at some point if you take "one makes you larger" you can stomp through rocks right? So you should go as far as to unlock the stomp effect then you should not take any more, correct?

[@justicepenguin7996]

Hit box is near the legs. Stomping through rocks can be dangerous if you touch a mushroom, bomb rock, and some rocks in womb burst into tears. Not bad, but still some downside to look out for.

[@fredohonius]

@@justicepenguin7996 thank you, I’ve known about the game for a while but just got into it recently. The mushrooms are definitely a hazard in that case yeah, never thought about that

[@Kapados_]

all hitboxes in the game are at the shadows on the ground

[@Kyropinesis]

i think i've used Lemon Party offensively once in my 640 hours of playing this game

[@DOOM_glazer]

I'm guessing that was in the when life gives you lemons challenge?😂

[@pikminman13]

i always "golden pill or no balls". i never take pills otherwise without lucky foot or phd or virgo (or if i forgot something, that too). false phd maybe.

[@Bob_the_awoken_one]

Pov you get bombs are keys when you get pyro: 🗿

[@trashpanda003]

Non pill enjoyers realizing they can gulp balls for 2 soul hearts 😳

[@soproductions2340]

range down is a range up with monstros lung :)

[@Sombrita00]

Range down could be useful, there's some runs i do want to find

[@Toumsters]

i have beef with the range down pill because when i was doing a dataminer run trying to get the funny number on one of my stats it already kept taking from my range, to the point i had 1.5 range then, this asshole pill decides to show up and because it cant even take a full 1 off of my range im stuck with 1 range as tlost to the point im using ball of bandages because it has the same range and higher dps than me and then, i find sausage from chaos, and it cant even make my range go up because of the range down pill holding a grudge and putting me in debt instead of letting me shoot farther than i could swing

[@greenshell1251]

NEVER use the i'm drowsy pill against hush. worst mistake of my life

[@amy_ama]

I use pheromones, but more in desperate way than offensive one

[@rappingtoad6168]

On their own, range up pills belong where they are on the list, but throw in libra+placebo and that's just infinite stats SS tier

[@ghostlessmusic2805]

Dam I think tears down is pretty goated ngl

[@Angreface]

I LOVE TAKING PILLS!!!!

[@user-zp9nf5qo8j]

So you think a pill that does nothing is less useful than a pill that makes you not move

[@dannacoleman5189]

Range down pill use: haemolacria, Ipecac, and forgotten when range is too much

[@simonw.1223]

12:02 too many bombs trough dr fetus?

[@isaacfaria5220]

I really like watching this videos, knowledge about The Binding of Isaac is never to much 🙃

[@theRedGman]

I thought it was going to be based of being usefull irl

[@serafimbarbu7711]

Luck up underrated asf

[@vladroman815]

Idk why but i always hear "imera room"instead of I AM error room

[@matt.w]

Shot speed up is the only positive, but not useful pill. Idk why, but it's kinda sad for Shot speed up pill.

[@marooniballooni03759]

balls of steel on bethany sounds pretty good.

[@agneccofgaming9316]

You want any stats down pills if you have false phd

[@zomble_Guy]

Pretty fly is my favourite pill.

[@monke8839]

I eat every pill I see and it never works but it's fun so you should do it too 😊

[@JyAre774]

Balls of Steel!!!

[@chrom_mage]

range is reversed for monstros lung. the other mat knows this smhhh also i believe edmund reversed the spiders doing more damage also also golden pill vuro doesnt give golden pill

[@emilydioptase]

I found pills is decent enough with Acid Baby.

[@deringjosuegarcia1531]

Almost every pill is decent with Acid Baby