Islet Cell Replacement & Diabetes Research | Dr. Manasi Jaiman, MD, MPH | TCOYD Podcast #54

[@greentokyo]

Great episode! I really hope they can speed up the process of making this! Please keep us updated!

[@TCOYDtv]

We will for sure!

[@sharongerdik6959]

I have been a T1D for four decades. I gained so much weight over that time and I just couldn't lose it. I started Ozempic three years ago for Insulin Resistance. I cut my insulin usage by 1/3. I lost 75 pounds over 3 years. I feel and look so much better. I never had nausea from the Ozempic. I realized it was because I've been taking CBD gummies with NO THC for 5 years, 2 years before starting Ozempic. It changed my life. I now sell these reputable USA gummies. Hang in there and be your own advocate. Find an endocrinologist who will listen to you and have your best interest in mind.

[@TCOYDtv]

Wow, congratulations! You lost weight slowly over 3 years and avoided nausea...impressive!

[@seanmartin8007]

I see you mention CRISPR but have you heard about 1. More targeted or localized immunotherapy like tegoprubart or the iTolerance trials OR 2. Using Mesenchymal stem cells to protect the islets like Symbiocelltech (company in Utah) are doing? This method should be in trials in 2025! Promising stuff!

[@TCOYDtv]

Hi Sean, We shared your comment with Dr. E, and here's his response: "To be honest, I do not know, but always happy to learn from folks like you! And this is a hot area, so there's probably even more than you and I know."

[@seanmartin8007]

Yes much more than I know for sure. But the next few years should be exciting to watch since there are so many innovative ideas being tested to stop the immune attack. Great video by the way!

[@TCOYDtv]

Agree...and thank you so much!

[@besnkinic]

may the most lucrative solution to maintaining T1D win! cant wait to see how much this will cost us

[@TCOYDtv]

Everything seems to be very expensive these days. But if it does cure my type 1, I will beg, borrow and steal to pay for it! 😉

[@mrandolph2720]

I am a Type 1 diabetic. I have taken insulin injections many times in my thigh and then I do HIIT (intense sprinting) for 12-15 minutes and then I do a lower body weight workout. I have never seen a decrease in my BG levels over the next hour after I take my pre-workout injection. Same for when I inject insulin in my tricep and then I do tricep and upper body exercises and I have never noticed my BG levels going lower. What are possible explanations for my BG levels not going lower? I should say that after I do a weightlifting session for 30-45 minutes and then I take insulin, my BG level will significantly go lower starting 45-50 minutes later. Is 12-15 minutes of anaerobic exercise not long enough to cause my BG levels to go lower even when I inject Humalog in the muscle I am working out?

[@TCOYDtv]

I don't know the answer to that question, but whatever you're doing is working well. Typically people can avoid getting low if they exercise in the morning, or by lifting weights before doing aerobic exercise, and for some reason you seem resistant to getting low. I'm not sure if it's because you have not given yourself too much insulin within 2 hours of exercise, but it's always good to go not immediately after eating, because then you have bad bolus on board. I don't have the answer, but your results are impressive. You can try reaching out to Dr. Mike Riddell who is a T1D exercise researcher at York University. [e-mail]

[@theresadavis5008]

Hypothetically could islet cells be put in a capsule/ pod/ patch with a very short tubing & moved every few days like a pump sit change?

[@TCOYDtv]

That's a very good thought, but the islet cells would not survive being on the outside of the body. They only start to work once they're in the body receiving nutrients and a blood supply, so unfortunately that would not work. But it's a nice thought!